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  • member
  • A gene on chromosome 17q22 that encodes a member of the DNA-binding heat-shock transcription factor family, which are rapidly induced by temperature and other forms of intracellular stress. (thefreedictionary.com)
  • tumor
  • Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity," Journal of Experimental Medicine , vol. 186, no. 8, pp. 1315-1322, 1997. (hindawi.com)
  • Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling," Journal of Biological Chemistry , vol. 282, no. 43, pp. 31688-31702, 2007. (hindawi.com)
  • and identified the tumor immunogenicity of heat shock proteins. (wikipedia.org)
  • interactions
  • Diversity of monomers (4 nucleotides versus 20 amino acids), interactions during folding, and consequences of changes in sequence are some of the hypotheses that attempt to explain why proteins were selected over ribozymes. (wikipedia.org)
  • organisms
  • Some members of the HSP family are expressed at low to moderate levels in all organisms because of their essential role in protein maintenance. (wikipedia.org)
  • maturation
  • Mycobacterial heat shock protein 70 induces interleukin-10 production: immunomodulation of synovial cell cytokine profile and dendritic cell maturation," Clinical and Experimental Immunology , vol. 135, no. 2, pp. 336-342, 2004. (hindawi.com)
  • Mycobacterium tuberculosis heat-shock protein 70 impairs maturation of dendritic cells from bone marrow precursors, induces interleukin-10 production and inhibits T-cell proliferation in vitro," Immunology , vol. 121, no. 4, pp. 462-472, 2007. (hindawi.com)
  • Inducible
  • P. Stocki, X. N. Wang, and A. M. Dickinson, "Inducible heat shock protein 70 reduces T cell responses and stimulatory capacity of monocyte-derived dendritic cells," The Journal of Biological Chemistry , vol. 287, no. 15, pp. 12387-12394, 2012. (hindawi.com)
  • ubiquitin
  • It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. (wikipedia.org)
  • aggregates
  • Since damaged proteins, called aggregates, are thought to play a role in many diseases, CytRx believes that arimoclomol could treat a broad range of diseases. (wikipedia.org)
  • kinase
  • De-repression of heat shock transcription factor-1 in interleukin-6- treated hepatocytes is mediated by downregulation of glycogen synthase kinase 3beta and MAPK/ERK-1," International Journal of Molecular Medicine , vol. 19, no. 3, pp. 413-420, 2007. (hindawi.com)
  • Drosophila
  • In 1962, Italian geneticist Ferruccio Ritossa reported that heat and the metabolic uncoupler 2,4-dinitrophenol induced a characteristic pattern of " puffing " in the chromosomes of Drosophila . (wikipedia.org)
  • genes
  • In the first aim, we will use RNA Sequence (RNASeq) profiling to identify stress responsive genes that are impacted by the rv0990c gene using 2 in vitro models for heat shock and multiple stressors. (grantome.com)
  • The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. (wikipedia.org)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
  • The operon contains two heat-shock genes, encoding inclusion body binding proteins A and B (IbpA/B), and is the most drastically upregulated operon under heat-shock in Escherichia coli. (wikipedia.org)
  • Luciferases are widely used in biotechnology, for microscopy and as reporter genes, for many of the same applications as fluorescent proteins. (wikipedia.org)
  • In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism. (wikipedia.org)
  • catalytic
  • Telomerase is a ribonucleoprotein complex that consists of an essential RNA molecule, hTR, with a template domain for telomeric DNA synthesis and of a catalytic protein, hTERT, with reverse transcriptase activity. (biomedcentral.com)
  • Dinoflagellate luciferase is a multi-domain protein, consisting of an N-terminal domain, and three catalytic domains, each of which preceded by a helical bundle domain. (wikipedia.org)
  • exposure
  • CXorf49 is found to be one of the components of a small group of the HL-60 cell proteome that were most prone to form 4-Hydroxy-2-nonenal(HNE) adducts, upon exposure to nontoxic (10 μM) HNE concentrations, along with heat shock 60 kDa protein 1. (wikipedia.org)
  • molecules
  • In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. (wikipedia.org)
  • Transmissible spongiform encephalopathy (TSE)s like BSE can arise in animals that carry an allele which causes previously normal protein molecules to contort by themselves from an alpha helical arrangement to a beta pleated sheet, which is the disease-causing shape for the particular protein[citation needed]. (wikipedia.org)
  • Factor
  • The infectious agent is distinctive for the high temperatures at which it remains viable, over 600 °C (1,112 °F). A contributory factor was the feeding of infected protein supplements to very young calves. (wikipedia.org)
  • pathway
  • After Fas stimulation, Daxx is activated and plays its role of pro-apoptotic protein in activating the c-JUN-N-Terminal Kinase (JNK) pathway. (wikipedia.org)
  • It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. (wikipedia.org)
  • receptor
  • Daxx, a Death domain-associated protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. (wikipedia.org)
  • Daxx interacts with the TGF-β type II receptor by binding of C-terminal domain of the protein. (wikipedia.org)
  • form
  • But on our first date I didn't see it in its shocking bare-naked form. (leitesculinaria.com)
  • A British and Irish inquiry into BSE concluded the epizootic was caused by cattle, which are normally herbivores, being fed the remains of other cattle in the form of meat and bone meal (MBM), a protein supplement in concentrated feeds. (wikipedia.org)
  • known
  • Several additional interacting proteins are known, but not always is there an understanding of the specific function and relevance of this interaction. (wikipedia.org)
  • human
  • HSPA1B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • CXorf49 has developed from aardvarks, to the human protein over 105.0 million years. (wikipedia.org)
  • found
  • IbpA is regulated by a ROSE element found in its 5' UTR, while IbpB has its own heat-sensitive cis-regulatory element. (wikipedia.org)
  • IbpB has been found to retain active for a significant time after a heat shock stimulus has been removed. (wikipedia.org)
  • closely
  • In this organism, the luciferase (Renilla-luciferin 2-monooxygenase) is closely associated with a luciferin-binding protein as well as a green fluorescent protein (GFP). (wikipedia.org)
  • contains
  • This crude coconut oil is not suitable for consumption because it contains contaminants and must be refined with further heating and filtering. (wikipedia.org)
  • function
  • The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. (wikipedia.org)
  • moisture
  • Store Propranolol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. (pharoptima.com)
  • Other processes to increase shelf life include using copra with a moisture content below 6%, keeping the moisture content of the oil below 0.2%, heating the oil to 130-150 °C (266-302 °F) and adding salt or citric acid. (wikipedia.org)
  • analysis
  • Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein. (springer.com)
  • disease
  • Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease. (springer.com)
  • Prion proteins carry the disease between individuals and cause deterioration of the brain. (wikipedia.org)