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  • Parasites
  • Parasites are considered an important source of information concerning the stability of ecosystems (Marcogliese 2005), and numerous publications propose the role of parasites, particularly helminths , as biological tags of environmental impacts (Sures 2001, Jankovska et al. (thefreedictionary.com)
  • More recent investigations have focused on the mechanisms by which the host senses helminth parasites to activate ILC2s. (frontiersin.org)
  • Formation and excretion of acetate as a metabolic end product of energy metabolism occurs in many protist and helminth parasites, such as the parasitic helminths Fasciola hepatica, Haemonchus contortus and Ascaris suum, and the protist parasites, Giardia lamblia, Entamoeba histolytica, Trichomonas vaginalis as well as Trypanosoma and Leishmania spp. (nih.gov)
  • For guidance regarding management of children with suspected or confirmed helminth infections (based on clinical features, eosinophilia, stool ova, cysts and parasites (OCP) exam) please contact the paediatric infectious disease team. (starship.org.nz)
  • biology
  • Helminth Genomics initiated at the dawn of the millennium with promised to provide novel tools to decipher the biology of several parasitic worms that are agents of some of the most prevalent neglected diseases. (frontiersin.org)
  • We propose this Research Topic as an open forum to present and discuss these innovative genetic and genomic-based approaches that are helping to develop tools and leading the community towards solutions to understand many of the challenging aspects of helminth biology. (frontiersin.org)
  • As we discuss here, new insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies. (nih.gov)
  • Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans. (nih.gov)
  • In nematodes and platyhelminths, there is an abundance of physiological evidence demonstrating that neuropeptides play critical roles in the biology of both free-living and parasitic helminths. (springer.com)
  • mechanisms
  • Integrated omics approaches to comprehensively study helminths at a molecular level: including efforts towards the development of a toolkit to unravel gene function, such as transgenesis, RNAi and CrispR-Cas9, and furthering our understanding of transcriptional regulation in helminths with special emphasis in particularities like transplicing, gene editing, post-transcriptional regulation and/or the role of non-coding RNA and epigenetic mechanisms. (frontiersin.org)
  • proteins
  • Finally, the applicability of helminth-derived therapeutic proteins in the treatment of allergic and autoimmune inflammatory disease is discussed. (hindawi.com)
  • Comparative genomics are highlighting the common presence of helminth exclusive conserved hypothetical proteins, challenging researchers to invent innovative ways to unravel their function and relevance. (frontiersin.org)
  • Genome
  • Improving genomics resources for helminths: including third-generation sequencing technologies for improving genome assembly and annotation, novel algorithms and packages, and new bioinformatic tools. (frontiersin.org)
  • clinical
  • This review outlines basic insight into the ability of helminths to modulate the onset and progression of T1D, and frames some of the challenges that helminth-derived therapies may face in the context of clinical translation. (nih.gov)
  • approaches
  • After implementation of the collaborative research project among scientists from southeast Asian countries supported by International Development Research Centre (IDRC), Canada, the socio-ecosystem-packaged strategy in GMS has been proposed in order to explore the transition approaches from control to eliminate of helminth zoonoses transmission, under a broader portfolio of eco-health research integrated with the emerging infectious diseases, climate change, food security and human health. (biomedcentral.com)
  • host
  • Immunologists have focused on the excretory and secretory products that are released by the helminths, since they can change the host environment by modulating the immune system. (hindawi.com)
  • 1995) Helminths of the opossum, Didelphis virginiana, in southern Illinois, with a compilation of all helminths reported from this host in North America. (thefreedictionary.com)
  • main
  • Putative targets found by predictive, comparative or genetic methods need validation and consequently a whole area of helminth functional genomics have emerged, with RNAi-mediated gene silencing as the main tool but also attempting to develop stable transgenesis methods. (frontiersin.org)
  • children
  • Under conditions of poverty, overcrowding and limited access to water and sanitation, children and adults are commonly infested by helminths , as shown in Limpopo and KwaZulu-Natal provinces, [5,and in Cape Town. (thefreedictionary.com)
  • Routine presumptive treatment is not recommended for children under the age of 1 year, due to the lack of safety data for anti-helminth medications in this population. (starship.org.nz)
  • presence
  • ILC2s have been intensively studied over the last decade, and are known to respond quickly and robustly to the presence of helminths-both by increasing in number and producing type 2 cytokines. (frontiersin.org)
  • human
  • Helminths are the largest and most complex pathogens to invade and live within the human body. (hindawi.com)
  • In GMS countries, helminth zoonoses are still imposing a huge impact on human and domestic animals, particularly schistosomiasis and liver fluke diseases (clonorchiasis, opithorchiasis and fasciolasis) which are emerging or re-emerging in some areas due to environmental change in the face of socioeconomic development. (biomedcentral.com)
  • Control
  • Global commitment focuses on school based chemotherapy programmes to implement helminth control strategies [ 8 ]. (hindawi.com)
  • Program
  • We do hope with more cooperative efforts and sharing the social-ecosystem-packaged strategy in GMS through this special thematic issue, the elimination program on helminth zoonosis in GMS will be accelerated. (biomedcentral.com)
  • People
  • Today, it is estimated that approximately one-third of the almost three billion people that live on less than two US dollars per day in developing regions of Sub-Saharan Africa, Asia, and the Americas are infected with one or more helminths [ 3 , 4 ]. (hindawi.com)
  • possible
  • Recently, helminth-derived antigens and molecules have been tested in vitro and in vivo to explore possible applications in the treatment of inflammatory and autoimmune diseases, including T1D. (nih.gov)
  • treatment
  • if child has an associated anaemia on the first FBC consider giving iron supplementation after completion of anti-helminth treatment and repeating FBC in 3-4 weeks. (starship.org.nz)