Hematologic solid tumors anticancer drugs or radiation. Medical search. Frequent questions

Tumor lysis syndrome arises most commonly after the start of initial chemotherapeutic treatment, but spontaneous cases have increasingly been documented in patients with high-grade hematologic malignancies. (medscape.com)
[ 6 , 7 ] The syndrome has also been reported with other hematologic malignancies and with solid tumors such as hepatoblastoma and stage IV neuroblastoma. (medscape.com)
Solid organ transplant recipients (SOTRs) are at increased risk for both skin and internal malignancies (IM). (ima.org.il)
Among the cell types being investigated for therapy, immune cells have excelled in the treatment of hematologic malignancies. (nature.com)
Capecitabine is an oral pro drug of 5-fluorouracil and used for the treatment of colorectal and other malignancies. (jbclinpharm.org)
6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
There are a variety of tyrosine kinase inhibitors (TKIs) that are used in oncology for the treatment of malignancies now and consequently there have been increased observations of tumour lysis syndrome (TLS) associated with these drugs. (touchoncology.com)
Albeit considerably more common in haematological malignancies such as acute leukaemia and Burkitt's lymphoma, it is now recognised that TLS may also occur in solid tumours. (touchoncology.com)

The activation of evofosfamide to the active drug Br-IPM and the mechanism of action (MOA) via cross-linking of DNA is shown schematically below: Phosphorodiamidate-based, DNA-crosslinking, bis-alkylator mustards have long been used successfully in cancer chemotherapy and include e.g. the prodrugs ifosfamide and cyclophosphamide. (wikipedia.org)
Evofosfamide (TH-302) is currently being evaluated in clinical studies as a monotherapy and in combination with chemotherapy agents and other targeted cancer drugs. (wikipedia.org)
This study is looking at how well the drug elimusertib (a type of targeted therapy known as an ATR inhibitor) works when combined with chemotherapy for treating people with advanced cancers, including urothelial, ovarian, gastric, endometrial, triple-negative breast cancer and others. (facingourrisk.org)
The purpose of this study is to compare any good and bad effects the study drug atezolizumab has on the cancer when combined with the standard chemotherapy drugs gemcitabine and cisplatin (or GC) in two different dosing schedules: chemotherapy (GC) before atezolizumab vs. GC after atezolizumab. (bcan.org)
In 1949, nitrogen mustard (mechlorethamine) became the first chemotherapeutic agent approved by the U.S. Food & Drug Administration, which was rapidly followed by a wave of chemotherapy development 1 . (cancerbiomed.org)
Combining some of these neoadjuvant approaches with standard-of-care chemotherapy or radiotherapy appears to "sensitize" tumor cells to treatment. (cancerbiomed.org)
The combination of immunotherapies or pairing of immunotherapies with other types of cancer treatments such as chemotherapy or radiation enhances the benefit associated with lymphocyte modulators. (yahoo.com)
We explore the pipeline of Akt inhibitors and their preclinical and clinical examination status, presenting the potential clinical application of these agents as a monotherapy or in combination with ionizing radiation, other targeted therapies, or chemotherapy. (spandidos-publications.com)
For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)
Among all patients, 28.0% of the lenvatinib/pembrolizumab group and 48.1% of the chemotherapy group received subsequent anticancer systemic therapy. (ascopost.com)
A Prospective Trial of Radiation Alone vs Combination Chemotherapy Alone for Early-Stage Hodgkin's Disease: Implications of 25-Year Follow-Up to Current Combined Modality Therapy. (yale.edu)
Longo D, Glatstein E, Duffey P, Young R, Fiem S, Jaffe E, Camphausen K, Wilson W, DeVita V . A Prospective Trial of Radiation Alone vs Combination Chemotherapy Alone for Early-Stage Hodgkin's Disease: Implications of 25-Year Follow-Up to Current Combined Modality Therapy. (yale.edu)
By comparison, TLS in patients with solid organ tumours treated with cytotoxic chemotherapy occurs within 3 days (95% CI 2.9-4.4). (touchoncology.com)
As opposed to cytotoxic chemotherapy, TKIs target specific mutated kinases that promote tumour angiogenesis and neoplastic cells growth, proliferation, and resistance to apoptosis. (touchoncology.com)
Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)

This investigational therapeutic approach of targeting the cytotoxin to hypoxic zones in tumors may cause less broad systemic toxicity that is seen with untargeted cytotoxic chemotherapies. (wikipedia.org)
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of neoplastic cells are killed rapidly, leading to the release of intracellular ions and metabolic byproducts into the systemic circulation. (medscape.com)
Norepinephrine transporter, organic cation transporters, and multidrug and toxin extrusion proteins play differential roles in tumor targeting, systemic elimination, and accumulation in normal tissues. (aspetjournals.org)
AZEDRA ® (iobenguane I 131) is indicated for the treatment of adult and pediatric patients 12 years and older with iobenguane scan positive, unresectable, locally advanced or metastatic pheochromocytoma or paraganglioma who require systemic anticancer therapy. (lantheus.com)
The trial supported the July 2021 regular approval of the combination for treatment of patients with advanced endometrial carcinoma that is not microsatellite instability-high or mismatch repair-deficient who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation. (ascopost.com)

The primary endpoint of the study is OS, and secondary endpoints include progression-free survival (PFS) and objective response rate (ORR) as assessed by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 modified for mesothelioma, safety and quality of life. (merck.com)
The primary endpoints were progression-free survival on blinded independent central review using Response Evaluation Criteria in Solid Tumors version 1.1 and overall survival assessed among the pMMR population and the total population. (ascopost.com)

Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma . (ucbraid.org)

Bridget Keenan, MD, discusses the tumor microenvironment (TME) and its crucial role in cancer immunotherapy responses. (oncologytube.com)
The immunosuppressive microenvironment of solid tumors, in particular, creates a favorable niche for systemically administered bacteria to engraft and release therapeutic payloads. (nature.com)
Current research areas studied include the interactions between newly formed tumor cells and both innate and adaptive immune cells, the role of myeloid cells (e.g. macrophages, antigen presenting cells) in the regulation of the tumor microenvironment, how lymphocytes traffic to tumors, and how tumors hide from them, and the relationship between a patient's microbiome and their immune cells in different cancers. (virginia.edu)

Tumor biomarkers were analyzed in patients with hypersecreting tumors (tumor biomarkers 1.5x above the upper limit of normal at baseline). (lantheus.com)

This multi-institution phase II trial of induction irinotecan/gemcitabine followed by twice-weekly gemcitabine and upper abdominal radiation has been initiated to determine the activity of this regimen in patients with unresectable pancreatic cancer. (cancernetwork.com)
Following the induction therapy, patients without disease progression received twice-weekly gemcitabine at 40 mg/mÂ² and radiation. (cancernetwork.com)
The combination of concurrent fluorouracil (5-FU)and ionizing radiation therapy for patients with unresectable disease hasresulted in a twofold increase in median survival: approximately 10 months vs 5months. (cancernetwork.com)
Because tumor lysis syndrome is potentially lethal, the main principles of management are (1) identification of high-risk patients with initiation of preventive therapy and (2) early recognition of metabolic and renal complications and the prompt administration of supportive care, including hemodialysis. (medscape.com)
Tumor lysis syndrome occurs most often in patients with acute leukemia with high white blood cell (WBC) counts and in those with high-grade lymphomas in response to aggressive treatment. (medscape.com)
Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)
There have been few treatment advances for patients with malignant pleural mesothelioma, which can be challenging to treat through surgery and radiation alone," said Dr. Quincy Chu, CCTG's study chair of the IND.227 trial/KEYNOTE-483 trial. (merck.com)
The TAPUR Study aims to describe the safety and efficacy of Food and Drug Administration (FDA)-approved, targeted anticancer drugs prescribed for treatment of patients with advanced cancer that has a potentially actionable genomic alteration. (facingourrisk.org)
STEP 0 (Screening): Patients undergo biopsy along with molecular characterization of the biopsy material for specific, pre-defined mutations, amplifications, or translocations of interest via tumor sequencing and immunohistochemistry. (iu.edu)
This phase II Pediatric MATCH trial studies how well palbociclib works in treating patients with Rb positive solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with activating alterations (mutations) in cell cycle genes that have spread to other places in the body and have come back or do not respond to treatment. (clinicaltrialsgps.com)
complete response + partial response) in pediatric patients treated with palbociclib with advanced solid tumors (including central nervous system [CNS] tumors), non-Hodgkin lymphomas or histiocytic disorders that harbor activating genetic alterations in cell cycle genes. (clinicaltrialsgps.com)
I. To estimate the progression free survival in pediatric patients treated with palbociclib with advanced solid tumors (including CNS tumors), non-Hodgkin lymphomas or histiocytic disorders that harbor activating genetic alterations in alterations in cell cycle genes. (clinicaltrialsgps.com)
Patients must have adequate tumor tissue available for PD-L1 testing. (bcan.org)
To determine the maximum tolerated dose of irinotecan when administrated with temozolomide every 28 days, in patients with recurrent malignant glioma who were also receiving CYP450 enzyme-inducing antiepileptic drugs (EIAED), and to characterize the pharmacokinetics of irinotecan and its metabolites. (aacrjournals.org)
Some of the information, including information about funding for cancer drugs, does not apply to all patients. (cancercareontario.ca)
For instance, in January 2019, the American Society of Haematology, an association comprising of clinical scientists and physicians that provides care to patients in diverse settings, sent a letter to USFDA highlighting the issue of shortage of critical hematologic drugs such as etoposide and methotrexate, which have no alternatives. (yahoo.com)
Professor of Endocrine Neoplasia and Hormonal Disorders at the University of Texas MD Anderson Cancer Center , delivered an oral presentation entitled: "Biochemical Tumor Marker Status and Its Role in Treatment Response in Patients Who Received High-Specific-Activity I-131 MIBG in Advanced Pheochromocytoma and Paraganglioma (PPGL): Results from a Pivotal Phase 2 Clinical Trial" on Saturday, March 20, 2021 . (lantheus.com)
In addition, the overall tumor biomarker response correlated significantly with both the primary and secondary endpoint responses in the study, underscoring the clinical utility and relevance of this important biochemical endpoint to the therapeutic benefit of AZEDRA in patients with these life-threatening tumors. (lantheus.com)
These risks of radiation associated with the use of AZEDRA are greater in pediatric patients than in adults. (lantheus.com)
Minimize radiation exposure to patients, medical personnel, and household contacts during and after treatment with AZEDRA consistent with institutional good radiation safety practices and patient management procedures. (lantheus.com)
Research at UVA has fundamentally contributed to these advances, beginning with the early identification of tumor proteins targeted by T cells in melanoma patients. (virginia.edu)
Will identifying genetic abnormalities in tumor cells help doctors plan better, more personalized treatment for cancer patients? (ucbraid.org)
This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. (ucbraid.org)
Genetic tests look at the unique genetic material (genes) of patients' tumor cells. (ucbraid.org)

These combinational therapies reduce the frequency of drug administration. (thebusinessresearchcompany.com)
In a recent discussion on adoptive T cell therapies for solid tumors, Anusha Kalbasi, MD, provided a comprehensive analysis of various modalities, shedding light on their challenges and potential breakthroughs. (oncologytube.com)
The logical gating of antigen recognition further addresses the perennial challenge of identifying suitable tumor antigens in CAR T cell therapy, showcasing the evolving landscape of adoptive T cell therapies. (oncologytube.com)
Preclinical success has led to a profusion of clinical trials on LB100 adjuvant therapies, including a phase I trial in extensive-stage small-cell lung cancer, a phase I/II trial in myelodysplastic syndrome, a phase II trial in recurrent glioblastoma, and a completed phase I trial assessing the safety of LB100 and docetaxel in various relapsed solid tumors. (cancerbiomed.org)
Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are currently the focus of anticancer drug development. (spandidos-publications.com)
There is a growing body of evidence that therapy-related myeloid neoplasms (t-MNs) with driver gene mutations arise in the background of clonal hematopoiesis (CH) under the positive selective pressure of chemo- and radiation therapies. (dana-farber.org)
Further translational research is being performed in the identification of specific cellular targets that can be used for anti-cancer therapies, the development of anti-tumor vaccines and the immunological optimization of these therapies. (virginia.edu)
1 TKIs are now therapies used routinely in the treatment of many solid tumours such as gastrointestinal stromal tumour (GIST), renal cell carcinoma (RCC), hepatocellular carcinoma (HCC), medullary thyroid cancer, breast cancer and non-small-cell lung carcinoma (Table 1) . (touchoncology.com)

Current Research and Scholarly Interests My research is on the translational application of next-generation sequencing technologies to breast cancer care: (1) the value of hereditary cancer genetic panel testing in clinical practice, (2) the mechanisms by which inherited genetic variants lead to breast cancer development, and (3) the analysis of somatic tumor sequencing data to inform understanding of breast tumorigenesis, metastasis, and development of resistance in response to therapeutics. (stanford.edu)

Tumor markers are tumor-derived or tumor-associated proteins, antigens, genes or hormones that can also aid in diagnosis, in the measurement of therapeutic response, in locating tumor origin or in determining recurrence. (oncolink.org)

These two important mechanisms of approaching cancer, principally through the clinical application of the P53 tumor suppressor gene and other apoptotic players that for the past 15 years have been included in my cancer strategy as a diagnostic, prognosis, and follow up treatment. (biobran.org)
Although PP2A has historically been identified as a tumor suppressor, inhibition of PP2A has paradoxically demonstrated potential as a therapeutic target for various cancers. (cancerbiomed.org)

Clinically significant tumor lysis syndrome can occur spontaneously, but it is most often seen 48-72 hours after initiation of cancer treatment. (medscape.com)
In some cases, such as the c-Kit mutation observed in GIST, tumour cells can be highly "addicted" to one or more oncogenic kinases 2-4 and the inhibition of these kinases with a TKI can lead to a striking tumour response and trigger tumour lysis syndrome (TLS). (touchoncology.com)

Dose expansion (Phase 2) will be to further explore the safety and tolerability of the MTD and/or RP2D, PK, PD, anti-tumor activity, and efficacy of TT-10. (survivornet.com)
Among the numerous available small molecule BH3 mimetics, ABT-737, a potent small molecule that binds to Bcl-2/Bcl-xL with high affinity, has anti-tumor activity in a wide variety of cancer cells. (oncotarget.com)

To assess whether radiomic phenotypes obtained from pre-treatment imaging and changes from pre- through post-therapy imaging can predict objective response and progression free survival and to evaluate the association between pre-treatment radiomic phenotypes and targeted gene mutation patterns of tumor biopsy specimens. (iu.edu)
Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)

The indications are a broad spectrum of solid tumor types and blood cancers. (wikipedia.org)
Moving to CAR T cell therapy for central nervous system (CNS) tumors, Kalbasi, MD, acknowledged the historic success in hematologic cancers and emerging victories in solid tumors. (oncologytube.com)
For treatment of neuroendocrine cancers (i.e., carcinoid tumors and pancreatic endocrine tumors) involving the liver. (aetna.com)
Single drugs may cure selected cancers (eg, choriocarcinoma, hairy cell leukemia). (msdmanuals.com)

This industry includes establishments that produce drugs to treat rheumatoid arthritis, muscle relaxants to reduce muscle pain, and other drugs used in treating osteoarthritis, analgesics drugs, immunosuppressive. (thebusinessresearchcompany.com)
During the presentation, Dr. Keenan explores targeting the TME through immunotherapies, focusing on tumor metabolism and immunosuppressive myeloid cells. (oncologytube.com)

Mainly the drug etoposide, which is a chemotherapeutic drug, that is a crucial component in treatment regimens designed to be curative for life-threatening conditions including leukaemia and lymphomas. (yahoo.com)

Patient is positive for EGFR or HER2 mutations based on DNA genetic testing of either tumor tissue or plasma samples, but tissue is preferred. (mycancergenome.org)
However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)

Patient has a metastatic solid tumor that meets at least one of the following criteria: - has progressed on a standard therapy - has no available standard therapy - In the opinion of the investigator, patient is not a candidate for or would be unlikely to tolerate or receive benefit from standard therapy 4. (mycancergenome.org)
This study is looking at the effectiveness of combining a PARP inhibitor called niraparib and an immunotherapy called dostarlimab for treating people with an inherited BRCA mutation (found with genetic testing) or a tumor mutation (found through tumor testing) who have breast, pancreatic, ovarian, fallopian tube or primary peritoneal cancer that is metastatic or advanced and cannot be removed by surgery (unresectable). (facingourrisk.org)
Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)

The indirect comparison of both studies shows comparable hematologic toxicity and efficacy profiles of evofosfamide and ifosfamide in combination with doxorubicin. (wikipedia.org)
More commonly, multidrug regimens incorporating drugs with different mechanisms of action and different toxicities are used to increase efficacy, reduce dose-related toxicity, and decrease the probability of drug resistance. (msdmanuals.com)

This review summarizes the intracellular functions of Akt as a pivotal point of converging signaling pathways involved in cell growth, proliferation, apoptotis and neo‑angiogenesis, and focuses on the drug design strategies to develop potent anticancer agents targeting Akt. (spandidos-publications.com)
Therefore, there have been recent attempts to develop effective anticancer strategies targeting apoptotic signaling pathways [ 2 ], such as through inhibiting anti-apoptotic survival factors, which are likely overexpressed in many tumors and may confer drug-resistant phenotypes [ 2 , 3 ]. (oncotarget.com)
Pathways to enhance T cell function in tumors. (virginia.edu)
Tyrosine kinase inhibitors (TKIs) are small anticancer molecules targeting protooncogenic tyrosine kinase signalling pathways. (touchoncology.com)

elicits antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. (medscape.com)
It also shows incredible cytotxicity and tumor suppressive ability in studies conducted both in vitro and in vivo as well as in studies conducted in humans. (ima.org.il)
Knockdown of Bcl-xL was identified as the top sensitizer to HDM201 in vitro, and Bcl- xL was enriched in relapsing tumors from mice treated with intermittent high doses of HDM201. (bace-signal.com)

Tumor-infiltrating lymphocytes (TILs) comprise of all lymphocytic cell populaces that have occupied the tumor tissue. (yahoo.com)
For instance, in January 2020, Lovance Biotherapeutics, a US-based start-up company, has licensed TALEN technology from Cellectis to develop gene-editing tumor-infiltrating lymphocytes (TIL) to treat several cancer indications. (yahoo.com)

Evofosfamide is being evaluated in clinical trials for the treatment of multiple tumor types as a monotherapy and in combination with chemotherapeutic agents and other targeted cancer drugs. (wikipedia.org)
Chemotherapeutic agents, corticosteroids, and monoclonal antibodies are used to reduce the disease burden, and bisphosphonates are used to promote bone healing and to provide secondary prophylaxis against skeletal-related events (eg, hypercalcemia, bone fracture, spinal cord compression, need for radiation, and need for surgery). (medscape.com)

Rapid tumor cell turnover results in release of intracellular contents into the circulation. (medscape.com)
The pathophysiology of TLS is characterised by an extensive breakdown of tumour cells releasing intracellular contents into the bloodstream, leading to acidosis, hyperuricemia, hyperphosphatemia, and hyperkalemia. (touchoncology.com)

Clinical and Translational Radiation Oncology. (elsevierpure.com)

Therefore, there is substantial interest in developing chemotherapeutic drugs that directly target pro-survival Bcl-2 proteins by mimicking the BH3 domain and unleashing pro-apoptotic molecules in tumor cells. (oncotarget.com)

Precise detection and diagnosis of specific tumor types and disease stages is essential for designing the appropriate and effective regimens for treatment. (aspetjournals.org)
Multidrug regimens typically are given as repetitive cycles of a fixed combination of drugs. (msdmanuals.com)

Cohort E: Exploratory Biopsy - Inclusive of participants with RCC, CRPC and/or NSCLC who have failed or are not eligible for standard of care treatment and have an accessible tumor for pre- and post dose biopsies. (survivornet.com)
Acceptable samples include core-needle biopsies for deep tumor tissue (minimum of three cores) or excisional, incisional, punch, or forceps biopsies for cutaneous, subcutaneous, or mucosal lesions. (bcan.org)
It is often used for detecting ascites, biliary or renal obstruction, or pelvic tumors, and is also useful for guiding biopsies. (oncolink.org)

Despite its selective uptake by neuroendocrine tumors, mIBG accumulates in several normal tissues and leads to tissue-specific radiation toxicities. (aspetjournals.org)

To demonstrate that known drugs of proven efficacy could serve as the basis of efficacious hypoxia-activated prodrugs, the 2-nitroimidizole HAP of the active phosphoramidate bis-alkylator derived from ifosfamide was synthesized. (wikipedia.org)
TILs have been depicted in various solid tumors including breast cancer, and are emerging as a significant biomarker in predicting the efficacy and result of treatment. (yahoo.com)

Transporters on the plasma membrane of tumor cells are promising molecular "Trojan horses" to deliver drugs and imaging agents into cancer cells. (aspetjournals.org)
mIBG enters cancer cells through the norepinephrine transporter (NET) where the radioactive decay of 131 I causes DNA damage, cell death, and tumor necrosis. (aspetjournals.org)
Notably, CAR T cells targeting IL 13 receptor alpha 2 and GD2 showcased early success in glioblastoma and midline glioma, respectively, indicating a shift in the narrative for solid tumor treatments. (oncologytube.com)
Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
However, ionizing radiation carries the risk of damage to host immune cells and engineered microbial cells 31 . (nature.com)
The ideal drug would target only cancer cells and have no adverse effects on normal cells. (msdmanuals.com)
Although older chemotherapeutic drugs are often toxic to normal cells, advances in genetics and cellular and molecular biology have led to development of more selective drugs. (msdmanuals.com)
Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)
In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)
Researches also show reduced blood supply to tumors which prevents cancer cells from obtaining nutrients. (superfoods-scientific-research.com)
Precis: Pulsed high doses versus sustained low doses of the p53-MDM2 inhibitor HDM201 elicit a pro-apoptotic response from wild-type p53 cancer cells, offering guidance to current clinical trials with this and other drugs that exploit the activity of p53. (bace-signal.com)

Chest Pain , sometimes accompanied by changes in electrocardiograms, occurs mostly in those with a previous history of cardiovascular disease or the presence of a bulky tumour within the chest. (cancercareontario.ca)

Imaging procedures play a vital role in diagnosis, allowing physicians to ascertain the presence of a mass, localize it for biopsy, characterize tissue, and determine anatomical extent of disease in preparation for subsequent therapy (surgery and radiation therapy, for example). (oncolink.org)

For pre-treatment archival tissue, representative urothelial carcinoma FFPE tumor specimens (tumor blocks or 30 unstained slides) must be provided. (bcan.org)

Bortezomib is the first drug approved in the group of anticancer agents known as proteasome inhibitors. (medscape.com)

For intravenous infusion, the evofosfamide drug product is diluted in 5% dextrose in WFI. (wikipedia.org)

Hazard ratios for overall survival were 0.78 (95% CI = 0.56-1.08) among those with and 0.62 (95% CI = 0.47-0.80) among those without prior pelvic radiation in the pMMR population and 0.69 (95% CI = 0.51-0.93) and 0.56 (95% CI = 0.44-0.72), respectively, in the total population. (ascopost.com)

In this report, we describe a case of TLS in a patient with gastrointestinal stromal tumour (GIST) that occurred 15 days after commencement of imatinib. (touchoncology.com)

Hence, a major goal in cancer drug development and therapy is to increase tumor-specific drug uptake while reducing uptake into normal tissues to minimize toxicities. (aspetjournals.org)
This study is comparing safety and effectiveness of a new drug called giredestrant compared to standard hormone therapy in people with early-stage, ER-positive breast cancer. (facingourrisk.org)
In a clinically relevant cancer model, ultrasound-activated therapeutic microbes successfully turn on in situ and induce a marked suppression of tumor growth. (nature.com)
Tumor-Infiltrating Lymphocyte Immunotherapy has been gaining popularity in recent times because of its positive results in anti-cancer treatments. (yahoo.com)
Mitsiades CS, Mitsiades N and Koutsilieris M: The Akt pathway: Molecular targets for anti-cancer drug development. (spandidos-publications.com)
Curr Cancer Drug Targets. (spandidos-publications.com)
Long-term cumulative radiation exposure is associated with an increased risk for cancer. (lantheus.com)
The National Cancer Institute maintains an up-to-date list of drugs used to treat cancer. (msdmanuals.com)
Most cancer drugs are given systemically, usually intravenously or subcutaneously, but some are given by mouth. (msdmanuals.com)
Resistance to cancer drugs is common. (msdmanuals.com)

For instance, in May 2019, Galt Pharmaceuticals has submitted a Supplemental Abbreviated New Drug Application to the U.S. Food and Drug Administration for Orphengesic Forte an oral formulation of aspirin, caffeine, and orphenadrine for the treatment of pain caused due to musculoskeletal disorders. (thebusinessresearchcompany.com)
Arencibia JM, Pastor-Flores D, Bauer AF, Schulze JO and Biondi RM: AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases. (spandidos-publications.com)

The aim of this study was to examine the effectiveness of Tumor Dissociation Enzyme (TDE) on the viability of follicles after digestion of fresh and cryopreserved ovarian cortex fragments (OCFs). (biomedcentral.com)

To avoid damaging healthy organs, it is crucial that the therapeutic activity of microbes be targeted to tumors. (nature.com)

Combination therapy involves use of more than one medication or drug to treat a disease. (thebusinessresearchcompany.com)
There is currently no cure for MM. However, advances in therapy, such as autologous stem cell transplantation, radiation, and surgical care in certain cases, have helped to lessen the occurrence and severity of adverse effects of this disease and to manage associated complications. (medscape.com)
The major modalities of therapy are Surgery (for local and local-regional disease) Radiation. (msdmanuals.com)
Nutritional compromise and changes in drug therapy increase this risk and require that any patient remaining on warfarin must undergo frequent monitoring of anticoagulant effect. (phosphorylase-signal.com)
However, TLS in solid tumours treated with TKIs has been repeatedly described during the second and third weeks following the initiation of therapy rather than within the first week. (touchoncology.com)

These changes are related to data protection such as the European Union's General Data Protection Regulation (GDPR), changes to drug approval procedures and other regulatory changes. (thebusinessresearchcompany.com)

Vinorelbine, a semi-synthetic vinca alkaloid, exerts its anti-tumour activity by binding to tubulin and inhibiting microtubule assembly, thereby preventing cell mitosis and causing cell death. (cancercareontario.ca)

The patient must have measurable disease according to RECIST v1.1 and must have one site amenable to biopsy that, in the opinion of the investigator and/or interventional radiologist, is likely to yield acceptable tumor sample for a core biopsy per the below pathology criteria. (bcan.org)
Patient was treated with neo adjuvant concurrent chemo radiation with capecitabine. (jbclinpharm.org)
clinical conditions of the patient, the existence of a tumors are considered rare (KLUSMANN et al. (bvsalud.org)

End-organ function should be assessed before giving drugs with organ-specific toxicities. (msdmanuals.com)

Medically reviewed by Drugs.com. (drugs.com)

Pomegranate extract reduced the number and size of experimentally induced colon tumors in animal subjects. (superfoods-scientific-research.com)

To address this limitation, we engineer therapeutic bacteria to be controlled by focused ultrasound, a form of energy that can be applied noninvasively to specific anatomical sites such as solid tumors. (nature.com)
Adjust AZEDRA therapeutic doses based on radiation dose estimates results from dosimetry, if needed. (drugs.com)

Anatomy11

Organisms5

Diseases55

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment62

Phenomena and Processes52

Disciplines and Occupations4

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