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  • progenitors
  • further, recent evidence shows that many examples of so-called stem cell developmental plasticity may represent fusions of hematopoietic stem cells with committed progenitors of nonhematopoietic tissues, generating cell hybrids that possess both donor and host genetic information ( 5 - 8 ). (pnas.org)
  • One interpretation of these observations is that cells other than those in the adherent population, where mesenchymal stem cells are thought to reside ( 3 ), are potent transplantable progenitors of osteoblasts, consistent with laboratory studies showing that nonadherent cells can give rise to bone ( 12 , 13 , 16 ). (pnas.org)
  • SCF also increases the survival of various hematopoietic progenitor cells, such as megakaryocyte progenitors, in vitro. (wikipedia.org)
  • hematopoietic system G-CSF is also a potent inducer of hematopoietic stem cell (HSC) mobilization from the bone marrow into the bloodstream, although it has been shown that it does not directly affect the hematopoietic progenitors that are mobilized. (wikipedia.org)
  • neutropenia
  • Filgrastim is used to treat neutropenia, stimulating the bone marrow to increase production of neutrophils. (wikipedia.org)
  • citation needed] G-CSF is used clinically (see Neutropenia) but tests in mice suggest it may lead to bone loss. (wikipedia.org)
  • fetal liver
  • In mammalian embryology, the first definitive HSCs are detected in the AGM (aorta-gonad-mesonephros), and then massively expanded in the fetal liver prior to colonising the bone marrow before birth. (wikipedia.org)
  • Sites where hematopoiesis takes place, such as the fetal liver and bone marrow, all express SCF. (wikipedia.org)
  • murine
  • Consistent with this idea is the observation, reported over a decade ago, that nonadherent CD34 bone marrow cells can differentiate to osteoblasts ( 12 ) and the quite recent report that murine bone marrow side population (SP) cells can engraft in bone after transplantation ( 13 ). (pnas.org)
  • We tested this prediction in a murine transplantation model by using gene-marked bone marrow cells and retroviral integration site-specific PCR analysis. (pnas.org)
  • citation needed] CD34 is expressed in roughly 20% of murine hematopoietic stem cells, and can be stimulated and reversed. (wikipedia.org)
  • Working under the supervision of Bruce (AACR Award), and in association with Till and McCulloch and a vibrant group of graduate students and post-doctoral fellows, Eaves completed his PhD in Medical Biophysics at the University of Toronto with a thesis entitled Studies on the Control of Murine Bone Marrow Function (1974). (wikipedia.org)
  • donors
  • After the initial donation, donors will receive injections of filgrastim to release bone marrow cells into the blood. (clinicaltrials.gov)
  • citation needed] In order to harvest stem cells from the circulating peripheral blood, blood donors are injected with a cytokine, such as granulocyte-colony stimulating factor (G-CSF), that induces cells to leave the bone marrow and circulate in the blood vessels. (wikipedia.org)
  • To facilitate the exchange of information and improve business relations, the WMDA provides access to contact data of organisations that are listing donors or cord blood products in the global database of Bone Marrow Donors Worldwide. (wikipedia.org)
  • The BMDW is the world's largest hematopoietic cell database, listing more than 29.5 million stem cell donors and over 721,289 cord blood units. (wikipedia.org)
  • acute
  • PLX-R18 were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and enhancement of bone marrow regeneration. (wikipedia.org)
  • Blood
  • As more donor T cells are collected with peripheral blood than bone marrow, most studies have shown GVHD to be increased. (oncologynurseadvisor.com)
  • Overall, survival is probably similar with both bone marrow and peripheral blood grafts, with the higher toxicity and improved tumor control associated with GVHD offsetting each other. (oncologynurseadvisor.com)
  • Number of patients with donor chimerism - percentage of donor cells in the patient via the peripheral blood or bone marrow. (clinicaltrials.gov)
  • Leukemia is a type of cancer that affects the blood and bone marrow. (uptodate.com)
  • All of the blood cells (red cells, white cells, platelets) are derived from stem cells in the bone marrow. (uptodate.com)
  • In CLL, high numbers of abnormal lymphocytes are found in the blood, lymph nodes, spleen, and bone marrow. (uptodate.com)
  • It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia. (wikipedia.org)
  • Hematopoietic stem cells (HSCs) are the stem cells that give rise to blood cells through the process of haematopoiesis. (wikipedia.org)
  • Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes). (wikipedia.org)
  • Instead, the drugs affect new blood cells that are being made by the bone marrow. (wikipedia.org)
  • Because the bone marrow is the manufacturing center of blood cells, the suppression of bone marrow activity causes a deficiency of blood cells. (wikipedia.org)
  • These predictive in-vitro assays reveal effects the administered compounds have on the bone marrow progenitor cells that produce the various mature cells in the blood and can be used to test the effects of single drugs or the effects of drugs administered in combination with others. (wikipedia.org)
  • Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation.Blood, 98(13), 3505-3512. (wikipedia.org)
  • White blood cells The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates proliferation and differentiation into mature granulocytes. (wikipedia.org)
  • The expanding population of eosinophils, initially formed in the bone marrow may spread to the blood and then enter into and injure various tissues and organs. (wikipedia.org)
  • Hematopoietic stem cells give rise to: 1) myeloid precursor cells that differentiate into red blood cells, mast cells, blood platelet-forming megakaryocytes, or myeloblasts, which latter cells subsequently differentiate into white blood cells viz. (wikipedia.org)
  • Some hematological malignancies exhibit increased numbers of circulating blood eosinophils, increased numbers of bone marrow eosinophils, and/or eosinophil infiltrations into otherwise normal tissues. (wikipedia.org)
  • Absent these causes, patients were diagnosed in the World Health Organization's classification as having either 1) Chronic eosinophilic leukemia, not otherwise specified, (CEL-NOS) if blood or bone marrow blast cells exceeded 2% or 5% of total nucleated cells, respectively, and other criteria were met or 2) idiopathic hypereosinophilic syndrome (HES) if there was evidence of eosinophil-induced tissue damage but no criteria indicating chronic eosinophilic leukemia. (wikipedia.org)
  • severe
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. (wikipedia.org)
  • chronic
  • In immunocompromised patients, B19 infection may persist for months, leading to chronic anemia with B19 viremia due to chronic marrow suppression. (wikipedia.org)
  • myeloid
  • However, counting CD34+ mononuclear cells may overestimate myeloid blasts in bone marrow smears due to hematogones (B lymphocyte precursors) and CD34+ megakaryocytes. (wikipedia.org)
  • diseases
  • Its isolation and characterization may suggest novel treatments for genetic bone diseases and bone injuries. (pnas.org)
  • Injection of CD34+ hematopoietic Stem Cells has been clinically applied to treat various diseases including Spinal Cord Injury, Liver Cirrhosis and Peripheral Vascular disease. (wikipedia.org)
  • tissue
  • This capacity may solely reflect the activities of multiple discrete stem cells with restricted genetic programs, such as hematopoietic stem cells able to differentiate to leukocytes, erythrocytes, or megakaryocytes and mesenchymal stem cells that can differentiate to bone, cartilage, or adipose tissue ( 3 ). (pnas.org)
  • Bone marrow is the spongy, red tissue that fills the large bones. (uptodate.com)
  • glycoprotein
  • Granulocyte-colony stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. (wikipedia.org)
  • Outcomes
  • Early research in bone marrow transplantation by E. Donnall Thomas and colleagues demonstrated that this process of splitting TBI into multiple smaller doses resulted in lower toxicity and better outcomes than delivering a single, large dose. (wikipedia.org)
  • commonly
  • The most commonly observed adverse effect is mild bone pain after repeated administration and local skin reactions at the site of injection. (wikipedia.org)
  • malignant
  • The Department of Oncology and Hematology at the Hospital Nordwest is a medical institution, which deals with the diagnosis, treatment and follow-up care of patients with benign and malignant tumors of the hematopoietic system, as well as all kinds of cancer. (bookinghealth.com)
  • Hematopoietic stem cell transplantation for children with bone marrow failure syndromes, immune deficiencies, malignant and inherited disorders. (fnkc.ru)
  • Malignant infantile osteopetrosis, also known as infantile autosomal recessive osteopetrosis or simply infantile osteopetrosis is a rare osteosclerosing type of skeletal dysplasia that typically presents in infancy and is characterized by a unique radiographic appearance of generalized hyperostosis - excessive growth of bone. (wikipedia.org)
  • Failure of remodeling of the distal femoral and proximal humeral metaphyses giving the affected bones a funnel shaped appearance known as (Erlenmeyer flask deformity) Alternating radiolucent femoral metaphyseal bands Pathologic fractures The differential diagnosis of malignant infantile osteopetrosis includes other genetic skeletal dysplasias that cause osteosclerosis. (wikipedia.org)
  • Neuropathic infantile osteopetrosis Infantile osteopetrosis with renal tubular acidosis Infantile osteopetrosis with immunodeficiency IO with leukocyte adhesion deficiency syndrome (LAD-III) Intermediate osteopetrosis Autosomal dominant osteopetrosis (Albers-Schonberg) Pyknodysostosis (osteopetrosis acro-osteolytica) Osteopoikilosis (Buschke-Ollendorff syndrome) Osteopathia striata with cranial sclerosis Mixed sclerosing bone dysplasia Progressive diaphyseal dysplasia (Camurati-Engelmann disease) SOST-related sclerosing bone dysplasias The only effective line of treatment for malignant infantile osteopetrosis is hematopoietic stem cell transplantation. (wikipedia.org)
  • citation needed] Radiographs of at least one case with malignant infantile osteopetrosis have demonstrated bone remodeling and recanalization of medullar canals following hematopoietic stem cell transplantation. (wikipedia.org)
  • tumors
  • The Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectiology specializes in the treatment of all diseases of the hematopoietic system and solid tumors. (bookinghealth.com)
  • leukemic
  • Clinically, the typical initial presentation of BPDCN is presence of asymptomatic cutaneous lesions that are subsequently followed by bone marrow involvement and leukemic dissemination (5, 10). (czytelniamedyczna.pl)
  • hematologic
  • Obliteration of bone marrow spaces and subsequent depression of the cellular function can result in serious hematologic complications. (wikipedia.org)
  • Hematologic manifestations related to bone marrow suppression and subsequent pancytopenia are a major source of morbidity and mortality. (wikipedia.org)
  • Treatment
  • When these findings are taken together, combination therapy with MNC transplantation and AM infusion may have additional or synergetic effects on therapeutic angiogenesis for the treatment of severe peripheral vascular disease. (ahajournals.org)
  • Development of the new methods of treatment of children with acquired and inherited bone marrow failures. (fnkc.ru)