• The thickening of the left ventricle, known as left ventricular hypertrophy , can result in complications such as heart failure, which is the inability of the heart to pump sufficient quantities of blood to the body. (medicalnewstoday.com)
  • In clinical medicine, cardiovascular risk is increasingly accepted as the appropriate criterion to use to identify those who will most benefit from interventions designed to prevent cardiovascular disease and death. (biomedcentral.com)
  • In this capacity, she has worked across federal and private partners to execute evidence-based strategies to prevent cardiovascular diseases and improve health. (cdc.gov)
  • Atherosclerotic cardiovascular disease (ASCVD), which mostly involves heart attacks and strokes caused by atherosclerosis, is one of the main causes of death worldwide [ 1 ]. (biomedcentral.com)
  • Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality in the United States. (jabfm.org)
  • Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality in the United States despite a strong emphasis on prevention, accounting for more than 800,000 deaths in 2017. (jabfm.org)
  • The objectives of our intervention were to reduce cardiovascular disease risk factors in Hispanics living in 2 low-income areas of El Paso, Texas, and to engage the community in a physical activity and nutrition intervention. (cdc.gov)
  • A worked example is given calculating the 10-year coronary heart disease risk for a 57 year-old non-diabetic male with no personal or family history of cardiovascular disease, who smokes 30 cigarettes a day and has a systolic blood pressure of 137 mmHg, a total cholesterol (TC) of 6.2 mmol/l, a high density lipoprotein (HDL) of 1.3 mol/l, and a body mass index of 21. (biomedcentral.com)
  • Roles of allostatic load, lifestyle and clinical risk factors in mediating the association between education and coronary heart disease risk in Europe. (umu.se)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Depart- ment of Health and Human Services, Atlanta, GA 30333. (cdc.gov)
  • Cardiovascular diseases (CVDs) are the leading cause of death, with 31% of global mortality. (ump.edu.my)
  • The relationship between increased short-term mortality rates after invasive pneumococcal disease (IPD) has been frequently studied. (cdc.gov)
  • However, studies on long-term mortality rates after IPD have been largely deficient, despite IPD being a reportable disease in Canada since 2000 ( 9 ). (cdc.gov)
  • Mortality from all causes, cardiovascular disease, and ischaemic heart disease. (bmj.com)
  • In the Whitehall study this gradient was similar in both diabetic and non-diabetic subjects, and it persisted for mortality from cardiovascular disease and from ischaemic heart disease. (bmj.com)
  • We confirm the existence of an inverse socioeconomic mortality gradient in diabetic people and suggest that this is largely due to conventional cardiovascular risk factors. (bmj.com)
  • In this study, the researchers examined the association between obesity and mortality among people with cardiovascular disease, comparing incident and prevalent disease cases in the same dataset. (nyu.edu)
  • As cardiovascular disease represents the number one cause of death in people with diabetes, there has been a major emphasis on understanding the mechanisms by which diabetes promotes cardiovascular disease, and how antidiabetic therapies impact diabetic heart disease. (ox.ac.uk)
  • With a wide array of models to study diabetes (both type 1 and type 2), the field has made major progress in answering these questions. (ox.ac.uk)
  • We will review the preclinical animal models of diabetes (based on their method of induction), appraise models of diabetes-related atherosclerosis and heart failure, and discuss in vitro models of diabetic heart disease. (ox.ac.uk)
  • Fisetin, a flavonoid phytonutrient present in almost all kinds of fruits and vegetables, has recently emerged as a powerful antioxidant for health promotion [ 9 , 10 ] and exerts multiple protective effects in different oxidative stress-related conditions in human, such as degenerative diseases (e.g., vascular dementia), cancer, diabetes, and cardiovascular diseases [ 11 - 14 ]. (hindawi.com)
  • The Whitehall cohort study and the London cohort of the WHO multinational study of vascular disease in diabetes. (bmj.com)
  • The ZAHARA I (Zwangerschap bij Aangeboren HARtAfwijkingen I) and CARPREG (CARdiac disease in PREGnancy) risk scores were calculated for each pregnancy, as was the total number of cardiovascular (TPc) or offspring risk predictors (TPo) from these and other studies combined. (eur.nl)
  • 8 C reactive protein and fibrinogen are sensitive markers used to evaluate the inflammatory status of an individual, and the results of prospective longitudinal studies indicate that these markers might be useful predictors for future cardiovascular events in various populations. (bmj.com)
  • We have invented a unique approach," he continues, "building 3D models for vessels where we need to simulate all details and using lower-order models for other parts. (europa.eu)
  • The model allowed the team to simulate the effects of different policies on eating habits. (npr.org)
  • The software and repository are used to simulate cardiovascular and pulmonary solid and fluid mechanics and to provide spatially and temporally resolved benchmark solutions that are used by academic, government, and industry researchers to verify their computational methods. (stanfordchildrens.org)
  • Finally, the predictive capability of valid NLHRS models has also been tested and adjusted for different strata of the population. (ump.edu.my)
  • For better prevention and intervention, relevant guidelines recommend using predictive models for early detection of ASCVD high-risk groups. (biomedcentral.com)
  • and may prevent long-term health problems, such as coronary heart disease, cancer, and stroke. (cdc.gov)
  • Now computer models suggest slashing its price by about a third could result in dramatically lower death rates from heart disease and stroke. (npr.org)
  • Now computer models suggest that making that produce more affordable may actually translate into lower death rates from heart disease and stroke. (npr.org)
  • I'm delighted to welcome you to today's COCA call, high burdens, great opportunities preventing heart attacks and stroke. (cdc.gov)
  • Discussed accomplishments of Million Hearts, state how evidence-based strategies can help identify and address the needs of those at greatest risk for heart attack and stroke, and discuss the use of standardized treatment approaches to improve outcomes for patients at risk for heart attack and stroke. (cdc.gov)
  • Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the National Birth Defects Prevention Study. (cdc.gov)
  • Objectives Adequate prepregnancy prediction of maternal cardiovascular and offspring risk is important for counselling and management of pregnancy in women with congenital heart disease (CHD). (eur.nl)
  • Pregnancies were also classified according to the modified WHO classification of maternal cardiovascular risk and according to disease complexity (DC). (eur.nl)
  • At the conclusion of today's session, the participant will be able to describe the key components of Million Hearts and the targets that must be met to prevent one million heart attacks and strokes. (cdc.gov)
  • It focuses on patient-specific modeling in pediatric and congenital heart disease, as well as adult cardiovascular disease. (stanfordchildrens.org)
  • Research related to congenital heart disease includes exploring the ability to grow hypoplastic hearts. (stanfordchildrens.org)
  • The Michael Ma Lab at the Stanford University School of Medicine studies congenital heart disease and its surgical therapies. (stanfordchildrens.org)
  • The estimated CVDs path model can be implemented as a disease delay strategy in clinical settings. (ump.edu.my)
  • Surveys were linked prospectively to clinical hospital records, and Cox proportional hazards models were used to estimate the risk of cardiovascular disease events or death according to oral hygiene. (bmj.com)
  • Previous smaller epidemiological studies that have examined the association between oral health and cardiovascular disease have generally used clinical assessments to identify periodontal disease. (bmj.com)
  • Heart rate and heart rate variability have been extensively researched in clinical settings over the past decades. (mdpi.com)
  • Moving from a clinical model of care to a community model of prevention requires a comprehensive approach to community engagement (2-5). (cdc.gov)
  • and other respected institutions, provides a way to capture medical images and patient data to create specific blood flow simulation and analysis models. (stanfordchildrens.org)
  • Because dietary factors 'contribute substantially to the burden of preventable illness and premature death in the United States,' the national health promotion and disease prevention objectives encourage schools to provide nutrition education from preschool through 12th grade (1). (cdc.gov)
  • I'm Loretta Jackson-Brown and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Center for Disease Control and Prevention. (cdc.gov)
  • To address cardiovascular disease risk factors among Hispanics, a community model of prevention requires a comprehensive approach to community engagement. (cdc.gov)
  • Community health promotion and disease prevention models are needed to compensate for the large number of uninsured, underinsured, and disadvantaged people living in these communities. (cdc.gov)
  • Page 2 of 9 year initiative introducing community-based participatory research (CBPR) to engage academia and communities in setting up programs with an ecological approach to health promotion and disease prevention. (cdc.gov)
  • The environmental restructuring is designed to promote community use of existing physical activity and nutrition facilities and to integrate promotores into public-sector settings such as public parks, to address cardiovascular health promotion and CVD prevention. (cdc.gov)
  • Further, it focuses on the development of various forms of local risk prediction models and simple heart risk scores using non-laboratory features and machine learning (ML) algorithms. (ump.edu.my)
  • In developing risk prediction models, two ML algorithms, linear support vector machine and artificial neural network outperformed the existing conventional logistic regression analysis (LRA) model. (ump.edu.my)
  • Secondly, the ML models offer better and consistent risk prediction models as compared to LRA-based model. (ump.edu.my)
  • Therefore, this study aims to establish a population ASCVD prediction model in rural areas of Xinjiang using survival analysis. (biomedcentral.com)
  • Traditional ASCVD prediction models (Framingham and China-PAR models) were constructed in the test set. (biomedcentral.com)
  • Different models' discrimination and calibration degrees were compared to find the optimal prediction model for this population according to different genders and further analyze the risk factors of ASCVD. (biomedcentral.com)
  • By comparing the discrimination and calibration degrees of each model, the RSF showed the best prediction performance in males and females (male: Area Under Curve (AUC) 0.791 (95%CI 0.767,0.813), C statistic 0.780 (95%CI 0.730,0.829), Brier Score (BS):0.060, female: AUC 0.759 (95%CI 0.734,0.783) C statistic was 0.737 (95%CI 0.702,0.771), BS:0.110). (biomedcentral.com)
  • The performance of the ASCVD prediction model based on the RSF algorithm is better than that based on Cox regression, Lasso-Cox, and the traditional ASCVD prediction model in the rural population of Xinjiang. (biomedcentral.com)
  • Currently, the most commonly used survival analysis method is the Cox proportional hazards model, and most traditional ASCVD prediction models are constructed based on this model. (biomedcentral.com)
  • None of the offspring prediction models perform adequately in our cohort. (eur.nl)
  • SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. (umu.se)
  • We used Cox proportional hazards modeling, and the primary outcome was time to all-cause deaths. (cdc.gov)
  • Studies have shown that the longevity-associated variant (LAV) of the BPIFB4 gene is associated with a longer lifespan in humans and has protective effects in rodent models of cardiovascular disease. (medicalnewstoday.com)
  • There is a need for a new cardiovascular disease model that includes a wider range of relevant risk factors, in particular lifestyle factors, to aid targeting of interventions and improve population models of the impact of cardiovascular disease and preventive strategies. (biomedcentral.com)
  • 14 ] This variation is an inevitable consequence of the exclusion of significant risk factors from the model. (biomedcentral.com)
  • If a model is derived in a particular population, the prevalence and impact of any missing risk factors is tacitly embedded in coefficients of the risk equations. (biomedcentral.com)
  • We sought to assess whether AI model had knowledge of cardiovascular disease (CVD) racial disparities, including disparities associated with CVD risk factors and associated diseases. (medrxiv.org)
  • The model was unique in paying for overall CVD risk reduction, measured by a novel, longitudinal risk calculator, rather than tying performance-based payments to control of individual risk factors," the authors write. (medscape.com)
  • The warppartial least square method was utilized to estimate the multi-layer hypothesized path model. (ump.edu.my)
  • The index of these weights is referred to as NLHRS, which was further used as a covariate in the simple LRA model to estimate the likelihood of CVDs. (ump.edu.my)
  • Issues linked to, for example, artifact detection and correction, accuracy in different populations (e.g., the relation between PPG in different body locations and skin color), and the relative contribution of heart rate and heart rate derived features in various applications (e.g., sleep stage estimation) should be addressed by the scientific community. (mdpi.com)
  • However, with an aging population at risk for IPD, and pneumococcal serotypes changing to evade current vaccinations, IPD remains a disease of public health concern ( 12 ). (cdc.gov)
  • These findings highlight the therapeutic potential of LAV-BPIFB4 for attenuating the adverse effects of aging on cardiovascular function. (medicalnewstoday.com)
  • Aging is associated with an increase in the risk of cardiovascular conditions, including heart attack , heart failure , and coronary artery disease . (medicalnewstoday.com)
  • Another change associated with aging involves the dysfunction of endothelial cells , which form the inner lining of blood vessels and the heart. (medicalnewstoday.com)
  • Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization. (who.int)
  • Global public health burden of heart failure. (crossref.org)
  • This paper describes the construction of the Cardiovascular Health Improvement Model that aims to meet these requirements. (biomedcentral.com)
  • Health care providers need to model future patterns of need for health services, and to identify the cost effectiveness of different intervention strategies. (biomedcentral.com)
  • 4 5 6 7 Systemic inflammation could represent the underlying mechanism that links oral health and cardiovascular disease. (bmj.com)
  • They're doing the modeling that will demonstrate how pricing affects health. (npr.org)
  • However, a new study by NYU College of Global Public Health and the University of Michigan finds that this 'obesity paradox' is not present among people with new cases of cardiovascular disease. (nyu.edu)
  • Additionally, continuous heart rate and heart rate variability measurements collected by means of novel technological developments can serve as input for the development of algorithms estimating other relevant parameters in the context of health and fitness, for example, energy expenditure, sleep stages, and cardiorespiratory fitness. (mdpi.com)
  • Could a so-called longevity gene help restore heart health? (medicalnewstoday.com)
  • The increasing rates of cardiovascular disease (CVD) among Hispanics, particularly those living in US-Mexico border communities, are of great public health concern (1). (cdc.gov)
  • These recommendations were based on numerous studies showing that statins are effective in reducing low-density lipoprotein cholesterol levels, and the risk of death and recurrent coronary and cardiovascular events in those with a history of ASCVD, even in older adults. (jabfm.org)
  • The purpose of this study is two folds such as the development of a statistically valid path model which considered the possible non-linear paths, mediators, and binary endogenous feature of CVDs status. (ump.edu.my)
  • Firstly, the study concludes that the adoptions of the flexible approach in estimation can model the binary feature of CVDs and non-linear paths in the complex path models. (ump.edu.my)
  • Carolina provides all the materials you need to help students study the anatomy of the heart . (carolina.com)
  • We can study the way blood interacts with this and help surgeons design better heart bypass surgery. (europa.eu)
  • But a smaller study conducted in Massachusetts between 2011-2012 mirrored the findings of the modeling done at Tufts and Imperial College. (npr.org)
  • In the Whitehall study, the prevalence of heart disease was higher in the lowest social group compared with the highest group, by 6% among non-diabetic people (P=0.0001) and by 14% among diabetic subjects (P=0.02). (bmj.com)
  • Conclusion Our study showed that an online chat-based AI model has a broad knowledge of CVD racial disparities, however persistent gaps in knowledge about minority groups. (medrxiv.org)
  • The study indicates that inducing the expression of LAV-BPIFB4 in aged mice improved cardiac function and regulation of blood flow to the heart. (medicalnewstoday.com)
  • A recent study published in Cardiovascular Research suggests that LAV-BPIFB4 , a gene variant that previous research ha shown to be highly expressed by individuals with an exceptionally long lifespan, could also protect cardiac and vascular function in old age. (medicalnewstoday.com)
  • This study demonstrates that it is also possible to make human cardiac cells younger and older mice hearts by transferring a gene expressed by centenarians. (medicalnewstoday.com)
  • The Marsden Lab at Stanford Engineering develops fundamental computational methods for the study of cardiovascular disease progression, surgical methods, treatment planning, and medical devices. (stanfordchildrens.org)
  • Table 1 Major cardiovascular risk models and their inputs and outputs. (biomedcentral.com)
  • Finally, for the carotid or coronary arteries, we describe the 3D behaviour of the blood so we use the lower-order models to provide accurate inputs to the more detailed 3D models," the professor continues. (europa.eu)
  • The rat thoracic aortic smooth muscle cells (A10 cells) stimulated by AngII were used as the in vitro neointimal hyperplasia model, where AngII significantly induced the proliferation and migration in A10 cells. (hindawi.com)
  • Methods To assess ChatGPT's responses to topic in cardiovascular disease disparities, we created six questions of twenty sets, with each set consisting of three questions with changes to text prompt based on differences in patient demographics. (medrxiv.org)
  • Most prior work examines people with more longstanding disease, where disease-related factors can bias findings towards the observation of a paradox. (nyu.edu)
  • Among those with prevalent disease, the researchers observed a strong and significant obesity paradox, replicating earlier findings. (nyu.edu)
  • The encouraging findings from the Million Hearts Model suggest that modernized payment models may be an affirmative strategy to [incentivize guideline-concordant CVD preventive care and improve outcomes], though further work is needed to ensure that these models are patient-centric, optimally deployed, and equity-enhancing," add the editorial writers. (medscape.com)
  • 2 Consequently, contributing factors associated with inflammation and chronic infections, including oral infections such as periodontal disease, have been investigated to explain the relation between dental disease and cardiovascular disease. (bmj.com)
  • Poor oral hygiene is the major cause of periodontal disease, a chronic infection of the tissue surrounding the teeth. (bmj.com)
  • Thus, oral infections might add to the inflammatory burden of the individual and result in increased levels of cardiovascular risk based on serum C reactive protein and fibrinogen concentrations as a consequence of the systemic inflammatory response subsequent to low grade chronic infections. (bmj.com)
  • This review aims to emphasize the advantages and disadvantages of each model, and to highlight the practical challenges and technical considerations involved. (ox.ac.uk)
  • Researchers assessed the Million Hearts CVD Risk Reduction Model in a pragmatic, cluster-randomized trial among 342 healthcare organizations - half in the intervention group and half in the standard care control group. (medscape.com)
  • Drawing on lessons learned in phase 1 (years 2005-2008) of the HEART Project, we used an iterative, community- based process to develop an intervention based on an ecological framework. (cdc.gov)
  • Past research has largely looked at people with existing cardiovascular disease (prevalent disease), rather than focusing on those newly diagnosed (incident disease). (nyu.edu)
  • It's the ability to model outcomes that's new here, says American Heart Association president Dr. Mark Creager , a cardiovascular disease expert. (npr.org)
  • If people categorized as normal weight have lost weight because of more severe disease, researchers will underestimate the adverse effects of being obese relative to normal weight. (nyu.edu)
  • Although obesity is a well-known risk factor for getting cardiovascular disease, a controversial body of research suggests that obesity may actually be associated with improved survival among people who have cardiovascular disease. (nyu.edu)
  • ML-based NLHRS and their associated models outperformed the existing semi-quantitative risk score-based model in terms of discrimination and calibration assessments. (ump.edu.my)
  • In about 74% (411) of cardiovascular disease events the principal diagnosis was coronary heart disease. (bmj.com)
  • when studying incident disease, they used their pre-diagnosis weights. (nyu.edu)
  • These guidelines will allow for researchers to select the appropriate model of diabetic heart disease, depending on the specific research question being addressed. (ox.ac.uk)
  • That's the message being touted by researchers this week at the American Heart Association's Epidemiology meeting in Phoenix. (npr.org)
  • Researchers from the U.K. and Tufts University created a tool called the U.S. IMPACT Food Policy Model that included projections of U.S. demographics and cardiovascular death rates to 2030. (npr.org)
  • Using incident disease data, however, can be valuable in helping researchers to control for confounding factors. (nyu.edu)
  • Disease can lead to both death and weight loss, and both are a sign of more severe disease. (nyu.edu)
  • Analyses by cause of death showed the largest relative declines (10.6%) among deaths due to coronary heart disease and CVD. (medscape.com)
  • However, the conversion of a complex form of ML algorithms into a simple statistical model is the prime concern. (ump.edu.my)
  • This conversion from a complex black-box nature of ML algorithms into simple statistical models yielded such models, which do not require automated systems for their implementation. (ump.edu.my)
  • Dr. Wright has served as Executive Director of Million Hearts since its launch in 2011. (cdc.gov)
  • I want to thank you and the entire COCA team for the opportunity to represent Million Hearts on the Webinar today. (cdc.gov)
  • The NLHRS and their associated models which are the outputs of novel methodology provide valid and simple forms of risk scores and can be used without automated systems. (ump.edu.my)
  • The association between oral hygiene and inflammatory markers and coagulation was examined in a subsample of participants (n=4830) by using general linear models with adjustments. (bmj.com)
  • Conclusions Poor oral hygiene is associated with higher levels of risk of cardiovascular disease and low grade inflammation, though the causal nature of the association is yet to be determined. (bmj.com)
  • We also conducted a multivariable logistic regression analysis to determine whether sociodemographic characteristics are associated with statin use during the 3 years that followed the publication of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline (2014 through 2016). (jabfm.org)
  • There were consistent themes in incorrect or hedging responses by ChatGPT, with 91% and 79% of incorrect and hedging responses related to a cardiovascular disease disparity that affects a minority or underserved racial group. (medrxiv.org)
  • The Stanford BASE program brings together experts from multiple specialties across the Stanford University campus and its hospitals-including computational modeling, tissue engineering, genetics, and molecular biology-to create bold new solutions for children with heart disease. (stanfordchildrens.org)
  • In addition, those who are both obese and have severe disease are more likely to die early, while more robust obese individuals survive and are ultimately studied. (nyu.edu)
  • Scientific basis / background: Stablishing the causes (i.e. aetiology) of cardiovascular conditions such as hypertension is key for their effective and efficient management. (kcl-mrcdtp.com)
  • A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. (harvard.edu)
  • The second difficulty is in modelling the topologies and geometries of the human body, both healthy and damaged. (europa.eu)
  • Smartphones and wearable sensors allow for non-invasive and continuous measurement of heart rate and heart rate variability, enabling new applications and a better understanding of human physiology in response to both physical and psychological stressors. (mdpi.com)
  • Results There were a total of 555 cardiovascular disease events over an average of 8.1 (SD 3.4) years of follow-up, of which 170 were fatal. (bmj.com)
  • A Cox regression, Lasso-Cox regression, and random survival forest (RSF) model were established in the training set. (biomedcentral.com)
  • Given that many diseases result in wasting at the end of life, the notion that extra catabolic reserve can prolong survival makes intuitive sense. (nyu.edu)
  • Objective To examine if self reported toothbrushing behaviour is associated with cardiovascular disease and markers of inflammation (C reactive protein) and coagulation (fibrinogen). (bmj.com)
  • Cardiovascular diseases are responsible for 50 % of natural deaths in the EU. (europa.eu)