Hematopoiesis promotes bone marrow bone marrow failure. Medical search. Frequent questions

Reduced levels of GATA1 due to reductions in the translation of GATA1 mRNA into its transcription factor product are associated with promoting the progression of myelofibrosis, i.e. a malignant disease that involves the replacement of bone marrow cells by fibrous tissue and extramedullary hematopoiesis, i.e. the extension of blood cell-forming cells to sites outside of the bone marrow. (wikipedia.org)
Primary myelofibrosis (PMF) is a type of cancer of bone marrow and is characterized by bone marrow fibrosis, extramedullary hematopoiesis, and JAK2 tyrosine kinase mutations. (picmonic.com)
Extramedullary hematopoiesis occurs over the course of primary myelofibrosis. (picmonic.com)
The spleen works as the primary site of extramedullary hematopoiesis. (picmonic.com)
Liver and lymph node enlargement can also occur due to the extramedullary hematopoiesis. (picmonic.com)
MF is characterized by variable degrees of cytopenias, a leukoerythroblastic blood picture, and extramedullary hematopoiesis resulting in progressive splenomegaly and debilitating disease-related constitutional symptoms, compromising quality of life. (haematologica.org)
While studying the role of type I IFNs in immunity to Pneumocystis infection, we discovered that mice lacking both lymphocytes and type I IFN receptor (IFrag−/−) developed progressive bone marrow failure following infection, while lymphocyte-competent type I IFN receptor-deficient mice (IFNAR−/−) showed transient bone marrow depression and extramedullary hematopoiesis. (montana.edu)
In approximately 15% of patients, however, myelofibrosis is accompanied by significant extramedullary hematopoiesis, hepatosplenomegaly, and transfusion-dependent anemia, which are manifestations of stem cell failure. (basicmedicalkey.com)

We have also discovered that infection can be a driver of Dnmt3a-loss of function clonal hematopoiesis, and defined the transcriptional and epigenetic mechanisms underlying the Dnmt3a-loss of function clonal selection advantage in the setting of chronic inflammation. (bcm.edu)
We also report that DDX41-GPV carriers do not have an increased prevalence of clonal hematopoiesis (CH). In fact, CH was significantly more common before sporadic vs DDX41-mutant MDS/AML, revealing distinct evolutionary paths. (bvsalud.org)
Clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias. (standardofcare.com)
Criteria for diagnosis of MDS consist of anemia, thrombocytopenia, or neutropenia that persist for six months or longer, dysplasia greater than 10% in at least one bone marrow cell lineage, and MDS associated clonal cytogenetic abnormalities or molecular markers. (standardofcare.com)
Mutation-driver genes cause clonal outgrowth and propagation of myelodysplastic hematopoiesis. (standardofcare.com)
Old age is associated with clonal hematopoiesis of indeterminate potential which is considered a precursor to MDS. (standardofcare.com)
Recently, a second clonal event involving the HMGA2 gene was reported in some PNH cases, and over expression of this gene was postulated to promote proliferation of the mutated clone. (annexpublishers.co)
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematologic disorder with typical clinical manifestations, including intravascular hemolysis, venous thrombosis, and defective hematopoiesis [ 1 ]. (annexpublishers.co)
Myelodysplastic syndrome (MDS) comprises a heterogeneous group of clonal disorders of haematopoietic stem cells, characterised by dysplastic haematopoiesis and dysregulated apoptosis resulting in various degrees of cytopenia, whereas canonical cytologic, cytogenetic and histopathologic findings guiding the diagnosis MDS are widely accepted, the MDS-phenotype can be masked by coexisting/paraneoplastic immunologic disease. (researcher.life)
To define the mechanistic basis of clonal hematopoiesis in SDS, we investigate somatic mutations acquired by patients with SDS followed longitudinally. (nature.com)
Current surveillance strategies for patients with SDS and other leukemia predisposition syndromes rely on monitoring hematologic status by serial peripheral blood counts to identify worsening cytopenias and bone marrow examinations to identify morphologic changes or development of clonal chromosomal abnormalities 11 . (nature.com)
Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
Telomere Length and Clonal Hematopoiesis. (cdc.gov)
A recent study proposes a key role for telomere maintenance in the development of clonal hematopoiesis. (cdc.gov)
Some persons with clonal hematopoiesis are at increased risk for the development of myeloid cancers such as acute myeloid leukemia or myelodysplastic syndromes, a risk that increases as the hematopoietic clone expands in size.16 Stopping this expansion may delay or avert leukemic progression, and therapeutic approaches to this end are being developed and tested. (cdc.gov)

The bone marrow microenvironment and inflammatory signaling can also determine the rate of development and progression of MDS. (standardofcare.com)
However, better understanding of the role of increased JAK-STAT signaling [either through activating mutations ( JAK2 , MPL515L/K ) within the signaling pathway, or mutations involving CALR ], the role of deregulated pro-inflammatory cytokine expression, and the impaired bone marrow microenvironment is transforming the treatment approach for MF. (haematologica.org)
The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
Stem cells release an antiinflammatory microenvironment around them that influences the behavior of neighboring cells, promoting tissue regeneration and improving muscle function. (rehealth.com)

Her research on the effects of inflammatory signaling on bone marrow stem cells may lead to novel ways to interrupt the development of aplastic anemia. (bcm.edu)
Bone marrow suppression is a risk factor for increased mortality for patients with chronic infections and aplastic anemia. (bcm.edu)
Conditions associated with bone marrow failure such as aplastic anemia with hypocellular marrow, typical bone marrow findings of MDS are a hypercellular marrow for a persons age, dysplasia in 1 to 3 lineages manifested by pseudo Pelger-Huet nuclei, hypogranular neutrophils, micro megakaryocytes, and/or ringed sideroblasts, glass Siri glass, and increased myeloblasts in a subset of patients. (standardofcare.com)
Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia (see the image below). (medscape.com)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
Paul Ehrlich introduced the concept of aplastic anemia in 1888 when he reported the case of a pregnant woman who died of bone marrow failure. (medscape.com)

6 Causes of early death include leukemic transformation, complications arising from progressive bone marrow failure, portal/pulmonary hypertension, infections, thrombosis and bleeding. (haematologica.org)

Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
Bone Marrow Transplantation, 2013. (nih.gov)

However, very little is known about the mechanisms by which inflammatory cytokines affect the hematopoietic progenitors that reside in bone marrow. (bcm.edu)
Increased expression of inflammatory cytokines, lysyl oxidase, transforming growth factor-β, impaired megakaryocyte function, and aberrant JAK-STAT signaling have all been implicated in the pathogenesis of bone marrow fibrosis. (haematologica.org)
Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Cytokines are - proteins, peptides, or glycoproteins secreted by specific cells of the immune system which mediate and regulate immunity, inflammation, and haematopoiesis - by rushing to the site and communicating to white blood cells which virus or cell to attack. (mahacbd.com)
Several studies mimicking lung damage caused by ARDS in mice show that CBD improved clinical symptoms significantly improved the levels of oxygen, and reduced the levels of inflammation-promoting cytokines caused by COVID-19-induced ARDS.4 Detailed examination showed that CBD partially or totally reversed the damage caused to the lungs, such as tissue overgrowth, scarring and swelling. (mahacbd.com)

Bone marrow biopsy is performed in addition to aspiration to assess cellularity qualitatively and quantitatively. (medscape.com)
A bone marrow aspirate and biopsy provide no specific diagnostic information because these may be normal or indistinguishable from ET or PMF. (basicmedicalkey.com)

Positive data from the dose-escalation stage of the study, which was recently presented at the 2014 ASH (American Society of Hematology) Conference, has shown substantial mobilization of AML cancer cells from the bone marrow to the peripheral blood and robust apoptosis of these cells, as well as an excellent safety and tolerability profile. (technologynetworks.com)
Hematopoietic stem cells (HSCs) are the precursors of all cells of the peripheral blood, and they usually reside in a quiescent state in the bone marrow. (bcm.edu)
Peripheral blood smear of patients with primary myelofibrosis can show dacrocytes, which results from red blood cells squeezing out from fibrotic tissue on bone marrow. (picmonic.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)

Bone marrow suppression and pancytopenia can result from chronic inflammation. (bcm.edu)
Pancytopenia, dacrocytes, and dry tap on bone marrow aspiration are diagnostic clues. (picmonic.com)
Fibrous bone marrow formation interrupts normal blood cell production, resulting in anemia, leukopenia, and thrombocytopenia i.e. pancytopenia. (picmonic.com)

This knowledge is a key to understanding the pathophysiology of bone marrow failure syndromes and will likely provide novel targets for drug development. (bcm.edu)
Non-FA (or underlying FA) patients harboring heterozygous germline FA gene mutations may also face an increased risk of developing bone marrow failure, primary immunodeficiency disease, and hereditary cancer predisposition syndromes. (frontiersin.org)

Oxidative stress can lead to neurogenerative diseases such as Parkinson's disease, as well as gene mutations and cancers, heart failure, inflammatory diseases and more. (besanawellness.com)
Targeted next-generation sequencing (NGS) of a panel of 80 genes was performed on her initial bone marrow aspirate sample and identified PTPN11, NRAS , and DNMT3A somatic mutations. (frontiersin.org)
She developed ovarian cancer, and then the altered FA pathway plus exposure to cytotoxic drugs promoted the emergence of acquired somatic mutations and the NUP98-HOXC11 fusion, all of which contributed to the development of secondary t-CMML. (frontiersin.org)

Interestingly, the presence of a low number of PNH cells, even in healthy individuals, confirms the hypothesis that defective stem cells actually predate the stem cell failure and depletion [ 11 ]. (annexpublishers.co)
Their treatments focus on well-targeted combinations of allogeneic umbilical cord stem cells, as well as autologous bone marrow stem cells. (aestheticsadvisor.com)
The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)
Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
Stem cells secrete angiogenic factors, which promote the formation of new blood vessels from pre-existing ones in a very similar way to a sprout and splitting behavior. (rehealth.com)
The regenerative properties of stem cells, such as increased energy efficiency and immune modulation, promote better functioning conditions. (rehealth.com)

The JAK2 gene is involved in the JAK/STAT pathway that works by promoting cell division and growth. (picmonic.com)
The specific effect on bone marrow fibrosis of JAK2 inhibition, and other rationally based therapies currently being evaluated in myelofibrosis, has yet to be fully elucidated. (haematologica.org)

The trial aims to improve the response of AML patients to the second stage of AML treatment, termed consolidation therapy, by eliminating the minimal residual disease left in the bone marrow after the first stage of the standard treatment regimen, called induction therapy. (technologynetworks.com)
In patients with unexplained anemia, thrombocytopenia, or neutropenia without dysplasia in the bone marrow but with abnormal chromosome activity in 5, 7 or 13 the diagnosis is consistent with MDS and occurs in less than 10% of patients with MDS. (standardofcare.com)
Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
Throughout the lifetime of patients with an FA gene mutation, DNA damage increasing accumulates, which would lead to a complex clinically and genetically heterogeneous disorder characterized by developmental abnormalities, bone marrow failure (BMF), immune deficiency, and a high risk of developing various cancers (e.g. (frontiersin.org)
We report eight patients diagnosed with MDS or bone marrow failure, who presented with paraneoplastic autoimmune diseases. (researcher.life)
In the Chinese proportion of patients who will not beneﬁt from these modalities literature, there is an abundance of basic science studies on the due to signiﬁcant comorbidities that preclude them from high risk activity of single herbs or herbal concoctions on haemopoiesis in treatment or other factors such as high cost or unavailability of normal or diseased marrow.Clinical reports of varying level of medical expertise. (healthdrugpdf.com)
Traditional Chinese herbal medicine in the supportive management of patients withchronic cytopaenic marrow diseases e A phase I/II clinical study, Complementary Therapies in Clinical Practice (2011), doi:10.1016/j.ctcp.2011.01.004 Y.-c. (healthdrugpdf.com)
Patients with severe acute radiation sickness receive reverse isolation, antimicrobial and anti-inflammatory agents, and bone marrow support. (msdmanuals.com)

We use the mouse as a model system to elucidate the genetic basis of human inherited anemias, which include defects in iron and heme metabolism and transport, sickle cell disease, bone marrow failure and the anemia of aging. (umaine.edu)
Erythropoietin is a glycoprotein hormone that stimulates red blood cell (RBC) production in bone marrow via binding to the cell-surface receptor on hematopoietic progenitor cells, and it has been widely used for treating anemia [ 13 ]. (hindawi.com)
Severe cases of anemia may manifest as tachycardia and congestive heart failure . (symptoma.com)

Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)

We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model of Mycobacterium avium infection (Nature 2010). (bcm.edu)
The biological roles of interleukin-2 receptor alpha chain (IL2RA) were confirmed in two genetically distinct acute myeloid leukemia mouse models, this revealed that IL2RA inhibited differentiation, promoted stem cell-related properties, and was required for leukemogenesis. (stemcellsciencenews.com)
Mechanical stretch combined with 20 IU/ml EPO promoted proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
EPO was able to promote the proliferation and osteogenic differentiation of BMSCs, and these effects were enhanced when combined with mechanical stretch. (hindawi.com)
Furthermore, mechanical stretch may induce the differentiation of BMSCs into mature osteoblasts and enhance the deposition of the bone matrix [ 18 - 20 ]. (hindawi.com)

Establish stromal cell layers and culture hematopoietic progenitors in "Dexter-type" long-term bone marrow cultures. (stemcell.com)

We recently also identified B cells as supporters of on-demand hematopoiesis following Pneumocystis infection that would otherwise be hampered due to systemic immune effects initiated in the context of a defective type I IFN system. (montana.edu)
IFN-I have potent direct antiviral activities, also mediate a multiplicity of immunoregulatory functions, which can either promote or dampen antiviral adaptive immune responses. (mdpi.com)

Bone marrow fibrosis is characterized by the formation of fibrous/scarring tissue in bone marrow leading to abnormalities in the formation of blood cells, including red blood cells, white blood cells, and platelets. (picmonic.com)

Bone marrow fibrosis is a central pathological feature and World Health Organization major diagnostic criterion of myelofibrosis. (haematologica.org)
However, modern myelofibrosis prognostication systems utilized in risk-adapted treatment approaches do not include bone marrow fibrosis as a prognostic variable. (haematologica.org)
Myelofibrosis appears to be part of the natural history of the disease but is a reactive, reversible process that does not itself impede hematopoiesis and by itself has no prognostic significance. (basicmedicalkey.com)

A number of studies indicate that bone marrow fibrosis is an adverse prognostic variable in myeloproliferative neoplasms. (haematologica.org)
Here we review the pathogenesis, biological consequences, and prognostic impact of bone marrow fibrosis. (haematologica.org)
Bone marrow fibrosis (BMF) is characterized by the increased deposition of reticulin fibers and in some cases collagen fibers. (haematologica.org)
European consensus on the grading of bone marrow fibrosis. (haematologica.org)
Conditions associated with bone marrow fibrosis. (haematologica.org)

While responses to inflammation may be necessary to maintain normal and emergency hematopoiesis, it may be deleterious over the long term, with prolonged inflammation leading to stem cell exhaustion (Cell Reports, 2016). (bcm.edu)

Learn more about bone marrow transplant for AML. (medicalnewstoday.com)

Acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes too many immature white blood cells called myeloblasts. (medicalnewstoday.com)
To understand the mechanisms that mediate germline genetic leukemia predisposition, we studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with high risk of myeloid malignancies at an early age. (nature.com)

The process of disintegration and the birth takes place continuously in the bone marrow and the spleen. (vsebolezni.com)
Red bone marrow and spleen are their place of birth. (vsebolezni.com)

Doctors can use stem cell transplants or bone marrow transplants to give people with AML higher doses of chemotherapy. (medicalnewstoday.com)
After two courses of a highly intensive induction chemotherapy regimen with DAC (decitabine) and HAA (homoharringtonine, cytarabine), the patient suffered from severe and persistent bone marrow failure (BMF). (frontiersin.org)
Consequently, she developed ovarian cancer and secondary t-CMML and then suffered from BMF and delayed post−chemotherapy bone marrow recovery after several chemotherapy courses. (frontiersin.org)

This initial treatment aims to clear as many leukemia cells as possible in the blood and bone marrow and to induce remission. (medicalnewstoday.com)

and hematopoietic cellularity of 80% with megakaryocytic hyperplasia demonstrating normal bone marrow function with Clinical Presentations increased platelet precursor cells. (cdc.gov)
Monocentric report on clinical phenotypes found in MDS or bone marrow failure with paraneoplastic inflammatory disease. (researcher.life)

When the bone marrow hematopoietic cells are mostly clonally derived cells, the disease is clinically manifested as cytopenia and morphologic dysplasia. (standardofcare.com)

We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)

Organ toxicity was characterized by depression of cell proliferation (hematopoiesis and spermatogenesis) and changes suggestive of reduced metabolism and/or physiological imbalances (e.g. (jaksignaling.com)

Its critical roles in red blood cell formation include promoting the maturation of precursor cells, e.g. erythroblasts, to red blood cells and stimulating these cells to erect their cytoskeleton and biosynthesize their oxygen-carrying components viz. (wikipedia.org)
Similar to the knockout of Gata1, knockout of the mouse gene for FOG1, Zfpm1, causes total failure of red blood cell development and embryonic lethality by day 11.5. (wikipedia.org)
Overcrowding the bone marrow also disrupts blood cell formation ( hematopoiesis ), leading to low blood cell count. (medicalnewstoday.com)
Overcrowded bone marrow can result in a low white blood cell count, or neutropenia . (medicalnewstoday.com)
Platelets help make blood clots, which slow or stop bleeding and promote wound healing. (medicalnewstoday.com)
Our research focuses on blood formation, or hematopoiesis, with a major emphasis on the development of red blood cells (erythropoiesis). (umaine.edu)
1999). First identified and isolated from the bone marrow (BM), MSCs can now be expanded from a variety of other tissues including adipose tissue (AT), umbilical cord blood (UCB), skin, tendon, muscle, and dental pulp (Im et al. (pdffox.com)

We demonstrate that adoptive transfer of B cells into IFrag−/− mice protects early hematopoietic progenitor activity during systemic responses to Pneumocystis infection, thus promoting replenishment of depleted bone marrow cells. (montana.edu)
2015. PPARa and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal. (umaine.edu)

HIV infection results in a complex immunodeficiency due to loss of CD4+ T cells, impaired type I interferon (IFN) responses, and B cell dysfunctions causing susceptibility to opportunistic infections such as Pneumocystis murina pneumonia and unexplained comorbidities, including bone marrow dysfunctions. (montana.edu)
Lymphocyte reconstitution of lymphocyte-deficient IFrag−/− mice pointed to B cells as a key player in bone marrow protection. (montana.edu)
Here we define how B cells protect on-demand hematopoiesis following Pneumocystis lung infection in our model. (montana.edu)
2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)
Low power, H and E showing a hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)

External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)
This activity is independent of CD4+ T cell help and B cell receptor specificity and does not require B cell migration to bone marrow. (montana.edu)
The three-dimensional organoid model was employed to investigate whether co-culture with paralleled cancer-associated fibroblasts promoted stem-like properties of oral squamous cell carcinoma. (stemcellsciencenews.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
Conditions with poor vascularization may benefit from stem cell therapy by promoting the creation of a more developed circulatory network. (rehealth.com)

Abnormal hematopoiesis may include erythrocytes, granulocytes and megakaryocytes. (symptoma.com)

Pathological causes due to system failure krovoobrashseniya. (vsebolezni.com)

Large bone defects resulting from trauma, congenital defects, neoplasm, failed arthroplasty, and infection are quite common [ 1 , 2 ], and the incidences of nonunion and delayed union are very high [ 3 ]. (hindawi.com)
It remains a great challenge for orthopedic surgeons to achieve osseous reconstruction for nonunion and bone defects. (hindawi.com)

Based primarily on mouse studies, it is proposed that the GATA1-FOG1 complex promotes human erythropoiesis by recruiting and binding with at least two gene expression-regulating complexes, Mi-2/NuRD complex (a chromatin remodeler) and CTBP1 (a histone deacetylase) and three gene expression-regulating proteins, SET8 (a GATA1-inhibiting histone methyltransferase), BRG1 (a transcription activator), and Mediator (a transcription co-activator). (wikipedia.org)
This dynamic relationship between the two proteins thus results in a feedback loop in which DNA damage-activated p53 promotes Mdm2 transcription while the translated Mdm2 protein inhibits p53 functions. (oncotarget.com)
Among them, bone morphogenic proteins (BMPs) are thought to be the most potent osteoinductive factors and play a key role in the process of bone formation during DO. (hindawi.com)

However, the risks associated with different variants remain unknown, as do the basis of their leukemogenic properties, impact on steady-state hematopoiesis, and links to other cancers. (bvsalud.org)

but the overall therapeutic process lasts for a relatively long period, and a variety of complications may arise, such as pin loss, infection around the transmucosal pin, bone fracture, and restriction in joint motion [ 8 ]. (hindawi.com)

Anatomy47

Organisms12

Diseases50

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes45

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science2

Named Groups2

Health Care5

Extramedullary hematopoiesis8

Clonal15

Microenvironment4

Aplastic anemia6

Progressive bone marrow failure1

Transplantation2

Cytokines6

Biopsy2

Peripheral blood4

Pancytopenia3

Syndromes2

Mutations3

Stem cells6

JAK22

Patients8

Anemia3

Hypocellularity1

Differentiation5

Hematopoietic progenitors1

Immune2

Abnormalities1

Myelofibrosis3

Fibrosis5

Inflammation1

Transplant1

Myeloid2

Spleen2

Chemotherapy3

Induce1

Clinical2

Clinically1

Transcriptional1

Depression1

Blood7

Progenitor2

Cells5

Cell5

Megakaryocytes1

Pathological1

Defects2

Proteins3

Cancers1

Complications1