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  • lymphoma
  • He led the initial clinical trials of the drug that resulted from the team's research, later known as rituximab, which demonstrated its safety and activity against CD20-positive B cells in patients with lymphoma. (wikipedia.org)
  • In 1997, rituximab became the first monoclonal antibody drug for cancer on the market, revolutionizing treatment for B-cell non-Hodgkin lymphoma. (wikipedia.org)
  • Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma. (wikipedia.org)
  • It is defined as a lymphoma of follicle center B-cells (centrocytes and centroblasts), which has at least a partially follicular pattern. (wikipedia.org)
  • Grade 3 is further subdivided into: grade 3A (centrocytes still present) grade 3B (the follicles consist almost entirely of centroblasts) The WHO 2008 update classifies grades 1 and 2 now as low grade follicular lymphoma, grade 3A as high grade follicular lymphoma, and grade 3B as Diffuse Large B Cell Lymphoma (DLBCL). (wikipedia.org)
  • On 5 June 2013 the FDA designated lenalidomide as a specialty drug requiring a specialty pharmacy distribution for "use in mantle cell lymphoma (MCL) in patients whose disease has relapsed or progressed after 2 prior therapies, 1 of which included bortezomib. (wikipedia.org)
  • tumor
  • Mechanistic studies showed that this compound mediated its cytotoxic effects by inducing tumor cell apoptosis through activation of caspase-3, but it did not inhibit DNA topoisomerase II? (jove.com)
  • This may kill more tumor cells while causing fewer side effects to healthy tissue. (clinicaltrials.gov)
  • Donor leukocyte infusion is the infusion in which lymphocytes from the original stem cell donor are infused, after the transplant, to augment an anti-tumor immune response or ensure that the donor stem cells remain engrafted. (wikipedia.org)
  • Another explanation of this observation is provided by a study that shows the ability of CXCL12 (and CCL2) producing tumors to entrain neutrophils that inhibit seeding of tumor cells in the lung. (wikipedia.org)
  • Frei and Peters developed the Solid Tumor Autologous Marrow Program (STAMP) regimen. (wikipedia.org)
  • 2010 Application of HLA-A*0201/WT1 pentamer combined with intracellular IFNgamma+ staining in detecting circulating WT1 specific T cells in leukemia 2010 "Comparison of Wilms' tumor antigen 1-specific T lymphocyte generation soon after nonmyeloablative allergenic stem-cell transplantation in acute and chronic leukemia patients", published in Int J Hematol. (wikipedia.org)
  • Two cytokines that down modulate FLT3 activity (& block FLT3-induced hematopoietic activity) are: TNF-Alpha (Tumor necrosis factor-alpha) TGF-Beta (Transforming growth factor-beta) TGF-Beta especially, decreases FLT3 protein levels and reverses the FLT3L-induced decrease in the time that hematopoietic progenitors spend in the G1-phase of the cell cycle. (wikipedia.org)
  • Rarely, the first sign of leukemia may be the development of a solid leukemic mass or tumor outside of the bone marrow, called a chloroma. (wikipedia.org)
  • immune
  • Replacement or modulation of an absent or poorly functioning hematopoietic or immune system. (nkch.org)
  • The generation and efficacy of donor lymphocyte infusions of T cells, including the traditional use of CD4+ and CD8+ _T cells, T regulatory cells, and the efficacy and mechanisms of innate immunity generated against leukaemia by _T cells and NKT cells are detailed, as are the implications of using dendritic cells to generate antigen specific adaptive immune responses towards leukaemia. (lincoln.ac.nz)
  • At the time, patients who underwent bone marrow transplantation all died from infections or immune reactions that weren't seen in the rodent studies. (wikipedia.org)
  • Building on his expertise with antibody-based cancer therapy and reduced-toxicity treatment approaches, Maloney is developing adoptive T cell therapy for cancer using chimeric antigen receptors, or CARs, synthetic versions of T-cell receptors that incorporate cancer-targeting antibodies, which allow the immune cells to specifically target cancer cells. (wikipedia.org)
  • These donated white blood cells contain cells of the immune system that can recognize and destroy cancer cells. (wikipedia.org)
  • Mature lymphocytes are infection-fighting immune system cells. (wikipedia.org)
  • IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant. (wikipedia.org)
  • In malignant B cells, miRNAs participate in pathways fundamental to the cells' development, such as receptor signalling, migration/adhesion, cell-cell interactions in immune niches, and the production and class-switching of immunoglobulins. (wikipedia.org)
  • patients
  • and the limited ability to use autologous stem cells to treat patients not in remission or with inherited nonmalignant lympho-hematopoietic diseases (Table I). (renalandurologynews.com)
  • Historically, most patients received high-dose cytotoxic therapy, the intensity of which was reached by determining non-hematopoietic end organ toxicity, that is, the highest non-lethal dose that could be rescued with transplanted hematopoietic stem cells. (oncologynurseadvisor.com)
  • Change in the engraftment rate of patients with non-malignant diseases (Stratum A) undergoing allogeneic HCT as compared to historic controls [ Time Frame: Participants will have engraftment blood studies starting approximately Day 30 post hematopoietic stem cell transplant and then monthly until stable. (clinicaltrials.gov)
  • Change in the full donor chimerism of patients with high-risk myeloid malignancies (Stratum B) undergoing allogeneic HCT as compared to historic controls [ Time Frame: Participants will have peripheral blood chimerism assessed at Day 100 post hematopoietic stem cell transplant and then monthly until stable. (clinicaltrials.gov)
  • Intensively treat malignant cells in patients with cancer. (nkch.org)
  • Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients older than 50 years of age," Blood , vol. 105, no. 4, pp. 1810-1814, 2005. (hindawi.com)
  • Risk factors for pericardial effusion in adult patients receiving allogeneic haematopoietic stem cell transplantation," British Journal of Haematology , vol. 169, no. 5, pp. 737-745, 2015. (hindawi.com)
  • Incidence and risk factors of probable and proven invasive fungal infection in adult patients receiving allogeneic hematopoietic stem cell transplantation," Journal of Microbiology, Immunology and Infection , 2015. (hindawi.com)
  • His expertise will be invaluable to our patients and to our team, as well as expand our services in our Blood and Marrow Transplant program. (nationwidechildrens.org)
  • The risk of sinusoidal obstruction syndrome in the pediatric population is not limited to a well-defined group of high-risk patients who have undergone transplantation. (medscape.com)
  • The company is developing a diverse pipeline based on its nicotinamide-, or NAM, -based cell expansion technology, addressing limitations of current cell therapies to provide new treatment alternatives for patients. (businesswire.com)
  • STEM CELL INFUSION: Patients undergo autologous peripheral blood stem cell transplant (PBSCT) on day 0 per standard of care. (clinicaltrials.gov)
  • Maloney leads an early-phase clinical trial for patients with certain advanced, treatment-resistant CD19-positive B-cell cancers, in which patients' CD4+ and CD8+ T cells are genetically engineered to express a CD19-specific CAR. (wikipedia.org)
  • Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation.Blood, 98(13), 3505-3512. (wikipedia.org)
  • Marcel R.M. van den Brink (born 1960) is a Dutch hematologist and researcher who is an expert in hematopoietic stem cell transplantation for cancer patients. (wikipedia.org)
  • Formerly, the only treatment option that offered relapsed bone marrow transplant patients hope of a cure was another bone marrow transplant. (wikipedia.org)
  • WHIM like mutations in CXCR4 were recently identified in patients with Waldenstrom's macroglobulinemia, a B-cell malignancy. (wikipedia.org)
  • The "Plasticity" of hematopoietic stem cells (HSC), i.e. the differentiation of HSC into cells of other organs, was intensively studied with Alexandros Spyridonidis in patients after allogeneic bone marrow transplantation. (wikipedia.org)
  • As a member of the clinical (Director Bayard Clarkson) and laboratory teams (Director Malcolm A.S. Moore), he carried out a systematic analysis of all patients with acute myeloid leukemia (AML) treated at MSKCC, defining the prognostic and predictive parameters of cell cytology, cell growth in vitro and enzymatic markers. (wikipedia.org)
  • The 6-year LFS and OS were 76.4% and 82.1%, respectively, in patients who received a high dose of donor CD3+ T cells, which were significantly higher than the LFS and OS in patients who received a lower dose of donor CD3+ T cells (49.5% and 55.3%, respectively). (wikipedia.org)
  • Absent these causes, patients were diagnosed in the World Health Organization's classification as having either 1) Chronic eosinophilic leukemia, not otherwise specified, (CEL-NOS) if blood or bone marrow blast cells exceeded 2% or 5% of total nucleated cells, respectively, and other criteria were met or 2) idiopathic hypereosinophilic syndrome (HES) if there was evidence of eosinophil-induced tissue damage but no criteria indicating chronic eosinophilic leukemia. (wikipedia.org)
  • A human study of IL-7 in patients with cancer demonstrated that administration of this cytokine can transiently disrupt the homeostasis of both CD8+ and CD4+ T cells with a commensurate decrease in the percentage of CD4+CD25+Foxp3+ T regulatory cells. (wikipedia.org)
  • Associated with antiretroviral therapy, IL-7 administration decreased local and systemic inflammations in patients that had incomplete T-cell reconstitution. (wikipedia.org)
  • High levels of wild-type FLT3 have been reported for blast cells of some AML patients without FLT3 mutations. (wikipedia.org)
  • for refractory AML - particularly in patients who went on to have a stem cell transplant. (wikipedia.org)
  • On July 1, 2004, in pursuit of a mission to improve transplantation access and outcomes for patients, the CIBMTR was established. (wikipedia.org)
  • Investigators, physicians, patients and others interested in hematopoeitic cell transplantation (HCT) outcomes can access these resources below. (wikipedia.org)
  • Lenalidomide was approved on June 17, 2013 by the European Medicines Agency for use in low- or intermediate-1-risk myelodysplastic syndromes (MDS) patients who have the deletion 5q cytogenetic abnormality and no other cytogenetic abnormalities, are dependent on red blood cell transfusions, and for whom other treatment options have been found to be insufficient or inadequate. (wikipedia.org)
  • One Phase 3 clinical trial being conducted by Celgene in elderly patients with B-cell chronic lymphocytic leukemia was halted in July 2013 when a disproportionate number of cancer deaths were observed during treatment with lenalidomide versus patients treated with chlorambucil. (wikipedia.org)
  • Leukemia
  • Nonablative versus reduced-intensity conditioning regimens in the treatment of acute myeloid leukemia and high-risk myelodysplastic syndrome: dose is relevant for long-term disease control after allogeneic hematopoietic stem cell transplantation," Blood , vol. 104, no. 3, pp. 865-872, 2004. (hindawi.com)
  • Lee CJ, Shiraz P , Muffly L, Pharmacologic maintenance strategies following allogeneic hematopoietic cell transplantation for acute myeloid leukemia. (stanford.edu)
  • Immunoglobulin and T Cell Receptor Gene High-Throughput Sequencing Quantifies Minimal Residual Disease in Acute Lymphoblastic Leukemia and Predicts Post-Transplantation Relapse and Survival. (stanford.edu)
  • In the past 10 years, significant progress has been made in basic and translational research using human embryonic stem cells (hESCs), with specific implications for pediatric diseases such as hypoxic-ischemic encephalopathy, 1 bone marrow failure syndromes, 2 leukemia, 3 and congenital heart disease. (aappublications.org)
  • Thomas and his wife and research partner Dottie Thomas developed bone marrow transplantation as a treatment for leukemia. (wikipedia.org)
  • By using all techniques available at the time for phenotypic characterization of leukemia cells, he was successful in discovering and describing novel subentities of acute leukemias. (wikipedia.org)
  • She is a pre-eminent expert in the use of hematopoietic stem cell transplantation for treating radiation injuries and blood disease, especially leukemia, aplastic anemia and myelodysplastic syndrome. (wikipedia.org)
  • 2005 Treatment of Jining serious radiation accidents and extremely severe bone marrow and intestinal radiation 2006 Developed an original creativity of microtransplantation for the treatment of leukemia. (wikipedia.org)
  • She has co-authored five monographs, including "Hematopoietic stem cell transplantation clinical and basic," "Modern leukemia study," "Clinical and basic research of radiation sickness," and two more books. (wikipedia.org)
  • B-cell prolymphocytic leukemia, referred to as B-PLL, is a rare blood cancer. (wikipedia.org)
  • Specifically, B-PLL is a prolymphocytic leukemia (PLL) that affects prolymphocytes - immature forms of B-lymphocytes and T-lymphocytes - in the peripheral blood, bone marrow, and spleen. (wikipedia.org)
  • This type of leukemia is characterized by: More than 55% of circulating cells in peripheral blood (red blood cells, white blood cells and platelets collectively) are prolymphocytes. (wikipedia.org)
  • Generally, prolymphocyte proportion exceeds 90% Minimal or absence of lymphadenopathy - abnormalities in size, number or consistency of lymph nodes Splenomegaly - Abnormal enlargement of the spleen High white blood cell count B-symptoms - Fever, night sweats and/or weight loss Similar to other leukemias, B-cell prolymphocytic leukemia is often asymptomatic. (wikipedia.org)
  • Mutations of the FLT3 receptor can lead to the development of leukemia, a cancer of bone marrow hematopoietic progenitors. (wikipedia.org)
  • Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells. (wikipedia.org)
  • The underlying mechanism involves replacement of normal bone marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. (wikipedia.org)
  • efficacy
  • Lymphocytes are critically important components of the graft from both efficacy and toxicity standpoints, and so "stem cell" and "hematopoietic cell" transplantation are really misnomers. (oncologynurseadvisor.com)
  • In a small human clinical trial to evaluate the safety and efficacy of fucoidan ingestion (brown seaweed extract), 3g daily of 75% w/w oral fucoidan for 12 days increased the proportion of CD34+CXCR4+ from 45 to 90% and the serum SDF-1 levels, which could be useful in CD34+ cells homing/mobilization via SDF-1/CXCR4 axis. (wikipedia.org)
  • A completed Phase II, multi-centre, single-arm, open-label study evaluated the efficacy and safety of Revlimid monotherapy treatment for achieving haematopoietic improvement in red blood cell (RBC) transfusion dependent subjects with low- or intermediate-1-risk MDS associated with a deletion 5q cytogenetic abnormality. (wikipedia.org)
  • toxicity
  • Regular and frequent laboratory evaluations are required to monitor kidney function, avoid drug-induced bladder complications and screen for bone marrow toxicity. (wikipedia.org)
  • diseases
  • Allogeneic blood and marrow transplantation (BMT) (also often called stem cell or hematopoietic cell transplantation) is the treatment of choice for many blood diseases, both malignant and non-malignant. (oncologynurseadvisor.com)
  • Allogeneic BMT is also curable therapy for non-malignant diseases that affect blood cells, including aplastic anemia and other autoimmune disorders, as well as inherited diseases such as hemoglobinopathies and immunodeficiencies. (oncologynurseadvisor.com)
  • Its isolation and characterization may suggest novel treatments for genetic bone diseases and bone injuries. (pnas.org)
  • Treatment of genetic diseases in which an insufficient expression of the affected gene product by the patient can be partially or completely overcome by circulating hematopoietic cells transplanted from a donor with normal gene expression. (nkch.org)
  • Research interests primarily involve medical diseases and transplantation pathology of the kidney and liver. (stanford.edu)
  • Gamida Cell is a clinical-stage biopharmaceutical company leveraging its proprietary technology to develop cell therapies that are designed to cure cancer and rare, serious hematologic diseases. (businesswire.com)
  • Human embryonic stem cell research has emerged as an important platform for the understanding and treatment of pediatric diseases. (aappublications.org)
  • Moreover, although a single cell biopsy may be performed in IVF cases to test for genetic diseases, it is unclear whether it would be appropriate to transfer to a uterus an embryo that underwent such biopsy for the creation of stem cell lines. (aappublications.org)
  • 2004 The study of HLA haploidentical blood related and unrelated matched donors nonmyeloablative transplantation for the treatment of blood diseases. (wikipedia.org)
  • Immunophenotyping helps distinguish B-PLL from similar diseases, one of its key identifiers is the absence in expression of the surface antigens CD10, CD11c, CD25, CD103 and cyclin D1 - an important regulator of cell-cycle progression. (wikipedia.org)
  • It is one of the myeloproliferative disorders, diseases of the bone marrow in which excess cells are produced at some stage. (wikipedia.org)
  • Andrew Louis Pecora (born 1957) is an American hematologist and oncologist who has been involved in the research on the use of stem cells and oncolytic viruses to treat diseases, including cancer. (wikipedia.org)
  • Lymphocytes
  • The doctors generated cytotoxic T lymphocytes from the bone marrow donors. (wikipedia.org)
  • This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. (wikipedia.org)
  • systemic
  • Bone marrow cells contribute to many diverse tissues after systemic transplantation in both mice and humans ( 1 , 2 ). (pnas.org)
  • The delivered cells (via local or systemic administration) remain viable for a relatively short period (days-weeks) and then die. (wikipedia.org)
  • Secondary haemophagocytic lymphohistiocytosis (acquired haemophagocytic lymphohistiocytosis) occurs after strong immunologic activation, such as that which can occur with systemic infection, immunodeficiency, or underlying malignancy. (wikipedia.org)
  • haploidentical transplantation
  • These outcomes are extremely encouragingā€¦ All the recent reports of unmanipulated haploidentical transplantation have fostered interest and debate in the field and, most importantly, served to substantially extend its use. (jefferson.edu)
  • However, higher-risk approaches such as haploidentical transplantation are becoming safer and more efficacious and are increasingly being used interchangeably with fully matched allogeneic approaches. (nkch.org)
  • progenitors
  • further, recent evidence shows that many examples of so-called stem cell developmental plasticity may represent fusions of hematopoietic stem cells with committed progenitors of nonhematopoietic tissues, generating cell hybrids that possess both donor and host genetic information ( 5 - 8 ). (pnas.org)
  • One interpretation of these observations is that cells other than those in the adherent population, where mesenchymal stem cells are thought to reside ( 3 ), are potent transplantable progenitors of osteoblasts, consistent with laboratory studies showing that nonadherent cells can give rise to bone ( 12 , 13 , 16 ). (pnas.org)
  • CD135 is an important cell surface marker used to identify certain types of hematopoietic (blood) progenitors in the bone marrow. (wikipedia.org)
  • aplastic anemia
  • Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)