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The current standard of care in HIV treatment involves a combination of at least two classes of antiretroviral agent, said session cochair Paula Munderi, MD, from the MRC/UVRI Uganda Research Unit on AIDS in Entebbe, Uganda. (medscape.com)
AIDS is the stage of HIV infection at which damage to the immune system is profound, and patients are unable to fight off a host of opportunistic infections. (uexpress.com)
But just because infection with HIV is no longer a near-certain path to developing AIDS, that doesn't mean living with the virus is problem-free. (uexpress.com)
And while the antiretrovirals do prevent an HIV infection from progressing to full-blown AIDS, the individual's immune system remains affected by the presence of the virus and, consequently, is less robust. (uexpress.com)
Objective To investigate whether PALSA PLUS, an on-site educational outreach programme of non-didactic, case based, iterative clinical education of staff, led by a trainer, can increase access to and comprehensiveness of care for patients with HIV/AIDS. (bmj.com)
Setting Public primary care clinics offering HIV/AIDS care, antiretroviral treatment (ART), tuberculosis care, and ambulatory primary care in Free State province, South Africa. (bmj.com)
The clinics cared for 400 000 general primary care patients and 10 136 patients in an HIV/AIDS/ART programme. (bmj.com)
Main outcome measures Provision of co-trimoxazole prophylaxis among patients referred to the HIV/AIDS/ART programme, and detection of cases of tuberculosis among those in the programme. (bmj.com)
Conclusion Though outreach education is an effective and feasible strategy for improving comprehensiveness of care and wellbeing of patients with HIV/AIDS, there is no evidence that it increases access to the ART programme. (bmj.com)
shifting tasks from doctors to nurses to mitigate the worst shortages in human resources, 4 decentralisation from hospitals to peripheral clinics to broaden geographical access to ART and equity, 5 and integration of HIV/AIDS and ART care with tuberculosis care and other primary care to strengthen quality and efficiency of care delivery. (bmj.com)
Many patients with HIV/AIDS experience numerous challenges beyond those posed by the physical effects of their disease-including poverty, mental illness, drug addiction, social alienation, racism, and homophobia. (psychiatrictimes.com)
On the basis of his extensive experience in treating patients with HIV/AIDS, he said it is also important to provide hope and to encourage treatment adherence. (psychiatrictimes.com)
AFR.RC54.14 Rev.1 Improving Acc.Care Tret.HIV.AIDS. (who.int)
1. HIV/AIDS is the leading cause of morbidity and mortality in the African Region. (who.int)
Despite these constraints, countries and international partners have renewed their determination to expand access to HIV/AIDS care and treatment. (who.int)
The Regional Office for Africa aims to prolong the lives of people living with HIV/AIDS (PLWHA) by providing guidance on implementing The 3 by 5 Initiative. (who.int)
Implementing these interventions for care and treatment should not detract from prevention as the most important, key response to HIV/AIDS. (who.int)
5. The implementation of the strategies and interventions discussed in this document will significantly contribute to improving access to care and treatment for HIV/AIDS in the African Region. (who.int)
6. The Regional Committee is requested to review and adopt these orientations for improving access to care and treatment for HIV/AIDS in the African Region. (who.int)
1. Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is the greatest health crisis the world is facing today, thwarting development and jeopardizing national security in developing countries through the premature death of millions of adults in their economically productive years. (who.int)
2. Comprehensive care for people living with HIV/AIDS (PLWHA) involves a number of important components. (who.int)
ART is essential in the response to the morbidity and mortality caused by HIV/AIDS and is critical for prolonging life. (who.int)
3. Provision of care and treatment in most African countries has been limited due to the high cost of medicines and diagnostics, inadequate health delivery infrastructure and laboratory facilities, and limited human resources due to brain drain and attrition related to HIV/AIDS. (who.int)
4. The Regional Committee has responded to the HIV/AIDS crisis by passing a number of resolutions2 on prevention, care and control of HIV in order to stimulate country action. (who.int)
The epidemics of HIV/AIDS and tuberculosis showed slow but sure declines. (who.int)
The potential HIV outbreak at ZC Hospital was declared a public health emergency, and a formal investigation began on January 25, 2017, supported by provincial (Zhejiang Health Commission and Zhejiang CDC) and national (National Health Commission and National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention [China CDC]) authorities and resources. (cdc.gov)
Tibotec is dedicated to the discovery and development of innovative HIV/AIDS drugs and anti-infectives for diseases of high unmet medical need. (biospace.com)
The new approach simplifies care for patients co-infected with HIV, the virus that causes AIDS , including in low-income countries. (pasteur.fr)
There are significant losses at each step of the post-exposure prophylaxis (PEP) 'treatment cascade,' according to a systematic review and meta-analysis of 97 studies presented to the 20th International AIDS Conference last month in Melbourne. (hivandhepatitis.com)
Less-toxic, more effective medications, and a change in the timing of treatment have led to improvements in the care of patients with HIV and AIDS and the neurologic complications that can accompany them. (reachmd.com)
Doctors have known about most neurologic complications of HIV and AIDS for a long time, Dr. Clifford said, but there have been isolated cases of a "very rare phenomenon"-cerebrospinal fluid escape-in which "the virus is present in the spinal fluid and presumably in the brain but is undetectable in the blood. (reachmd.com)
One study of nearly 7000 men with HIV infection found that annual mortality rates decreased from 7% in 1996 to 1.3% in 2004, although the findings highlighted the fact that non-AIDS-related illnesses were accounting for a greater proportion of deaths. (medscape.com)
A National Cancer Institute study attributed increased non-AIDS-defining cancer mortality to the 4-fold expansion in the HIV-infected population in the United States, which was largely driven by greater numbers of people aged 40 years and older. (medscape.com)
It makes HIV treatment a new priority prevention option," said Michel Sidibé, Executive Director of the Joint United Nations Programme on HIV/AIDS (UNAIDS). (unaids.org)
An increase in the uptake of testing for HIV would have a significant impact on the AIDS response, particularly if more people gain access to treatment in light of the new findings. (unaids.org)
Thirty years after the first description of AIDS, an estimated 35.0 million [33.2 million-37.2 million] people were living with HIV at the end of 2013. (benthamscience.com)
Today we have a buffet of HIV prevention options (such as, oral daily PrEP, once-a-month vaginal dapivirine ring for women, 2-monthly long-acting injectable) along with a bouquet of improved treatment modalities (monthly and 2-monthly long-acting injectables) adorning the HIV/AIDS arena, thanks to the untiring efforts of the scientific community. (mediaforfreedom.com)
Moving effective treatment and prevention tools fast enough to the people who need them most is crucial if countries are serious about ending AIDS by 2030. (mediaforfreedom.com)
Even today 25% of people living with HIV are not on treatment and last year (2020), 690,000 people died from AIDS related illnesses and 1.5 million were newly infected with HIV, despite the best tools that science has doled out. (mediaforfreedom.com)
There is no cure for HIV or AIDS. (natap.org)
Both institutions participated on behalf of civil society in the updating of the Clinical Practice Guidelines (CPG) based on scientific evidence for the care of HIV/AIDS infection in adults, pregnant women and adolescents. (unaids.org)
The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. (unaids.org)
He works to educate people about HIV and AIDS, oversees an ever-expanding empire of real estate holdings and businesses, and serves as vice president and co-owner of his former team, the L.A. Lakers. (oprah.com)
At the time, you know, HIV and AIDS were looked at as this horrible disease that you could catch just by touching someone. (oprah.com)
I talked to [Elizabeth] about two or three times and she said, 'The only thing I want you to do is to become the face of HIV and AIDS. (oprah.com)
You're going to live for a long time because there are a lot of great medicines coming down the pipeline, but I really want you to go public because people really need to know that HIV and AIDS are out here in a big way. (oprah.com)
Spurred by Magic's announcement, the public, especially in minority communities, became educated about the realities of HIV and AIDS. (oprah.com)
You're going to still live a normal life [with HIV and AIDS]. (oprah.com)
In May 2020, Waters, the BHIVA and the European AIDS Clinical Society released a statement that combined multiple clinical studies to evaluate the risk of HIV-positive people to become infected with coronavirus disease, and said that were was no additional risk for people living with HIV. (wikipedia.org)
So we at the NIMH Division of AIDS Research are very happy to be co-sponsoring this conference with the Ragon Institute, recognizing the importance of macrophages in HIV pathogenesis and cure efforts. (nih.gov)
Healthcare workers (HCWs) in South Africa widely use job-aids as practical tools to enhance the provision of HIV services, thereby improving patient-provider interactions during the care process. (biomedcentral.com)
Our sponsors generously donate cash, services, and products so that our riders and crew can give 100% of the donations they raise to benefiting HIV/AIDS agencies to use for direct services. (thesmartride.org)
ViiV Healthcare's aim is to take a deeper and broader interest in HIV/AIDS than any company has done before and take a new approach to deliver effective and innovative medicines for HIV treatment and prevention, as well as support communities affected by HIV. (thesmartride.org)
Clear Health Alliance is a health plan for people on Medicaid who are living with HIV/AIDS. (thesmartride.org)
Members of the plan can see highly trained HIV/AIDS doctors. (thesmartride.org)
Gilead's portfolio of products and pipeline of investigational drugs includes treatments for HIV/AIDS, liver diseases, cancer, inflammatory and respiratory diseases, and cardiovascular conditions. (thesmartride.org)
A systematic review was undertaken incorporating studies from PubMed, EMBASE, CINAHL, Web of Science and Global Health, the International AIDS Society Abstract Archive, the World STI & HIV Congress Abstract Archive and the Conference on Retroviruses and Opportunistic Infections Abstract Archive published between 2016 and 2021, updating previous systematic reviews. (frontiersin.org)
The National Institute on Drug Abuse (NIDA) is interested in research that addresses gaps related to the delivery of comprehensive, integrated health services to include the full continuum of HIV/AIDS services, addiction prevention and treatment services, and primary care services, with a goal of improving the coordination of care, and improving health outcomes related to HIV, Hepatitis (optional), and substance use disorder (SUD) in the US. (nih.gov)
Nearly a year ago, UNAIDS launched the ambitious "90-90-90" targets to help end the AIDS epidemic: by 2020, 90% of people living with HIV will be diagnosed, 90% of those diagnosed will be on sustained antiretroviral therapy (ART), with 90% viral suppression in those on ART. (dndi.org)
The Journal of the International AIDS society has published a special supplement on paediatric HIV. (dndi.org)
Cryptococcal meningitis is an opportunistic fungal infection, the number two killer of people living with HIV/AIDS after tuberculosis. (msf.org.za)
In 2010, the White House issued a National HIV/AIDS Strategy for the United States (NHAS) . (blr.com)
One step identified in the NHAS is to reduce stigma and discrimination against people living with HIV/AIDS. (blr.com)
In fiscal year 2014, the EEOC resolved almost 200 charges of discrimination based on HIV status and obtained more than $825,000 for job applicants and employees with HIV/AIDS who were unlawfully denied employment and reasonable accommodations . (blr.com)
As those cases make clear, failing to accommodate or discriminating against an employee or a job applicant with HIV/AIDS can be extremely costly for employers. (blr.com)
Thus, it's important to understand how to best accommodate employees and potential employees who have HIV/AIDS. (blr.com)
In addition to its increased enforcement and litigation proceedings, at the end of 2015, the EEOC issued two publications addressing workplace rights for individuals with HIV/AIDS. (blr.com)
The first " Helping Patients with HIV Infection Who Need Accommodations at Work " is intended to educate healthcare professionals on how to assist HIV/AIDS patients with requesting and receiving reasonable accommodations at work. (blr.com)
The second " Living with HIV Infection: Your Legal Rights in the Workplace Under the ADA " ‚aims to educate individuals with HIV/AIDS on their rights under the Americans with Disabilities Act (ADA) . (blr.com)
The guides can also help employers understand how employees and job applicants may request accommodations and detail the different accommodations employees with HIV/AIDS may require. (blr.com)
First and foremost, the EEOC guidance articulates the fact that HIV/AIDS is a disability under the ADA. (blr.com)
Because HIV/AIDS is a disability under the ADA, an employer must provide reasonable accommodations if an HIV-positive employee or applicant needs them, as long as the accommodations don't result in undue hardship for the employer. (blr.com)
Both guides list potential reasonable accommodations that individuals with HIV/AIDS may request, including altered break and work schedules, changes in supervisory methods, accommodations for visual impairments, ergonomic office furniture, unpaid leave, and permission to work from home. (blr.com)
Employers should be aware of the EEOC's current focus on HIV/AIDS discrimination in employment. (blr.com)
The agency's new guidance provides ideas on how best to accommodate employees with HIV/AIDS as well as information about the medical questions you can and cannot legally ask employees and their doctors. (blr.com)
HIV is a virus that attacks the body's immune system and if not treated, can lead to AIDS (acquired immune deficiency syndrome). (voxafrica.com)
The adoption of DSD in this facility has helped reduce the workload, "from attending to about 70 clients per day to between 4 to 5 clients per day, Dr Cheta Otodile, the ART Coordinator HIV/AIDS resource centre in Rivers State said. (voxafrica.com)
In his contribution, Dr Clement Adesigbin, the head of the treatment component of the National AIDS and STIs Control Programme (NASCP) said, "DSD has played a significant role in tailoring HIV service delivery to meet the needs of PLHIV and relieve the burden on the health systems. (voxafrica.com)
HIV infection was the main predictor of death in men (HR = 3.5, 95% CI: 2.1-5.7) and women (HR = 3.2, 95% CI: 1.2-8.7 ) and main cause of death was HIV/AIDS. (biomedcentral.com)
Approximately 90,000 patients receive methadone treatment in Spain, and this figure has remained constant since the early 1990's, when OST was focused to reduce the impact of HIV/AIDS and drug overdose [ 17 ]. (biomedcentral.com)
What inspired you to make a documentary about this often forgotten chapter in HIV/AIDS history? (hepmag.com)
Before HIV/AIDS, the hemophilia community went through a similar situation in which people were exposed accidentally to hepatitis B. Were the lax response to that incident and the resulting infections warning signs of things to come? (hepmag.com)
Although current HAART regimens have substantially and dramatically decreased AIDS-related opportunistic infections (OIs) and deaths, prevention and management of OIs remain critical components of care for HIV-infected children. (medscape.com)
The AIDS epidemic chal enged us, span of just a few years, the number Africa (UNAIDS, 2017a), where fund- not just as a global health community of people living with HIV receiving ing for AIDS is stagnating (Fig. 17.3) but also as a col ective humanity. (who.int)
The fall in the annual numbers of new HIV infections and of AIDS-related deaths. (who.int)
United Nations Programme on HIV from the AIDS response with a view ties in cancer. (who.int)
Our goal has always been to stop transmission and reduce the burden of HIV/AIDS. (cdc.gov)
The manifestations of the HIV/AIDS epidemic in Poland, as in other countries, have been received with stigma and discrimination towards those living with the disease. (bvsalud.org)
This quantitative study had as its main objectives to survey: 1) the degree of fear of acquiring HIV at work among surgeons and surgical nurses, and 2) the impact of HIV/AIDS training and practical experience with HIV patients on support for a testing policy of admitted patient and those who would undergo surgery among the same sample. (bvsalud.org)
HIV/AIDS became an urgent medical and social problem that the literature of social knowledge that explains cancer as a in the early 1980s. (bvsalud.org)
Research investigating the psychological experience of Stigma and discrimination fuel the HIV/AIDS epidemic by people living with HIV/AIDS (PLWHA) indicates that these creating a culture of secrecy, silence, ignorance, blame, shame patients do not suffer only from the physical disease process. (bvsalud.org)
HIV/AIDS is most prevalent in populations that have been leads to social rejection of patients. (bvsalud.org)
National Center for Infectious Diseases Division of HIV/AIDS Kenneth G. Castro, M.D. (cdc.gov)
REVISED HIV CLASSIFICATION SYSTEM FOR ADOLESCENTS AND ADULTS The etiologic agent of acquired immunodeficiency syndrome (AIDS) is a retrovirus designated human immunodeficiency virus (HIV). (cdc.gov)
ALA produces and distributes pamphlets and videos on TB and HIV/AIDS. (cdc.gov)

In Georgia, clusters are inferred using a genetic distance threshold of 0.005 nucleotide substitutions per site among persons with HIV infection diagnosed during the most recent 3 years, with priority clusters defined as those that include four or more diagnoses during the most recent 12 months. (cdc.gov)
And thanks to the stunning success of antiretroviral therapies, infection with HIV now fits that definition of chronic disease. (uexpress.com)
The loss of these white blood cells leaves HIV-positive individuals vulnerable to disease, infection and complications of illness. (uexpress.com)
Add in the ability of HIV, like all viruses, to rapidly mutate and become resistant to existing drugs, and infection remains a serious condition. (uexpress.com)
Forstein has treated a number of patients who have had HIV infection since the 1990s but who have no detectable viral loads after years of ART. (psychiatrictimes.com)
All patients with HIV infection will find it difficult to adjust to changes in their medical status, regardless of whether their symptoms are getting better or worse, said Forstein. (psychiatrictimes.com)
The US Food and Drug Administration has approved a new once-a-day combination drug to treat the HIV-1 infection in adults who haven't previously been treated for the disease. (pharmaceutical-technology.com)
The FDA had previously green-lit the first over-the-counter home-use HIV test kit, while approval was also awarded to the first medication for pre-exposure prophylaxis to reduce the risk of sexually acquired HIV infection in adults at high risk. (pharmaceutical-technology.com)
Acute HIV infection was diagnosed in 5 persons. (cdc.gov)
This incident provides evidence of a lapse in infection control causing HIV transmission, highlighting the need for stronger measures to protect patients from infectious disease exposure. (cdc.gov)
On January 24, 2017, a woman receiving LIT at ZC Hospital in Hangzhou, China, called a hospital staff member, Dr. X, asking if she had risk for HIV infection. (cdc.gov)
She explained that her husband had just received a confirmed diagnosis of HIV infection and that on December 30, 2016, she had received LIT using lymphocytes her husband donated. (cdc.gov)
Co-infection with HIV and hepatitis B or C is quite common. (aidsmap.com)
Upon approval, it is expected that TMC278, in combination with other antiretroviral medicinal products, will be indicated for the treatment of HIV-1 infection in treatment-naïve adult patients. (biospace.com)
This course covers transmission of HIV and infection control, Washington laws concerning confidentiality and testing, clinical manifestations and treatment, psychosocial issues, and legal and ethical issues. (wildirismedicaleducation.com)
A large-scale clinical trial has demonstrated the efficacy of a new therapeutic protocol to treat cryptococcal meningitis associated with HIV infection and shown that it leads to fewer adverse effects. (pasteur.fr)
They also say that the problems with PEP give insight into the challenges for adherence to pre-exposure prophylaxis (PrEP), which also involves HIV negative people taking antiretroviral drugs to prevent HIV infection. (hivandhepatitis.com)
HIV enters the nervous system within two weeks of a person's primary infection, said Deanna Saylor, MD, MHS, associate professor of neurology and a neuro-infectious disease and neuroimmunology specialist at Johns Hopkins Hospital. (reachmd.com)
Syphilis can be a latent infection, and in the setting of HIV [it] can involve the brain earlier and more aggressively," Dr. Clifford said. (reachmd.com)
Results from this pilot study suggest that LPV/r monotherapy may be an option for management of HIV infection. (researchgate.net)
monotherapy may be an option for management of HIV infection. (researchgate.net)
Cotrimoxazole in HIV-1 infection. (ajtmh.org)
Treatment guidelines for HIV infection are age-specific. (medscape.com)
guidelines for adults and adolescents are compiled by the Panel on Clinical Practices for Treatment of HIV Infection. (medscape.com)
For discussion of antiretroviral drugs and regimens, see Antiretroviral Therapy for HIV Infection . (medscape.com)
The Infectious Diseases Society of America (IDSA) issued updated guidelines in November 2021 for the management of HIV infection. (medscape.com)
A systematic review published in 2021 examined programs and services in Canada that address the prevention and management of infectious disease in people who inject drugs and found that discussion of HCV and/or HIV infection far outweighed discussion of other diseases related to injection drug use (41). (ohtn.on.ca)
Higher rates of infection with HIV are exhibited among injection drug users mainly because of unsafe injecting behavior. (benthamscience.com)
5, 2019-- Gilead Sciences, Inc. (NASDAQ: GILD) announced today that the company has submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration ( FDA ) for Descovy ® (emtricitabine 200 mg and tenofovir alafenamide 25 mg tablets) for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 infection among individuals who are HIV-negative and at risk for HIV. (gilead.com)
The filing is based on the results of the Phase 3 DISCOVER trial which evaluated the safety and efficacy of Descovy compared to Truvada in men and transgender women who have sex with men at high-risk for sexually acquired HIV infection. (gilead.com)
We look forward to working with the FDA to help evaluate bringing this option to people at risk of acquiring HIV infection. (gilead.com)
In the United States , Descovy is approved in combination with other antiretroviral agents for the treatment of HIV infection in patients weighing ≥25 kg and is not indicated for PrEP. (gilead.com)
the Truvada label also carries a Boxed Warning for the risk of drug resistance with PrEP in undiagnosed early HIV infection. (gilead.com)
Descovy is not approved for the treatment of chronic hepatitis B virus (HBV) infection and the safety and efficacy of Descovy have not been established in patients coinfected with HIV-1 and HBV. (gilead.com)
Welcome to the Macrophage Infection of HIV Implications for Pathogenesis and Cure meeting, jointly organized by the National Institute of Mental Health and the Ragon Institute of MGH, MIT, and Harvard. (nih.gov)
Although CD4 T cells are the main targets of HIV infection, macrophages also become infected and resist the cytopathic effects of infection, contributing potentially to HIV reservoir persistence. (nih.gov)
So this meeting will examine emerging data relating to macrophage interactions with the immune system during HIV infection, macrophage reservoirs and approaches to their elimination, and the involvement of CNS myeloid reservoirs and associated comorbidities. (nih.gov)
So on day one, Session 1 will focus on macrophages and the immune system during HIV and SARS-CoV-2 infection, Session 2 will focus on challenges to study HIV/SIV reservoirs, and Session 3 will really have the highlights from recent awardees of the NIMH/NINDS/NIDA Myeloid Reservoir RFA. (nih.gov)
We aim to recruit 1200 African and Indian children aged below 16 years with non-severe TB, with or without HIV infection. (biomedcentral.com)
207 The SPARTAC trial set out to discover if giving short-course antiretroviral treatment to patients soon after the discovery of HIV infection had any advantage over treatment when their CD+ count had fallen to a prespecified level. (bmj.com)
It wasn't a big hit: "We found that a 48-week course of ART during primary HIV infection delayed a decline in the CD4+ count to less than 350 cells per cubic millimetre or the initiation of long-term ART, but this delay was not significantly longer than the 48-week treatment period. (bmj.com)
The global burden of Hepatitis B virus (HBV) and HIV co-infection is enormous. (biomedcentral.com)
Baseline and on-treatment ALT may be a useful non-invasive predictor of Hepatitis B viremia in resource-constrained countries in sub-Saharan Africa where infection is endemic and viral load tests are not widely available. (biomedcentral.com)
The natural history of chronic HBV is negatively affected by HIV co-infection. (biomedcentral.com)
The most recent HIV treatment guidelines recommend the use of tenofovir (TDF) plus 3TC or emtricitabine in patients with HBV/HBV co-infection [ 14 ]. (biomedcentral.com)
Opioid substitution therapy has improved the survival of heroin users with and without HIV infection. (biomedcentral.com)
However, HIV infection shows a great impact on survival, particularly among HIV-infected women. (biomedcentral.com)
Spanish drug users were heavily impacted by HIV infection to a point that there was a reduction in life expectancy for the general population during the early 1990's [ 18 ]. (biomedcentral.com)
A high prevalence of infections, such as candidiasis and varicella-zoster virus infection, must also be anticipated, and appropriate prevention and treatment strategies must be initiated. (medscape.com)
Human immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent infection are the main goal of HIV vaccine discovery. (bvsalud.org)
The median length of known HIV infection was 27 years, and the median duration of ART was 22 years. (bvsalud.org)
Many patients living with HIV infection are taking complex regimens involving multiple pills. (msdmanuals.com)
Treatment Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
in Human Immunodeficiency Virus (HIV) Infection. (msdmanuals.com)
The next decade promises new hope as three primary areas of HIV prevention are emphasized: early detection of persons who are HIV positive and referral to treatment and care services, prevention for persons living with HIV, and prevention for persons who are at high risk for HIV infection. (cdc.gov)
CDC has revised the classification system for HIV infection to emphasize the clinical importance of the CD4+ T-lymphocyte count in the categorization of HIV-related clinical conditions. (cdc.gov)
The CD4+ T-lymphocyte is the primary target for HIV infection because of the affinity of the virus for the CD4 surface marker (3). (cdc.gov)
Studies of the natural history of HIV infection have documented a wide spectrum of disease manifestations, ranging from asymptomatic infection to life-threatening conditions characterized by severe immunodeficiency, serious opportunistic infections, and cancers (4-13). (cdc.gov)
The classification system for HIV infection among adolescents and adults has been revised to include the CD4+ T-lymphocyte count as a marker for HIV-related immunosuppression. (cdc.gov)
The objectives of these changes are to simplify the classification of HIV infection, to reflect current standards of medical care for HIV-infected persons, and to categorize more accurately HIV-related morbidity. (cdc.gov)
The revised CDC classification system for HIV-infected adolescents and adults * categorizes persons on the basis of clinical conditions associated with HIV infection and CD4+ T- lymphocyte counts. (cdc.gov)

Improvements in overall adherence to treatment and in satisfaction with treatment when using a fixed-dose combination, especially single-tablet regimens, have been well documented," Dr Munderi told Medscape Medical News . (medscape.com)
New combination HIV drugs like Stribild help simplify treatment regimens. (pharmaceutical-technology.com)
This randomized study evaluated the efficacy and tolerability of continued treatment with protease inhibitor plus nucleoside-analogue combination regimens (n = 79) or a change to the simplified regimen of abacavir-lamivudine-zidovudine (n = 84) in patients with suppressed human immunodeficiency virus type 1 (HIV-1) RNA for ⩾6 months who did not have the reverse transcriptase 215 mutation. (uzh.ch)
Regarding viral suppression and disease reduction, treatments incorporating DTG-based regimens have demonstrated greater adherence due to their lower incidence of adverse events while presenting enhanced effectiveness, safety, and reduced likelihood of resistance development. (unaids.org)
Drug optimization aims to support the expanded use of more simplified, less toxic drug regimens with high barriers to drug resistance that require minimal clinical monitoring while maintaining therapeutic efficacy. (dndi.org)
HIV care programs in high prevalence, resource-limited settings have developed innovative approaches to improve linkage, retention and viral suppression, including simplified treatment regimens, task-shifting, and peer support. (hhs.gov)
Cumulative resistance profiles were constructed and genotypic sensitivity scores were calculated for current regimens and also for new simplified regimens, if applicable. (aahivm.org)
But as no nAb-eliciting vaccines are yet available, only data from HIV-1 neutralizers-persons with HIV-1 who naturally develop broad and potent nAbs-can inform about the dynamics and durability of nAb responses in humans, knowledge which is crucial for the design of future HIV-1 vaccine regimens. (bvsalud.org)
Thus, the goal is to simplify treatment regimens while maintaining effectiveness. (bvsalud.org)
More- and second- and third-line treatment fections per year has been reduced over, the majority of people who are regimens. (who.int)

The superiority of the dolutegravir-based regimen does not appear to be attributable to a difference in adherence between the two treatment arms, so it's a regimen that works," said Catherine Orrell, MD, from the University of Cape Town in South Africa. (medscape.com)
Forstein also said simplifying dosing schedules can increase adherence. (psychiatrictimes.com)
Therapies that address the individual needs of patients are critical to enhancing adherence and increasing the potential for treatment success, and we are proud to introduce a new single tablet regimen for the healthcare and patient communities. (pharmaceutical-technology.com)
The problems with uptake, adherence, and completion point to a need for a simplified approach, researchers said. (hivandhepatitis.com)
With rapidly expanding treatment options, providers must keep pace with scientific advances to offer personalized care and support long-term engagement and adherence. (primeinc.org)
For HIV care and treatment, this means expanding active referral and decentralization of treatment outlets, full implementation of policies to treat all patients, adherence support services, differentiated care and treatment, and improving patient monitoring through viral load testing. (who.int)
In addition, unintended pregnancies in women living with HIV (WLHIV) are associated with late presentation for antenatal care and therefore delayed access to ART for prevention of mother-to-child transmission (PMTCT) and reduced adherence to ART, both of which increase the risk of mother-to-child HIV transmission ( 10 ). (frontiersin.org)
A positive result from this trial could simplify and shorten treatment, improve adherence and be cost-saving for many children with TB. (biomedcentral.com)
DiSC will be evaluated through a cluster randomized trial at 20 high-volume HIV clinics, looking at both effectiveness (6 and 12-month retention, viral suppression, ART adherence) and implementation outcomes (feasibility and acceptability). (hhs.gov)

DURBAN, South Africa - A fixed-dose single-tablet antiretroviral regimen for treatment-naïve HIV-positive women is successful in large part because of low rates of virologic nonresponse and of discontinuation related to adverse events, new research shows. (medscape.com)
In the study, 248 treatment-naive women received the dolutegravir-based regimen and 247 received the atazanavir-based regimen. (medscape.com)
According to one school of thought, the antiretroviral drugs that are now the main treatment regimen for people living with HIV amount to a functional cure. (uexpress.com)
A number of factors also contribute to treatment fatigue and noncompliance with the therapeutic regimen. (psychiatrictimes.com)
In April 2022, the World Health Organization (WHO) updated its guidelines to endorse a simplified treatment regimen. (msf.org.za)
Patients in the simplified group had their regimen reduced by a median of 6 pills/day to a median of 2 pills/day: most were simplified to a single-tablet or two-tablet regimen. (aahivm.org)
With the availability of new co-formulated HIV drugs, many patients could benefit from simplification of their ART regimen, guided by HIV DNA archive genotype testing (GenoSure Archive). (msdmanuals.com)

Member States have responded to the need for care and treatment by providing services for the management of opportunistic infections, counselling, testing, palliative care and ART. (who.int)
Forty years ago, doctors saw high rates of central nervous system opportunistic infections as well as higher rates of significant neuro-cognitive impairments and peripheral neuropathies-both of which "are caused by direct effects of HIV itself, especially when advanced immunosuppression is present," Dr. Saylor said. (reachmd.com)
Cotrimoxazole as prophylaxis against opportunistic infections as HIV-infected Zambian children (CHAP): a chap double-blind randomized placebo-controlled trial. (ajtmh.org)
Data presented at The Liver Meeting (and also at the recent Conference on Retroviruses and Opportunistic Infections ) evaluated the success of a strategy to streamline HCV treatment delivery and the associated laboratory monitoring without compromising efficacy or safety. (medscape.com)
The treatment of human immunodeficiency virus (HIV) disease depends on the stage of the disease and any concomitant opportunistic infections. (medscape.com)
[ 13 ] In general, the goal of treatment is to prevent the immune system from deteriorating to the point that opportunistic infections become more likely. (medscape.com)
Results from the DISCOVER trial, presented at the 2019 Conference on Retroviruses and Opportunistic Infections, demonstrated that Descovy achieved non-inferiority to Truvada in study participants who were at substantial and sustained risk of HIV acquisition. (gilead.com)
We now offer more intensive service delivery for people starting newly on HIV treatment, PLHIV with opportunistic infections and other illnesses, people who need follow-ups and others. (voxafrica.com)
An expert panel issued updated guidelines in December 2013 for the prevention and treatment of opportunistic infections in HIV-exposed and infected children. (medscape.com)

This opens the door for candid discussions about HIV prevention and nonoccupational exposure prophylaxis. (psychiatrictimes.com)
Do starter packs improve outcomes for people taking HIV post-exposure prophylaxis? (hivandhepatitis.com)
1999 . Efficacy of trimethoprim-sulphamethoxazole prophylaxis to decrease morbidity and mortality in HIV-1-infected patients with tuberculosis in Abidjan, Cote d'Ivoire: a randomised controlled trial. (ajtmh.org)
N'Dri-Yoman T, Salamon R: Early chemo-prophylaxis with trimethoprim-sulphamethoxazole for HIV-1-infected adults in Abidjan, Côte d'Ivoire: a randomised trial. (ajtmh.org)
Cotrimoxazole prophylaxis by HIV-infected persons in Uganda reduces morbidity and mortality among HIV-uninfected family members. (ajtmh.org)
Oral PrEP (Pre-Exposure Prophylaxis), the first biomedical intervention for prevention of HIV, was approved by US FDA for adults in 2012. (mediaforfreedom.com)

Among changes, clinicians are treating HIV earlier and more aggressively, rather than waiting for patients to show signs of advanced immunosuppression, and antiretroviral therapies have become less toxic. (reachmd.com)
It's remarkable to folks these days that in the earlier days of the epidemic we recommended not using our HIV therapies until the immune system had become compromised to some degree," said David Clifford, MD, FAAN, the Melba and Forest Seay Professor of Clinical Neuropharmacology at Washington University in St. Louis. (reachmd.com)
These investigational agents have potential for use in HIV long-acting therapies for treatment and prevention, as well as cure strategies. (natap.org)

Tibotec specializes in the research and development of new medicines for infectious diseases including HIV. (biospace.com)
The panel represents the National Institutes of Health, the Centers for Disease Control and Prevention, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics. (medscape.com)
Regarding infectious diseases, any virus such as HIV that crosses the blood-brain barrier (BBB) and causes encephalitis or other related conditions should be considered in the differential. (medscape.com)

For example, some patients who have been treated with ART and have HIV that is clinically considered to be "undetectable" (meaning that the viral load is below the ability of the current available tests to detect the level of virus) does not mean that there is no HIV, and thus the risk of viral transmission, though lower, is still possible. (psychiatrictimes.com)
Patients may misinterpret the term "undetectable" and fail to understand that they still have HIV, said Forstein. (psychiatrictimes.com)
The results of the study demonstrated that between 88% and 90% of patients who received Stribild had an undetectable amount of HIV in their blood, compared with 84% of patients treated with Atripla and 87% of patients treated with Truvada ples atazanavir and ritonavir. (pharmaceutical-technology.com)
With suppressed viral load (undetectable HIV Virus), Flora is now married and with HIV-negative children. (voxafrica.com)

By harnessing the body's own immune system against HIV, we seek to continue driving scientific innovation that will transform care and improve overall outcomes for all people living with HIV. (natap.org)
Timely access to effective HIV treatment can save lives, improve health outcomes, enhance the quality of life, and contribute to the overall well-being of individuals living with HIV. (unaids.org)
The purpose of this notice of funding opportunity (NOFO) is to address research gaps in understanding how to improve health outcomes among persons who are at heightened risk for HIV or living with HIV, Hepatitis, and substance use in the US, and to inform novel strategies for integrating primary care, HIV, Hepatitis, and substance use disorder (SUD) prevention and treatment services. (nih.gov)
The NOFO will support research that promotes scalable strategies of integrated care and services designed to improve health outcomes related to HIV, Hepatitis B and C (optional) and SUD. (nih.gov)
Our data-informed stepped care (DiSC) intervention pairs stepped care with a clinical prediction tool to optimize limited resources and improve HIV care and treatment outcomes. (hhs.gov)
This observational, retrospective cohort study described virologic outcomes of a single-center initiative evaluating ART simplification among PWH with a history of multi-drug resistance and treatment failure. (aahivm.org)

Qualitative interviews identified barriers to accessing HIV prevention and care services, including language barriers, immigration- and deportation-related concerns, and cultural norms regarding sexuality-related stigma. (cdc.gov)
35 means we can empower more people living with HIV to challenge stigma with our information workshops, videos and broadcasts. (aidsmap.com)
It will also significantly contribute to reducing the stigma and discrimination surrounding HIV. (unaids.org)
Finally, Sudan health partners will work to reduce HIV stigma and discrimination in health care settings, improving quality of services, ensuring the accessibility of HIV and sexually transmitted diseases prevention and treatment services in humanitarian settings, strengthening HIV strategic information, creating conducive environment for prevention and treatment services, and ensuring enough financing for the HIV response. (who.int)
This low case identification rate is due to many reasons including the limited availability of HIV testing services, inappropriate approaches to service delivery for people who are at risk of HIV, reluctance of health care providers to offer an HIV test to their clients and stigma and discrimination. (who.int)
The social implications of stigma are worsened when they hinder the provision of effective treatment by members of the health sector. (bvsalud.org)

Stable HIV-associated morbidity and mortality, concerns about possible increases in HIV incidence, and the recent availability of a simple, rapid HIV test combined with strong prevention collaborations among communities heavily affected by HIV support the need to reassess and refocus some of CDC's HIV-prevention activities. (cdc.gov)
An emphasis on greater access to testing and on providing prevention and care services for persons living with HIV can reduce new infections and lead to reductions in HIV-associated morbidity and mortality. (cdc.gov)

On January 25, 2017, a physician from ZC Hospital in Hangzhou, China, reported to the Zhejiang Provincial Center for Disease Control and Prevention that a potential HIV outbreak might have occurred during lymphocyte immunotherapy (LIT) performed at the hospital on December 30, 2016. (cdc.gov)
SeyedAhmad SeyedAlinaghi , " Frontiers in HIV Research ", Bentham Science Publishers (2016). (benthamscience.com)
Between 2012 and 2016 the number of people living with HIV receiving antiretroviral treatment increased steadily to more than double in number. (who.int)

This study evaluated the safety and efficacy of switching HIV-infected patients with stable viral suppression on nonnucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor (NNRTI/NRTI) therapy to lopinavir/ritonavir (LPV/r) monotherapy. (researchgate.net)
24/28 (85.7%) in the simplified group achieved or maintained virologic suppression at their most recent clinic visit, versus 16/22 (72.7%) in the non-simplified group. (aahivm.org)

Routine informed consent for HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), and syphilis testing (oral or written) and for contact tracing (oral) was obtained. (cdc.gov)
Does hepatitis C virus remain in the body after successful treatment? (aidsmap.com)
Nowhere has this been more apparent than in our ability to simplify the care of patients with hepatitis C virus (HCV). (medscape.com)
HIV and hepatitis C virus (HCV) are two bloodborne pathogens (37) of concern for people who use drugs (38, 39). (ohtn.on.ca)

Not only is taking one pill once a day easier for patients, fixed-dose combinations also simplify the procurement process where there is only one bottle to fill, rather than three, she pointed out. (medscape.com)
The approval comes off the back of two clinical studies where 1,408 adult patients were given either Stribild or Atripla, an HIV drug containing Truvada and efavirenz, once daily, or Stribild or Truvada plus atazanavir and ritonavir once daily. (pharmaceutical-technology.com)
It plays a key role in the Johnson & Johnson Global Access & Partnerships Program, which is committed to improving and saving lives by addressing unmet medical needs and ensuring the availability of HIV medicines to patients in need. (biospace.com)
It occurs most often in severely immunocompromised patients, primarily late stage HIV patients, and it is the second leading cause of HIV-related death worldwide, claiming approximately 180,000 lives each year, mainly in Sub-Saharan Africa. (pasteur.fr)
It is the largest randomized clinical trial to have been conducted, including 844 advanced-stage HIV patients presenting with cryptococcal meningitis. (pasteur.fr)
The unit is also involved in the design and development of an innovative antigen diagnostic approach based on a quantitative PCR method that will facilitate diagnosis and monitoring of patients receiving treatment for cryptococcal meningitis. (pasteur.fr)
Over the past 20 years, the treatment of patients with HIV-related neurologic complications has evolved and improved. (reachmd.com)
That includes a shift to treating patients with HIV immediately rather than waiting for them to show signs of advanced immunosuppression, as had been standard practice for years. (reachmd.com)
Delayed treatment therefore allows patients' CD4 cell counts to drop and further exposes their brains to circulating virus, Dr. Clifford said, which "results in both potentially direct damage in the brain from the inflammation that the activated cells generate in the brain. (reachmd.com)
People with HIV who are not well-treated today resemble what the medical community encountered in patients early in the epidemic, said Jessica Robinson-Papp, MD, MS, FAAN, a neurologist and professor of neurology at Icahn School of Medicine at Mount Sinai in New York City. (reachmd.com)
As the immune system becomes compromised in untreated HIV, patients may develop toxoplasmic encephalitis, a condition that housecats can carry and which can cause large abscesses in the brain. (reachmd.com)
Neurologists who spoke to Neurology Today offered differing opinions about when the shift to immediate treatment of patients with HIV occurred, but they agreed it happened at least within the last 15 years. (reachmd.com)
This program allows patients to receive HCV care and treatment with their known local provider, thus overcoming many of the obstacles to healthcare access. (medscape.com)
Our telehealth service allowed us to further simplify the treatment of patients with HCV. (medscape.com)
Severe acute exacerbations of hepatitis B have been reported in patients who are coinfected with HIV-1 and HBV and have discontinued products containing emtricitabine (FTC) and/or tenofovir disoproxil fumarate (TDF), and may occur with discontinuation of Descovy. (gilead.com)
International non-profit developing safe, effective, and affordable treatments for the most neglected patients. (dndi.org)
Hepatitis B and HIV co-infected patients who were ART-naïve or had received at least 9 months of lamivudine-containing ART were enrolled in a cross-sectional study at Korle-Bu Teaching Hospital. (biomedcentral.com)
Of 3108 HIV-infected patients screened, 257 (8.3 %) were HBsAg-positive, of which 235 enrolled. (biomedcentral.com)
In treatment experienced patients, elevated ALT (OR 4.8 CI 2.0 - 12.1) and male sex (OR 2.1, 95 % CI 1.0 - 4.2) were associated with Hepatitis B viremia. (biomedcentral.com)
An abnormal serum ALT was significantly associated with hepatitis B viremia in HBV and HIV co-infected patients irrespective of treatment status. (biomedcentral.com)
Although HIV patients are increasingly screened for HbsAg, HBV DNA testing is not routinely done in Ghana due to cost implications. (biomedcentral.com)
Evaluation of treatment simplification strategies in patients living with HIV with multi-drug resistance. (aahivm.org)
Baseline characteristics were generally similar between patients who underwent simplification (median baseline GSS 3) and those who did not (median baseline GSS 2.5), although there were more patients with darunavir-specific mutations in the non-simplified group. (aahivm.org)
3 patients in the simplified group and 5 in the non-simplified group experienced virologic failure, however no emergence of new resistance mutations was observed. (aahivm.org)
Appropriate antiretroviral therapy (ART) and treatment of specific infections and malignancies are critical in treating patients who are HIV positive. (medscape.com)
Based on proviral DNA genotyping results, ART was simplified in 17 patients. (bvsalud.org)
Because disease-related complications can occur in untreated patients with high CD4 counts and because less toxic drugs have been developed, treatment with antiretroviral therapy (ART) is now recommended for all patients. (msdmanuals.com)
One such limitation is the perceived need for mandatory HIV testing among hospital patients. (bvsalud.org)

Trials in adults with smear-negative tuberculosis suggest that treatment can be effectively shortened from 6 to 4 months. (biomedcentral.com)
Although recent trials of TB treatment-shortening in adults with sputum-positivity have not been successful, the question has never been addressed in children, who have mainly paucibacillary, non-severe smear-negative disease. (biomedcentral.com)
Furthermore, in countries with high HIV prevalence, the peak age-prevalence of TB has shifted towards younger adults. (biomedcentral.com)
Historically, studies of anti-tuberculosis treatment in children have lagged substantially behind adult studies and data regarding TB treatment extrapolated from adults. (biomedcentral.com)

After a median follow-up of 84 weeks, virologic failure was 6% in the continuation and 15% in the simplified group (P = .081). (uzh.ch)

The drug, known commercially as Stribild and produced by Gilead Sciences , contains the previously approved HIV drugs emtricitabine and tenofovir disoproxil fumarate as well as two new compounds, elvitegravir and cobicistat. (pharmaceutical-technology.com)
FOSTER CITY, Calif.--(BUSINESS WIRE)--Jan. 9, 2020-- Gilead Sciences, Inc. (NASDAQ: GILD) announced today that the company has licensed The Rockefeller University's portfolio of broadly neutralizing antibodies (bNAbs) against HIV, including the two clinical-stage agents 3BNC117 and 10-1074. (natap.org)
"The Rockefeller University's broadly neutralizing HIV antibodies are well studied and have shown exceptional promise in early clinical trials," said Diana Brainard, MD, Senior Vice President, HIV and Emerging Viruses, Gilead Sciences. (natap.org)
FOSTER CITY, Calif. --(BUSINESS WIRE)--Mar. 7, 2019-- Gilead Sciences, Inc. (NASDAQ:GILD) today announced findings from two studies that support the further development of GS-6207, a novel, selective, first-in-class inhibitor of HIV-1 capsid function, for potential future use as part of long-acting HIV combination therapy. (gilead.com)
Ahead of Gilead Sciences' annual meeting of stockholders today, Doctors Without Borders (MSF) called on the US pharmaceutical corporation to finally fulfil its 2018 promise and ensure that the lifesaving drug L-AmB (marketed as Ambisome) for the treatment of cryptococcal meningitis in people with HIV is immediately available to all the 116 low- and middle-income countries (LMICs) eligible for Gilead's 'access price. (msf.org.za)

Only people living with HIV with a CD4 cell count of between 350 and 550, thus not yet eligible for treatment for their own health according to latest WHO guidelines, were enrolled in the study. (unaids.org)
The findings from this study will further strengthen and support the new guidance that WHO is releasing in July to help people living with HIV protect their partners. (unaids.org)
People living with HIV can now, with dignity and confidence, take additional steps to protect their loved ones from HIV," said Mr Sidibé. (unaids.org)
It is currently estimated that only about half of the 33 million people living with HIV know their HIV status. (unaids.org)
the fore the promise of more effective and long-term solutions to help people living with HIV to thrive and not just survive. (mediaforfreedom.com)
Scientific interventions alone will not help unless they are made accessible to those living with HIV or are at risk of it. (mediaforfreedom.com)
We know that it took a lot of time initially for antiretroviral therapy to become accessible and affordable for the people living with HIV, especially in the global South - thanks to the untiring community-led stewardship of global but grounds-up campaign to improve access to lifesaving medicines for all. (mediaforfreedom.com)
Also, let us not forget that Dolutegravir was approved for use by adult people living with HIV in 2013 and quickly became one of the most widely prescribed treatments for HIV in most high-income countries. (mediaforfreedom.com)
Today, it is estimated that more than 12 million people living with HIV globally receive antiretroviral therapy provided by Gilead or one of the company's manufacturing partners. (natap.org)
The data presented at CROI support advancing GS-6207 to the next phase of clinical trials to gain a deeper understanding of its potential role as a long-acting agent for people living with HIV. (gilead.com)
Gilead has initiated a Phase 1b study of GS-6207 in people living with HIV. (gilead.com)
This resolution is a step forward to provide equal and sustainable access to best HIV treatment options for all people living with HIV in Colombia, nationals and migrants. (unaids.org)
The government issued national guidelines in 2021, in line with WHO recommendations, but until now high prices of DTG have remained an obstacle to make it widely accessible to people living with HIV in Colombia. (unaids.org)
During the COVID-19 pandemic Waters worked to provide guidance for people living with HIV (PLWH). (wikipedia.org)
Participation of children living with HIV (CLWHIV) in healthcare is increasingly gaining traction in primary healthcare clinics (PHCs) in resource-poor settings given the chronic nature of HIV. (biomedcentral.com)
The realisation by healthcare providers in resource-constrained settings that scale-up of antiretroviral drugs requires people living with HIV (PLWHIV), including children, to adhere to medical advice and medication has been one of the important considerations [ 7 , 8 , 9 , 10 ]. (biomedcentral.com)
Children living with HIV can no longer be passive bystanders during their care and care consultation [ 13 ]. (biomedcentral.com)
CAN is a private, not-for-profit organization dedicated to the treatment, care, and continual wellness of people living with HIV, hepatitis C, STDs, and other diseases. (thesmartride.org)
This year marks twelve years of ViiV Healthcare innovating on behalf of people living with HIV and advancing their efforts to leave no person living with HIV behind. (thesmartride.org)
Eighty-five per cent (85%) of people living with HIV in the region and who need life-saving antiretroviral therapy do not receive it. (who.int)
There is substantial unmet need for family planning (FP) among women living with HIV (WLHIV), leading to unintended pregnancies and may contribute indirectly to increasing the risk of transmission of HIV. (frontiersin.org)
The HIV epidemic continues to present an immense global public health challenge with ~37.7 million individuals living with HIV in 2020, two thirds being in sub-Saharan Africa ( 1 ). (frontiersin.org)
The DSD model is a client-centred approach that simplifies and adapts HIV services to reflect the preferences and expectations of various groups of people living with HIV (PLHIV) while reducing unnecessary burdens on the health system. (voxafrica.com)
Resistance to multiple antiretroviral drugs among people living with HIV (PLWH) can result in a high pill burden, causing toxicity and drug interactions. (bvsalud.org)
In knowing their HIV status, people living with HIV can access treatment and care services and lead a normal life without illness. (who.int)
Unfortunately our Region is facing a huge gap in diagnosis, in which only 3 out of 10 people living with HIV know their HIV status. (who.int)
Additionally, testing the partners of people living with HIV has long been neglected or practised in an unethical manner that deters people from testing. (who.int)
The rising numbers of people living with HIV and receiving antiretroviral therapy during 2000-2017, with the target for 2020. (who.int)
BACKGROUND: Successful linkage to HIV services and initiation of antiretroviral treatment (ART) for children living with HIV (CLHIV) is critical to improve pediatric ART coverage. (cdc.gov)
Despite the success of these efforts in reducing HIV incidence in the late 1980's and early 1990's, the number of new HIV infections is estimated to have remained stable around 40,000 per year since the early 1990's and the number of persons living with HIV continues to increase. (cdc.gov)

Since the US Food and Drug Administration's approval of these DAA therapeutic agents for children and adolescents, our approach was to schedule a baseline clinical visit, with follow-up clinic visits and laboratory monitoring at treatment weeks 4 and 12 and then at week 24 (12 weeks after treatment). (medscape.com)
This manuscript summarizes the progress made and outlines further critical steps required to ensure that the right drugs are available to start children and adolescents on treatment and to keep them virologically suppressed. (dndi.org)
However, clear policies and practices for enrolling adolescents in HIV services and research, as well as systematic strategies that identify adolescents who need more intensive care to successfully achieve key milestones along the HIV care continuum, are lacking. (hhs.gov)
Formative work in UG3 will include establishment of a clinic-based prospect cohort of adolescents ages 10-19 and their care givers at 6 high volume HIV clinics in Western Kenya. (hhs.gov)
These aims have potential to provide a generalizable, systematic approach to deliver differentiated adolescent HIV care that integrates with diverse HIV care programs and available support options to accelerate progress toward achieving the 90-90-90 targets for adolescents. (hhs.gov)
Combination ART is recommended for all infants, children, and adolescents who meet treatment criteria. (medscape.com)

The trial, conducted by the HIV Prevention Trials Network, enrolled more than 1 700 sero-discordant couples (one partner who is HIV-positive and one who is HIV-negative) from Africa, Asia, Latin America and the United States of America. (unaids.org)
HIV has probably originated from multiple zoonotic transmissions of Simian Immunodeficiency Virus (SIV) from non-human primates to humans in West and Central Africa. (benthamscience.com)

Evidence for tuberculosis treatment in children is largely extrapolated from adult studies. (biomedcentral.com)
New paediatric, fixed-dose combination anti-tuberculosis treatments have recently been introduced in many countries, making the implementation of World Health Organisation (WHO)-revised dosing recommendations feasible. (biomedcentral.com)
Nested pharmacokinetic studies will evaluate anti-tuberculosis drug concentrations, providing model-based predictions for optimal dosing, and measure antiretroviral exposures in order to describe the drug-drug interactions in a subset of HIV-infected children. (biomedcentral.com)
The trial will also fill existing gaps in knowledge on dosing and acceptability of new anti-tuberculosis formulations and commonly used HIV drugs in settings with a high burden of TB. (biomedcentral.com)

GDPH and the health districts expanded coordination, initiated culturally concordant HIV prevention marketing and educational activities, developed partnerships with organizations serving Hispanic communities to enhance outreach and services, and obtained funding for a bilingual patient navigation program with academic partners to provide staff members to help persons overcome barriers and understand the health care system. (cdc.gov)
2. The main impediments to comprehensive care and treatment have been inadequacies in funding, human resources, medicines and diagnostic technologies. (who.int)
They should take action to lower the costs of medicines and diagnostics as well as provide care and treatment for health care workers. (who.int)
A treatment protocol combining several drugs (a single drip for intravenous administration of high dose liposomal amphotericin B, together with oral flucytosine and fluconazole) significantly reduced the risk of adverse events, while proving as effective as the standard of care in preventing death at 10 weeks of treatment. (pasteur.fr)
Different approaches, such as rapid point-of-care testing, routinized testing (where protocol is to offer all clients testing with the option to decline), and streamlined testing (a brief statement about the test is offered with the option to decline) in substance use treatment programs have all been found to be effective and feasible (21). (ohtn.on.ca)
Facilitating HIV and/or HCV point-of-care testing in pharmacies may be another way to increase screening uptake among people who use drugs (16, 17). (ohtn.on.ca)
The company strives to transform and simplify care for people with life-threatening illnesses around the world. (natap.org)
For more than 30 years, Gilead has been a leading innovator in the field of HIV, driving advances in treatment, prevention, testing and linkage to care, and cure research. (natap.org)
This study provided evidence on how the Talk tool storybook addresses barriers to child-participation in the HIV care process. (biomedcentral.com)
ViiV Healthcare is a global specialist HIV company dedicated to delivering advances in treatment and care for people living with or at risk for HIV. (thesmartride.org)
In this respect, the Eastern Mediterranean Region and Sudan have witnessed progress in HIV surveillance, prevention, treatment and care. (who.int)
For Sudan, scaling up the cascading steps of prevention, care and treatment are among the key priorities, which are also included in the new National Strategic Plan (2018-2020). (who.int)
It features the lowest coverage of HIV prevention, diagnosis, treatment and care services in the world. (who.int)
In Sudan, scaling up prevention, care and treatment have very specific objectives and targets. (who.int)
For prevention, this includes targeting HIV prevention at key high risk populations, including testing among TB, STI and hospital inpatients, improving antenatal care and early infant diagnosis (EID), and HIV partner notification services to increase the number of people who know their status. (who.int)
This review aims to determine whether integration of FP into HIV testing and care results in increased use of contraception, a reduction in unmet need for FP, improved use of safer conception methods and a reduction in unintended pregnancies in low and middle-income countries. (frontiersin.org)
To deliver ART to large numbers of people, many HIV care programmes in low and middle income countries (LMIC) with generalized HIV epidemics use a public health approach using standardized simplified treatment protocols and decentralized service delivery ( 3 ). (frontiersin.org)
The purpose of this notice of funding opportunity (NOFO) is to support the development and testing of enhanced models of care that optimally integrate HIV, Hepatitis B and C, addiction, and primary care services. (nih.gov)
Research is sought that will leverage existing resources available to public health researchers to develop and test new methods and models for implementing prevention and treatment services to improve care for at risk individuals. (nih.gov)
Until this lifesaving drug is available across all eligible HIV programmes at Gilead's access price, I will remain very concerned about access to L-AmB for HIV-positive people with advanced disease outside of MSF's care as, in the private sector in India, this drug is three to four times the access price. (msf.org.za)
Our team, which has worked with pediatric and adult HIV programs in Kenya for over two decades, including an established repertoire of adolescent HIV studies, proposes to implement this combination data- driven intervention using a stepped care model to inform public health decision-making and improve adolescent HIV care in Kenya. (hhs.gov)
We will conduct focus groups and interviews to understand and optimize adolescent consent and representative participation in HIV care and research. (hhs.gov)
But with proper medical care, HIV can be controlled. (voxafrica.com)
Mrs Okon recalled that at the initial stage, taking time off work to get to the health facility for medical care and to pick up her drugs was cumbersome, but thanks to the government-introduced Differentiated Service Delivery for HIV Treatment (DSD ART), access to HIV care has become much easier. (voxafrica.com)
Our region features the lowest coverage of HIV prevention, diagnosis, treatment and care services in the world. (who.int)
Similarly, HIV testing is a critical step for accessing HIV treatment and care. (who.int)

The use of Descovy for the prevention of HIV is investigational and has not been determined to be safe or efficacious and is not approved anywhere globally. (gilead.com)

More than one-quarter of each treatment group had a viral load above 100,000 copies/mL at study entry, and about half had a CD4+ cell count below 350 cells/mm³. (medscape.com)
Plasma viral load is considered as the strongest determinant of sexual transmission of HIV. (benthamscience.com)
The HIV treatment guidelines also recommend using HBV viral load (where available) and ALT for treatment initiation and monitoring. (biomedcentral.com)

In April 2020, Waters criticised the Government of the United Kingdom's decision to send a text message to HIV-positive people encouraging them to stay at home because of risk to coronavirus disease, as there was no evidence that people with well controlled HIV needed to shield. (wikipedia.org)

Initial pre-clinical and clinical research has shown that HIV bNAbs can produce an enhanced, prolonged immune response to HIV, representing a promising new approach for HIV treatment or prevention in combination with other long-acting agents, or prolonged virologic remission in the absence of antiretroviral use. (natap.org)
A panel will discuss research gaps and priorities related to human macrophage reservoirs and inflammation/comorbidities and treatment strategies for HIV remission and cure. (nih.gov)

From the beginning of this epidemic, NIMH has supported a rigorous and integrated research agenda to understand the mechanisms involved in the pathophysiology of HIV-induced CNS dysfunction and the establishment and persistence of the HIV reservoir in CNS. (nih.gov)
With over 94% of diagnosed PLHIV placed on treatment, Nigeria is near achieving epidemic control," WHO Country Representative, Dr Walter Kazadi Mulombo mentioned. (voxafrica.com)

As most of our readers probably know, HIV is shorthand for the human immunodeficiency virus. (uexpress.com)
Dolutegravir (DTG) is an antiretroviral integrase inhibitor, recommended by the World Health Organization (WHO) as a first-line treatment option for people living with the human immunodeficiency virus (HIV). (unaids.org)
Before her wedding plans in 2009, Floral Okon was unaware of what Human Immunodeficiency Virus (HIV) was. (voxafrica.com)
ART is the mainstay in human immunodeficiency virus (HIV) treatment. (medscape.com)

2.1 million [1.9-2.4 million] had become newly contaminated with HIV in 2013, including 240000 children, and 1.5 million [1.4-1.7 million] HIV-infected persons died. (benthamscience.com)

The availability of Treatment for Prevention will not only empower people to get tested for HIV, but also to disclose their HIV status, discuss HIV prevention options with their partners and access essential HIV services. (unaids.org)
UNAIDS and WHO recommend that couples make evidence-informed decisions on which combination of HIV prevention options is best for them. (unaids.org)
Treatment for Prevention needs to be used in combination with other HIV prevention options. (unaids.org)
We have a wealth of evidence-based interventions and tools that enable us to broaden prevention options, simplify diagnosis, optimize treatment and save lives. (who.int)

The Equal Employment Opportunity Commission (EEOC) has been utilizing its enforcement and litigation functions in recent years in an attempt to eradicate employment discrimination based on HIV status. (blr.com)

von Kleist M, Metzner P, Marquet R, Schütte C (2012) HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance Selection. (plos.org)
Data have shown that when used in combination with other agents for HIV treatment, Descovy offers high efficacy and additional benefits with respect to renal and bone safety compared with Truvada. (gilead.com)
The efficacy of detoxification as the main treatment intervention is limited, as compared to other therapeutic options such as opioid substitution therapy (OST) [ 5 ]. (biomedcentral.com)

the majority (n=23, 68%) received it within one week of HIV diagnosis. (cdc.gov)

Interventions to improve uptake and retention, and a simplified approach, are needed, say the researchers. (hivandhepatitis.com)
Interventions that provide HIV and/or HCV testing have been offered in a variety of settings. (ohtn.on.ca)
Some evidence illustrates that technology-based interventions (delivered via tablet or computer) may also be useful to increase HIV and/or HCV testing uptake when delivered on-site to clients of syringe exchange programs (31, 32). (ohtn.on.ca)
Early detection and frequent and responsible testing for HIV are among the key interventions highlighted in the statement of Dr. Jaouad Mahjour, Acting Regional Director, WHO Eastern Mediterranean Region . (who.int)
Four calendar periods were defined according to the introduction of preventive and treatment interventions in Spain. (biomedcentral.com)
Such health and social interventions while in substitution therapy are common for Methadone Treatment Programs (MTP). (biomedcentral.com)

An international clinical trial has explored alternative approaches to second-line HIV therapy - with promising results. (edu.au)
SAMU provides strategic, clinical and implementation support to various MSF projects with medical activities related to HIV and TB. (msf.org)
Additionally, Rockefeller will retain rights to perform non-clinical and early-stage clinical research on the portfolio of HIV antibodies. (natap.org)
Are new antiretroviral treatments increasing the risks of clinical obesity? (wikipedia.org)
In such a way, and in combination with the simplified coding, it can be integrated seamlessly in the routine of clinical documentation. (who.int)
Measures of CD4+ T-lymphocytes are used to guide clinical and therapeutic management of HIV-infected persons (22). (cdc.gov)

An estimated 36 million people worldwide now live with HIV, and while scientific advances don't always make headlines, they do make a difference. (uexpress.com)
Today, with the advances in HIV testing technologies and the advent of highly sensitive and specific rapid HIV tests, HIV testing has become simpler than ever. (who.int)
It reflects critical advances in science and medicine, aligning classification with the latest knowledge of disease treatment and prevention. (who.int)

Increasing treatment access and reducing undiagnosed infections is vital for combating HIV, UNSW researchers have shown. (edu.au)
Nucleoside analogs ( NA s) represent an important drug class for the treatment of viral infections and cancer. (plos.org)
has fal en by more than 51% since of new HIV infections in 2017 oc- the peak in 2004 (Fig. 17.1). (who.int)

Her doctoral research involved ways to switch and simplify antiviral drugs. (wikipedia.org)

Our model correctly predicts for HIV-1 that resistance against nucleoside analog reverse transcriptase inhibitors (NRTIs) can be conferred by decreasing their incorporation rate, increasing their excision rate, or decreasing their affinity for the polymerase enzyme. (plos.org)
Through mathematical modeling, we assess the mechanisms by which HIV-1 can develop resistance against nucleoside analog reverse transcriptase inhibitors (NRTI). (plos.org)
Previous zidovudine monotherapy or dual therapy and archived reverse transcriptase resistance mutations in HIV-1 DNA at baseline were significant predictors of failure. (uzh.ch)
They inhibit the HIV reverse transcriptase enzyme competitively and terminate synthesis of DNA chains. (msdmanuals.com)
Nucleotide reverse transcriptase inhibitors (nRTIs) competitively inhibit the HIV reverse transcriptase enzyme, as do NRTIs, but do not require initial phosphorylation. (msdmanuals.com)

Others may see HIV now as a chronic disease, so they may think becoming HIV infected is no longer a significant medical illness. (psychiatrictimes.com)

I grew up with Mathew Kleiner [an HIV-positive advocate who died in 2003 of hepatitis and complications due to HIV] in Brooklyn. (hepmag.com)

In 2021, molecular HIV analysis in Georgia identified clusters of rapid HIV transmission among Hispanic or Latino (Hispanic) gay, bisexual, and other men who have sex with men (MSM) in metropolitan Atlanta. (cdc.gov)
During February 2021-June 2022, the Georgia Department of Public Health (GDPH) detected five clusters of rapid HIV transmission concentrated among Hispanic or Latino (Hispanic) gay, bisexual, and other men who have sex with men (MSM) in metropolitan Atlanta. (cdc.gov)
Beginning in spring 2021, GDPH partnered with health districts with jurisdiction in four metropolitan Atlanta counties (Cobb, DeKalb, Fulton, and Gwinnett) and CDC to investigate factors contributing to HIV spread, epidemiologic characteristics, and transmission patterns. (cdc.gov)
In February 2021, GDPH identified three HIV clusters among Hispanic MSM using molecular analysis of HIV-1 nucleotide sequence data collected through routine surveillance ( 1 ). (cdc.gov)
Readers, this is the concluding article in the series of an exclusive trilogy authored by CNS head and IAS HIV Science 2021 Media Fellowship Awardee Shobha Shukla. (mediaforfreedom.com)

While this approach has enabled the scale-up of ART in overwhelmed health systems, broader health needs of people with HIV are often not addressed. (frontiersin.org)

A multicomponent investigation identified factors that might limit access to HIV services, including language barriers, immigration- and deportation-related concerns, and sexuality-related cultural norms. (cdc.gov)
Hispanic MSM can face important barriers to accessing HIV services. (cdc.gov)
Detecting and responding to HIV clusters among MSM can mobilize resources to strengthen services and improve health equity. (cdc.gov)
We believe that voluntary licensing is an important mechanism by which to expand access to our HIV portfolio, including our newest medicines," said Will Stephens , Vice President of Global Access & Partnerships for Janssen Global Services, LLC. (biospace.com)
In Sudan, improving the quality and completeness of the HIV strategic information system with a special focus on electronic patient monitoring is a priority, as is improving coverage of most-at-risk populations with preventive and treatment services and improving knowledge about other key populations and arranging the necessary coverage with preventive and treatment services. (who.int)
HIV testing services constitute an essential part of the HIV prevention package. (who.int)
People at risk who test negative for HIV can use a wide range of HIV prevention services which are available to help them maintain a life without HIV. (who.int)
Overall, integrated facilities have the potential of improving reproductive health of women accessing HIV services in LMICs. (frontiersin.org)
Dr Otodile noted that the strategy has allowed the health facility to move away from the "one size fits all" model, to tailored HIV services to serve the diverse group of PLHIV who seek treatment in the facility. (voxafrica.com)
Therefore, I call upon all of us, governments, civil society, private sector and technical partners to commit to making HIV testing services available and easily accessible, particularly for key population groups at risk of HIV. (who.int)
HIV testing and counselling services should also be routinely offered to pregnant women, where mother-to-child transmission of HIV can be prevented. (who.int)
The number of new HIV in- cess the services they need. (who.int)
Additional services could help caregivers with decision-making around treatment initiation for their children. (cdc.gov)

To increase access to the Treatment for Prevention option, the Treatment 2.0 initiative must be urgently implemented to innovate, simplify, reduce costs and mobilize communities to scale up HIV testing and counseling and treatment. (unaids.org)

Knowledge is power: Test for HIV. (who.int)
Test for HIV! (who.int)

Although multifactorial in nature (transmission mode and patient educational level are independent risk factors for these events) there may also be a direct role of HIV in these events, or an indirect role mediated through the subsequent immune dysfunction. (medscape.com)

The risk of HIV transmission varies widely by the type of exposure. (benthamscience.com)
Generally, the risk of HIV transmission for receptive anal intercourse, receptive vaginal intercourse and receptive oral intercourse is 0.5%, 0.1% and 0.01% per act, respectively. (benthamscience.com)
Truvada ® (emtricitabine 200 mg and tenofovir disoproxil fumarate 300 mg tablets) for PrEP is currently the only FDA approved product indicated to reduce the risk of sexually acquired HIV-1 in individuals (≥35 kg) who are HIV-negative and at risk for HIV. (gilead.com)
Truvada is indicated in combination with safer sex practices for HIV PrEP to reduce the risk of sexually acquired HIV in at-risk individuals who are HIV-negative and weigh ≥35 kg. (gilead.com)
CDC's HIV prevention activities over the past two decades have focused on helping uninfected persons at high-risk for acquiring HIV change and maintain behaviors to keep them uninfected. (cdc.gov)

This licensing agreement provides an additional pathway for innovations in Gilead's HIV pipeline in areas of evolving and unmet medical need. (natap.org)
WLHIV have a much higher unmet need for FP than HIV negative women ( 11 ). (frontiersin.org)

UNAIDS urges that Treatment for Prevention be one of the options made available to couples. (unaids.org)
This builds on a series of expert consultations which have been convened by UNAIDS and WHO on Treatment for Prevention during the last two years. (unaids.org)
UNAIDS and WHO will work with countries and partners to make Treatment for Prevention an integral part of the HIV response and to ensure it is made available to people who wish to use it as soon as possible. (unaids.org)
The cosponsored nature of UNAIDS as a human rights imperative and a ble access to treatment, lobbied to enables it to address HIV through a matter of social justice. (who.int)

Anatomy7

Organisms5

Diseases23

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Psychiatry and Psychology34

Phenomena and Processes21

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena16

Humanities2

Information Science13

Named Groups14

Health Care73

Geographicals34

AIDS95

Infection61

Regimens10

Adherence9

Regimen7

Opportunistic infections9

Prophylaxis6

Therapies3

Infectious diseases3

Undetectable4

Outcomes6

Stigma6

Morbidity and morta2

20163

Suppression2

Hepatitis C vir4

Patients28

Adults4

Virologic Failure1

Gilead Sciences5

Living with HIV30

Adolescents6

Africa2

Tuberculosis4

Care26

Investigational1

Viral load3

20201

Remission2

Epidemic2

Human immun4

Newly1

Prevention options4

Discrimination1

Efficacy3

Diagnosis1

Interventions6

Clinical6

Advances3

Infections3

Antiviral1

Reverse transcriptase5

Becoming HIV infected1

Complications1

20215

People with HIV1

Services13

Mobilize1

Test for HIV2

Immune1

Risk5

Unmet2

UNAIDS4