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  • Schistosomiasis
  • In GMS countries, helminth zoonoses are still imposing a huge impact on human and domestic animals, particularly schistosomiasis and liver fluke diseases (clonorchiasis, opithorchiasis and fasciolasis) which are emerging or re-emerging in some areas due to environmental change in the face of socioeconomic development. (biomedcentral.com)
  • Guidelines for Overseas Presumptive Treatment of Strongyloidiasis, Schistosomiasis, and Soil-Transmitted Helminth Infections. (starship.org.nz)
  • genomics
  • Comparative genomics are highlighting the common presence of helminth exclusive conserved hypothetical proteins, challenging researchers to invent innovative ways to unravel their function and relevance. (frontiersin.org)
  • Putative targets found by predictive, comparative or genetic methods need validation and consequently a whole area of helminth functional genomics have emerged, with RNAi-mediated gene silencing as the main tool but also attempting to develop stable transgenesis methods. (frontiersin.org)
  • Improving genomics resources for helminths: including third-generation sequencing technologies for improving genome assembly and annotation, novel algorithms and packages, and new bioinformatic tools. (frontiersin.org)
  • mechanisms
  • Integrated omics approaches to comprehensively study helminths at a molecular level: including efforts towards the development of a toolkit to unravel gene function, such as transgenesis, RNAi and CrispR-Cas9, and furthering our understanding of transcriptional regulation in helminths with special emphasis in particularities like transplicing, gene editing, post-transcriptional regulation and/or the role of non-coding RNA and epigenetic mechanisms. (frontiersin.org)
  • evolutionary
  • These complex interactions suggest that a consideration of the evolutionary history of human-helminth interactions, as well as the ecological context of infections, can help to clarify an understanding of these host-parasite interactions and provide direction for future investigations. (dovepress.com)
  • Genome
  • As we discuss here, new insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies. (nih.gov)
  • biology
  • We propose this Research Topic as an open forum to present and discuss these innovative genetic and genomic-based approaches that are helping to develop tools and leading the community towards solutions to understand many of the challenging aspects of helminth biology. (frontiersin.org)
  • elimination
  • We do hope with more cooperative efforts and sharing the social-ecosystem-packaged strategy in GMS through this special thematic issue, the elimination program on helminth zoonosis in GMS will be accelerated. (biomedcentral.com)
  • approaches
  • After implementation of the collaborative research project among scientists from southeast Asian countries supported by International Development Research Centre (IDRC), Canada, the socio-ecosystem-packaged strategy in GMS has been proposed in order to explore the transition approaches from control to eliminate of helminth zoonoses transmission, under a broader portfolio of eco-health research integrated with the emerging infectious diseases, climate change, food security and human health. (biomedcentral.com)
  • clinical
  • Clinical and field studies of populations in endemic areas have, over many years, produced convincing evidence of individual, racial and breed variation in ability to develop resistance to helminth infections (Wakelin, 1978a). (springer.com)
  • treatment
  • Routine presumptive treatment is not recommended for children under the age of 1 year, due to the lack of safety data for anti-helminth medications in this population. (starship.org.nz)
  • if child has an associated anaemia on the first FBC consider giving iron supplementation after completion of anti-helminth treatment and repeating FBC in 3-4 weeks. (starship.org.nz)