Helices of proteins. Medical search. Frequent questions

Enzymes in this group unwind double helix RNA and DNA. (medscape.com)
DNA is made up of two strands that wind around each other and looks like a twisting ladder (a shape called a double helix). (cdc.gov)
Each DNA molecule is a long double helix that resembles a spiral staircase containing millions of steps. (msdmanuals.com)
The DNA molecule is a long, coiled double helix that resembles a spiral staircase. (msdmanuals.com)

Cysteine-Selective Modification of Peptides and Proteins via Desulfurative C-C Bond Formation CHEMISTRY-A EUROPEAN JOURNAL. (nottingham.ac.uk)

Recent advances in biophysical methods have been able to shed more light on the structures of helical bundles formed by the transmembrane segments of bitopic membrane proteins. (huji.ac.il)
Finally, the structures of the best characterized instances of transmembrane α-helical bundles formed by bitopic membrane proteins are described in detail. (huji.ac.il)
Crystal structures often deviate from the natural system: Proteins, especially membrane-bound ones, do not necessarily crystallize in their biologically active structures and the measures needed to obtain suitable GPCR crystals tend to increase the diversity between the natural environment and the crystal. (gauss-centre.eu)
Small residues (Gly/Ala/Ser/Thr) are found to be highly conserved as a group in the helix-helix interface of MIP structures. (biomedcentral.com)
Small residues are group-conserved in the helix-helix interface of MIP structures and they seem to be important for close helix-helix interactions. (biomedcentral.com)
The high-resolution structures of several members of MIP family have been determined and are available in the Protein Data Bank (PDB) [ 15 ]. (biomedcentral.com)
However, because 3 10 helices are much more common in the tertiary structures of proteins than pi helices, extension of the Lifson-Roig model to accommodate 3 10 helices - resulting in a 9x9 transfer matrix when capping is included - has found a greater range of application. (wikipedia.org)
How do scientists use protein structures to develop new drugs? (nih.gov)
It is actually proteins that make up most of the structures in our bodies and perform most of life's functions. (cdc.gov)
This model, hereafter formation of three-dimensional protein structures. (lu.se)
Proteins are not just building blocks for muscles, connective tissues, skin, and other structures. (msdmanuals.com)
Even if the DNA sequence - the set of genes - is the same in all cells, only certain genes are expressed, i.e. only information from certain genes is copied (transcribed) and used to build protein structures or regulate processes. (lu.se)

A leucine zipper structure present in the measles virus fusion protein is not required for its tetramerization but is essential for fusion. (microbiologyresearch.org)
These activators are called leucine-zipper proteins. (brainkart.com)
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (cancerindex.org)

Class A basic helix-loop-helix protein 15 (bHLHa15) also known as class B basic helix-loop-helix protein 8 (bHLHb8) or muscle, intestine and stomach expression 1 (MIST-1) is a protein that in humans is encoded by the BHLHA15 gene. (wikipedia.org)

This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. (nih.gov)
The ALK gene is a hotspot for chromosomal translocation events that result in several fusion proteins that cause a variety of human malignancies 3 . (nature.com)
Fusion of a kinase gene, ALK , to a nucleolar protein gene, NPM , in non-Hodgkin's lymphoma. (nature.com)
What does this gene/protein do? (cancerindex.org)
Cluster of differentiation 97 is a protein also known as BL-Ac [F2] encoded by the ADGRE5 gene. (abcam.com)
However, an 11th protein, called gene. (cdc.gov)
This ing to Kozak's analysis (5), which explains why PB1-F2 novel protein is translated from an alternative open reading can be translated when an alternative start codon is used at frame (ORF) in the PB1 gene. (cdc.gov)
The BLM gene provides instructions for making a member of a protein family called RecQ helicases. (medlineplus.gov)
BLM gene mutations result in the absence of functional BLM protein. (medlineplus.gov)
The specific order, or sequence, of these bases determines the exact information carried in each gene (for example, instructions for making a specific protein). (cdc.gov)
DNA mutations in a gene can change what protein is made. (cdc.gov)
A gene is a part of DNA that carries the information needed to make a protein. (cdc.gov)
Gene expression refers to the process of making proteins using the instructions from genes. (cdc.gov)
Changes in gene expression can affect how much of a protein is made, as well as when the protein is made. (cdc.gov)
A gene is a segment of DNA that provides the code to construct a protein or RNA molecule. (msdmanuals.com)
Gene expression generally produces proteins, but there are also non-coding genes that produce RNA molecules (rRNA, tRNA). (lu.se)
Transcription factors are a group of proteins that are needed for a gene to start being copied to RNA, i.e. for transcription to start. (lu.se)

Using heteronuclear NMR spectroscopy, we have determined the structure of this hairpin to an overall precision of 2.0 A. Both adenine bases stack into the helix, and while all available NOE and coupling constant data are consistent with both possible A.U base pairs, the base pair involving the 5'-proximal adenine appears to be the major conformation. (rcsb.org)
The 2'-OH of the bulged adenine adopts a regular A-form helical geometry, suggesting that in order to participate in the splicing reaction, the conformation of the branch-point helix in the active spliceosome may change from the conformation described here. (rcsb.org)
Conclusions: The conformation of the N-terminal α helix is quite different from that reported in a recent NMR structure of S15 from Thermus thermophilus. (caltech.edu)
[2] it is a refinement of the Zimm-Bragg model that recognizes that a polypeptide alpha helix is only stabilized by a hydrogen bond only once three consecutive residues have adopted the helical conformation. (wikipedia.org)
The infectious agent in the prion disease is composed mainly or entirely of an abnormal conformation of a host-encoded glycoprotein called the prion protein. (medscape.com)
The replication of prions involves the recruitment of the normally expressed prion protein, which has mainly an alpha-helical structure, into a disease-specific conformation that is rich in beta-sheet. (medscape.com)
Delipidization reduces the fraction of dry keratin that is in the a-helix conformation, suggesting that lipids hold the keratins in a conformation conducive to optimal hydration. (cdc.gov)

The binding sites for S15 on both mRNA and rRNA have been narrowed down to less than a hundred nucleotides each, making the protein an attractive candidate for the study of protein-RNA interactions. (caltech.edu)
This conformational variability of the N-terminal helix has implications for the range of possible S15-RNA interactions. (caltech.edu)
These are found in structural proteins like myosin as well as in a class of transcrip-tional regulators that dimerize by these interactions. (brainkart.com)
Cholesterol interactions with the receptor are apparently essential for stabilizing and maintaining its physiological architecture, since the transmembrane structure contracts, involving displacements of the helices at the outer membrane surface by ∼2 Å (1-3 Å), when this lipid is extracted. (iucr.org)
Another aspect of Hirst's research focuses on the study of protein-ligand interactions, using techniques including QSAR, machine learning, neural networks, docking, molecular dynamics (MD) simulations and quantum chemistry. (nottingham.ac.uk)
long range interactions within the protein molecule. (flashcardmachine.com)

This involves a large conformational change in residues 81 to 83 and smaller shifts that extend 20 angstroms across the protein surface. (rcsb.org)
Structure-based sequence alignments were generated and the residues in the helix-helix interfaces were analyzed. (biomedcentral.com)
d ) A sectional view through the map and superimposed model, showing details of the central transmembrane pore (functionally important amino acid residues on the α -subunit pore-lining M2 helices, 9′Leu, uppermost, and −1′Glu, are shown in red). (iucr.org)
To consider three consecutive residues each with two states (helix and coil), the Lifson-Roig model uses a 4x4 transfer matrix instead of the 2x2 transfer matrix of the Zimm-Bragg model, which considers only two consecutive residues. (wikipedia.org)
The Lifson-Roig model is characterized by three parameters: the statistical weight for nucleating a helix, the weight for propagating a helix and the weight for forming a hydrogen bond, which is granted only if three consecutive residues are in a helical state. (wikipedia.org)
For sequences with a typical fraction of hydrophobic residues, we impact on how permissive with respect to sequence specificity find that the nonrandomness can be interpreted as anticorrela- the protein folding process is-- only sequences with nonran- tions. (lu.se)

Three of these helices form the core of the protein, while the N-terminal helix protrudes out from the body of the molecule to make contacts with a neighboring molecule in the crystal lattice. (caltech.edu)
The intermolecular contacts that this α helix makes with a neighboring molecule in the crystal, however, closely resemble the intramolecular contacts that occur in the NMR structure. (caltech.edu)
DNA contains the code, or blueprint, used to synthesize a protein or a ribonucleic acid (RNA) molecule. (msdmanuals.com)

The Typically Disordered N-Terminus of PKA Can Fold as a Helix and Project the Myristoylation Site into Solution. (expasy.org)
Bottom: To become active, proteins must twist and fold into their final, or 'native,' configuration. (nih.gov)
The trick has been figuring out how and why the proteins fold. (nih.gov)
This new work helps scientists understand not only how proteins fold but also how they misfold and malfunction in diseases such as Alzheimer's and cystic fibrosis. (nih.gov)
wavelength corresponding to -helix structure, as one might have statistical analysis on the sequences that fold well indicates expected, but also at large wavelengths. (lu.se)

14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices. (bvsalud.org)
Ca2+ /CaM-dependent protein kinase kinases 1 and 2 (CaMKK1 and CaMKK2) phosphorylate and enhance the catalytic activity of downstream kinases CaMKI, CaMKIV, and protein kinase B . Accordingly, CaMKK1 and CaMKK2 regulate key physiological and pathological processes , such as tumorigenesis , neuronal morphogenesis , synaptic plasticity , transcription factor activation, and cellular energy homeostasis , and promote cell survival . (bvsalud.org)
But these effects are much stronger on CaMKK1 than on CaMKK2 because the CaMKK114-3-3Î³ complex has a more compact and rigid structure in which the active site of the kinase domain directly interacts with the last two C-terminal helices of the 14-3-3Î³ protein , thereby inhibiting CaMKK1. (bvsalud.org)
Therefore, Ca2+ /CaM binding suppression and the interaction of the kinase active site of CaMKK1 with the last two C-terminal helices of 14-3-3Î³ protein provide the structural basis for 14-3-3-mediated CaMKK1 inhibition. (bvsalud.org)
A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. (bvsalud.org)

Helix-aspersa a potent snail extract with copper peptides and super nutrients - hyaluronic acid , glycoprotein enzymes , proteoglycans and muco-ploysaccharides - stimulate collagen synthesis and skin renewal increasing hydration levels, leaving facial skin feeling smooth and skin texture refined. (woodberg.de)
And proteins called enzymes have grooves and pockets that help them hold onto other molecules to speed chemical reactions. (nih.gov)
For example, many proteins are enzymes that aid biochemical reactions. (nih.gov)
Enzymes are complex proteins that control and carry out nearly all chemical processes and reactions within the body. (msdmanuals.com)

In essence, your DNA is a long chain of molecules that spells out instructions for building proteins, which are each built by our body to perform a certain function. (helix.com)

A polypeptide chain must reverse direc-tion many times in a typical globular protein. (brainkart.com)

The observed conformational changes illustrate a general mechanism by which proteins can tolerate mutations. (rcsb.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
More than 70 disease-causing mutations have been described, the majority being stop codon mutations, splice mutations, or small ins/del-producing truncations of the protein and/or non-sense-mediated decay of mutant mRNA. (medscape.com)

Protein Sci;32(11): e4805, 2023 11. (bvsalud.org)

Some sections of proteins form standard "motifs": corkscrew-like coils called alpha helices and flat sections called beta sheets. (nih.gov)
Delipidization converts a fraction of keratin a-helixes to turns and random coils, while water sorption converts a fraction of keratin a-helixes to B-sheets, turns, and random coils. (cdc.gov)

We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body or the code for functional ribonucleic acid (RNA) molecules. (msdmanuals.com)
Protein synthesis is controlled by genes, which are contained on chromosomes. (msdmanuals.com)
Genes vary in size, depending on the sizes of the proteins or RNA for which they code. (msdmanuals.com)
It is not only the genes that code for proteins that are methylated, but also parts of the DNA that code for regulatory functions (RNA molecules), which can have a greater effect than genes. (lu.se)

The Discovery of the Α-Helix and Β-Sheet, the Principal Structural Features of Proteins. (helix.com)
To investigate the relation between protein stability and the predicted stabilities of individual secondary structural elements, residue Pro86 in an alpha-helix in phage T4 lysozyme was replaced by ten different amino acids. (rcsb.org)
The existence of the alpha helix was predicted by Pauling and Cory from careful structural studies of amino acids and peptide bonds. (brainkart.com)
The alpha helix is found in most proteins and is a fundamental structural element. (brainkart.com)
The beta-strand is a second important structural element of proteins. (brainkart.com)
Institute of Physiology of the Czech Academy of Sciences, Laboratory of Structural Biology of Signaling Proteins, Division BIOCEV, Vestec, Czech Republic. (bvsalud.org)
Arkin, IT 2002, ' Structural aspects of oligomerization taking place between the transmembrane α-helices of bitopic membrane proteins ', Biochimica et Biophysica Acta - Biomembranes , vol. 1565, no. 2, pp. 347-363. (huji.ac.il)
SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Structural biologists are particularly interested in proteins because they do so much of the work in the body. (nih.gov)
His calculations on protein circular dichroism spectroscopy, a key technique in structural biology, are the most accurate to be published. (nottingham.ac.uk)

As reported earlier, the helical arrangement of the protein component of the vesicles facilitates image averaging and enables us to determine how cholesterol and phospho-lipid molecules are distributed in the surrounding matrix, using headgroup size as a means to discriminate between the two kinds of lipid. (iucr.org)
Increasingly, biologists are investigating large molecules made up of combinations of RNA and proteins, called RNA-protein complexes. (nih.gov)
Proteins are molecules that contribute to virtually every activity in the body. (nih.gov)
Top: Protein molecules are made up of amino acids hooked together like beads on a string. (nih.gov)
Proteins are made of long strands of small molecules called amino acids. (nih.gov)
For instance, antibodies are shaped like a Y. This helps these immune-system proteins bind to foreign molecules such as bacteria or viruses with one end while recruiting other immune-system proteins with the other. (nih.gov)
His research spans a wide range, from the quantum chemistry of small molecules and the spectroscopic properties of proteins, to the application of state-of-the-art statistical and computer science methodology to problems in bioinformatics, drug design and sustainable chemistry. (nottingham.ac.uk)

These proteins are highly conserved across all kingdoms of life and thus likely share a common transport mechanism. (nature.com)

Unexpectedly, all ten amino acid substitutions marginally reduce protein thermostability. (rcsb.org)
In the alpha helix, hydrogen bonds are formed between the carbonyl oxygen of one peptide bond and the amide hydrogen of the amino acid located three and a third amino acids away. (brainkart.com)
Every third and then every fourth amino acid lies on one side of the helix (Fig. 6.13). (brainkart.com)
If every third and then every fourth amino acid were hydrophobic, two such helices could bind together through their parallel strips of hydrophobic amino acids. (brainkart.com)
Some proteins consist of multiple amino acid strands wound together. (nih.gov)
Our analysis has been the amino acid sequences in proteins differ from what is carried out using two different methods, which differ substantially expected from random sequences in a statistically significant from what is used in ref. 3, although the starting point is similar. (lu.se)
PROT data base (6) of functional proteins, this method yields model containing only two amino acid types, hydrophobic and clear evidence for nonrandomness. (lu.se)

In order to understand the fusion mechanism and identify fusion inhibitors of Newcastle disease virus (NDV), a member of the Paramyxoviridae family, we have developed an E. coli system that separately expresses the F protein HR1 and HR2 regions as GST fusion proteins. (microbiologyresearch.org)

Aquaporins and aquaglyceroporins belong to the ancient superfamily of Major Intrinsic Proteins (MIPs) and facilitate passive transport of water and small solutes across membranes of various organisms [ 1 , 2 ]. (biomedcentral.com)

A new study by researchers at Mahidol University in Bangkok, Thailand, reports a COVID-19 vaccine candidate called HexaPro in producing neutralizing antibodies against the SARS-CoV-2 spike protein in an animal model. (news-medical.net)
These amyloid plaques are immunoreactive with antibodies to the prion protein and do not immunoreact with antibodies to other amyloidogenic proteins, such as the amyloid-beta (which is deposited in Alzheimer disease). (medscape.com)

Metabolites are the chemicals that are produced by the cells in the body when they break down sugars, fats, and proteins to make energy. (cdc.gov)

Protein-making factories in cells resemble a helical parking garage. (nih.gov)
most prevalent and stable form of helical structure in naturally occurring proteins. (flashcardmachine.com)
Hydrogen bonds between the carbonyl oxygen and the amido hydrogen four a.a. upstream, toward the C-Terminus of the helix, stabilize the helical structure. (flashcardmachine.com)

Thus, while the adenine site preferences of the spliceosome and of phage GA may be due to protein factors, the preferred adenine is predisposed in the free RNA to conformational rearrangement involved in formation of the active complexes. (rcsb.org)

functional proteins. (lu.se)

G-protein coupled receptors (GPCRs) are membrane proteins that transmit the effects of extracellular ligands to effect changes in the intracellular G-protein signaling system. (gauss-centre.eu)
Plasma membrane intrinsic proteins (PIPs), tonoplast intrinsic proteins (TIPs), Nod26-like intrinsic protein (NIPs) and small and basic intrinsic proteins (SIPs) are subfamilies of plant MIPs. (biomedcentral.com)
Phylogenetic analysis of plant MIP sequences revealed four major subfamilies: the plasma membrane intrinsic proteins (PIPs), tonoplast intrinsic proteins (TIPs), nodulin 26-like intrinsic proteins (NIPs) and small and basic intrinsic proteins (SIPs). (biomedcentral.com)
Here, cryo-EM is used to examine the protein-lipid architecture of this membrane in tubular vesicles obtained from the (muscle-derived) electric organ of the Torpedo ray. (iucr.org)
Here, we analyse by cryo-EM the architecture of this membrane in vesicles isolated from the (muscle-derived) electric organ of the Torpedo ray, with view to defining the protein-lipid interplay required to achieve an optimal neurotransmitter response. (iucr.org)
Another type, called transporter proteins, are embedded in the cell's outer membrane and form channels that help vital substances such as sodium or potassium pass into or out of the cell. (nih.gov)

The coat protein can bind helices with bulged adenines at either position, but the 3'-proximal site binds with greater affinity. (rcsb.org)

When bound to phage GA coat protein, the bulged adenine loops out of the helix and occupies a binding pocket on the surface of the protein, forming a nucleation complex for phage assembly. (rcsb.org)
We have studied this RNA motif in a 21 nucleotide hairpin containing a GA coat protein-binding site whose four nucleotide loop has been replaced by a more stable loop from the related phage Ms2. (rcsb.org)

This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit. (bvsalud.org)

The major intrinsic proteins (MIPs) facilitate the transport of water and neutral solutes across the lipid bilayers. (biomedcentral.com)

We present a Monte Carlo study of a model protein with 54 amino acids that folds directly to its native three-helix-bundle state without forming any well-defined intermediate state. (lu.se)

A good example of this multidisciplinary approach can be found in the work of renowned physicist Dr. Herman Branson, who helped discover a pivotal protein structure called the alpha helix . (helix.com)
In the late 1940s, Dr. Herman Branson and his colleagues Dr. Linus Pauling and Dr. Robert Corey would made a breakthrough discovery when they accurately described the alpha helix protein structure , which is present in numerous proteins1,2. (helix.com)
This structure is a critical part of many proteins that help read the DNA. (helix.com)
Prior to the discovery by Branson and his colleagues, there were hints that proteins contained this structure, but no one had yet figured out the molecular configuration of it. (helix.com)
2002. Chapter 3, Protein Structure and Function. (helix.com)
The structure consists of four α helices. (caltech.edu)
Paramyxoviruses may adopt a similar fusion mechanism to other enveloped viruses, in which an anti-parallel six-helix bundle structure is formed post-fusion in the heptad repeat (HR) regions of the envelope fusion protein. (microbiologyresearch.org)
Structure-function study of a heptad repeat positioned near the transmembrane domain of Sendai virus fusion protein which blocks virus-cell fusion. (microbiologyresearch.org)
Its crystal structure reveals a previously unknown outward-facing state of the protein family. (nature.com)
c ) The 5.8 Å density map and superimposed 2.7 Å structure of the Torpedo receptor (PDB entry 6uwz ) obtained from detergent-solubilized protein complexed with α -bungarotoxin. (iucr.org)
The protein's triple-helix structure also makes collagen incredibly strong. (forbes.com)
What you see in this picture is a structure called the endoplasmic reticulum (ER)-a protein-producing factory that is present in every single cell in your body. (nih.gov)
The little nubs on the surface of this membranous structure are ribosomes-they produce the proteins that are then modified in the ER. (nih.gov)
The free energy of stabilization of most folded proteins' structure is typically 20 kcal/mol at 25C, but the aggregate size of the electrostatic forces holding the folded structure together is on the order of thousands of kcal/mol. (bio.net)
Using an approach called structure-based drug design, scientists can make a template for a protein and use that blueprint for creating new medicines. (nih.gov)
Atomic coordinates have been deposited in the Protein Data Bank (PDB) with accession codes 7N00 (cryoEM structure of ALK-ECR ABR -ALKAL2), 7MZY (X-ray structure of ALK-ECR ABR (ΔEGF)), 7MZW (NMR structure of ALK-ECR ABR ), 7MZX (NMR structure of ALKAL2) and 7MZZ (NMR structure of ALKAL1). (nature.com)
Attenuated total reflection-Fourier transform infrared spectroscopy was used to investigate effects of extraction on protein secondary structure. (cdc.gov)
Thus, the entire structure and function of the body is governed by the types and amounts of proteins the body synthesizes. (msdmanuals.com)
This structure forms an interrupted helix and binds to the inside surface of the tubulin heterodimer, the protein that forms microtubules. (lu.se)
The protein structure that surrounds the DNA, chromatin, largely comprises histone proteins and can be open or closed and thus allow or prevent factors binding to the DNA. (lu.se)

The Drosophila Extramacrochaetae protein antagonizes the proneural function of the Achaete and Scute proteins in the generation of the adult fly sensory organs. (biologists.com)

This pre-diction came before identification of the alpha helix in X-ray diffraction patterns of proteins. (brainkart.com)

The motion along individual reaction coordinates is roughly diffusive on timescales beyond the reconfiguration time for a single helix. (lu.se)

Scientists are beginning to solve that puzzle with research into how amino acids interact, and they are using powerful new computer programs that help predict protein motifs. (nih.gov)
The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. (cancerindex.org)

Multiple alternatively spliced transcript variants that encode different proteins have been described. (nih.gov)

The findings suggest the spike protein turns into a locked state to stabilize the spike protein during virus egress. (news-medical.net)

To under- denoted the AB model, consists of chains of two kinds of stand the statistical distribution of hydrophobicity along proteins ``amino acids'' interacting with Lennard-Jones potentials. (lu.se)
Flagella are complex molecular machines that consists of up to 1000 different proteins, which are neatly arranged around a complex microtubule cytoskeleton consisting of nine doublet microtubules surrounding two central singlet microtubules. (lu.se)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. (helixlabs.ai)
The side chains of the amino acids extend outward from the helix, and the hydrogen bonds are nearly parallel to the helix axis (Fig. 6.12). (brainkart.com)
ments of the amino acids along the protein chains. (lu.se)

If they were precisely parallel to the axis, the helix pitch would be 3.33 amino acids per turn, but due to steric constraints, the hydrogen bonds are somewhat skewed, and the average pitch is found to be 3.6 to 3.7 amino acids per turn. (brainkart.com)
however, it is straightforward to extend the model to 3 10 helices and pi helices , with i+3 and i+5 hydrogen bonding patterns respectively. (wikipedia.org)

If we look down the axis of an alpha helix, we see the amino acids winding around in a circle. (brainkart.com)
amid group and carbonyl group are parallel along axis of the helix with the carbonyl groups pointing towards the carboxyl end and amido groups toward the amino end. (flashcardmachine.com)
narrow channel that extends along the helix axis (12). (lu.se)

Antibody probing of Western blots is a method for analyzing the apparent M r of a protein in any given preparation (Renart, J., Reiser, J., and Stark, G., Proc. (elsevierpure.com)
Planck, SR & Wilson, SH 1985, ' Native species of helix destabilizing protein-1 in mouse myeloma identified by antibody probing of Western blots ', Biochemical and Biophysical Research Communications , vol. 131, no. 1, pp. 362-369. (elsevierpure.com)
An image of an antibody, an immune system protein that rids the body of foreign material, including bacteria. (nih.gov)
This fluorescence assay (IFA) by type-specific monoclonal new protein product was discovered serendipitously dur- antibody (Dako, Cambridgeshire, UK). (cdc.gov)

First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)
The Lifson-Roig model may be solved by the transfer-matrix method using the transfer matrix M shown at the right, where w is the statistical weight for helix propagation, v for initiation, n for N-terminal capping, and c for C-terminal capping. (wikipedia.org)

Anatomy11

Organisms16

Diseases1

Chemicals and Drugs115

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes76

Disciplines and Occupations6

Technology, Industry, Agriculture6

Information Science8

Health Care2

Double Helix4

Peptides and proteins1

Structures12

Leucine zipper3

Basic helix-loop-he1

Gene17

Conformation7

Interactions6

Residues6

Molecule3

Fold5

Kinase5

Enzymes4

Instructions for building1

Polypeptide1

Mutations3

20231

Coils2

Genes5

Structural10

Molecules7

Highly conserved1

Amino acid7

Fusion proteins1

Superfamily1

Antibodies2

Fats1

Helical3

Conformational1

Functional1

Membrane6

Bind1

Phage2

Subunits1

Intrinsic1

Folds1

Structure20

Proneural1

Diffraction1

Coordinates1

Motifs2

Encode1

Stabilize1

Consists2

Chains3

Hydrogen2

Axis3

Antibody4

Initiation2