• During 9 years of follow-up beginning in 1995, the authors documented 157 hematologic malignancies, including 119 cases of lymphoid neoplasms and 36 cases of myeloid neoplasms. (greenmedinfo.com)
  • Here, through an evaluation for TRK fusions across more than 7,000 patients with hematologic malignancies, we identified TRK fusions in acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), histiocytosis, multiple myeloma, and dendritic cell neoplasms. (elsevierpure.com)
  • We performed a systematic review of clinical studies conducted in the United States that evaluated any social determinants that could impact survival in patients with hematologic malignancies. (onclive.com)
  • Chimeric antigen receptor (CAR) T-cell therapy is an example of how immunotherapy is revolutionizing the treatment of hematologic malignancies with unprecedented response rates in patients with relapsed/refractory lymphoma, multiple myeloma, and acute lymphoblastic leukemia. (ajmc.com)
  • During 2003-2014, we identified 26 patients whose hematological malignancies and HEV infection and report- laboratory test results showed HEV replication. (cdc.gov)
  • For example, over one-half of patients diagnosed with hematological malignancies have some evidence of malnutrition, and more than a third have impaired physical function. (dana-farber.org)
  • Hematological malignancies. (bvsalud.org)
  • Salman joined IU School of Medicine from Stony Brook University and Stony Brook Cancer Center, where she founded the hematological malignancies section as well as the Cancer Center Adolescence and Young Adult Program. (beaconhealthsystem.org)
  • A leukemia survivor herself, Salman's clinical expertise is focused on hematological malignancies and bone marrow transplantation and cellular therapy, particularly for acute and aggressive lymphomas. (beaconhealthsystem.org)
  • Depressive symptoms during the first month of chemotherapy and survival in patients with hematological malignancies: A prospective cohort study [posted online July 2, 2019]. (hematologyadvisor.com)
  • Gamida Cell), a substantially modified allogeneic cord blood-based cell therapy, to quicken the recovery of neutrophils in the body and reduce the risk for infection in adults and pediatric patients aged ≥12 years with hematologic malignancies who have a planned umbilical cord blood transplant after a myeloablative conditioning regimen, such as radiation or chemotherapy. (oncpracticemanagement.com)
  • Introduction: Patients with head and neck cancer or hematologic malignancies who receive chemotherapy or radiotherapy present oral complications as side effects of the treatment. (bvsalud.org)
  • Researchers sought to investigate the influence of depressive symptoms in patients with hematologic malignancies before and 1 month after the initiation of chemotherapy. (hematologyadvisor.com)
  • Dana-Farber's Older Adult Hematologic Malignancy (OHM) Program is a unique research and clinical service that addresses the specialized needs of older patients with blood cancers. (dana-farber.org)
  • Implement cancer immunotherapy treatments for melanoma, lung, genitourinary, head and neck, and/or hematologic cancers into clinical practice appropriately. (sitcancer.org)
  • New stem cell transplantation research conducted by physicians at selected stem cell transplant centers and at Miami Cancer Institute , part of Baptist Health, is showing promise in the fight against relapse, a leading cause of death in patients with hematologic cancers. (broadcastmed.net)
  • PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. (ox.ac.uk)
  • Here, we summarize the current knowledge about the role of PIM serine/threonine kinases for the pathogenesis and therapy of hematologic malignancies and solid cancers, and we highlight structural principles and recent progress on small molecule PIM kinase inhibitors that are on their way into first clinical trials. (ox.ac.uk)
  • Hematologic malignancies are one of the most common cancers , and the incidence has been rising in recent decades. (bvsalud.org)
  • Low-dose radiotherapy has been used as palliative care for splenomegaly in patients with hematologic disorders such as primary myelofibrosis. (medscape.com)
  • These lesions most commonly appear as ulcers in Sweet syndrome patients with hematologic disorders. (medscape.com)
  • At the European Hematology Association 2023 meeting in June, Guenther Koehne, M.D., Ph.D. , deputy director and chief of Blood & Marrow Transplantation and Hematologic Oncology at the Institute, presented initial results from a first-in-human study in patients with acute myeloid leukemia (AML). (broadcastmed.net)
  • If you have a patient that would benefit from geriatric management in addition to hematologic oncology consultation, please contact our new patient office at 617-632-6028 . (dana-farber.org)
  • We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH 2021," said Peter Lebowitz, M.D., Ph.D., Global Therapeutic Area Head, Oncology, Janssen Research & Development, LLC. (jnj.com)
  • The novel BCL-2 inhibitor, lisaftoclax (APG-2575), elicited encouraging responses and acceptable tolerability in patients with relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and other hematologic malignancies, according to results of a phase 1 study presented at the American Society of Clinical Oncology 2021 virtual annual meeting. (oncpracticemanagement.com)
  • Children with hematologic malignancies, including leukemia and lymphoma, are treated through the Hematologic Malignancy Center at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, an integrated pediatric hematology and oncology partnership between Dana-Farber Cancer Institute and Boston Children's Hospital . (childrenshospital.org)
  • This educational activity is based on case presentations and subsequent small group discussions of patients with hematologic malignancies that are being evaluated, treated and followed in the Department of Hematology and Oncology, and that have diagnostic or follow-up material evaluated in the Division of Hematopathology. (mcw.edu)
  • The International Congress on Hematologic Malignancies offers the latest updates from the advancing field of hematology," said Talamo. (gotoper.com)
  • Innovations in immunotherapy have led to the development of multiple immune-targeted therapies to manage malignancy. (ajmc.com)
  • Recent advances in molecular biology are transforming the treatment of hematologic malignancies by providing powerful new tools useful in both diagnosis and the assessment of new therapies. (upm.edu.my)
  • This module covers clinical data on the efficacy of approved therapies, the mechanism of action of approved therapies, patient selection for approved therapies, and dosing and sequencing of approved therapies for the treatment of hematologic malignancies. (sitcancer.org)
  • Among the most revolutionary therapies for hematologic malignancies is stem cell transplantation, which had its beginnings in the 1950s. (broadcastmed.net)
  • Purpose of ReviewAn intact DNA damage response is crucial to preventing cancer development, including in myeloid and lymphoid malignancies. (sagepub.com)
  • Acquired alpha-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies. (ox.ac.uk)
  • Acquired alpha-thalassemia is the best characterized of the acquired red blood cell disorders in patients with hematologic malignancy, and it is almost always associated with a myelodysplastic syndrome (MDS). (ox.ac.uk)
  • This series of interactive webinars will provide clinicians across the care spectrum treating hematologic malignancies with a foundational understanding of genomics, current applications and advances, and practical strategies to apply these findings to treating patients. (schoolandyouth.org)
  • These findings identified 5 key variables primarily associated with worse overall survival outcomes for patients with hematologic malignancies: lack of access to health insurance, treatment at a non-academic research institution, economic instability, low education level, and marital status. (onclive.com)
  • Our results support several previous findings regarding the incidence of hematopoietic and colorectal malignancies in RA patients. (nih.gov)
  • The Duke Division of Hematologic Malignancies and Cellular Therapy is internationally recognized for its novel approaches to treating leukemia, lymphoma, myeloma, and other life threatening diseases through integrated, innovative, and holistic patient care, research, and education. (duke.edu)
  • The mission of the division of Hematologic Malignancies and Cellular Therapy is to promote health and improve lives by preventing, diagnosing, and treating blood cancer and other life threatening diseases through integrated, innovative, and holistic patient care, education, and research. (duke.edu)
  • Informal family caregivers (FCs) of adults with various diseases including hematologic malignancy (HM) experience low quality of life and psychological well-being. (duke.edu)
  • Finding other patients that share similar journeys, connecting with physicians who have the expertise in managing these diseases, locating all available clinical trial options, answering important research questions using real-world data, even designing prospective clinical trials to recruit enough patients with hematologic malignancies have barriers -- because it is hard to navigate and find all the right needles within a national haystack. (flatiron.com)
  • Leukemia cutis (LC) and eosinophilic dermatosis of hematologic malignancy (EDHM) are rare cutaneous manifestations of hematologic malignancies. (jefferson.edu)
  • BACKGROUND: Cryopreserved hematopoietic stem cell products are widely used for certain hematologic malignancies. (lu.se)
  • Our study demonstrated that persistent use of statins is associated with a lower overall cancer risk and particularly the risk of incident hematopoietic malignancies. (cdc.gov)
  • Marisol Miranda-Galvis, DDS, MS, PhD, highlights the importance of understanding which social determinants of health have the greatest influence on treatment-related outcomes in patients with hematologic malignancies, expands on key variables identified in a systematic review of these disparities, and emphasizes the importance of continuing to implement new strategies to increase access to quality treatments. (onclive.com)
  • Although the continued development of novel treatment strategies and the emergence of new agents have improved survival outcomes for patients with hematologic malignancies, socio-economic disparities could affect survival rates for different patients in the United States, according to a systemic review evaluating social determinants of health and patient survival outcomes. (onclive.com)
  • The Dana-Farber/Boston Children's Hematologic Malignancy Center treats children with hematologic malignancies, including leukemia and lymphoma. (childrenshospital.org)
  • Of those, 34 patients (50%) had an underlying malignancy, of which more than half were splenic marginal zone lymphoma. (medscape.com)
  • These data identify that despite their individual rarity, collectively, TRK fusions are present in a wide variety of hematologic malignancies and predict clinically significant therapeutic responses to TRK inhibition. (elsevierpure.com)
  • In an interview with OncLive ® , Miranda-Galvis highlighted the importance of understanding which social determinants of health have the greatest influence on treatment-related outcomes in patients with hematologic malignancies, expanded on key variables identified in this systematic review, and emphasized the importance of continuing to implement new strategies to increase access to quality treatments, allowing for a more equitable distribution of benefit across all patient subgroups. (onclive.com)
  • Alarmingly, and despite indisputable success achieved in the treatment of these malignancies, their incidence in westernized countries during the last 3 decades has been increasing more rapidly than that of most other tumors. (univ-mrs.fr)
  • Electrolyte abnormalities are frequently seen in patients receiving treatment for hematologic malignancies and can affect ongoing treatment. (ons.org)
  • Conclusions and Implications The presence of two primary malignancies may translate into a unique diagnostic and treatment situation where the presence of the other may impact surgical, medical, and radiation management for one cancer. (bmj.com)
  • There was no correlation of the type of hematologic malignancy, occurrence or type of treatment, peripheral blood counts, or spleen size to survival. (nebraska.edu)
  • This educational event is intended for community-based hematologists and medical oncologists, nurse practitioners, nurses, physician assistants, pharmacists and health care professionals interested in the treatment of hematologic malignancies. (gotoper.com)
  • The clinical and molecular features of hematologic malignancies are highly heterogenous, and some hematologic malignancies are incurable, challenging the treatment , and prognosis of the patients . (bvsalud.org)
  • Whereas elevated levels of PIM1 and PIM2 were mostly found in hematologic malignancies and prostate cancer, increased PIM3 expression was observed in different solid tumors. (ox.ac.uk)
  • Here we review the clinical, hematologic, and molecular genetic features of alpha-thalassemia arising in a clonal myeloid disorder, and we discuss howATRX might affect gene expression in normal and abnormal hematopoiesis through epigenetic mechanisms. (ox.ac.uk)
  • Even with these impressive advances in medicine, there is still so much more to do for patients with hematologic malignancies. (flatiron.com)
  • She uses a multidisciplinary approach to diagnose and treat blood disorders, head and neck cancer, and solid malignancies. (uclahealth.org)
  • What was the rationale for investigating the effect of social determinants of health on survival outcomes for patients with hematologic malignancies? (onclive.com)
  • The goal of the Hematologic Malignancies Transdisciplinary Cancer Team is to bring expertise from different disciplines in basic and clinical research to advance our understanding of hematologic malignancies and to translate that information to clinical trials to improve patient care in South Carolina. (musc.edu)
  • This pilot clinical trial studies the side effects of irradiated donor cells following stem cell transplant in controlling cancer in patients with hematologic malignancies. (bioseek.eu)
  • Join the experts at the Miami Cancer Institute Global Summit on Immunotherapies for Hematologic Malignancies, March 8-9, 2024, at the JW Marriott Brickell, 1109 Brickell Ave., in Miami, to learn more. (broadcastmed.net)
  • Research in CAR T-cell therapy is expected to improve tolerability and expand indications to more types of malignancies and earlier phases of disease. (ajmc.com)
  • Sweet syndrome (acute febrile neutrophilic dermatosis) is a hypersensitivity reaction that occurs in response to systemic factors, such as hematologic disease, infection, inflammation, vaccination, or drug exposure. (medscape.com)
  • Abnormalities of hemoglobin synthesis are usually inherited but may also arise as a secondary manifestation of another disease, most commonly hematologic neoplasia. (ox.ac.uk)
  • Ulcers and bullae are more common in malignancy-associated disease than in other forms. (medscape.com)
  • Management of HEV characteristics and treatments of patients with hematologic infection in the context of allogeneic stem cell transplanta- malignancies before or within the 6 months after the diag- tion (SCT) has been a matter of controversy ( 5 , 6 ). (cdc.gov)
  • abstract = "Five cases of pathologic rupture of the spleen in patients with hematologic malignancy are presented along with a review of the 48 cases previously described in the English literature. (nebraska.edu)
  • abstract = "Several biologic studies have reported that green tea constituents have antitumor effects on hematologic malignancies. (elsevierpure.com)
  • [ 26 ] Bruns et al reported that low-dose splenic irradiation produced hematologic response and long-term relief of splenic pain in four of five patients with symptomatic congestive splenomegaly. (medscape.com)
  • 2,3 Cellular therapy centers, manufacturers, payers, and policy makers will need to work together to address barriers to care as new CAR T-cell products with improved efficacy and tolerability are approved for use in more diverse malignancies. (ajmc.com)
  • We encourage clinicians to identify patients with hematologic malignancies who present with [socio-economic] disadvantages [associated with worse survival] and implement some socially targeted interventions," Marisol Miranda-Galvis, DDS, MS, PhD, said. (onclive.com)
  • We've leveraged technology to learn from patients with hematologic malignancies in order to break these barriers rare populations have to advance research and improve access to clinical trials. (flatiron.com)
  • In Hematologic Malignancies: Methods and Techniques, a panel of acknowledged experts review many of the key mo. (upm.edu.my)
  • In some reports, the lesions of Sweet syndrome are the first clue of underlying malignancy. (medscape.com)
  • [ 2 ] Cases associated with malignancy can present with bullous or ulcerative lesions, which can resemble atypical pyoderma gangrenosum . (medscape.com)
  • Evidence of frailty is very common in older patients with hematologic malignancy. (dana-farber.org)