Loading...
  • HSPCs
  • Glycoprotein ligands on HSPCs help guide their migration to specialized microvascular beds in the bone marrow that express vascular selectins (E- and P-selectin). (edu.sa)
  • Collectively, these data demonstrate that EC-derived jagged-2 activates Notch2 signaling in HSPCs to promote hematopoietic recovery and has potential as a therapeutic target to accelerate balanced hematopoietic reconstitution after myelosuppression. (jci.org)
  • Cells
  • Several intraosseous cavities filled with densely packed hematopoietic cells are shown at low magnification ( top ). (rupress.org)
  • Recent data suggest that E-selectin is constitutively expressed on endothelial cells of human and murine hematopoietic tissues (( 8 ), ( 14 )), but the role of E-selectin in HPC homing has not been addressed. (rupress.org)
  • We have previously shown in vitro that vascular endothelial growth factor (VEGF), produced by almost all tumors, is one of the tumor-derived factors responsible for the defective function of these cells. (bloodjournal.org)
  • Fucosyltransferase VII improves the function of selectin ligands on cord blood hematopoietic stem cells. (edu.sa)
  • PRH expression was first detected in avian and human haematopoietic cells [ 1 , 2 ]. (biochemj.org)
  • The lymphatic vascular system serves key physiological functions: it maintains fluid homeostasis by absorbing water and macromolecules from the interstitium, enables uptake of dietary lipids and vitamins in the intestine, and serves as a trafficking route for immune cells. (rupress.org)
  • Using human atherosclerotic samples, cultured cells, and a mouse model of advanced atherosclerosis, we investigated the role of intraplaque hemorrhage on macrophage function with respect to angiogenesis, vascular permeability, inflammation, and plaque progression. (jci.org)
  • Within these cells, activation of HIF1α via inhibition of prolyl hydroxylases promoted VEGF-mediated increases in intraplaque angiogenesis, vascular permeability, and inflammatory cell recruitment. (jci.org)
  • For hematopoietic stem cells, lineage acquisition is regulated by well-defined colony-stimulating factors. (ahajournals.org)
  • Hematopoietic stem cells were first found in the marrow. (ahajournals.org)
  • We focus on the oncogenic transcription factors TAL1, LMO2 , and NOTCH1 and highlight the significance of the transcriptional regulatory programs in normal hematopoietic stem cells and T-ALL. (frontiersin.org)
  • By 24 hpf, mpo -expressing cells were observed along the ICM and within the developing vascular system. (bloodjournal.org)
  • niche
  • These results demonstrate that the BM vascular EC niche plays a key role in regulating hematopoietic system aging and that the HSC aging phenotype is characterized by impaired instructive functions of ECs. (sciencemag.org)
  • We hypothesized that the presence of a vascular niche that produces Notch ligands jagged-1 (JAG1) and delta-like ligand-4 (DLL4) drives definitive hematopoiesis. (angiocrinebioscience.com)
  • Long-term engraftment and the myeloid-to-lymphoid ratio achieved with vascular niche induction were similar to levels achieved for cord blood-derived MPP and up to 20-fold higher than those achieved with hPSC-derived MPP engraftment. (angiocrinebioscience.com)
  • myelosuppressive
  • When young mice were exposed to myelosuppressive total body irradiation (TBI), infusion of young ECs promoted rapid hematopoietic recovery, whereas infusion of aged ECs promoted an aged phenotype including impaired HSC function and myeloid bias. (sciencemag.org)
  • Although additional studies are required to further characterize the pathways and signals contributing to the EC-mediated HSC aging phenotype, the results suggest that cellular therapy with young ECs is a potentially promising strategy to revive aged HSC pools and accelerate hematopoietic recovery following myelosuppressive treatment regimens in elderly patients. (sciencemag.org)
  • HSPC
  • 1) showed that the truncated cleaved form of neurotransmitter neuropeptide Y (NPY) actively promotes a breach of BM vascular sinusoidal portals, thereby augmenting HSPC trafficking to the circulation. (jci.org)
  • Here, we show that enzymatically altered NPY signaling in ECs caused reduced VE-cadherin and CD31 expression along EC junctions, resulting in increased vascular permeability and HSPC egress. (jci.org)
  • Moreover, selective NPY2 and NPY5 receptor antagonists restored vascular integrity and limited HSPC mobilization, demonstrating that the enzymatically controlled vascular gateway specifically opens by cleavage of NPY by CD26 signaling via NPY2 and NPY5 receptors. (jci.org)
  • Thus, our results point to ECs as gatekeepers of HSPC trafficking and identify a CD26-mediated NPY axis that has potential as a pharmacologic target to regulate hematopoietic trafficking in homeostatic and stress conditions. (jci.org)
  • microenvironment
  • The function of the aging BM microenvironment-in particular, that of ECs-in the hematopoietic aging process is not well understood. (sciencemag.org)
  • Compared with young mice, the BM microenvironment of aged mice was characterized by increased vascular leakiness, metabolic dysregulation, and fewer ECs with impaired instructive function and decreased angiogenic potential. (sciencemag.org)
  • These effects were, in part, related to mitigation of radiation-mediated damage to BM vascular microenvironment by the co-infused young ECs. (sciencemag.org)
  • zebrafish
  • We find that it is possible to isolate cell populations from Tg(fli1:egfp)(y1) zebrafish embryos that are enriched in vascular, hematopoietic and pharyngeal arch cell types. (umassmed.edu)
  • In addition, models, such as zebrafish and frog tadpoles, are emerging as powerful tools for studying lymphatic vascular development. (rupress.org)
  • 4 Homologues of known mammalian hematopoietic transcription factors, such as gata-1, gata-2, c-myb , scl, fli-1, Imo2 , and cbfb are all appropriately expressed during zebrafish embryogenesis. (bloodjournal.org)
  • Biology
  • Although potential artifacts, such as fusion, need to be taken into consideration, these new developments in vascular biology open important therapeutic avenues. (ahajournals.org)
  • Calcification
  • 16-19 On the basis of physiological experiments, vascular calcification is known to increase aortic stiffness, resulting in systolic hypertension, coronary insufficiency, left ventricular hypertrophy, ischemia, and congestive heart failure. (ahajournals.org)
  • phenotype
  • All patients are alive and well with no new vascular events and resolution of hematological and immunological phenotype at a median follow-up of 18 months (range, 5 months to 13 years). (uu.nl)
  • system
  • The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. (rupress.org)