InfectionGastritisEradicationColonizationInfectionsInduceCagABacteriumEpithelialIsolatesBacteriaStomachPathogenesisPathogenicity islandImmunologyVitroMicrobiologyGenomeSpeciesGeneATCCCampylobacterMechanisms2023MacrophagesVaccinesGeneticInducesPrevalenceChlamydiaProbioticDuodenalOrganismsVariantsGastrointestinal tractReactivePatientsHelical shapeDifferProduces
Infection42
- To look for evidence of intrafamilial infection, we isolated 107 Helicobacter pylori clones from biopsied specimens taken from both parents and four children. (cdc.gov)
- H. pylori infection is considered a risk factor for developing gastric carcinoma ( 2 , 3 ). (cdc.gov)
- Use of an H. pylori whole genome microarray is an effective method to identify differences in gene content between H. pylori strains that induce distinct pathological outcomes in a rodent model of H. pylori infection. (jci.org)
- Infection with Helicobacter pylori is a major risk factor for the development of gastric cancer, and infection with strains carrying the virulence factor CagA significantly increases this risk. (zfin.org)
- Shahid S. Helicobacter Pylori Infection in Children. (webmedcentral.com)
- H.pylori infection should be suspected in children with history suggestive of hyperacidity and in those who have a first degree family member with gastric cancer. (webmedcentral.com)
- Non-invasive tests on breath, stool, serum, urine and saliva can also diagnose H.pylori infection reliably. (webmedcentral.com)
- Awareness of H.pylori infection is vital due to its high rate of colonization and risk of gastric malignancies. (webmedcentral.com)
- H.pylori infection in children differs from that in adults in its prevalence, presence, site and degree of gastric/duodenal inflammation, lesser likelihood of gastric malignancies, problems in diagnosis and higher rate of antibiotic resistance [14]. (webmedcentral.com)
- Infection with Helicobacter pylori eradication to prevent gastric cancer in a population with varied ethnic origins but shared geography get zyloprim online . (margottriesthegoodlife.com)
- Infection with Helicobacter pylori eradication to prevent liver lipid deposition. (margottriesthegoodlife.com)
- We are also interested in the generalized effects of chronic infection and are investigating the molecular mechanisms by which chronic infection with H. pylori or Chlamydia pneumoniae may pre dispose the development of atherosclerosis. (viin.org.au)
- We have developed adult and suckling mouse models of these diseases to investigate transmission and immune responses to infection. (viin.org.au)
- Clinical evidence suggests that infection with H. pylori cagA + strains dramatically increases the risk of developing gastric cancer. (medicalxpress.com)
- Helicobacter pylori infection causes a variety of gastrointestinal diseases, including peptic ulcers and gastric cancer. (rcsb.org)
- The second part of the review discusses potential host-directed interventional strategies based on existing translational and clinical knowledge of infection-induced inflammation, as well as cancer initiation/progression models. (frontiersin.org)
- See the article "Eradication of Helicobacter pylori Infection Using 7-day PCR-based Tailored Therapy" on page 125. (helicojournal.org)
- Helicobacter pylori infection is associated with important gastric pathologies. (elsevierpure.com)
- Probiotics could present an alternative solution to prevent or decrease H. pylori infection. (elsevierpure.com)
- In this work, the ability of L. fermentum UCO-979C to modulate immune response in AGS cells and PMA phorbol 12-myristate 13-Acetate (PMA)-differentiated THP-1 (human monocytic leukaemia) macrophages in response to H. pylori infection was evaluated. (elsevierpure.com)
- We demonstrated that the UCO-979C strain is able to differentially modulate the cytokine response of gastric epithelial cells and macrophages after H. pylori infection. (elsevierpure.com)
- These findings strongly support the probiotic potential of L. fermentum UCO-979C and provide evidence of its beneficial effects against the inflammatory damage induced by H. pylori infection. (elsevierpure.com)
- Although our findings should be proven in appropriate experiments in vivo, in both H. pylori infection animal models and human trials, the results of the present work provide a scientific rationale for the use of L. fermentum UCO-979C to prevent or reduce H. pylori-induced gastric inflammation in humans. (elsevierpure.com)
- Following siRNA-mediated RPTPα knockdown in AZ-521 cells, infection with wild-type H. pylori and treatment with VacA did not induce CagA phosphorylation. (elsevierpure.com)
- People commonly use L. acidophilus for diarrhea from antibiotics, as well as irritable bowel syndrome (IBS), overgrowth of bacteria in the vagina, and an infection caused by the bacteria Helicobacter pylori (H. pylori). (medlineplus.gov)
- Helicobacter pylori colonizes half of the world's population as the dominant member of the gastric microbiota resulting in a lifelong chronic infection. (nimml.org)
- During chronic H. pylori infection hosts develop complex immune responses to cope with bacterial persistence that result in a variety of outcomes ranging from peaceful co-existence to detrimental disease. (nimml.org)
- Additionally, we found that H. pylori induces a unique regulatory gene module with an early transient peak during infection including the anti-inflammatory cytokine Il10 . (nimml.org)
- Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model. (intestinal-microbiota.de)
- The colonization ability of the strains, the intensity of gastritis and gene expression of various inflammatory cytokines in the stomach were determined at 9 weeks after experimental infection. (biomedcentral.com)
- High-level antral colonization was seen for 4 strains, while colonization of 4 other strains was more restricted and one strain was not detected in the stomach at 9 weeks post infection. (biomedcentral.com)
- A reduced antral expression of H + /K + ATPase was seen in the stomach after infection with 3 highly colonizing strains and 2 highly colonizing strains caused an increased gastrin expression in the fundus. (biomedcentral.com)
- This study demonstrates diversity in bacterium-host interactions within the species H. heilmannii s.s. and that the pathogenesis of gastric infections with this microorganism is not identical to that of an H. pylori infection. (biomedcentral.com)
- Several infection studies in experimental animal models have been performed to investigate the pathogenesis of H. pylori infections in humans. (biomedcentral.com)
- In this context, Helicobacter pylori (Hp) has been identified by the WHO as one of the pathogens for which it is urgent to find new antibacterial compounds, due to the high incidence of antibiotic-resistant strains along with the fact that half of the world's population suffers from gastric infections caused by Hp, and because Hp infection constitutes a risk factor for gastric cancer. (fz-borstel.de)
- By the early-to-mid 1990s, further evidence supported a link between chronic gastritis of H pylori infection in adults and malignancy, specifically gastric lymphoma and adenocarcinoma. (medscape.com)
- Objectives of current and future research on H pylori include improving the understanding of the immunopathogenesis of gastric disease associated with H pylori infection, elucidating the modes of transmission, and improving the safety and efficacy of vaccines to prevent H pylori infection. (medscape.com)
- Children differ from adults with respect to H pylori infection in terms of the prevalence of the infection, the complication rate, the near-absence of gastric malignancies, age-specific problems with diagnostic tests and drugs, and a higher rate of antibiotic resistance. (medscape.com)
- Helicobacter pylori infection revealed by endoscopy (nodular gastropathy). (medscape.com)
- In contrast, infection with CagA-positive strains greatly increases the risk of peptic ulcer disease and gastric cancer. (medscape.com)
- CagA in situ expression is increased in children with H pylori infection who have peptic ulcers and may play a role in the pathogenesis of peptic ulcer disease (PUD). (medscape.com)
- Helicobacter pylori Infection Helicobacter pylori ( H. pylori ) infection is a bacterial infection that causes stomach inflammation ( gastritis), peptic ulcer disease, and certain types of stomach cancer. (msdmanuals.com)
Gastritis7
- Helicobacter pylori is the major cause of chronic gastritis and peptic ulcers and must be treated to prevent relapse ( 1 ). (cdc.gov)
- Gastric ulcer strain B128 induced more severe gastritis, proliferation, and apoptosis in gerbil mucosa than did duodenal ulcer strain G1.1, and gastric ulceration and atrophy occurred only in B128+ gerbils. (jci.org)
- An aggressive proinflammatory immune response is generated in the gastric tissue infected with H. pylori, resulting in gastritis and a series of morphological changes that increase the susceptibility to cancer development. (elsevierpure.com)
- The induction of an antrum-dominant chronic active gastritis with formation of lymphocytic aggregates was shown for 7 strains. (biomedcentral.com)
- All strains inducing a chronic active gastritis caused an up-regulation of the pro-inflammatory cytokine IL-1β in the antrum. (biomedcentral.com)
- Although this bacterium has been associated with chronic active gastritis in cats and dogs [ 12 ], its pathogenic significance remains enigmatic and is probably strain-dependent. (biomedcentral.com)
- An individual infected with CagA-negative strains is likely only to develop chronic gastritis and have only a small chance of developing peptic ulcer disease or gastric cancer. (medscape.com)
Eradication2
- Consensus statements with 100% agreement and "high" evidence level indicated that specific probiotics help reduce overall symptom burden and abdominal pain in some patients with IBS and duration/intensity of diarrhoea in patients prescribed antibiotics or H. pylori eradication therapy, and have favourable safety. (medscape.com)
- Specific probiotics can relieve lower GI symptoms in IBS, prevent diarrhoea associated with antibiotics and H. pylori eradication therapy, and show favourable safety. (medscape.com)
Colonization3
- There are a number of challenges to applying GWAS to bacterial infections, including the difficulty of obtaining matched controls, multiple strain colonization and the possibility that causative strains may not be present when disease is detected. (biomedcentral.com)
- The findings of our previous study suggest that the motility of L. agilis BKN88 enables gut colonization in murine models. (nature.com)
- Helical cell shape is necessary for efficient stomach colonization by Helicobacter pylori, but the molecular mechanisms for generating helical shape remain unclear. (princeton.edu)
Infections5
- A probiotic containing Bacillus clausii strains O/C, N/R, SIN and T (EG) established its effectiveness and safety over decades and has been an effective adjunct to triple therapy (two antibiotics and a PPI) for treatment of Helicobacter pylori infections, in preventing digestive symptoms originally attributed to antibiotics [4, 5]. (efsm.online)
- Helicobacter pylori (H. pylori) infections are commonly associated with abdominal pain, bloating, and acidity. (medicalxpress.com)
- In summary, the researchers conclude that through this study, they were able to elucidate the molecular mechanisms involved in gastric carcinogenesis induced by H. pylori, gain insights into the role of the Wnt/PCP pathway in carcinogenesis, and propose it as a potential target for clinical interventions against H. pylori cagA + infections. (medicalxpress.com)
- Gnotobiotic mouse models and metagenomic analyses will provide new insights into the intricate interaction between Yersinia , the intestinal microbiota and the mucosal immune system, and might result in novel strategies for treatment of enteric infections. (intestinal-microbiota.de)
- Helicobacter pylori (Hp) is a gram-negative bacillus responsible for one of the most common infections found in humans worldwide. (medscape.com)
Induce5
- We examined the ability of two H. pylori isolates to induce differential host responses in vivo or in vitro, and then used an H. pylori whole genome microarray to identify bacterial determinants related to pathogenesis. (jci.org)
- We further utilized this model to demonstrate that oncogenic cooperation between CagA and a loss-of-function allele of p53 is sufficient to induce high rates of intestinal small cell carcinoma and adenocarcinoma, establishing the utility of our transgenic zebrafish model in the study of CagA-associated gastrointestinal cancers. (zfin.org)
- Next we investigated how innate pattern recognition receptors (PRRs) may facilitate the recognition of H. pylori to subsequently induce classic molecular cascades that efficiently modulate immunity. (nimml.org)
- For example, individuals at high risk of developing colon cancer carry in their guts strains of Escherichia coli that produce a DNA-damaging toxin as well as strains of Bacteroides fragilis that induce severe diarrhea and colon inflammation and are able to cause cancer in mouse models. (microbiomepost.com)
- Furthermore, CagA-positive strains are known to induce the expression of a DNA-editing enzyme, which leads to accumulation of mutations in the tumor suppressor p53. (medscape.com)
CagA11
- Neal, J.T., Peterson, T.S., Kent, M.L., and Guillemin, K. (2013) H. pylori Virulence Factor CagA Increases Intestinal Cell Proliferation by Wnt Pathway Activation in a Transgenic Zebrafish Model. (zfin.org)
- A specialized protein delivered by H. pylori to the host, oncoprotein "CagA," has been shown to interact with multiple host proteins and promote gastric carcinogenesis (transformation of normal cells to cancer cells ). (medicalxpress.com)
- In order to carry out their study, the researchers expressed oncoprotein CagA in three different models-embryos of Xenopus laevis (lab frog), adult mouse stomach, and cultured human gastric epithelial cells-and tried to understand its effect on the host cells and pathways. (medicalxpress.com)
- The experiments clearly demonstrated that a small region of the CagA oncoprotein was interacting with amino acid residues from the proteins VANGL1/2, thus leading to its displacement (a phenomenon also observed in the mouse model) and resulting in disruption of the Wnt/PCP pathway-a key biological "relay" that affects development. (medicalxpress.com)
- Corresponding author Masanori Hatakeyama, Laboratory Head, Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, says, "Perturbation of Wnt/PCP signaling by the H. pylori CagA-VANGL interaction induces hyperplastic changes, along with impaired cell differentiation in gastric pyloric glands. (medicalxpress.com)
- Atsushi Takahashi-Kanemitsu, The Helicobacter Pylori CagA Oncoprotein Disrupts Wnt/PCP Signaling and Promotes Hyperproliferation of Pyloric Gland Base Cells, Science Signaling (2023). (medicalxpress.com)
- Helicobacter pylori, a major cause of gastroduodenal diseases, produces vacuolating cytotoxin (VacA) and cytotoxin-associated gene A (CagA), which seem to be involved in virulence. (elsevierpure.com)
- Src is responsible for tyrosine phosphorylation of CagA at its Glu-Pro-Ile-Tyr-Ala (EPIYA) variant C (EPIYA-C) motif in Helicobacter pylori-infected gastric epithelial cells, resulting in binding of CagA to SHP-2 phosphatase. (elsevierpure.com)
- Challenging AZ-521 cells with wild-type H. pylori induced phosphorylation of CagA, but this did not occur when challenged with a vacA gene-disrupted mutant strain. (elsevierpure.com)
- CagA phosphorylation was observed in cells infected with a vacA gene-disrupted mutant strain after addition of purified VacA, suggesting that VacA is required for H. pylori-induced CagA phosphorylation. (elsevierpure.com)
- Individuals infected with East-Asian type cagA strains are reported to have higher risk of PUD or gastric cancer than those with Western-type cagA strains. (medscape.com)
Bacterium9
- The bacterium Helicobacter pylori can colonize the stomach for years without causing any symptoms [ 1 ], but its presence is associated with several serious clinical diseases including peptic ulcer, gastric cancer and MALT lymphoma. (biomedcentral.com)
- For example, causative strains may be absent when disease is detected, particularly because precancerous lesions change the physiology of the stomach and can destroy the niche that the bacterium previously occupied. (biomedcentral.com)
- Ten chemoreceptors have been identified in the gram-positive model bacterium Bacillus subtilis , 10 chemoreceptors have been found, and some have been characterized. (nature.com)
- H.pylori is a gram-negative helical microaerophilic flagellated bacterium found in the sterile gastric mucosa of majority of the world's population [15]. (webmedcentral.com)
- Host responses toward the bacterium can result in asymptomatic, pathogenic or even favorable health outcomes, however, mechanisms underlying the dual role of H. pylori as a commensal versus pathogenic bacterium are not well characterized. (nimml.org)
- Our data suggest that mechanisms of mononuclear phagocyte response to H. pylori occur sequentially and may depend on the location of the bacterium with respect to the host cell. (nimml.org)
- Helicobacter (H.) heilmannii sensu stricto (s.s.) is a zoonotic bacterium that naturally colonizes the stomach of dogs and cats. (biomedcentral.com)
- Therefore, a Mongolian gerbil model was used to study bacterium-host interactions of 9 H. heilmannii s.s. strains. (biomedcentral.com)
- Therefore, the aim of the present study was to study bacterium-host interactions of 9 H. heilmannii s.s. strains, isolated from the gastric mucosa of different cats. (biomedcentral.com)
Epithelial3
- These results indicate that the ability of H. pylori to regulate epithelial cell responses related to inflammation depends on the presence of an intact cag pathogenicity island. (jci.org)
- H. pylori strains differentially alter gastric epithelial cell apoptosis ( a ) and proliferation ( b ) in Mongolian gerbil gastric mucosa. (jci.org)
- We previously isolated Lactobacillus fermentum UCO-979C from human gastric tissue and demonstrated its capacity to reduce adhesion of H. pylori to human gastric epithelial cells (AGS cells). (elsevierpure.com)
Isolates3
- We performed a genome-wide association study (GWAS) on 173 H. pylori isolates from the European population (hpEurope) with known disease aetiology, including 49 from individuals with gastric cancer. (biomedcentral.com)
- Pulsed-field gel electrophoresis of 45 strains showed that these CTX-M-producing isolates belonged to 34 different types. (who.int)
- Conjugation experiments demonstrated that the blaCTX-M and blaTEM genes could be transferred to E. coli strain J53, while conjugative transfer of the blaSHV-5 gene from two isolates was not detectable. (who.int)
Bacteria7
- Helicobacter pylori are stomach-dwelling bacteria that are present in about 50% of the global population. (biomedcentral.com)
- This chemotactic signaling pathway is relatively conserved across bacteria, whereas chemoeffectors and chemoreceptors vary among bacterial species/strains. (nature.com)
- The organosulfur compounds of garlic exhibit a range of antibacterial properties such as bactericidal, antibiofilm, antitoxin, and anti-quorum sensing activity against a wide range of bacteria including multi-drug resistant (MDR) strains. (frontiersin.org)
- We show that the helical centerline pitch and radius of wild-type H. pylori cells dictate surface curvatures of considerably higher positive and negative Gaussian curvatures than those present in straight- or curved-rod bacteria. (princeton.edu)
- Among them, the use of immunomodulatory lactic acid bacteria represents a promising option to reduce the severity of chronic inflammatory-mediated tissue damage and to improve protective immunity against H. pylori. (elsevierpure.com)
- The first microbes to be linked with cancer were Helicobacter pylori and human papillomavirus, but over the past decade it has become clear that several other microorganisms - including some commensal bacteria - could provoke tumor formation. (microbiomepost.com)
- H pylori organisms are spiral-shaped gram-negative bacteria that are highly motile because of multiple unipolar flagella. (medscape.com)
Stomach6
- It was only 3 decades back that there was renewed interest in the microbiology of the stomach with the discovery and successful isolation and culture of the H. pylori (formerly called Campylobacter pylori ) [17-19]. (webmedcentral.com)
- Helicobacter pylori reside in more than 80% of the stomach of people in the developing world and 40% of those in the western world. (webmedcentral.com)
- This model was optimized to simulate the full GI tract including retention times and pH and consisted of a combined stomach + small intestine reactor. (efsm.online)
- Helicobacter pylori infects the stomach of approximately half the world's population. (viin.org.au)
- We are investigating the nature of the inflammatory response generated against H. pylori , and employing a vaccination model to attempt to understand how a protective immune response can be induced in the stomach. (viin.org.au)
- Taking L. acidophilus by mouth along with most standard drug therapies helps treat stomach ulcers caused by H. pylori. (medlineplus.gov)
Pathogenesis2
- Dr. Carrasco's research interests have focused on understanding the role of Borrelia burgdorferi's virulence factors and macrophage scavenger receptor CD36 in the pathogenesis of arthritis and carditis in the mouse model of Lyme disease. (mit.edu)
- klebsiella pneumoniae , and pneumocystis murina ), spontaneous neoplasias in colonies of NHPs, Lyme disease pathogenesis, N -nitrosodimethylamine (NDMA)-induced hepatic carcinogenesis, and toxicopathology of novel engineered sACE2 decoy receptors in mouse models of SARS-CoV2. (mit.edu)
Pathogenicity island3
- DNA hybridization to the microarray identified several strain-specific differences in gene composition including a large deletion of the cag pathogenicity island in strain G1.1. (jci.org)
- The gastric cancer phenotype was associated with the presence of babA and genes in the cag pathogenicity island, one of the major virulence determinants of H. pylori , as well as non-synonymous variations in several less well-studied genes. (biomedcentral.com)
- cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. (semanticscholar.org)
Immunology1
- His collaborative research focuses on phenotyping and comparative pathology in diverse translational research areas, including infectious diseases, cancinogenesis, immunology, aging, microbiome, toxicopathology, mouse models for immuno-oncology research, and mouse models of SARS-CoV2. (mit.edu)
Vitro4
- In vitro, gerbil-passaged B128 derivatives significantly increased IL-8 secretion and apoptosis compared with G1.1 strains. (jci.org)
- Partial and complete disruption of the cag island in strain B128 attenuated induction of IL-8 in vitro and significantly decreased gastric inflammation in vivo. (jci.org)
- 2023) set up an in vitro Triple-M-SHIME model for 9 weeks using fecal samples from a donor with high levels of butyrate-producing species ( Fig. 1 ). (efsm.online)
- Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
Microbiology1
- H.pylori is a widely prevalent and important component of gastric microbiology. (webmedcentral.com)
Genome2
- These areas are approached by investigations that span from structural characterization of single molecules, macromolecular interactions and supramolecular assemblies, over mapping of molecular pathways in different model organisms, to whole genome sequencing of human pathogens. (ki.se)
- The 5300-year-old Helicobacter pylori genome of the Iceman. (cdc.gov)
Species3
- H. pylori is one of the most genetically diverse bacterial species, displaying from 2.7% to 8.0% of DNA sequence polymorphism ( 14 - 16 ). (cdc.gov)
- R-M system gain and loss is observed even on the level of strains of the same species, strains often carry different sets of R-M systems. (biomedcentral.com)
- Within a species, there may be different types, called strains. (msdmanuals.com)
Gene2
- We present the first ever time-series global gene expression dataset for H. pylori infected macrophages identifies three novel response modules: early transient, sustained and late waves. (nimml.org)
- M. smegmatis is commonly used as a model for studying gene function in M. tuberculosis because it proliferates rapidly and is non-pathogenic. (biomedcentral.com)
ATCC1
- E. coli NovaBlue (Novagen, Madison, WI) and ER2566 (Novagen) strains were routinely grown in Luria-Bertani media (LB, Invitrogen, Carlsbad, CA). The M. smegmatis mc 2 155 (ATCC, USA) strain was grown in LB broth containing 0.05% (v/v) Tween 80 (LBT) or LB agar at 37°C. Antibiotics were added at appropriate concentrations if needed. (biomedcentral.com)
Campylobacter1
- 1] Warren and Marshall first cultured and identified the organism as Campylobacter pylori in 1982. (medscape.com)
Mechanisms5
- Several mechanisms, such as point mutations, intragenic recombination, and introduction of foreign (African) alleles, were shown to enhance strain diversity within the family. (cdc.gov)
- Disease models & mechanisms. (zfin.org)
- DMM Disease Models and Mechanisms , 9 (12), 1473-1481. (elsevierpure.com)
- Mechanisms of microbe-host interactions are specified by the use of germ-free mouse models largely focusing on inflammatory bowel diseases (IBD). (intestinal-microbiota.de)
- In addition to mechanisms of microbe-host interaction, the role of cell stress related to unfolded protein responses (UPR) of the endoplasmic reticulum (ER) and mitochondria is characterized in the context of inflammatory and tumorigenic processes using novel tissue-specific mouse models. (intestinal-microbiota.de)
20231
- The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2023;23(2):81-83. (helicojournal.org)
Macrophages3
- We combined computational modeling, bioinformatics and experimental validation in order to investigate interactions between macrophages and intracellular H. pylori . (nimml.org)
- Our results investigate a series of hypotheses driven by computational and mathematical modeling and suggest one mechanism required by macrophages to ensure survival and intracellular H. pylori without overzealous inflammatory signaling. (nimml.org)
- We performed a time series RNAseq experiement on macrophages infected with H. pylori to gain a global perspective of host-pathogen interactions. (nimml.org)
Vaccines1
- Sometimes certain drugs and vaccines are effective only against certain strains. (msdmanuals.com)
Genetic2
- Here, we use comparative genomics approaches to understand how genetic variation amongst bacterial strains influences disease progression. (biomedcentral.com)
- Strains differ in genetic makeup and chemical components. (msdmanuals.com)
Induces1
- Intracellular Helicobacter pylori induces temporal waves in macrophage immunity. (nimml.org)
Prevalence1
- Helicobacter pylori prevalence varies depending on the geographic region, age, race, ethnicity and socio-economic status of individual. (webmedcentral.com)
Chlamydia1
- High-resolution multilocus sequence typing reveals novel urogenital Chlamydia trachomatis strains in women in Mopani district, South Africa. (cdc.gov)
Probiotic2
- The study demonstrated the probiotic effects of B. clausii on gut microbiota health following PPI-induced dysbiosis using the Simulator of the Human Intestinal Microbial Ecosystem ® (SHIME) model. (efsm.online)
- In addition, many clinical trials report conflicting findings, and results of meta-analyses have been published that compare non-identical probiotic strains, making the evidence difficult to interpret. (medscape.com)
Duodenal1
- Helicobacter pylori-associated peptic ulcer in the duodenal bulb. (medscape.com)
Organisms1
- A wide range of technical platforms and model organisms are applied to pursue relevant research topics. (ki.se)
Variants1
- Strains expressing CcmA variants with altered polymerization properties lose helical shape and associated positive Gaussian curvatures. (princeton.edu)
Gastrointestinal tract1
- human gut microbiome, data repositories, large-scale and integrative computational tools, modelling, immunomodulation, drug screening Background The human gastrointestinal tract is a complex ecosystem in which eukaryotic cells continuously interact with nutrients and with the complex microbial population of the gut microbiota [1]. (deepdyve.com)
Reactive1
- Catalase helps H pylori survive in the host by preventing the formation of reactive oxygen metabolites from hydrogen peroxide. (medscape.com)
Patients5
- We compared the sequences of two housekeeping genes ( hspA and glmM ) from these clones with those of 131 unrelated strains from patients living in different geographic regions. (cdc.gov)
- Identical alleles found in some strains isolated from the children and parents, but not in the strains isolated from unrelated patients, demonstrated that strains have circulated within the family. (cdc.gov)
- A better understanding of the role of H. pylori in causing disease and identification of virulent strains would allow intervention to be targeted at patients most at risk of the subsequent disease. (biomedcentral.com)
- justifiant de ce fait une meilleure prise en charge de ces patients. (bvsalud.org)
- La présente étude détermine la prévalence de l'infection par le virus de l'hépatite C en en determinant les génotypes ainsi que les facteurs y associés dans ce groupe de patients. (bvsalud.org)
Helical shape1
- We thus propose a model where CcmA and MreB promote PG synthesis at positive and negative Gaussian curvatures, respectively, and that this patterning is one mechanism necessary for maintaining helical shape. (princeton.edu)
Differ1
Produces1
- They are consistent with our LPS-ischemia-hypoxia rat model that produces myelin aggregates that colocalize with Aβ and resemble amyloid-like plaques. (neurology.org)