Hematopoietic and lymphoid tissues hematopoietic stem. Medical search. Frequent questions

or (3) solid organ transplantation involving organs containing lymphoid tissue. (medscape.com)
Our limited understanding of the complex cellular composition, anatomy, and function of this tissue has slowed the establishment of effective tissue regenerative (repair) and/or cell replacement (transplantation) therapies. (ohsu.edu)
This phase II trial studies how well total marrow and lymphoid irradiation works as a conditioning regimen before hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute leukemia. (survivornet.com)
Total body irradiation can lower the relapse rate but has some fatal side effects such as irreversible damage to normal internal organs and graft-versus-host disease (a complication after transplantation in which donor's immune cells recognize the host as foreign and attack the recipient's tissues). (survivornet.com)
TRANSPLANT: Patients undergo hematopoietic cell transplantation on day 0. (survivornet.com)
Studies have increasingly focused on the potential therapeutic effects of stem cell transplantation for neurological diseases [ 10 ]. (hindawi.com)
and Ly6d+ bone tissue marrow progenitors by intrathymic transplantation. (lavoixdesrroms.org)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
WO 2001/046401 discloses embryonic or stem-like cells produced by cross species nuclear transplantation. (justia.com)
Both cells have common applications in various cell-based therapies such as tissue regeneration and transplantation. (differencebetween.com)
I'm excited that this study can contribute to the understanding of this common and life-threatening complication in stem cell transplantation. (businesswire.com)
Intestinal aGvHD can occur after stem cell transplantation when the immune cells of the donor (the graft) consider the recipient's body (the host) as foreign and attack the organs and tissue. (businesswire.com)
In patients with relapsing or unresponsive disease, hematopoietic stem-cell transplantation significantly prolongs disease-free survival. (medscape.com)
Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. (medscape.com)
SCID is considered a pediatric emergency because survival depends on expeditious stem cell reconstitution, usually by bone marrow transplantation (BMT). (medscape.com)

In support of this initial hypothesis, we found that different secondary lymphoid organs (SLOs) imprint distinct homing receptor phenotypes on evolving alloreactive effector T cells in vivo. (nih.gov)
Among the organs that contribute to our immune response, there are two categories: primary lymphoid organs and secondary lymphoid organs. (lymphomainfo.net)
Yet, the maturation and activations of these cells occurs throughout the body, either in secondary lymphoid organs or the blood itself. (brainimmune.com)
B-cells and selected T-cells migrate to the secondary lymphoid organs (lymph nodes, spleen, Mucosa-Associated Lymphoid Tissue, etc). (wikilectures.eu)

Lymphoid cells include T cells, B cells, natural killer cells, and innate lymphoid cells. (wikipedia.org)

In vertebrates, the vast majority of hematopoiesis occurs in the bone marrow and is derived from a limited number of hematopoietic stem cells that are multipotent and capable of extensive self-renewal. (wikipedia.org)
Hematopoietic stem cells are found in the bone marrow of adults, especially in the pelvis, femur, and sternum. (wikipedia.org)
Another CFU, the colony-forming unit-spleen (CFU-S), was the basis of an in vivo clonal colony formation, which depends on the ability of infused bone marrow cells to give rise to clones of maturing hematopoietic cells in the spleens of irradiated mice after 8 to 12 days. (wikipedia.org)
Hematological cancers (blood cancers) arise in the blood-forming tissues, such as bone marrow, lymph nodes, and lymphatic system. (atlasantibodies.com)
The more aggressive forms of hematopoietic and lymphoid tissue diseases require treatment with chemotherapy, radiotherapy, immunotherapy and, in some cases, a bone marrow transplant. (atlasantibodies.com)
Monocytes (MC) are bone marrow (BM) derived mononuclear phagocytes that play an important role in innate immune response and are the major immune cell population in chronic tissue inflammatory ( 1 , 2 ). (frontiersin.org)
Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
Total body irradiation is a form of radiotherapy that involves irradiating the patient's entire body in an attempt to suppress the immune system, prevent rejection of the transplanted bone marrow and/or stem cells and to wipe out any remaining cancer cells. (survivornet.com)
Total marrow and lymphoid irradiation is a method of using IMRT to direct radiation to the bone marrow. (survivornet.com)
Total marrow and lymphoid irradiation may allow a greater dose of radiation to be delivered to the bone marrow as a preparative regimen before hematopoietic cell transplant while causing less side effects to normal organs than standard total body irradiation. (survivornet.com)
Bone marrow stem cells, including the pluripotent hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs), are being considered as potential targets for cell and gene therapy-based approaches against a variety of different diseases. (hindawi.com)
The bone marrow is one of two primary lymphoid organs, along with the thymus. (lymphomainfo.net)
Bone marrow is a sponge-like tissue found at the center of the body's large, flat bones. (lymphomainfo.net)
Two types of stem cells are made in the bone marrow: stromal cells, which make fat, cartilage and bone, and hematopoietic stem cells, which make blood cells. (lymphomainfo.net)
Because the bone marrow is where hemopoietic stem cells are made, it plays a very important role in lymphoma . (lymphomainfo.net)
When you consider how important the job of the bone marrow is - creating the cells that will become the blood cells that carry oxygen through the body and remove carbon dioxide from tissue, defending the body against infection and disease, and helping the process of clotting so that we don't bleed to death with a simple cut - you can begin to see how devastating any bone marrow disease can be. (lymphomainfo.net)
In diseases of the bone marrow, stem cells might produce too many, too few, or abnormal and non-functional blood cells. (lymphomainfo.net)
These cells are not constantly produced by bone marrow derived hematopoietic stem cells but are maintained in tissues and self-renew throughout life. (pasteur.fr)
The bone marrow is made of many cells as well as fat cells (stromal cells), forming rich connective tissue. (wikilectures.eu)
bone tissue marrow had been stained to examine adjustments in the proportions of MPP, ALP, BLP, and pre-pro-B cells. (lavoixdesrroms.org)
Hematopoietic stem cells (HSCs) are immature cells found in the peripheral blood and bone marrow. (differencebetween.com)
SDF-1 (CXCL12), a CXC chemokine, has a primary role in signalling the recruitment of haematopoietic stem-cell precursors to the bone marrow during embryonic development. (biomedcentral.com)
Normally, hematopoietic stem cells within the bone marrow mature into a common lymphoid progenitor cell, which then becomes either a B-cell or a T cell . (osmosis.org)
Mesenchymal stem cells are mobilized from the bone marrow during inflammation , Frontiers in Antigen Presenting Cell Biology , 2013, Front. (vumc.nl)
Acute leukopenia, with almost total absence of granular leukocytes, leukoblastic groups and lymphoid tissue in the bone marrow, was reported in the case of a 36-year-old chemist who had worked with radium for 14 years (Reitter and Martland 1926). (cdc.gov)
Among the leukemias, the most prevalent type is acute lymphoblastic leukemia (ALL), which is characterized by accumulation of immature lymphoid cells in the bone marrow 2,3 and accounts for roughly 80% of all cases of leukemia in childhood. (bvsalud.org)

Lymphocytes are stored within lymph nodes and may also be found in other lymphatic tissues. (rarediseases.org)
We are delineating the cellular and molecular mechanisms that mediate the differentiation of stromal cells towards lymphoid tissue organizing cells, allowing the attraction of hematopoietic cells to the developing lymph nodes. (vumc.nl)

NK muscle, like many lymphocytes, come from CD34+ hematopoietic stem tissue in the bones marrow one to distinguish because of a good common lymphoid progenitor phase. (proserv-fzc.com)
These multipotent progenitor cells differentiate into either common myeloid progenitor (CMP) or common lymphoid progenitor cells (CLP). (differencebetween.com)

The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. (wikipedia.org)
They are commonly expressed in pluripotent embryonic stem cells, germ cells, certain committed progenitors, and cancer cells 18 . (atlasantibodies.com)
Hematopoiesis is disrupted profoundly, with a reduction of hematopoietic stem cells and common lymphoid progenitors causing a severely depleted acquired immune system. (ox.ac.uk)
During embryonic development multiple waves of hematopoietic progenitors with distinct lineage potential are differentially regulated in time and space. (pasteur.fr)
These particular cell subsets are produced from lymphoid restricted progenitors only found in the first days of fetal liver hematopoietic activity. (pasteur.fr)
Growing evidence of the heterogeneity and layered organization of the hematopoietic system is leading to a common view that some lymphocyte subsets are functionally different because they follow distinct developmental programs and emerge from distinct waves of lymphoid progenitors. (pasteur.fr)
For the 2′-O-beta-L-Galactopyranosylorientin initial seed, we utilized the reasonable mixture Package high AND high to represent the progenitors Mpl, as both are portrayed on early hematopoietic 2′-O-beta-L-Galactopyranosylorientin cells however, not mature B cells. (lavoixdesrroms.org)
Although previous protocols have generated clonogenic progenitors and various differentiated hematopoietic cells, there is no confirmation of their definitive identity or functional HSC properties. (researchsquare.com)
Many protocols have been described that achieve the generation of clonogenic progenitors and various differentiated hematopoietic cells. (researchsquare.com)
However, these progenitors cannot self-renew, and have limited lymphoid potential. (researchsquare.com)
It has been proposed that hematopoietic differentiation from pluripotent stem cells is biased toward the generation of the yolk sac like differentiation-primed progenitors. (researchsquare.com)

HSCs are pluripotent, self-renewing stem cells of the marrow cavity. (brainimmune.com)
is a practical, case-based guide to flow cytometric analysis in the workup of hematopoietic neoplasms presenting in the peripheral blood, marrow, lymphoid tissue, and extranodal sites. (cap.org)

In shape, hematopoietic stem cells resemble lymphocytes. (wikipedia.org)
Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
Lymphatic tissue or circulating lymphocytes may also be located in other regions of the body, such as the skin, small intestine, liver, and other organs. (rarediseases.org)
Consistent with this view, some specialized lymphocytes emerge during a limited time-window in embryogenesis and migrate to the tissues where they contribute to organogenesis and to tissue homeostasis. (pasteur.fr)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
In post-natal life, SDF-1 is widely expressed and is induced in chronically inflamed tissues such as psoriatic skin and the rheumatoid synovium, but has also been implicated in the migration of lymphocytes to lymphoid organs. (biomedcentral.com)
Lymphopoiesis has two main goals - to generate a diverse set of lymphocytes, each with a unique antigen receptor, and to get rid of lymphocytes that have receptors that are self-reactive, meaning that they could attack one's own healthy tissue. (osmosis.org)
This is in part because the gut is the largest lymphoid organ in the body, containing the majority of lymphocytes and producing large amounts of immunoglobulin (Ig). (medscape.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)

Progenitor cells are capable of differentiating into cells that belong to the same tissue or organ of each progenitor cell. (differencebetween.com)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)

They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder. (lookformedical.com)

A stem cell commences as an undifferentiated cell that can either undergo self-renewal, whereby it generates daughter cells that remain as stem cells, or mature into a specific cell type via differentiation (Can/Hematol 2008). (papersowl.com)
We describe a two-step differentiation protocol that starts with differentiation of H1 human embryonic stem cells (hESCs) into embryoid bodies (EBs) in mesoderm-inducing conditions followed by maturation of EB derived CD34+ cells on OP9M2 stroma on HSC supportive conditions. (researchsquare.com)
Here, we describe a two-step differentiation protocol for H1 hESC that combines 2 weeks of embryoid body differentiation in mesoderm inducing conditions followed by OP9M2 stroma co-culture in HSC supportive conditions, which enables the generation of hematopoietic cells that resemble foetal liver HSPCs by immunophenotype (CD34+CD38loCD90+CD45+GPI80+) 2 and molecular profile. (researchsquare.com)
Background: Bivalent chromatin domains consisting of the activating histone 3 lysine 4 trimethylation (H3K4me3) and repressive histone 3 lysine 27 trimethylation (H3K27me3) histone modifications are enriched at developmental genes that are repressed in embryonic stem cells but active during differentiation. (researchgate.net)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

Autologous graft versus host disease (GVHD) involving the skin of a patient's arm shortly after showing signs of engraftment after an autologous peripheral blood stem cell transplant for ovarian cancer. (medscape.com)
White adipose tissue (WAT) plays a key homeostatic role, not only by ensuring efficient energy storage but also by its quick mobilisation (lipids) to ensure peripheral demands. (springer.com)
Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. (epa.gov)

Among all cancerous cells, a few act as stem cells that reproduce and sustain the tumor, much like stem cells normally renew and sustain our organs and tissues. (atlasantibodies.com)
Once T-cells have successfully completed positive and negative selection, they leave the thymus and enter the bloodstream, where they travel to various organs and tissues to carry out their functions. (osmosis.org)

Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
Most common cancers grow slowly compared with normal tissues, and the growth rate may be decreased in large tumors. (medscape.com)

Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. (wikipedia.org)
In vertebrates, the very first definitive HSCs arise from the ventral endothelial wall of the embryonic aorta within the (midgestational) aorta-gonad-mesonephros region, through a process known as endothelial-to-hematopoietic transition. (wikipedia.org)
Although human HSCs as vehicles to treat metachromatic leukodystrophy (MLD) has been used to treat patients with early onset MLD in a phase I/II trial, the HSCs give rise to all different blood cell lineages, such as the myeloid and lymphoid cell lineages [ 11 ]. (hindawi.com)
Hematopoiesis is the development of immune and other blood cells from a small population of stem cells known as hematopoietic stem cells (HSCs). (brainimmune.com)
HSCs develop into different types of blood cells in lines called myeloid and lymphoid , which are involved in dendritic cells formation. (differencebetween.com)
Definitive HSCs are generated in a narrow time window of development in the major arteries in the embryo and extraembryonic tissues from a specialized type of haemogenic endothelium. (researchsquare.com)

Hematopoietic stem cells give rise to different types of blood cells, in lines called myeloid and lymphoid. (wikipedia.org)
Myeloid and lymphoid lineages both are involved in dendritic cell formation. (wikipedia.org)

Tachykinins are small neuropeptides from 10-12 amino acids long synthesized in various nuclei of the central nervous system such as the substania gelatinosa of the dorsal spinal cord and certain nuclei of the limbic lobes as well as in a number of non-neuronal tissues like stromal cells of the BM [3]. (brainimmune.com)

Following that, patients may be eligible for a stem cell transplant, and/or an extended course of immunotherapy that is meant to prolong cancer remission. (rarediseases.org)
ECIL-6 guidelines recommend quantitative PCR of whole blood, plasma, or serum to screen for EBV DNA in allogeneic hematopoietic stem cell transplant (HSCT) recipients and to monitor EBV DNA-emia. (medscape.com)
Lower GI aGvHD represents a critical unmet need in patients undergoing allo-HSCT," said Yi-Bin Chen, MD, Director, Hematopoietic Cell Transplant & Cell Therapy Program, Mass General Cancer Center. (businesswire.com)

We hypothesized that blocking access to distinct lymphoid priming sites may alter the specific organ tropism and prevent aGVHD development. (nih.gov)
The gastrointestinal tract is the largest lymphoid organ in the body, so it is not surprising that intestinal diseases are common among immunodeficient patients. (medscape.com)

Using multi-color techniques pioneered by Brent Wood, the text demonstrates a unique approach to diagnosis of hematopoietic malignancies as well as identification of small abnormal populations in the posttherapy setting (minimal residual disease testing). (cap.org)
Adulthood residential ultraviolet radiation, sun sensitivity, dietary vitamin D, and risk of lymphoid malignancies in the California Teachers Study. (medscape.com)
Acute myeloid leukemia (AML), which accounts for 15-20% of all leukemias in childhood, belongs to a heterogeneous group of hematopoietic malignancies of monoclonal origin, which result from the malignant transformation of a stem cell. (bvsalud.org)

Endogenous formaldehyde clearance alone is therefore critical for hematopoiesis and in limiting mutagenesis in somatic tissues. (ox.ac.uk)
In the embryo, hematopoiesis takes place within the yolk sac, in special tissue called blood islands [1]. (brainimmune.com)
The publication contains an introduction to immunophenotypic changes seen in normal hematopoiesis along with an overview of the evaluation of lymphomas, leukemias, and myeloid stem-cell neoplasms. (cap.org)

Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)

This proposal will investigate the mechanisms regulating the function of blood-forming stem cells during fetal development. (grantome.com)

tips for humanization -- Biology of Human Hematopoietic Stem Cell Xenotransplantation in Mice -- Impact of the mouse IL-2Rg chain on lymphoid tissue development and human reconstitution in immunodeficient mice -- BM hematopoietic niche occupancy defect of HSC in scid mice -- Improvement of human multilineage hematopoietic engraftment by cytokine knockin replacement in human-hemato-lymphoid system mice -- Part II. (edu.au)

The lack of immuno-response to transmissible spongiform encephalopathies (TSE), neurodegenerative diseases caused by prions, could stem from the tolerance for PrPSc. (biolegend.com)
A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
Furthermore, similar processes are examined during the development of tertiary lymphoid structures in chronic inflammatory diseases. (vumc.nl)
Chronic Granulomatous Disease , autoimmune diseases Autoimmune diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. (lecturio.com)

Cancer stem cells (CSCs) are generated by a combination of DNA mutations, epigenetic events, and tissue microenvironment factors from normal stem cells or precursor/progenitor cells, to which they are closely related and share many of the behaviors and features 1 . (atlasantibodies.com)
This study aimed to clarify the role of mesenchymal stem cells (MSCs) as a component of the cancer microenvironment. (cancerindex.org)

Totipotent stem cells contain all the constituents necessary to produce a living being, given that these cells can supply all embryonic and extraembryonic tissues required for proper growth (Can/Hematol 2008). (papersowl.com)

Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

A pluripotent stem cell can generate more stem cells (self-renewal) or differentiate into lymphoid or myeloid stem cells, becoming committed progenitor cells/unipotent stem cells. (wikilectures.eu)
In this first renewal application of this award, we propose to pursue the regulation of self-renewal and lineage potential of the developmentally restricted hematopoietic stem cells (drHSCs) that we discovered in the current award period. (grantome.com)
self-renewal and multilineage potential - are established during development and maintained for life and we are excited to put these powerful tools to work to pioneer developmental hematopoietic fate decisions. (grantome.com)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

Flow Cytometry in Evaluation of Hematopoietic Neoplasms provides pathologists, residents, laboratory technologists, and hematologists with both a study guide and an atlas for regular consultation in the clinical flow cytometry laboratory. (cap.org)
The 2016 revision of the World Health Organization classification of lymphoid neoplasms. (medscape.com)

Blood cell formation is the process in which stem cells differentiate into the red or white blood cells. (wikilectures.eu)
The key difference between hematopoietic stem cells and progenitor cells is that hematopoietic stem cells have the ability to differentiate into different types of cells while progenitor cells are more specific and they differentiate into target cells. (differencebetween.com)
Progenitor cells are descendants of stem cells that further differentiate into specialized cell types. (differencebetween.com)
Progenitor cells are the cells that originate from stem cells and further differentiate to create specialized cell types. (differencebetween.com)
Hematopoietic stem cells differentiate into multipotent progenitor cells. (differencebetween.com)
On the other hand, progenitor cells are more specific than hematopoietic stem cells and can differentiate into target cells. (differencebetween.com)
To delve further into the specifics, embryonic and adult stem cells fall into potency categories reflecting their ability to differentiate: totipotent, pluripotent, multipotent, and unipotent. (papersowl.com)
Until recently, it was believed that they were tissue-specific…however, this concept has been challenged… (multipotent cells) can differentiate in vitro and in vivo into various cell types not only from the tissue of origin" (Can/Hematol 2008). (papersowl.com)
Oligopotent stem cells, though not often widely discussed, have the ability to differentiate into a few cells (Kara et al. (papersowl.com)

is portrayed just on T cells and for that reason this mixture would remove arrays of heterogeneous populations (e.g., whole-tissue arrays). (lavoixdesrroms.org)

Interleukin-3, which promotes the proliferation of both pluripotent stem cells and unipotent progenitor cells. (wikilectures.eu)
Finally, unipotent stem cells, which can only produce differentiated daughter cells of one type, are another category of stem cells. (papersowl.com)
Using these definitions, embryonic stem cells can be classified as totipotent or pluripotent at different developmental stages and locations, whereas adult stem cells can be categorized as pluripotent, multipotent, or unipotent (Figure 1). (papersowl.com)

During phase 1 (Afferent phase), tissue injured by chemotherapy and irradiation releases proinflammatory cytokines such as tumor necrosis factor (TNF) alpha and interleukin (IL)-1, which subsequently increases expression of adhesion molecules, major histocompatibility complex (MHC) molecules, and costimulatory molecules. (medscape.com)
While working in these companies, Dr. Streeter led research efforts in the engineering of hematopoietic cytokines, the development of anti-tumor vaccines, and the identification of selective inhibitors of autoimmune disease. (ohsu.edu)
Another extremely important function of NK cells are production of expert-inflammatory cytokines, as well as IFN-γ, where NK cells control almost every other resistant tissues. (proserv-fzc.com)
Macrophages play a significant role in many processes, such as the human immune function, parasite infection, and tissue remodeling by secreting cytokines and producing reactive oxygen and nitrogen intermediates. (frontiersin.org)
Another characteristic is that senescent cells that accumulate in body tissues over time cause chronic inflammation through the secretion of proinflammatory cytokines, termed senescence-associated secretory phenotype. (biomedcentral.com)

To deliver on that promise, our laboratory is collaborating with the laboratories of Markus Grompe, M.D., OHSU, and Gordon Keller, Ph.D., University Health Network, Toronto, Canada, in the development and characterization of monoclonal antibodies directed against cell surface molecules expressed by pancreatic cell subsets as well as pancreatic progenitor cells derived from pluripotent stem cells. (ohsu.edu)

Marking a vast leap in reproductive therapy, it became possible to isolate these human embryonic stem cells for reproductive purposes, such as in vitro fertilization. (papersowl.com)

citation needed] Hematopoietic stem cells can be identified or isolated by the use of flow cytometry where the combination of several different cell surface markers (particularly CD34) are used to separate the rare Hematopoietic stem cells from the surrounding blood cells. (wikipedia.org)
This protocol generates cells that resemble human foetal liver hematopoietic stem/progenitor cells (HSPC) by immunophenotype (CD34+CD38loCD90+CD45+GPI80+/-) and molecular profile. (researchsquare.com)

The very first hematopoietic stem cells during (mouse and human) embryonic development are found in aorta-gonad-mesonephros region and the vitelline and umbilical arteries. (wikipedia.org)

Macrophages are phagocytes found in tissues and maintain tissue homeostasis, regulate inflammation, and play a significant role in host protection. (frontiersin.org)

Ly6C high MC is the pro-inflammatory subset and the counterpart of human CD14 ++ CD16 + intermediate MC which contributes to systemic and tissue inflammation in various metabolic disorders, including hyperhomocysteinemia (HHcy). (frontiersin.org)

Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis. (cancerindex.org)
CD140b is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues. (thermofisher.com)

Hematopoietic stem cells are immature cells that develop into all types of blood cells. (differencebetween.com)

Stem/progenitor cells offer the promise that transplantable beta cells may be generated in the laboratory. (ohsu.edu)
The generation of definitive, transplantable haematopoietic stem cells (HSC) from pluripotent stem cells (PSC) is an unmet challenge. (researchsquare.com)
The attempts to generate definitive, transplantable hematopoietic stem cells (HSC) from human pluripotent stem cells have not been successful. (researchsquare.com)

A pluripotent stem cell has the potential to form all cells of the embryo, but cannot form a placenta. (papersowl.com)

Lymphoid and myeloid stem cells are ideal examples of oligopotent stem cells. (papersowl.com)

Dr. Streeter continued his studies as a Postdoctoral Fellow in the Department of Pathology at Stanford University, investigating the molecular mechanisms involved in leukocyte recruitment to diverse lymphoid and extralymphoid tissues. (ohsu.edu)

Hematopoietic stem cells are essential to haematopoiesis, the formation of the cells within blood. (wikipedia.org)
Hematopoietic stem cells can replenish all blood cell types (i.e., are multipotent) and self-renew. (wikipedia.org)
We show that formaldehyde is a common substrate of ALDH2 and ADH5 and establish methods to quantify elevated blood formaldehyde and formaldehyde-DNA adducts in tissues. (ox.ac.uk)
This whole tissue is surrounded by blood vessels called blood sinuses, where new blood cells are discharged. (wikilectures.eu)
All blood cells come from the haematopoietic stem cell, which is pluripotent as it gives rise to all differentiated types of blood cell. (wikilectures.eu)
Progenitor cells are an intermediary step in the development of mature cells in tissues, organs, blood, and the central nervous system. (differencebetween.com)
Hematopoietic progenitor cells (HPCs) are also intermediates in the development of blood cells. (differencebetween.com)
Hematopoietic stem cells, which can produce several different types of blood cells, are prime examples of multipotency. (papersowl.com)
The full-color presentation integrates images of blood and tissue findings where they are cited in the text. (digibookee.com)
2011 - 2018, ARC Stem Cells Australia program - blood theme. (edu.au)

This model provides a powerful tool to investigate the pathways involved in cell-migration into lymphoid organs and potentially to target them for therapeutic purposes. (biomedcentral.com)

Lack of expression of lineage markers is used in combination with detection of several positive cell-surface markers to isolate hematopoietic stem cells. (wikipedia.org)

Anatomy63

Organisms18

Diseases27

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Psychiatry and Psychology1

Phenomena and Processes45

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science3

Named Groups2

Health Care3

Transplantation15

Secondary lymphoid organs4

Innate lymphoid cells1

Bone26

Lymph Nodes2

Common lymphoid progenitor2

Progenitors11

Marrow2

Lymphocytes10

Progenitor cell3

Mucosa-Associ1

Differentiation5

Peripheral3

Organs and tissues2

Tumors3

HSCs6

Myeloid and lymphoid2

Stromal cells1

Transplant3

Organ2

Malignancies3

Hematopoiesis3

Lineages1

Fetal1

Reconstitution1

Diseases6

Microenvironment2

Extraembryonic tissues1

Lymphoma3

Self-renewal4

Neoplasms2

Differentiate9

Heterogeneous1

Unipotent3

Cytokines5

Cell subsets1

Human embryonic stem1

CD342

Embryonic development1

Macrophages1

Disorders1

Mesenchymal2

Immature1

Transplantable3

Pluripotent stem1

Oligopotent1

Pathology1

Blood10

Pathways involved1

Isolate1