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  • stem cell transplants
  • Other conditions treated with stem cell transplants include sickle-cell disease, myelodysplastic syndrome, neuroblastoma, lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease and Hodgkin's disease. (wikipedia.org)
  • In 2006 a total of 50,417 first hematopoietic stem cell transplants were reported as taking place worldwide, according to a global survey of 1327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
  • protein
  • C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. (wikipedia.org)
  • This bind results in gp41, the other protein product of gp160, to be released from its metastable conformation and insert itself into the membrane of the host cell. (wikipedia.org)
  • It is a type I transmembrane protein that is in various forms present on all differentiated hematopoietic cells, except erythrocytes and plasma cells, that assists in the activation of those cells (a form of co-stimulation). (wikipedia.org)
  • CD45R is the longest protein and migrates at 200 kDa when isolated from T cells. (wikipedia.org)
  • In addition, CD45 was shown to be the target of the species D adenovirus 19a E3/49K protein to inhibit the activation of NK and T cells. (wikipedia.org)
  • The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4/6 complexes, and thus functions as a regulator of cell cycle progression at G1 and S phase. (wikipedia.org)
  • identified a protein p21 (WAF1) which was present in cells expressing wild type p53 but not those with mutant p53, moreover constitutive expression of p21 led to cell cycle arrest in a number of cell types. (wikipedia.org)
  • Myeloid Leukemia
  • Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells. (wikipedia.org)
  • In 1989 Nova Pharmaceutical took over development of the compound and in 1992, it submitted a new drug application to the FDA for using perfosamide to purge malignant cells in transplants for the treatment of acute myeloid leukemia. (wikipedia.org)
  • CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells, but CD45 positioning within lipid rafts is modified during their oncogenic transformation to acute myeloid leukemia. (wikipedia.org)
  • tissues
  • Together these results suggest that miR-155-5p is expressed in a number of tissues and cell types and, therefore, may play a critical role in a wide variety of biological processes, including hematopoiesis Although very few studies have investigated the expression levels of miR-155-3p, Landgraf et al. (wikipedia.org)
  • hematopoiesis
  • The study of hematopoiesis has been greatly facilitated by transplantation of blood cell populations into recipient animals. (nih.gov)
  • Hematopoiesis is the process by which all mature blood cells are produced. (wikipedia.org)
  • There are 2 types of hematopoiesis that occur in humans: Primitive hematopoiesis - blood stem cells differentiate into only a few specialized blood lineages (typically isolated to early fetal development). (wikipedia.org)
  • The pioneering work of Till and McCulloch in 1961 experimentally confirmed the development of blood cells from a single precursor hematopoietic stem cell (HSC), creating the framework for the field of hematopoiesis to be studied over the following decades. (wikipedia.org)
  • lymphocytes
  • Sublethal irradiation doses of 20 Gy predominantly ablated lymphocytes and permitted transplantation of a lethal T-cell leukemia. (nih.gov)
  • Donor leukocyte infusion is the infusion in which lymphocytes from the original stem cell donor are infused, after the transplant, to augment an anti-tumor immune response or ensure that the donor stem cells remain engrafted. (wikipedia.org)
  • RAG-1 and RAG-2 are essential to the generation of mature B and T lymphocytes, two cell types that are crucial components of the adaptive immune system. (wikipedia.org)
  • In the nodules, T lymphocytes (cells which help to fight viruses) are located in the T cell zone. (wikipedia.org)
  • B lymphocytes (cells which help to fight certain bacteria) are located in the B cell follicle. (wikipedia.org)
  • The lymph tissue in the lymph nodes consists of immune cells (95%), for example lymphocytes, and stromal cells (1% to 5%) The genesis of lymph nodes begins within the blood and the lymphatic system. (wikipedia.org)
  • The molecular signaling systems (chemokines) that distribute lymphocytes to appropriate localities within the lymph node (T and B cell segregation) are also created by lymph node stromal cells. (wikipedia.org)
  • Lymphocytes leave the lymph node, as effector immune cells, via the efferent lymph vessels. (wikipedia.org)
  • Cytokine
  • citation needed] In order to harvest stem cells from the circulating peripheral blood, blood donors are injected with a cytokine, such as granulocyte-colony stimulating factor (G-CSF), that induces cells to leave the bone marrow and circulate in the blood vessels. (wikipedia.org)
  • Theory 2: Hypoxic events in body regions may increase the high metabolic activity of dividing blast cells and lead to an increase in cytokine production. (wikipedia.org)
  • Therefore, hypoxia in addition to various cytokine accumulations, act in unison to further damage tissue and attract leukemic blast cells to form a triad of damage. (wikipedia.org)
  • tissue
  • HSCs constitute 1:10.000 of cells in myeloid tissue. (wikipedia.org)
  • Some people with AML may experience swelling of the gums because of infiltration of leukemic cells into the gum tissue. (wikipedia.org)
  • This is the process by which T cells are attracted to specific tissue and organ targets. (wikipedia.org)
  • Lymph node stromal cells express peripheral tissue-restricted antigens (PTAs) on their surface. (wikipedia.org)
  • It is characterized by an extremely elevated blast cell count and symptoms of decreased tissue perfusion. (wikipedia.org)
  • Symptomatic Hyperleukocytosis (Leukostasis) is defined by a tremendously high blast cell count along with symptoms of decreased tissue perfusion. (wikipedia.org)
  • receptors
  • The cells interact with the RetroNectin molecule via cell surface receptors, and lentiviral and retroviral particles bind to the H-domain of RetroNectin. (clontech.com)
  • HIV-1 most commonly uses the chemokine receptors CCR5 and/or CXCR4 as co-receptors to enter target immunological cells. (wikipedia.org)
  • These receptors are located on the surface of host immune cells whereby they provide a method of entry for the HIV-1 virus to infect the cell. (wikipedia.org)
  • and B cells exhibit CXCR5 receptors for chemokine CXCL13. (wikipedia.org)
  • Dendritic cells exhibit C-type lectin receptors (CLEC-2), which bind to gp38 on the surface of lymphatic endothelial cells. (wikipedia.org)
  • Various chemokines and receptors are involved in the homing of hematopoietic stem cells. (wikipedia.org)
  • proliferation
  • However, many of these additives are highly cytotoxic and often negatively impact cell viability and/or proliferation. (clontech.com)
  • Cold Spring Harbor conferences on cell proliferation , v. 5. (worldcat.org)
  • This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. (wikipedia.org)
  • CD45 colocalizes with lipid rafts on AML cells, which contributes to elevated GM-CSF signal intensity involved in proliferation of leukemic cells. (wikipedia.org)
  • regulator
  • The Transcription factor Aire (autoimmune regulator) that controls the expression of PTAs on mTEC cells in the thymus is only expressed at low levels by uncharacterized double negative stromal cells. (wikipedia.org)
  • diseases
  • Therapeutic strategies aimed at increasing fetal globin production in diseases such as beta thalassemia and sickle cell anemia by inhibiting BCL11A are currently being explored. (wikipedia.org)
  • receptor
  • The efficiency of lentiviral and retroviral infection of hematopoietic cells is strongly dependent on various factors, including the cell cycle status of the target cells and cell surface receptor expression. (clontech.com)
  • RetroNectin reagent enhances transduction by facilitating co-localization of viral particles and hematopoietic cells-virus particles bind to the RetroNectin peptide via interaction with the heparin-binding domain, and hematopoietic cells bind mainly through the interaction of the cell surface integrin receptor VLA-4 with the CS-1 site. (clontech.com)
  • The hemangioblast theory, which posits that the RBCs and ECs derive from a common progenitor cell, was developed as researchers observed that receptor knockout mice, such as flk1-/-, exhibited defective RBC formation and vessel growth. (wikipedia.org)
  • The recombination-activating genes (RAGs) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules, however there is no evidence to suggest the developing T cells can undergo receptor editing in the same way that B cells do. (wikipedia.org)
  • During HIV-1 infection, the Gp120 envelope glycoprotein subunit binds to a CD4 glycoprotein and a HIV-1 co-receptor expressed on a target cell- forming a heterotrimeric complex. (wikipedia.org)
  • For example, Naive T cells express the CCR7 receptor for the chemokine CCL21. (wikipedia.org)
  • In an inflammatory state, lymphatic endothelial cells increase their surface adhesion molecules, and dendritic cells express a surface CCR7 receptor. (wikipedia.org)
  • This type of receptor interacts with the chemokine CCL21, produced by fibroblastic reticular cells. (wikipedia.org)
  • dendritic cells
  • Even though the function of miR-155-3p has been largely ignored, several studies now suggest that, in some cases (astrocytes and plasmacytoid dendritic cells), both miR-155-5p and -3p can be functionally matured from pre-mir-155. (wikipedia.org)
  • CCR5 is predominantly expressed on T cells, macrophages, dendritic cells, eosinophils, microglia and a subpopulation of ether breast or prostate cancer cells. (wikipedia.org)
  • Antigens are also presented on the surface of dendritic cells. (wikipedia.org)
  • Due to this interaction, dendritic cells move to the T cell zone or to the B cell follicle along the fibroblast reticular cell network. (wikipedia.org)
  • endothelial
  • As the embryo requires rapid oxygenation due to its high mitotic activity, these islands are the main source of red blood cell (RBC) production via fusing endothelial cells (ECs) with the developing embryonic circulation. (wikipedia.org)
  • apheresis
  • In most circumstances, adequate numbers of cells can be collected using granulocyte colony-stimulating factor (G-CSF, filgrastim [Neupogen]) to prime the patient prior to one to three apheresis procedures. (renalandurologynews.com)
  • leukemic
  • Play media Most signs and symptoms of AML are caused by the replacement of normal blood cells with leukemic cells. (wikipedia.org)
  • Other chemotherapy agents, specifically epipodophyllotoxins and anthracyclines, have also been associated with treatment-related leukemias, which are often associated with specific chromosomal abnormalities in the leukemic cells. (wikipedia.org)
  • Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. (wikipedia.org)
  • macrophages
  • These sinuses are cavities containing macrophages (specialised cells which help to keep the extracellular matrix in order). (wikipedia.org)
  • degradation
  • Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. (wikipedia.org)
  • human embryonic stem
  • Haseltine was briefed on the project to isolate human embryonic stem cells and embryonic germ cells at Geron Corporation in collaboration with researchers at the University of Wisconsin-Madison and Johns Hopkins School of Medicine. (wikipedia.org)
  • Studies of human embryonic stem cells (hESCs) commonly report the nonfunctional p53-p21 axis of the G1/S checkpoint pathway, and its relevance for cell cycle regulation and the DNA damage response (DDR). (wikipedia.org)