• Helicobacter pylori (H. pylori) is by far the best known Helicobacter species, primarily because humans infected with it may develop gastrointestinal tract diseases such as stomach inflammation, stomach ulcers, duodenal ulcers, stomach cancers of the nonlymphoma type, and various subtypes of extranodal marginal zone lymphomass, e.g. those of the stomach, small intestines, large intestines, and rectumn. (wikipedia.org)
  • Other non-H. pylori species that are known to be associated with these gastrointestinal diseases are Helicobacter bizzozeronii, Helicobacter salomonis, Helicobacter suis, and Helicobacter heilmannii s.s. (wikipedia.org)
  • Ammonia production is of great importance for the gastric pathogen Helicobacter pylori as a nitrogen source, as a compound protecting against gastric acidity, and as a cytotoxic molecule. (pasteur.fr)
  • Phylogenetic trees based upon the sequences of H. pylori amiE and amiF genes and their respective homologs from other organisms as well as the amidase gene distribution among Helicobacter species are strongly suggestive of amidase acquisition by horizontal gene transfer. (pasteur.fr)
  • Mongolian gerbils infected with Helicobacter pylori (Hp) develop goblet cell intestinal metaplasia and adenocarcinoma, but the presence of SPEM has not been studied in gerbils. (fujita-hu.ac.jp)
  • Helicobacter pylori bacterial factors, components of the host genetics and immune response, dietary cofactors and decreased acid secretion resulting in bacterial overgrowth are all considered important factors for induction of gastric cancer. (breakawaymatcha.com)
  • In this study, we assessed the bactericidal and/or bacteriostatic effect of green tea against Helicobacter felis and H. pylori in vitro and evaluated the effects of green tea on the development of Helicobacter-induced gastritis in an animal model. (breakawaymatcha.com)
  • Helicobacter pylori" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. (rush.edu)
  • This graph shows the total number of publications written about "Helicobacter pylori" by people in this website by year, and whether "Helicobacter pylori" was a major or minor topic of these publications. (rush.edu)
  • Below are the most recent publications written about "Helicobacter pylori" by people in Profiles. (rush.edu)
  • Helicobacter Pylori cagA+ Genotype is Associated With Consumption of Untreated Drinking Water in North-Eastern Brazil. (rush.edu)
  • Brandt S, Shafikhani S, Balachandran P, Jin S, Hartig R, K?nig W, Engel J, Backert S. Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements. (rush.edu)
  • Ethnic difference of Helicobacter pylori gastritis: Korean and Japanese gastritis is characterized by male- and antrum-predominant acute foveolitis in comparison with American gastritis. (rush.edu)
  • Here we demonstrated that an inflammasome molecule, absent in melanoma 2 (Aim2), was upregulated in patients with gastric cancer and in spasmolytic polypeptide-expressing metaplasia of chronically Helicobacter felis-infected stomachs in mice. (jci.org)
  • C ) Representative CD3 immunohistochemistry (brown) of WT, Aim2 -/- , IFNAR1 -/- , and Aim2 -/- IFNAR1 -/- 6-month H . felis -infected gastric mucosa. (jci.org)
  • E ) Representative H&E image of 6-month H . felis -infected Aim2 -/- versus Aim2 -/- IFNAR1 -/- gastric mucosa. (jci.org)
  • Among the gastric species, H. acinonychis possessed both amiE and amiF, H. felis carried only amiF, and H. mustelae was devoid of amidases. (pasteur.fr)
  • Components within natural remedies such as green tea could be further used for prevention and treatment of Helicobacter-induced gastritis in humans. (breakawaymatcha.com)
  • Because of their disease associations, these four Helicobacter species plus H. felis are often group together and termed Helicobacter heilmannii sensu lato. (wikipedia.org)
  • It is important to diagnose H. felis and other H. heilmannii sensu lato infections in patients with the cited upper gastrointestinal tract diseases, including in particular extranodal marginal zone lymphoma of the stomach, because some of them have been successfully treated and cured using antibiotic-based drug regimens (e.g.amoxicillin, clarithromycin, plus a proton pump inhibitor or metronidazole, clarithromycin, plus a proton pump inhibitor) directed against the instigating bacterium. (wikipedia.org)
  • Spasmolytic polypeptide (TFF2)-expressing metaplasia (SPEM) is observed in mucosa adjacent to human gastric cancer and in fundic glands showing oxyntic atrophy in Helicobacter felis-infected mice. (fujita-hu.ac.jp)
  • Helicobacter infection, one of the most common bacterial infections in man worldwide, is a type 1 carcinogen and the most important risk factor for gastric cancer. (breakawaymatcha.com)
  • Our data clearly demonstrate profound growth effects of green tea against Helicobacter and, importantly, demonstrate that green tea consumption can prevent gastric mucosal inflammation if ingested prior to exposure to Helicobacter infection. (breakawaymatcha.com)
  • Rodent models of Helicobacter infection need to be refined to investigate any causal links to ID. (bmj.com)
  • The aim of this study is to examine haematological parameters during the acute phase of Helicobacter infection in mice fed on iron-replete and iron deficient diets. (bmj.com)
  • H felis infection was confirmed by urease test and histology. (bmj.com)
  • This decrease was abrogated by H felis infection in dietary replete groups due to a slight increase (NS) in haemoglobin. (bmj.com)
  • H felis infection made no difference to the levels observed. (bmj.com)
  • This suggests that H felis has no impact on haematological parameters of iron status in the acute stage of the infection. (bmj.com)
  • Other markers of iron status such as serum iron, TIBC and serum ferritin are needed to explore further the impact of Helicobacter infection. (bmj.com)
  • Methods Five-week-old female SPF C57Bl/6 mice were fed on iron deficient (2-6 ppm) or iron-replete (48 ppm) diets 3 weeks before oral gavage with H felis . (bmj.com)
  • 0.001) in H felis infected and control mice on iron deficient diet compared to matched groups fed on iron-replete diet. (bmj.com)
  • 0.001) in mice fed on iron defiecient diet, regardless of H felis status. (bmj.com)
  • NHPH represents a group of closely related but distinct bacterial species, mainly found in different animal species, such as H. felis , H. salomonis , H. bizzozeronii , H. heilmannii sensu stricto (s.s. (biomedcentral.com)
  • Helicobacter felis is a bacterial species in the Helicobacteraceae family, Campylobacterales order, Helicobacter genus. (wikipedia.org)
  • We tested for the presence of the amiE and amiF genes and for amidase and formamidase activities in eleven Helicobacter species. (pasteur.fr)
  • Since amidases are found only in Helicobacter species able to colonize the stomach, their acquisition might be related to selective pressure in this particular gastric environment. (pasteur.fr)
  • B ) RT-qPCR of IFN-β gene mRNA expression in 6-month H . felis -infected Aim2 -/- versus WT stomachs, relative to uninfected controls. (jci.org)
  • D ) RT-qPCR analyses of gastric CD3 mRNA expression in 6-month H . felis -infected WT, Aim2 -/- , IFNAR1 -/- , and Aim2 -/- IFNAR1 -/- stomachs relative to uninfected controls. (jci.org)
  • Reports suggest that individuals, including children, are infected with this bacterium by having close contact with one of these infected animals: H. heilmanni s.l.-associated diseases, including those associated with H. felis, appear to be zoonotic diseases, i.e. infectious diseases that are caused by pathogen that spread from animals to humans. (wikipedia.org)
  • Helicobacter (H.) heilmannii sensu stricto (s.s.) is a zoonotic bacterium that naturally colonizes the stomach of dogs and cats. (biomedcentral.com)
  • A ) RT-qPCR of Ifnb1 (IFN-β gene) mRNA expression in Aim2 -/- versus WT bone marrow-derived macrophages (BMDCs) transfected with metaplastic gastric DNA from 6-month H . felis -infected stomach, relative to untransfected controls. (jci.org)
  • Humans infected with H. felis may also develop some of the same gastrointestinal diseases viz. (wikipedia.org)
  • All other parameters measured showed no difference due to H felis status in either diet cohort. (bmj.com)
  • Results Red blood cell count (RBC) and mean corpuscular haemoglobin concentration were similar in groups on both diets regardless of H felis status at 4 and 8 weeks. (bmj.com)
  • Other non-H. pylori species that are known to be associated with these gastrointestinal diseases are Helicobacter bizzozeronii, Helicobacter salomonis, Helicobacter suis, and Helicobacter heilmannii s.s. (wikipedia.org)
  • Because of their disease associations, these four Helicobacter species plus H. felis are often group together and termed Helicobacter heilmannii sensu lato. (wikipedia.org)
  • It is important to diagnose H. felis and other H. heilmannii sensu lato infections in patients with the cited upper gastrointestinal tract diseases, including in particular extranodal marginal zone lymphoma of the stomach, because some of them have been successfully treated and cured using antibiotic-based drug regimens (e.g.amoxicillin, clarithromycin, plus a proton pump inhibitor or metronidazole, clarithromycin, plus a proton pump inhibitor) directed against the instigating bacterium. (wikipedia.org)
  • 7. Gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma in an animal model of 'Helicobacter heilmannii' infection. (nih.gov)
  • All the H. heilmannii and H. felis PCR positive patients were also positive for H. pylori PCR amplification. (biomedcentral.com)
  • The fourth cluster contained isolates from human and feline hosts, and should provisionally be considered a unique bacterial species, for which the name 'Candidatus Helicobacter heilmannii' is proposed. (uibk.ac.at)
  • Fifteen gastrospirilla detected in humans, primates and pigs clustered with 'Candidatus Helicobacter suis', thus expanding the host range for this organism. (uibk.ac.at)
  • [ 291 ] Paradoxically, in vivo neutralization of IFN-γ was shown to alleviate H. felis -associated gastritis in mice, without affecting vaccine-induced protection, [ 292 ] and studies employing IFN-γ-knockout mice demonstrated that immunized animals were capable of inducing a protective immune response to H. pylori infection. (medscape.com)
  • 2007. Host response to Helicobacter pylori infection before initiation of the adaptive immune response. (nih.gov)
  • Helicobacter pylori infection is responsible for gastric carcinogenesis but host factors are also implicated. (oncotarget.com)
  • Meanwhile, the definitions of 'etiological factor' and 'causality' do not support ' H. pylori infection is an etiological factor of peptic ulcers', and existing literatures have presented a controversial view on the role of Helicobacter pylori in peptic ulcers. (preprints.org)
  • By comparison, based on 16S rRNA data, the remaining 11 gastrospirilla could not be differentiated from Helicobacter felis, Helicobacter bizzozeronii and Helicobacter salomonis. (uibk.ac.at)
  • 2. Helicobacter pylori-specific tumour-infiltrating T cells provide contact dependent help for the growth of malignant B cells in low-grade gastric lymphoma of mucosa-associated lymphoid tissue. (nih.gov)
  • 3. Helicobacter pylori and mucosa-associated lymphoid tissue: what's new. (nih.gov)
  • Reports suggest that individuals, including children, are infected with this bacterium by having close contact with one of these infected animals: H. heilmanni s.l.-associated diseases, including those associated with H. felis, appear to be zoonotic diseases, i.e. infectious diseases that are caused by pathogen that spread from animals to humans. (wikipedia.org)
  • Currently, peptic ulcers are widely studied as an infectious disease caused by Helicobacter pylori primarily due to 3 supporting evidences, and this etiology may explain the other 3 observations, but cannot confront the challenges of the 15 major characteristics and the other 75 observations/phenomena of peptic ulcers. (preprints.org)
  • In-depth analyses find that all the 3 evidences supporting "peptic ulcers are an infectious disease caused by Helicobacter pylori " are deceiving, and 2 of the 3 explainable observations may have been misinterpreted. (preprints.org)
  • Interestingly, if "peptic ulcers are an infectious disease caused by Helicobacter pylori " is considered an illusion, all the characteristics of the disease, along with all the clinical, epidemiological, and laboratory observations/phenomena, can be fully understood. (preprints.org)
  • Peptic ulcers are identified as a psychosomatic disease triggered by psychological stress, where Helicobacter pylori plays a secondary role in only the late phase of ulceration. (preprints.org)