• should be added to the list of microorganisms causing invasive fungal disease in neutropenic patients with hematologic malignancies. (cdc.gov)
  • Until a few years ago, the most frequent microbiologically documented cause of severe bloodstream infections among patients with hematologic malignancies was gram-positive bacteria ( 1 ). (cdc.gov)
  • However, over the years, gram-negative bacteria have become the main infectious cause of death among patients with hematologic malignancies, and rates of different phenotypes associated with antimicrobial drug resistance are increasing ( 2 ). (cdc.gov)
  • We reviewed records of all patients affected by hematologic malignancies who were admitted to the hospital hematology department from January 2009 through December 2012 and in whom a bloodstream infection caused by gram-negative bacteria developed. (cdc.gov)
  • Assess anti-tumor response rates in patients with hematologic malignancies [ Time Frame: Participants will be followed on an intention-to-treat basis, and data from all enrolled participants will be collected, irrespective of outcome, for the scheduled minimum follow-up period of 3 years. (clinicaltrials.gov)
  • Additional disease staging procedures and studies for other hematologic malignancies as clinically indicated. (clinicaltrials.gov)
  • This Phase 1 clinical study is designed to examine the safety and feasibility of using anti-CD3 /CD28 activated marrow infiltrating lymphocytes (MILs) as treatment of relapse after allogeneic hematopoietic cell transplantation (alloHCT) for patients with hematologic malignancies with bone marrow involvement of their relapsed disease. (clinicaltrials.gov)
  • Adoptive Immunotherapy Utilizing Activated Marrow Infiltrating Lymphocytes Derived From Patients With Bone Marrow Relapse of Hematologic Malignancies After Allogeneic Hematopoietic Cell Transplantation Using Post-Transplantation Cyclophosphamide Graft-Versus-Host Disease Prophylaxis. (clinicaltrials.gov)
  • We also investigate how the presence of asthma and autoimmune diseases affects the risk of hematologic malignancies. (au.dk)
  • Feb 27th, 2019 - Now in its 23rd year, the annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma provides practitioners who manage hematologic malignancies the practical tools to translate emerging data into the best therapy for patients with these tumors, personalize care based upon patient and tumor characteristics, and apply novel management strategies to thei. (allmedx.com)
  • In our opinion, the high mortality rate related to KPC-Kp bloodstream infections in patients with hematologic malignancies could be related to various factors. (cdc.gov)
  • First, patients with hematologic malignancies usually receive antimicrobial drugs recommended for the management of fever in immunocompromised patients with cancer but rarely receive empirically administered drugs active against KPC-Kp bloodstream infections. (cdc.gov)
  • There have been compelling clinical data showing that PI3K delta inhibition may provide a therapeutic benefit in patients with hematologic malignancies, in addition to our own preclinical data of IPI-145 showing activity in several models of inflammatory disease,' stated Pedro Santabárbara, M.D., Ph.D., chief medical officer at Infinity. (news-medical.net)
  • The second Phase 1 trial is an open-label, dose-escalation study designed to evaluate the safety, pharmacokinetics and clinical activity of IPI-145 in patients with advanced hematologic malignancies. (news-medical.net)
  • Following the determination of the maximum tolerated dose in the dose escalation phase, an expansion phase will follow in patients with selected hematologic malignancies. (news-medical.net)
  • Dr. Starczynowski's laboratory investigates the molecular and cellular basis of hematologic malignancies with the goal to advance novel therapeutic strategies. (cincinnatichildrens.org)
  • We found the increase was not related to voriconazole use but most probably to an increase in high-risk patients, particularly those with underlying hematologic malignancies. (cdc.gov)
  • Bristol-Myers Squibb Company (NYSE: BMY) and The University of Texas MD Anderson Cancer Center today announced a novel clinical research collaboration to evaluate multiple immunotherapies, including Opdivo (nivolumab), Yervoy (ipilimumab) and three early-stage clinical immuno-oncology assets from Bristol-Myers Squibb, as potential treatment options for acute and chronic leukemia as well as other hematologic malignancies. (eurekalert.org)
  • The agreement represents an innovative approach to research by focusing numerous clinical trials using multiple agents, in mono and combination regimens, on a specific disease target, in this case select hematologic malignancies. (eurekalert.org)
  • Hematologic malignancies represent significant areas of high unmet need marked by poor outcomes among the elderly, high-risk patients and for those with multiple relapses. (eurekalert.org)
  • Existing clinical research, including studies by MD Anderson, support further research into the potential of immunotherapies as treatment options for leukemia and other hematologic malignancies. (eurekalert.org)
  • Leukemia Research Reports (LRR) , a companion title to Leukemia Research , is a peer-reviewed publication devoted to the rapid publication of short, high-quality papers related to a broad scope of therapeutic areas of hematology, including hematologic malignancies and other non-malignant diseases, such. (elsevier.com)
  • Bone marrow biopsy and aspirate for patients with hematologic malignancy and prior bone marrow involvement (pre-transplant, Day 100, 6 months, year 1, year 2). (clinicaltrials.gov)
  • A new prophylactic posaconazole dosing regimen of 120mg/m² tid is evaluated pharmacologically in children 13 years and younger, suffering from a hematologic malignancy. (clinicaltrials.gov)
  • The number of patients belonging to the risk groups diabetes mellitus, solid organ transplantation, hematologic disorder/malignancy, and hematopoietic stem cell transplantation was determined based on International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM), codes entered in the hospital information system (available up to the end of 2008). (cdc.gov)
  • Nonexcision biopsy should be reserved for patients with a past history of malignancy, suspicion of hematologic disease, and with high operative risk. (elsevier.com)
  • Among the 18 patients diagnosed with clonal diseases, one had acute myeloid leukemia (positive for trisomy 8), and 17 had myeloproliferative neoplasms (MPNs), including chronic myeloid leukemia (CML), essential thrombocythemia (ET), primary myelofibrosis (PMF), and polycythemia vera (PV). (cdc.gov)
  • Epidemiology of hematologic diseases concerns the risk and prognosis of both benign and malignant hematologic diseases. (au.dk)
  • Within malignant hematologic diseases research, we focus on the role of patient-related factors, such as comorbidity and socioeconomic status, and clinical factors, such as the presence of anemia, in relation to treatment and overall survival. (au.dk)
  • Conclusions: The results of the study showed that: a) the nature of the disease does not influence the outcome of laparoscopic splenectomy, b) the size of the spleen might increase the risk of conversion, but it is no longer a contraindication to laparoscopic splenectomy, and c) laparoscopic splenectomy can be effectively performed in the treatment of malignant hematologic diseases. (elsevier.com)
  • It is one of the very few malignant hematologic diseases that can be recognized by viewing the peripheral blood smear using a microscope. (news-medical.net)
  • Over the last decade, a remarkable number of genetic variations associated with the development of hematologic disorders have been discovered," said Jorge DiPaola, MD, of the University of Colorado, and chair of one of two hematology expert panels that will drive this effort. (unchealthcare.org)
  • These MILs will be derived from the bone marrow of the relapsed patient who had previously received post-transplantation cyclophosphamide (PTCy) as graft-versus-host disease (GVHD) prophylaxis (PTCy-MILs). (clinicaltrials.gov)
  • Stem cell transplantation for hematologic disease can result in many skin changes, including graft versus host disease, which can present with lesions in the mouth and rashes. (medicalxpress.com)
  • Patients and methods: Between August 1997 and March 2002, 63 unselected patients with hematologic diseases underwent a laparoscopic splenectomy. (elsevier.com)
  • A case report in the American Journal of Clinical Pathology highlights the need to evaluate hemoglobin A1c levels carefully in patients with hematologic diseases that impact red blood cell survival. (empr.com)
  • These effects impact normal and dysfunctional hematopoietic and immune function, which may allow an avenue for improved treatment and support of patients suffering from hematologic disorders. (mdpi.com)
  • In this review, we will summarize the role of vitamin D in normal hematopoiesis, discuss ways in which vitamin D may improve outcomes, and discuss a potential role of vitamin D for treating hematologic disorders and modulating the immune system to improve the outcome of allogeneic stem cell transplant. (mdpi.com)
  • Results from some clinical trials indicate that gene therapy can cure or improve many inherited or acquired hematologic disorders. (mhmedical.com)
  • Gene therapy is a promising treatment for several inherited or acquired hematologic disorders. (mhmedical.com)
  • It provides an overview of the interface between epidemiology and molecular biology (Chapter 6) and discusses issues of surveillance in birth defects and genetic disorders ( Chapter 7 ), with a focus on hematologic diseases ( Chapter 8 ). (cdc.gov)
  • Coverage of the common diseases veterinary technicians are likely to encounter in practice keeps you up-to-date with the diseases and disorders you are most likely to assist in diagnosing and managing. (elsevier.com)
  • The etiological categories of CLD included alcoholic and nonalcoholic fatty liver disease (NAFLD) and viral, cryptogenic, and vascular disorders of the liver. (thefreelibrary.com)
  • What are Hematologic Disorders? (gastroclinic.in)
  • Hematologic diseases are disorders which primarily affect the blood. (gastroclinic.in)
  • Hematologic diseases include rare genetic disorders, anemia, HIV, sickle cell disease & complications from chemotherapy or transfusions. (popflock.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Saving Lives, Protecting People Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Standard bone marrow transplantation is associated with prohibitive toxicities in patients with end stage renal disease, and is generally not considered an option for those patients. (clinicaltrials.gov)
  • A less toxic bone marrow transplantation protocol, utilizing low dose total body irradiation and anti-thymocyte globulin, combined with renal transplantation, could provide an opportunity for cure of the myeloma or amyloidosis and correction of end stage renal disease. (clinicaltrials.gov)
  • In addition to renal disease, cardiovascular effects, and reproductive toxicity, lead may cause irreversible neurologic damage. (cdc.gov)
  • In June 2018, the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Environmental Health Sciences sponsored a workshop to identify research gaps in an increasingly common form of chronic kidney disease in agricultur al communities, often termed "CKDu. (cdc.gov)
  • I am committed to a scientific career focused on the structure and function of protein interactions that regulate cell death, with direct application to the development of novel pharmacologic strategies to treat hematologic disease. (elsevier.com)
  • It was natural for me to combine these interests to treat hematologic pediatric cancers and sickle cell disease. (rochester.edu)
  • Juckett, M.B. The Role of Vitamin D in Hematologic Disease and Stem Cell Transplantation. (mdpi.com)
  • Filamentous Basidiomycetes molds are ubiquitous and able to colonize in patients with chronic pulmonary disease. (cdc.gov)
  • Many clinical trials have involved gene therapy for patients with various gene-deficient hematologic diseases, such as severe combined immunodeficiency, hemophilia, Wiskott-Aldrich syndrome, chronic granulomatous disease, aplastic anemia, hemoglobinopathies, HIV infection, and leukemia. (mhmedical.com)
  • We also report the association between BDV in the thymus with the lack, or loss, of encephalitis in neonatally inoculated rats or adult-inoculated rats during the chronic stage of disease. (elsevier.com)
  • Human genetic variation is associated with many, if not all, human diseases and disabilities, including the common chronic diseases of major public health impact. (cdc.gov)
  • Together with indolent SM, aggressive SM, and mast cell leukemia, the World Health Organization (WHO) recognizes another major disease subgroup: SM with an associated hematological neoplasm, which is characterized by the presence of a concurrent neoplasm, more commonly, a chronic myelomonocytic leukemia. (elsevier.com)
  • Patients of chronic liver disease (CLD) and end-stage cirrhosis have varying grades of cytopenia and other hematologic derangements either due to the compromised synthetic capacity of the diseased liver itself or resulting from the innumerable medical or surgical insults [1]. (thefreelibrary.com)
  • Chronic kidney diseases in agricultur al communities: report from a workshop. (cdc.gov)
  • Specifically, we will use proteomic analysis, flow cytometry and genomic sequencing to detect early signs of myeloma, chronic lymphocytic leukemia and myelodysplastic syndromes in these cases, to enable potentially disease altering therapeutic interventions for these cancers. (cdc.gov)
  • The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are recognized as important causes of gastrointestinal disease in children and adults. (asm.org)
  • More people in the conventional treatment group than the intervention group died from diabetic kidney disease (six vs. one). (eurekalert.org)
  • A mechanistic trial is defined as "A study designed to understand a biological of behavioral process, the pathophysiology of a disease, or the mechanism of action of an intervention. (nih.gov)
  • Emerging Infectious Diseases , 20 (7), 1235-1236. (cdc.gov)
  • The word 'leukemia' means 'white blood,' and is used to indicate the high white blood cell counts of the disease. (medindia.net)
  • Monitoring immunoglobulin heavy chain and T-cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia. (medindia.net)
  • Thrombopenia is often seen in hematologic diseases such as primary immune thrombopenia, leukemia and aplastic anemia as well as in connective tissue diseases, liver diseases and tumor chemotherapy. (marketresearch.com)
  • Acute myeloid leukemia (AML) is a heterogeneous disease. (annexpublishers.com)
  • It causes serious diseases in humans, including adult T-cell leukemia/lymphoma (ATL) and an incapacitating neurological disease (HTLV-associated myelopathy/tropical spastic paraparesis [HAM/TSP]) besides other afflictions such as uveitis, rheumatic syndromes, and predisposition to helminthic and bacterial infections, among others. (asm.org)
  • Pathophysiologic alterations in Notch signaling have been linked to several diseases, including certain forms of leukemia. (asm.org)
  • This section further deals with public health assessment in the genetics of cancer ( Chapter 9 ), infectious diseases ( Chapter 10 ), and occupational health ( Chapter 11 ). (cdc.gov)
  • Among 85 patients who were diagnosed with splenomegaly through abdominal palpation or ultrasound at any point after resettlement, 53 had some hematologic abnormality (leukopenia, anemia, or thrombocytopenia), 16 had evidence of current or recent malaria infection, and eight had evidence of schistosomiasis. (cdc.gov)
  • Background and Aim: A missense variant of the nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) gene (R139C) predisposes Asian patients with inflammatory bowel disease (IBD) to thiopurine-induced leukopenia. (elsevier.com)
  • Another NIH study found that in older adults with longstanding type 2 diabetes and high cardiovascular disease risk, very intensive glucose control to near normal levels actually increased mortality. (eurekalert.org)
  • A genetic variant that protects the heart against cardiovascular disease has been discovered by researchers at the Wellcome Trust Sanger Institute and their collaborators. (medicalxpress.com)
  • Background Pharmacist- or nurse-led team care decreases patient blood pressure (BP) and cardiovascular disease (CVD) risk. (elsevier.com)
  • This paper summarizes presentations given at the 2011 Experimental Biology meetings about the latest research and a paleoanthropological perspective pertaining to the relationship between dietary cholesterol intake and cardiovascular disease risk. (elsevier.com)
  • In recent years, however, there have been a number of epidemiological studies that did not support a relationship between cholesterol intake and cardiovascular disease. (elsevier.com)
  • Aug 4th, 2017 - Hypomethylating agents (HMAs) improve survival in patients with higher-risk myelodysplastic syndromes (MDS) but are less well-studied in lower-risk disease. (allmedx.com)
  • The hematologic and immunologic status was evaluated after 5 years of continuously disease‐free survival for 71 consecutive patients treated for Hodgkin's disease by radiotherapy. (elsevier.com)
  • Kun, LE & Johnson, RE 1975, ' Hematologic and immunologic status in Hodgkin's disease 5 years after radical radiotherapy ', Cancer , vol. 36, no. 5, pp. 1912-1916. (elsevier.com)
  • Hematologic and Immunologic Diseases 6. (elsevier.com)
  • Hematologic and Immunologic Diseases 19. (elsevier.com)
  • The most common causes of death - not all necessarily related to diabetes - were cardiovascular diseases (22 percent), cancer (20 percent), acute diabetes complications - where blood glucose became dangerously high or low (18 percent) - and accidents/suicide (17 percent). (eurekalert.org)
  • Obesity increases risk for type 2 diabetes, heart and kidney diseases, some types of cancer, and other health conditions. (eurekalert.org)
  • Introduction: The results of a 2001-2005 polycythemia vera (PV) investigation in Eastern Pennsylvania revealed a disease cluster plus underreporting and false reporting to the Pennsylvania Cancer Registry (PCR). (cdc.gov)
  • Feasibility of generating activated PTCy-MILs in patients with relapsed disease involving the bone marrow. (clinicaltrials.gov)
  • Hematologic diseases comprise a heterogeneous group of benign and malignant diseases originating from the cells of the bone marrow and the lymphatic system, which contributes substantially to global mortality and morbidity. (au.dk)
  • Carbone, K. M. / Hematologic consequences of Borna disease virus infection of rat bone marrow and thymus stromal cells . (elsevier.com)
  • Genomic DNA from 47 patients was extracted from peripheral blood and bone marrow using the EZ1 DNA Blood Kit (Qiagen, Valencia, CA) and quantified by the Quant-iT PicoGreen dsDNA Assay Kit (Invitrogen, San Diego, CA). After clinical history, cytogenetics, and molecular tests, patients were diagnosed with either clonal or nonclonal hematologic diseases. (cdc.gov)
  • Specifically, I aim to (1) synthesize structurally-reinforced alpha-helices corresponding to the BH3 death domain of BAX to identify and characterize its interaction(s) with pro-apoptotic BAX, (2) determine the solution structures of the BAX SAHB-BAX complex and an intermediate BAX conformer, and (3) investigate the mechanism of BAX propagation and the impact of its pharmacologic inhibition in hematologic cells. (elsevier.com)
  • Feb 4th, 2019 - Apellis Pharmaceuticals Inc. (Nasdaq:APLS), a clinical-stage biopharmaceutical company focused on the development of novel therapeutic compounds to treat diseases through inhibition of the complement system, today announced that its C3 complement inhibitor, APL-2, has been granted orphan drug designation by the U.S. Food and Drug Administration (FDA) for the treatment of autoimmune hemolytic an. (allmedx.com)
  • Further, a number of recent clinical trials that looked at the effects of long-term egg consumption (as a vehicle for dietary cholesterol) reported no negative impact on various indices of cardiovascular health and disease. (elsevier.com)
  • Autoimmune hemolytic anemia refers to both cold agglutinin disease and warm autoimmune hemolytic anemia, which affect a combined 40,000 people in the United States and Europe. (allmedx.com)
  • The co-existence of high prevalence of vitamin D inadequacy among Canadians and high prevalence of systematic autoimmune rheumatic diseases (SARDs) raise the question on relationship between the two situations. (mdpi.com)
  • We report a lung-invasive fungal disease with possible cutaneous needle tract seeding in a patient with a febrile neutropenia caused by the Basidiomycetes mold Inonotus spp. (cdc.gov)
  • Computed tomography of the lungs in patient with invasive fungal disease caused by Inonotus spp. (cdc.gov)
  • Skin lesion at biopsy site 4 weeks after the biopsy in patient with invasive fungal disease caused by Inonotus spp. (cdc.gov)
  • Catherine Cowie, Ph.D., of NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the primary funder of the study. (eurekalert.org)
  • Teen-LABS clinical centers had specialized experience in the surgical evaluation and management of young people with severe obesity, and both studies were funded primarily by NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). (eurekalert.org)
  • This funding opportunity announcement (FOA) seeks US domestic research projects that address how food insecurity effects HIV comorbidities, coinfections, and complications (CCCs) within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). (nih.gov)
  • Unfortunately, transplantation is also associated with a higher relapse rate and more than half of CK-AML patients relapse from disease within the first 2 years. (springer.com)
  • There are more adults than children living with congenital heart disease (CHD) in the United States. (springer.com)
  • Most adults with congenital heart disease should be seen at least periodically by adult congenital heart disease (ACHD) specialists. (springer.com)
  • Task force 1: the changing profile of congenital heart disease in adult life. (springer.com)
  • Mortality in adult congenital heart disease. (springer.com)
  • Pillutla P, Shetty KD, Foster E. Mortality associated with adult congenital heart disease: trends in the US population from 1979 to 2005. (springer.com)
  • Marelli AJ, Mackie AS, Ionescu-Ittu R, Rahme E, Pilote L. Congenital heart disease in the general population. (springer.com)
  • Best practices in managing transition to adulthood for adolescents with congenital heart disease: the transition process and medical and psychosocial issues. (springer.com)
  • ACC/AHA 2008 guidelines for the management of adults with congenital heart disease. (springer.com)
  • Congenital heart disease in the older adult: a scientific statement from the American Heart Association. (springer.com)
  • Goldberg SW, Fisher SA, Wehman B, Mehra MR. Adults with congenital heart disease and heart transplantation: optimizing outcomes. (springer.com)
  • Cyanotic congenital heart disease: hematologic management. (springer.com)
  • In addition, posaconazole has been shown to be clinically effective for adult patients who have invasive fungal infections, including aspergillosis, zygomycosis, and candidiasis, and who are intolerant of or have disease refractory to other antifungal agents ( 28 ). (asm.org)
  • Primary immune thrombopenia is a clinically common hemorrhagic disease, accounting for 1/3 of hemorrhagic diseases. (marketresearch.com)
  • Aim: The role of laparoscopic splenectomy in the treatment of hematological diseases is still controversial. (elsevier.com)
  • Each disease is presented in monograph form, with clinical signs, diagnostic laboratory work-up, treatment options, and client information to ensure the information you need is always at hand. (elsevier.com)
  • Genetic diagnosis of disease and personalization of treatment have the potential to dramatically improve strategies for diagnosis and therapy. (medicalxpress.com)
  • There are approximately 90,000 individuals in the United States with sickle cell disease (SCD). (clinicaltrials.gov)
  • Studies have shown that up to 98 percent of patients with Sickle Cell Disease have a vitamin D deficiency, defined as a 25-hydroxyvitamin D level (25(OH)D) less than or equal to 20 ng/mL. (clinicaltrials.gov)
  • Thus, the main purpose of this study is to find the amount of nutritional vitamin D that needs to be taken by patients with sickle cell disease in order to correct vitamin D deficiency. (clinicaltrials.gov)
  • This is an observational cohort study to follow vitamin D levels over time in patients with sickle cell disease receiving doses of vitamin D as part of their clinical care for vitamin D deficiency. (clinicaltrials.gov)
  • Site principal investigator for the EPIC clinical trial: Evaluation of MST-188 in patients with sickle cell disease in vaso-occlusive crisis. (rochester.edu)
  • Management of Sickle Cell Disease in Children. (rochester.edu)
  • the WBCs fight off infections and diseases while the platelets are responsible for blood coagulation. (medindia.net)
  • As genome technology moves from the laboratory to the healthcare setting, a complex array of challenges will face medical and public health professionals in the appropriate use of genetic information to improve health and prevent disease in individuals, families, and communities. (cdc.gov)
  • Genetic variation interacts with environmental factors and sociocultural influences to modify the risk of various disease. (cdc.gov)
  • Fanconi anemia is a rare genetic disease characterized by hematologic symptoms that include low platelet count and unusually large red blood cells. (medicalxpress.com)
  • Giant axonal neuropathy (GAN) is an extremely rare genetic disease with only 73 known patients worldwide. (medicalxpress.com)
  • A worldwide consensus co-authored by more than 40 scientists sets out ways to address research bottlenecks as the international community strives to diagnose most rare genetic diseases by 2020. (medicalxpress.com)
  • Increased numbers of circulating lymphocytes and large granular lymphocytes (LGL) were observed in 115 individuals splenectomized for haematological disease (74 cases) or for trauma (41 cases). (elsevier.com)
  • In reality, the immunopathogenesis of this retrovirus is intriguing, since its lifelong persistence in CD4 + lymphocytes determines a prolonged interaction between the virus and the immune system, which may result in the broad spectrum of diseases associated with HTLV-1. (asm.org)
  • Information thus obtained would allow subsequent submission of R01 applications focusing on research problems relevant to the study of hematologic diseases and their complications. (nih.gov)
  • Thanks to the findings over the years from the landmark DCCT/EDIC study, millions of people with diabetes may prevent or delay debilitating and often fatal complications from the disease," said NIDDK Director Griffin P. Rodgers, M.D. "NIH's mission is to help improve lives through biomedical research. (eurekalert.org)
  • Because of its role as a gatekeeper of cell death, pharmacologic modulation of BAX has the potential to alternatively block or reactivate cell death in diseases of deregulated apoptosis. (elsevier.com)
  • PUBLIC HEALTH RELEVANCE: Programmed cell death or apoptosis regulates the critical balance between cellular life and death and, when deregulated, contributes to the pathogenesis of a wide variety of hematologic diseases characterized by too many or too few blood cells. (elsevier.com)
  • 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease. (springer.com)
  • Here, we report a detailed description of clinical management and biological features of a systemic mastocytocis case associated with multiple hematologic non-mast cell lineage diseases. (elsevier.com)
  • The aim of this study was to assess whether the benign or malignant nature of hematological diseases may influence the outcome of laparoscopic splenectomy. (elsevier.com)
  • Patients were divided into two groups according to the benign (Group A, 38 patients) or malignant (Group B, 25 patients) nature of the hematological diseases. (elsevier.com)
  • however, further advances in gene replacement techniques are needed prior to application to hematological diseases. (elsevier.com)
  • Excess death rates also occurred for cancers of the pancreas and urinary tract, and hematologic diseases. (cdc.gov)