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  • Genes
  • This entailed mining available transcriptomic and/or genomic sequence datasets for the presence of homologues of known TIMPs, predicting secondary structures of defined protein sequences, systematic phylogenetic analyses and assessment of differential expression of genes encoding putative TIMPs in the developmental stages of A. suum , N. americanus and Schistosoma haematobium which infect the mammalian hosts. (biomedcentral.com)
  • A detailed understanding of the molecular biology of parasitic helminths, and in particular of the structure and function of key genes and gene products playing essential roles in host-parasite interactions, could provide a basis for the design of novel therapeutics. (biomedcentral.com)
  • SmedGD integrates in a single web-accessible portal all available data associated with the planarian genome, including predicted and annotated genes, ESTs, protein homologies, gene expression patterns and RNAi phenotypes. (nih.gov)
  • This down regulation requires specialised forms of chromatin (DNA and the proteins that package it) that prevents the transcription machinery from gaining access to the genes. (gla.ac.uk)
  • Fatty Acid-Bin
  • We collaborate widely with other biologists and chemists and currently have particular interests in the biophysics and application of natural surfactant proteins, in fatty acid binding proteins from nematode parasites, in the structural basis of epigenetic gene regulation, in the regulation of viral life cycles, in the molecular basis of endotoxin sensing, and in ultraviolet light perception by plants. (gla.ac.uk)
  • Brian's group studies the structures and ligand binding properties of novel fatty acid binding proteins from parasites. (gla.ac.uk)
  • The parasites must scavenge metabolites, including fatty acids and retinoids, from their hosts and maintain a reservoir of fatty acid binding proteins in their pseudocoelemic fluid. (gla.ac.uk)
  • humans
  • The tight association between the secretion of VALs and the onset of parasitism has triggered a particular interest in this group of proteins, as improved knowledge on their biological functions may assist in designing novel protection strategies against parasites in humans, livestock, and important food crops. (wur.nl)
  • Amino Acids
  • High affinity binding of many protein ligands, including Fg, to α M β 2 involves a segment of ∼200 amino acids in the α M subunit, termed the I (or A) domain ( 23 )( 26 )( 27 ). (rupress.org)
  • These proteins are 60-80 amino acids in length, contain four disulfide bonds, and when injected produce paralysis in marine and terrestrial vertebrata. (frontiersin.org)
  • actin-interac
  • Here, I show that UNC-78 is a homologue of actin-interacting protein 1 (AIP1) and functions as a novel regulator of actin organization in myofibrils. (nih.gov)
  • FABP
  • Brian's group have determined the structures of nematode polyprotein antigen subunits (NPAs) and fatty acid and retinoid binding proteins (FARs) and more typical FABP proteins and are examining their lipid binding in detail. (gla.ac.uk)
  • Genome
  • Protein homology is queried in the Swissprot, SMART, PFAM and proteome hits to the genome (Figure 2A and B). Gene Ontology terms can be searched by cellular location, molecular function or biological process (Figure 3A). (nih.gov)
  • Cells
  • Since then our work at Johns Hopkins University and the University of Michigan has helped define how Toxoplasma uses adhesive proteins to actively invade target cells and showed that its hybrid exo-endocytic system supports both protein secretion and ingestion of host derived material. (mbl.edu)
  • Consistent with its actin bundling activity in vitro, UNC-87 tagged with green fluorescent protein associated with and promoted the formation of actin stress fiber bundles in living cells. (pmu.ac.at)
  • High-resolution molecular structures are normally determined in vitro, but Brian was part of the team that solved the first structure of a protein inside living cells. (gla.ac.uk)
  • molecular
  • Molecular chaperones are highly conserved and ubiquitous proteins that help other proteins in the cell to fold. (tcd.ie)
  • The Neutral Theory of Molecular Evolution is considered the most powerful theory to understand the evolutionary behavior of proteins. (tcd.ie)
  • Molecular chaperones, also known as heat-shock proteins, refold misfolded proteins and help other proteins reach their native conformation. (tcd.ie)
  • The molecular domain structure of the protein reveals similarity to the C-terminal repeat region of the smooth muscle actin-binding protein calponin. (pmu.ac.at)
  • novel
  • These data identify UNC-87 as an actin-bundling protein and highlight the calponin-like repeats as a novel actin-binding module. (pmu.ac.at)
  • distinct
  • The peaks arising from the amide NH of each amino acid residue are seen to jump from one position to another as oleate is titrated into the protein indicating that it can bind multiple ligands, adopting a distinct conformation in each case. (gla.ac.uk)
  • residues
  • Point mutations in unc-78 alleles change conserved residues within different WD repeats of the UNC-78 protein and cause less severe phenotypes than a deletion allele, suggesting that these mutations partially impair the function of UNC-78. (nih.gov)
  • Figure 1 Three views of a cartoon of the structure of the solution form of the surfactant protein latherin showing the locations of the many leucine (yellow) and isoleucine (orange) residues as spheres. (gla.ac.uk)
  • UVR8, the protein through which plants sense ultraviolet light, is unusual in using tryptophan residues, rather than an additional chromophore. (gla.ac.uk)
  • structures
  • Brian's group use the technique to study the structures and functions of proteins and nucleic acids involved in interesting processes in a variety of systems. (gla.ac.uk)
  • Brian's group study the structures of the proteins that recognise and interpret these modifications. (gla.ac.uk)
  • several
  • Proteins that act as cell compatible surfactants have arisen independently several times in evolution. (gla.ac.uk)
  • This enzyme catalyzes the cis-trans isomerization of proline-imidic peptide bonds in oligopeptides and has been demonstrated to accelerate the refolding of several proteins, including collagens [Bachinger, J. Biol. (google.com)