• Concurrent collapse of keratin filaments, aggregation of organelles, and inhibition of protein synthesis during the heat shock response in mammary epithelial cells. (rupress.org)
  • Sensitive, ELISA kit for this key transcription factor for heat shock protein (chaperone) research. (enzolifesciences.com)
  • To lower the threshold for the heat shock response activation, we used the chaperone co-inducer BGP-15 that was previously shown to have beneficial effects on several proteinopathic disease models. (springer.com)
  • Small heat shock proteins including HSP27 and the crystallins form large oligomeric complexes that function to prevent protein aggregation. (enzolifesciences.com)
  • These reductions were prevented by HSP-inducing pretreatments: mild heat shock, geranylgeranylacetone (GGA), and transfection with human HSP27 or the phosphorylation-mimicking HSP27-DDD. (ahajournals.org)
  • Brg1 further confers an open chromatin conformation at the promoter region that is pivotal to the heat shock induced fully activation of the hsp90beta gene in Jurkat cells. (uniprot.org)
  • We show that Jak2, a Janus kinase specifically associated with the beta subunit of IFNgamma receptor, and PKCepsilon an isoform of the atypical PKC family, are the two dominant kinases responsible for the heat shock induced phosphorylation on Y701 and S727 of Stat1. (uniprot.org)
  • Thermotolerance could be induced in protein synthesis and KFs, but not in actin filaments, by a conditioning heat treatment. (rupress.org)
  • The heat-shock factor can be activated very quickly once stress is recognized, which allows it to be a very effective protective mechanism. (stanford.edu)
  • The heat shock response is an evolutionarily well-conserved cellular defence mechanism against protein-damaging stresses, such as elevated temperatures, heavy metals, and viral and bacterial infections. (btk.fi)
  • Heat shock response (HSR) is a universal mechanism in all organisms. (plantphysiol.org)
  • This is a novel example of how multiple activation steps occur under heat shock, first on the kinases and then the Stat1 and the SWI/SNF chromatin remodeling complex that follows to conduct an auto-regulation based fully activation of the gene. (uniprot.org)
  • However, the complex dynamics of this physiological response have eluded mathematical modeling efforts. (nih.gov)
  • By reviewing the literature, we argue that the response contributes towards preserving a key functional parameter of neurons- neuronal activity- within their narrow physiological ranges at elevated temperatures. (frontiersin.org)
  • The heat shock response in neurons and astroglia and its role in neuro" by Rebecca San Gil, Lezanne Ooi et al. (edu.au)
  • A simpler enzyme kinetic model presented here provides a better basis for understanding the possible role of heat-shock proteins in the evolution of dominance. (queensu.ca)
  • Further study of the pathways implicated by these results and future comparisons among populations of T. californicus may help us understand the role and importance of HSF-1 in the heat shock response and, more broadly, in organismal thermal tolerance. (biologists.org)
  • Rick Morimoto Director of the Rice Institute of Biomedical Research and the Bill and Gayle Cook Professor of Biology at Northwestern University, is renowned for his insights into the heat shock response and its role in protein-folding diseases and aging. (biologists.org)
  • The sequence of heat shock-induced perturbations in protein synthesis and cytoskeletal organization was investigated in primary cultures of mouse mammary epithelial cells (MMEC). (rupress.org)
  • To investigate the heat-shock response of L. monocytogenes, whole-genome expression profiles of cells that were grown at 37 °C and exposed to 48 °C were examined using DNA microarrays. (wur.nl)
  • This expression pattern is in line with the observation that heat shock results in cell elongation and prevention of cell division. (wur.nl)
  • High-throughput methods for identifying modulators (activators or inhibitors) of HSP or HSF expression in a cell by treating the cell with an agent, such as a compound or composition, exposing the cell to a stress, and measuring responses of the cell to the stress in the presence or absence of the agent are also provided. (patentsencyclopedia.com)
  • Heat shock thus can efficiently disarrange the KF system in a large population of epithelial cells, thereby facilitating studies on the functions of this cytoskeletal component. (rupress.org)
  • We applied the method to the heat shock response model involving 9 species and 18 reactions and derived simplified models in three time scales which capture the dynamics of the full model. (biomedcentral.com)
  • Intriguingly, treatment with well-known potent HDAC inhibitors trichostatin A and valproic acid enhanced the heat shock response and improved cytoprotection. (springer.com)
  • Although several computational models have attempted to characterize the heat-shock response, they were unable to model its dynamics across diverse experimental datasets. (nih.gov)
  • Overall, this model represents a step forward in the quantitative understanding of the dynamics of the heat-shock response. (nih.gov)