Heavy molecular chains. Medical search. Frequent questions

Three embryonic class II myosin heavy chains (MYHs) were cloned from the common carp ( Cyprinus carpio L.), MYH emb1 ,MYH emb2 and MYH emb3 . (biologists.com)
Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. (nih.gov)
On the basis of molecular modelling, the two mutations affecting the myosin head were predicted to impose electrostatic and conformational changes, whereas the truncating mutation deleted the unique carboxy-terminal tailpiece. (nih.gov)
Several chronic conditions leading to skeletal muscle dysfunction are known to be associated with changes in the expression of myosin heavy chain (MHC) isoforms at both the mRNA and protein level. (biomedcentral.com)
Synthetic peptide corresponding to Human heavy chain Myosin/MYH3 aa 100-200 conjugated to keyhole limpet haemocyanin. (abcam.com)
Ifm(2)2 is a myosin heavy chain allele that disrupts myofibrillar assembly only in the indirect flight muscle of Drosophila melanogaster. (rupress.org)
Using a combination of molecular and genetic techniques we demonstrate that Ifm(2)2 is an allele of the single-copy sarcomeric myosin heavy chain gene. (rupress.org)
Flies homozygous for this allele accumulate wild-type levels of mRNA and protein in tubular muscle of adults, but fail to accumulate detectable amounts of myosin heavy chain mRNA or protein in the indirect flight muscle. (rupress.org)
Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the importance of myosin motor activity cell and tissue shape changes. (elifesciences.org)
Myosin is a hexamer composed of two myosin heavy chains, two regulatory light chains (RLCs), and two essential light chains (ELCs) ( Figure 1A ). (elifesciences.org)
The motor domain at the N-terminus of the myosin heavy chain binds actin filaments in an ATP-dependent manner. (elifesciences.org)
The light chains bind to the central neck domain of the myosin heavy chain and have structural and regulatory functions ( Heissler and Sellers, 2014 ). (elifesciences.org)
The C-terminal tail of the myosin heavy chain associates with the tails of other myosin heavy chains and promotes the assembly into bipolar filaments. (elifesciences.org)
A ) Domain organization of the myosin heavy chain and myosin fragments used to study the biochemical properties of myosin. (elifesciences.org)
The top panel shows the myosin hexamer composed of two myosin heavy chains (green), two ELCs (light blue) and two RLCs (gray). (elifesciences.org)
The myosin motor domain, the light chain binding neck and the tail domain of the heavy chain are indicated. (elifesciences.org)
The MYH11 gene provides instructions for making a protein called smooth muscle myosin heavy chain 11. (medlineplus.gov)
Smooth muscle myosin heavy chain 11 forms part of a myosin protein complex found in smooth muscles. (medlineplus.gov)
Each myosin protein complex consists of two pairs of light chains, which regulate the complex and are produced from several other genes, and two heavy chains such as that produced from the MYH11 gene. (medlineplus.gov)
The long tail region of the myosin heavy chain interacts with other proteins, including the tail regions of other myosins, enabling them to form thick filaments. (medlineplus.gov)
The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain. (medlineplus.gov)

A heavy-chain antibody is an antibody which consists only of two heavy chains and lacks the two light chains usually found in antibodies. (wikipedia.org)
The immunoglobulin new antigen receptor (IgNAR) of cartilaginous fishes (for example sharks) is a heavy-chain antibody. (wikipedia.org)
Heavy-chain camelid antibodies have been found to be just as specific as a regular antibody and in some cases they are more robust. (wikipedia.org)
The following product was used in this experiment: Ferritin Heavy Chain Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-27500, RRID AB_2544976. (thermofisher.com)
Western blot was performed using Anti-Ferritin Heavy Chain Rabbit Polyclonal Antibody (Product # PA5-27500) and a 20kDa band corresponding to Ferritin Heavy Chain was observed across cell lines and tissues tested. (thermofisher.com)
We have identified eight recombinant human single-chain variable region fragments (scFvs) against the S1 domain of spike (S) protein of the SARS-CoV from two nonimmune human antibody libraries. (nih.gov)
However, producing the desired bispecific antibody was like a molecular lottery because there are 16 different possibilities to combine each antibody's two heavy chains with its two light chains resulting in 10 different antibodies, because normally all heavy chains can pair with each other and every light chain can bind unspecifically to two regions at the top of the heavy chains. (roche.com)
The problem was to find a trick to prevent unspecific binding of the light antibody chains to its heavy counterparts to prevent unwanted side products. (roche.com)
The bio-engineers solved it like LEGO® players: by exchanging the molecular bricks between heavy and light chain, only specific interaction can take place in the short arm of the Y-shaped antibody. (roche.com)
A VHH antibody ( or nanobody) is the antigen binding fragment of heavy chain only antibodies. (cdc.gov)
We unveiled the molecular details of antibody binding to two distinct protective epitopes within the NANP repeat. (rcsb.org)
Combined, our findings illustrate the power of exploring human anti-CSP antibody responses to develop tools for malaria control in the mammalian and the mosquito vector and provide a molecular basis for the structure-based design of next-generation CSP malaria vaccines. (rcsb.org)
The antibody TB28-2 recognizes human Ig kappa light chains of both secreted and cell surface immunoglobulin. (exbio.cz)

FTH1 is the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. (thermofisher.com)
Protein C (PROC) is a vitamin K-dependent serine protease synthesized in liver as a single-chain precursor (1). (rndsystems.com)
Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. (bmj.com)
The molecular consequence of translocation is overexpression of the protein cyclin D1 (coded by the PRAD1 gene located close to the breakpoint). (medscape.com)
Function of cytomegalovirus-encoded homologues of G protein-coupled receptors, MHC class I heavy chains and chemokines. (kegg.jp)
Molecular genetic methods were implemented into the screening examinations for thrombophilic disorders in the 1990's along with the first discoveries of coagulation inhibitors (AT, protein C and protein S). The discovery of the molecular cause of activated protein C (APC) resistance by Bertina in 1994 greatly expanded their utilization. (intechopen.com)
With growing therapeutic potential, however, the molecular complexity increases, thus intensifying the demand for innovative protein engineering and analytical strategies. (bvsalud.org)
It is a 24-subunit protein that consists of light and heavy chains and can store up to 4500 atoms of iron. (medscape.com)

In common antibodies, the antigen binding region consists of the variable domains of the heavy and light chains (VH and VL). (wikipedia.org)
Heavy-chain antibodies can bind antigens despite having only VH domains. (wikipedia.org)
In addition to the expected four-chain antibodies, they identified simpler antibodies consisting only of two heavy chains. (wikipedia.org)
In 1995 a research team at the University of Miami found a different type of heavy-chain antibodies in sharks. (wikipedia.org)
It has five constant domains (CH) per chain instead of the usual three, several disulfide bonds in unusual positions, and the complementarity-determining region 3 (CDR3) forms an extended loop covering the site which binds to a light chain in other antibodies. (wikipedia.org)
The only mammals with heavy-chain (IgG-like) antibodies are camelids such as dromedaries, camels, llamas and alpacas. (wikipedia.org)
This is a secondary development: The heavy chains of these antibodies have lost one of their constant domains (CH1) and undergone modifications in the variable domain (VH), both structural elements necessary for the binding of light chains. (wikipedia.org)
Despite their different overall structure, camelid heavy-chain antibodies share several properties with IgNAR, for example the extended CDR3 loop and the conformation of the CDR1. (wikipedia.org)
About 50% of the antibodies in camelids are of the ordinary mammalian heavy/light-chain type. (wikipedia.org)
It is not known whether any type of animal has only heavy-chain antibodies and completely lacks the common type with two heavy and two light chains. (wikipedia.org)
According to Klein, the correct pairing of heavy chains from different antibodies was already achieved by a technology invented at Genentech back in 1997. (roche.com)
A "knob" and a "hole" built into the two heavy chains of different antibodies promoted correct pairing. (roche.com)
A major challenge for multispecific antibodies is the correct assembly of light and heavy chains. (bvsalud.org)

Department of Molecular Genetics, Ohio State University, Columbus 43210. (rupress.org)

It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. (curehunter.com)
C1q is a 459 kDa molecule consisting of three individual polypeptide chains. (origene.com)

Methods in Molecular Biology. (wikipedia.org)

These data indicate that digestion of native HF to form HFa precedes cleavages that fragment the molecule and diminish its molecular weight. (jci.org)
Yeast produces different types of acids, beginning with short chain fatty acids, so called because each molecule typically comprises two carbon units linked together. (whiskymag.com)
The alcohol produced in the greatest quantity is ethanol, which is a short chain alcohol as each molecule comprises two carbon units linked together. (whiskymag.com)

Molecular Metabolism. (lu.se)

Immunoglobulin Heavy Chain High-Throughput Sequencing in Pediatric B-Precursor Acute Lymphoblastic Leukemia: Is the Clonality of the Disease at Diagnosis Related to Its Prognosis? (frontiersin.org)
High-throughput sequencing (HTS) of the immunoglobulin heavy chain ( IgH ) locus is a recent very efficient technique to monitor minimal residual disease of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). (frontiersin.org)
This translocation involves the immunoglobulin heavy-chain gene on chromosome 14 and the BCL1 locus on chromosome 11. (medscape.com)

Accordingly, laboratory investigation of thrombophilic disorders has expanded due to incorporation of modern molecular assays. (intechopen.com)

Molecular Immunology, 44 (8), 2066 - 2075. (up.pt)
Molecular immunology, 44 (8), 2056 - 2065. (up.pt)

The light chain consists of Gla (gamma-carboxy-glutamate) domain and two EGF-like domains. (rndsystems.com)
The heavy chain consists of an activation peptide (aa 200‑211) and serine protease domain (aa 212-450). (rndsystems.com)
HFf consists of two molecular weight species of 28,500 and 30,000. (jci.org)
The volatile hydrocarbon fraction of gasoline, which consists primarily of short-chain (C4-C5) alkanes and alkenes and some aromatics, partitions to the atmosphere where photochemical oxidation is the main removal process. (cdc.gov)
Cellular Components of the Immune System The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)

[ 1 ] A database of BTK mutations ( BTKbase: Mutation registry for X-linked agammaglobulinemia ) lists 544 mutation entries from 471 unrelated families showing 341 unique molecular events. (medscape.com)
Specific molecular analysis is made by single-strand confirmation polymorphism (SSCP), direct DNA analysis, denaturing gradient gel electrophoresis, or reverse transcriptase-polymerase chain reaction to search for the BTK mutation. (medscape.com)

The increasing prevalence of infectious and genetic diseases is a significant factor in promoting the polymerase chain reaction market growth. (medgadget.com)

Está compuesta por dos cadenas polipeptídicas, ligera (B) y pesada (A), con un peso molecular de 75,000. (bvsalud.org)

Thank you for sharing this Molecular Pharmacology article. (aspetjournals.org)
Message Body (Your Name) thought you would be interested in this article in Molecular Pharmacology. (aspetjournals.org)

Emergence of new viruses with clade 2.3.4.4 hemagglutinin (HA) that infect poultry and humans emphasizes the need for detailed characterization of molecular properties of these viruses. (cdc.gov)

A new and valuable immunoreagent for the analysis of small molecular weight environmental chemicals, VHH will overcome many pitfalls encountered with conventional reagents. (cdc.gov)
At the same time, they also possess the character of low-molecular-weight organic compounds," says Kunio Kondo, vice president of Frontier Carbon Corporation. (nature.com)
both having a molecular weight of 22.5kDa). (exbio.cz)
Medium and long chain esters have a heavier molecular weight than short chain esters, and so are far less prone to loss through evaporation," says Jane Millar. (whiskymag.com)
SDS-PAGE and two-dimensional gel electrophoresis (2-DE) analyses demonstrated that the olive flounder serum contained at least two different types of Ig in terms of molecular weight and pI of heavy chain. (go.jp)
In the present study, kuchijirosho associated proteins (KAPs) with molecular weight of 100-120 kDa were detected in brain tissues of tiger puffer by western blot analysis with sera of tiger puffer which survived kuchijirosho, but not in the kidney or spleen tissues. (go.jp)
Bioconcentration and sorption of gasoline hydrocarbons to soils and sediments may be important only for higher molecular weight hydrocarbons that are resistant to biodegradation. (cdc.gov)
Its molecular weight is about 440 kilodalton. (medscape.com)

When compared to functional assays, molecular assays provide clear results without different cut-off values. (intechopen.com)
Serum free light chain (FLC) assays remain a research tool. (medscape.com)

The heavy chain diseases (HCDs) are B-cell proliferative disorders characterized by production of abnormal, structurally incomplete, immunoglobulin heavy chains without the corresponding light chains. (medscape.com)

The global " Polymerase Chain Reaction (PCR) Market Industry " is expected to reach USD 8.14 billion by 2026, on account of the advent of digitalization and the gradual shift from traditional PCR to digital PCR for diagnostics purposes. (medgadget.com)
Monoclonal rearrangements of IgH and TCRγ were studied using seminested polymerase chain reaction (PCR). (bmj.com)
EU MCL MRD Group: Minimal residual disease detection in mantle cell lymphoma: methods and significance of four-color flow cytometry compared to consensus IGH-polymerase chain reaction at initial staging and for follow-up examinations. (exbio.cz)

Patients with mutations in μ heavy chain tend to develop symptoms earlier and are more likely to have severe symptoms. (lu.se)

Molecular side chains can be attached to modify properties such as solubility, electronic behaviour and thin-film formation, he explains. (nature.com)

Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition. (lu.se)

In contrast, B cells from immunocytomas showed light chain restriction and monoclonal rearrangement for IgH, confirming their neoplastic nature. (bmj.com)

The associated light chains were identified by subjecting iodinated proteins to two-dimensional slab gel electrophoresis in which the second dimension is run reduced. (jci.org)
For each humoral defense factor, history of researches, chemical and molecular characteristics, and functions of the following factors are presented here with some critical comments: lectins (agglutinins), lysozymes, antimicrobial peptides, pro-phenoloxidase (PO) activating system, and other humoral foctors (protease inhibitors, lysosomal enzymes, heat-shock proteins). (go.jp)

Although not necessary for the diagnosis or staging of CLL, additional molecular testing now exists that may help predict prognosis or clinical course. (medscape.com)

Furthermore, C1q can also recognize molecular patterns associated with pathogens and it can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. (origene.com)

The light atoms form the stars which form the heavy atoms which form the planets which form the molecules, etc. (astronoo.com)
Light atoms generate stars which generate heavy atoms which generate planets which generate molecules, which generate prebiotic oceans. (astronoo.com)

The synthesis of light chains is down-regulated, suggesting either a 2-gene defect or a negative feedback effect. (medscape.com)

and molecular components that work together to destroy antigens (Ags). (msdmanuals.com)

EHEC), enteropathogenic E. coli (EPEC), ditional and molecular diagnostic methods enteroinvasive E. coli (EIEC), and entero- in patients with acute diarrhoea in Hamedan aggregative E. coli (EAEC). (who.int)

Because of their utilisation in the in vivo modelling of disease, there is a requirement to develop molecular methods that accurately differentiate the different MHC mRNAs in the guinea pig to enable rapid profiling of muscle composition in appropriate disease models. (biomedcentral.com)
The methods developed here are suitable for the characterisation of muscle MHC expression at the molecular level from animal tissue samples and biopsy material. (biomedcentral.com)
A variety of currently used molecular methods fulfill many, but not all of these criteria. (intechopen.com)
Prevalence and risk of individual thrombophilic markers with a time line representing their discovery[ 1 ] Despite the expansion of these methods, the following years brought forth discoveries of defects on a molecular basis, which posed decreasing risks of thrombosis, as can be seen in Fig 1 . (intechopen.com)

We have investigated the structure of these active fragments and demonstrate that upon reduction, each possesses a heavy chain of 28,000. (jci.org)
The 28,500-dalton light chain of HFa becomes the heavy chain of each of the fragmentation products while cleavage at different points along the heavy chain of HFa determines which fragments will be produced. (jci.org)

In the particular case of the impact of heavy metals, information available suggests that the immune system is a target for low-dose Pb exposure. (scielo.org.ar)

Whereas conventional solar cells use heavy, rigid silicon slabs, the light-harvesting semiconductors used in OPVs are thin, flexible films of organic molecules. (nature.com)
For most organic molecules, adding an electron greatly affects their molecular structure, making it very unstable," Kondo says. (nature.com)
Consequently, ethanol and acid molecules interact within the wort, creating additional short chain esters. (whiskymag.com)

For example, we can form thin films from them by vacuum evaporation and then modify their molecular structures by chemical synthesis. (nature.com)

Let's look at the history of molecular diagnosis of thrombophilia. (intechopen.com)
The diagnosis is confirmed by abnormally low or absent numbers of mature B lymphocytes, as well as low or absent expression of the µ heavy chain on the surface of the lymphocyte. (medscape.com)
The differential diagnosis (see DDx ) of CLL includes several other entities, such as hairy cell leukemia , which is moderately positive for surface membrane immunoglobulins of multiple heavy-chain classes and is typically negative for CD5 and CD21. (medscape.com)

Protons have a higher charge to mass ratio and will be accelerated quicker than heavy ions. (lu.se)

Jeong H, Yoo SJ, Won J, Lee HJ, Chung JM , Kim HU , Kim GJ, Kim JG, Jung HS , Hyun J. Analysis of nano-crystals: Evaluation of heavy metal-embedded biological specimen by high voltage electron microscopy. (academictree.org)
10]. Developments in molecular analysis of accurate investigations in developing techniques have increased our ability to countries, the problem of diarrhoeal dis- identify potential enteropathogens in stool eases in these regions is much greater than specimens, and, in recent years, several new it seems [3]. (who.int)

In CNS and peripheral nervous system diseases associated with axonal injury or degeneration, the concentration of neurofilament light chain (NfL) has been found to increase in cerebrospinal fluid (CSF) and blood. (bmj.com)

Patients with γ-heavy chain disease (γ-HCD) have a poor prognosis. (medscape.com)

Ethanol also reacts with medium and long chain acids (which are present in much smaller quantities) creating medium and long chain esters. (whiskymag.com)

Anatomy19

Organisms9

Diseases4

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes75

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science5

Health Care4

Myosin21

Antibody13

Protein8

Antibodies13

Genetics1

Polypeptide chains2

Biology1

Molecule3

Metabolism1

Immunoglobulin heavy chain3

Laboratory1

Immunology2

Consists5

Mutation2

Genetic1

75,0001

Pharmacology2

Characterization1

Weight8

Assays2

Disorders1

Polymerase3

Mutations1

Side chains1

Cellular1

Monoclonal1

Proteins2

Clinical1

Bind1

Atoms2

Defect1

Antigens1

Diagnostic1

Methods4

Fragments2

Immune system1

Molecules3

Structures1

Diagnosis3

Mass1

Analysis2

Diseases1

Prognosis1

Reacts1