• In the study we performed, we observed a significant, strong and negative correlation between the concentration of EPO, hemoglobin, and red blood cell count. (bvsalud.org)
  • Additionally, there is a high oxygen concentration in the lungs and a low carbon dioxide concentration, which causes oxygen to move toward hemoglobin, increasing the amount of oxygen that is bound to hemoglobin. (medicalessays.com)
  • Hemoglobin concentration (Hb) is used clinically to determine the presence of anemia , which is functionally defined as insufficient red blood cell (RBC) mass to adequately deliver oxygen to peripheral tissues. (medscape.com)
  • Hemoglobin concentration (Hb) is usually reported as grams of hemoglobin per deciliter of blood (g/dL). (medscape.com)
  • Automated blood cell counters usually measure hemoglobin concentration by a modified cyanmethemoglobin or an alternate lauryl sulphate method. (medscape.com)
  • In the lungs, hemoglobin binds tightly to oxygen and releases carbon dioxide due to the slightly cooler body temperature and slightly less acidic pH. (medicalessays.com)
  • The cellular environment causes hemoglobin to change its shape in a way that makes it more likely to bind to carbon dioxide (which is a waste product of active cells) and to release oxygen (which the cells need). (medicalessays.com)
  • Measured arterial oxygen saturations of less than 92% may be associated with the development of a secondary polycythemia. (medscape.com)
  • Formulas are available in which the measured arterial and venous oxygen saturations can be used to calculate the partial pressure of oxygen (PaO 2 ) at which hemoglobin is 50% saturated with oxygen. (medscape.com)
  • This partial pressure value is a good estimate of the entire oxygen dissociation curve, because the shape of the dissociation curve varies only minimally, even with very high and very low oxygen affinity hemoglobins. (medscape.com)
  • Hemoglobin is the main component of red blood cells and serves as the transporter for oxygen and carbon dioxide in the blood. (medscape.com)
  • Hemoglobin Hemoglobin determinations will usually be performed by an automated cell counter from a tube of well-mixed EDTA-anticoagulated blood filled to a predetermined level. (medicalessays.com)
  • The materials needed are: Lancets Alcohol prep pads Gauze pads Microhematocrit tubes (heparinized) Sealant ("Seal-Ease," "Crit-Seal," etc) Microhematocrit centrifuge Microhematocrit reader If venipuncture is required: tourniquet, syringe, tube containing anticoagulant (EDTA, citrate) For hematocrits obtained by fingerstick, wipe the fingertip pad of the fourth finger of the nondominant hand with the alcohol prep pad. (medicalessays.com)
  • Causes of the second category include blood loss (hemorrhage), hemolysis of various etiologies (both intrinsic and extrinsic), and hemoglobin disorders (hemoglobinopathies and thalassemias). (medscape.com)
  • An abdominal computed tomography (CT) scan or an intravenous pyelogram to investigate the kidneys and their function may be indicated in a minority of patients who may have a tumor or renal abnormalities that may be causing the polycythemia. (medscape.com)
  • If JAK2 V617F mutation testing is negative but the EPO level is low, then testing for other mutations in exon 12 and 13 of JAK2 helps identify a small minority of patients with polycythemia vera. (medscape.com)
  • All the other patients with wild-type JAK2 and a normal or elevated EPO level have secondary polycythemia. (medscape.com)
  • Carboxyhemoglobin levels of greater than 8% in individuals who smoke or those who may have an occupational exposure to carbon monoxide may be associated with the development of polycythemia. (medscape.com)
  • The pressing issue in these disorders is to define factors other than elevated hematocrit that determine thrombotic risk. (haematologica.org)
  • The absorbance of the solution at 540 nm reflects the amount of hemoglobin present. (medscape.com)
  • Demographic characteristics, delivery times of the baby and placenta, duration of uterine massage, amount of postpartum hemorrhage and postpartum hemoglobin values of both groups were recorded. (researchgate.net)
  • For hematocrits obtained by venipuncture, draw a sample of blood into the tube containing anticoagulant and mix well. (medicalessays.com)
  • Dip the hematocrit tube into the blood and allow the blood to rise to the desired two-thirds to three-quarters level. (medicalessays.com)
  • In this assay, all forms of hemoglobins are converted to the colored protein cyanomethemoglobin and measured by a colorimeter. (medicalessays.com)
  • All forms of hemoglobin are detected except sulfhemoglobin (SHb). (medscape.com)
  • Plasma volume can also be calculated indirectly using total red blood cell mass and the hematocrit value. (medscape.com)
  • Hb is commonly measured by the cyanhemoglobin (hemoglobin cyanide) method. (medscape.com)