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  • myocardial injury
  • In this experiment, we studied the effects of the Dangguibuxue decoction (DBD) on the myocardial injury induced by cyclophosphamide in mice. (hindawi.com)
  • The myocardial injury was evaluated by the levels of lactate dehydrogenase (LDH) and Creatine kinase (CK) in the coronary effluent. (bmj.com)
  • A better understanding of the processes involved in myocardial injury has stimulated the search for new drugs that could limit the myocardial damage. (ahajournals.org)
  • Our previous results indicated that a single dosing of CP pretreatment at 0.8 g/kg attenuates ischemia/reperfusion- (I/R-) induced myocardial injury and cardiac microcirculatory disturbance. (hindawi.com)
  • CP was administrated daily by gavage for six days at 0.1, 0.4, and 0.8 g/kg/day before I/R. Results showed that multiple dosing of CP at three doses significantly reduced I/R-induced myocardial injury, microcirculatory disturbance, and oxidative stress. (hindawi.com)
  • These data suggested that multiple dosing of CP at doses ranging from 0.1 to 0.8 g/kg/day reduced I/R-induced rat myocardial injury and microcirculatory disturbance, which was mediated by inhibition of NADPH oxidase activation. (hindawi.com)
  • Myocardial injury induced by I/R accounts for the majority of death induced by various forms of cardiovascular diseases [ 1 ]. (hindawi.com)
  • Given to the central role of ROS in I/R injury, alleviating the oxidative stress is considered to be a potential option in limiting I/R-induced myocardial injury. (hindawi.com)
  • pulmonary
  • In the early treatment model PD123319 attenuated cardiopulmonary injury by reducing alveolar septal thickness, pulmonary influx of inflammatory cells, including macrophages and neutrophils, medial wall thickness of small arterioles, and extravascular collagen III deposition, and by preventing RVH. (sigmaaldrich.com)
  • At low concentrations PD123319 attenuates cardiopulmonary injury by reducing pulmonary inflammation and fibrosis and preventing PAH-induced RVH but does not affect alveolar and vascular development in newborn rats with experimental BPD. (sigmaaldrich.com)
  • The project originated about two years ago when Katz, who chairs the Department of Materials Science and Engineering, was contacted by Allen D. Everett, a Johns Hopkins Children's Center pediatric cardiologist who studies biomarkers linked to pulmonary hypertension and brain injury. (engineersjournal.ie)
  • In addition, the severity of intestinal and pulmonary injury was assessed with different scoring methods, respectively. (clinicaltrials.gov)
  • A study published in The Journal of the American Medical Association reports a 30 percent increase in the risk of heart attack, stroke, pulmonary embolism, DVT, and even death in men who take these drugs. (cartermario.com)
  • Langendorff
  • Methods Langendorff perfused hearts were perfused with vehicle (normoxic control) or Sunitinib for 120 min and either stained with triphenyl-tetrazolium chloride to assess the level of infarct to risk size (n = 4) or analysed by real time PCR for the expression profile of MKK7 mRNA (n = 6) or analysed by western blot to assess the level of MKK7 activation (n = 4). (bmj.com)
  • stroke
  • Researchers in that study found that the men who used testosterone supplements had nearly a 30 percent increased risk of stroke, heart attack and death. (clarkperdue.com)
  • If you or a loved one suffered a heart attack, stroke or death following use of a testosterone product, you may be entitled to compensation. (clarkperdue.com)
  • High cholesterol is a serious problem as it can increase one's risk of heart disease, heart attack, and stroke. (belmarrahealth.com)
  • LDL cholesterol is the "bad" cholesterol, which increases your risk of stroke and heart attack. (belmarrahealth.com)
  • But if you or your husband, son, father, or other loved one suffered a heart attack, stroke, or other clotting injury after taking testosterone-boosting products, the drug's manufacturer may be to blame. (cartermario.com)
  • apoptosis
  • However, when persistent or too intense, ERs will induce and activate ER proapoptosis fators such as CHOP, caspase-12, This study aimed to elucidate Ischaemic postconditioning (IPO) whether attenuates I/R injury by suppressing ER stress-induced apoptosis. (bmj.com)
  • strokes
  • Sometimes called " silent strokes ," these injuries are symptomless and are a risk factor for future strokes. (heart.org)
  • arteries
  • However, if it does happen, it is usually related to the use of catheters or other devices that travel through your arteries and heart. (emedtv.com)
  • deposition
  • Parameters investigated included lung and heart histopathology, fibrin deposition, vascular leakage, and differential mRNA expression. (sigmaaldrich.com)
  • We found that amylin deposition negatively affects cardiac myocytes by inducing sarcolemmal injury, generating reactive aldehydes, forming amylin-based adducts with reactive aldehydes, and increasing synthesis of the proinflammatory cytokine interleukin-1β (IL-1β) independently of hyperglycemia. (diabetesjournals.org)
  • Amylin deposition in the pancreas and in extrapancreatic tissues, including the heart, was mirrored in a rat model of type 2 diabetes expressing human amylin in the pancreas (HIP) ( 6 , 7 , 11 - 16 ). (diabetesjournals.org)
  • Cardiovascular
  • Cholesterol can take a toll on your heart health and set you up for a cardiovascular event like heart attack or heart disease. (belmarrahealth.com)
  • If you or someone you love suffered a clotting injury or developed a cardiovascular illness after using a testosterone replacement therapy product, you may be entitled to compensation for your damages. (cartermario.com)
  • sensitivity
  • Specific over expression of MKK7 in hearts has been shown to increase the sensitivity of cardiomyocytes to external stresses. (bmj.com)
  • tissues
  • After 17 hours, histopathological observations and left ventricular pressure-volume analysis to assess cardiac function with a Millar microtip pressure-volume conductance catheter were performed, and levels of biochemicals of the heart tissues were measured. (ahajournals.org)
  • myocardium
  • In myocardium that has not been irreversibly injured by ischaemia, reperfusion induces additional injury in the area at risk. (bmj.com)
  • Ischaemic postconditioning (IPO), brief intermittent ischaemia during the onset of reperfusion, both are known as endogenous protective mechanism, which could markedly limit myocardial infarction and render the myocardium more resistant to the subsequent I/R injury. (bmj.com)
  • It is possible that while the expanding fibroblast population is depositing excess extracellular material, a process that stiffens the heart, it also simultaneously stimulates capillary growth, to deliver more oxygen and nutrients to the expanding myocardium. (innovations-report.com)
  • protein
  • They compared their microRNA results with those of a protein currently used to diagnose injury to heart muscle: cardiac troponin. (medicalxpress.com)
  • This protein occurs within healthy heart muscle cells , but when injured, these cells leak cardiac troponin out into the blood stream, causing its levels to spike in circulation. (medicalxpress.com)
  • In the latest issue of the journal Chemical Science , the team reported on laboratory tests demonstrating that the prototype sensor had successfully detected a protein associated with brain injuries. (engineersjournal.ie)
  • In lab tests, this small biosensor detected a protein associated with brain injuries. (engineersjournal.ie)
  • To address these problems, Everett sought an engineer to design a biosensor that responds to glial fibrillary acidic protein (GFAP), which is a biomarker linked to brain injuries. (engineersjournal.ie)
  • myocyte
  • Although further studies are necessary, these data also suggest that IL-1β might function as a sensor of myocyte amylin uptake and a potential mediator of myocyte injury. (diabetesjournals.org)
  • occurs
  • The reason it gets a special name is because of its stereotypical pattern of occurrence - namely, it occurs several weeks after some type of injury to the heart muscle. (verywellhealth.com)
  • chest
  • A stray piece of wire flung from a riding mower had entered the boy's chest, piercing his heart. (ljworld.com)
  • Effusions (fluid accumulations) around the heart or lungs can often be seen on a chest x-ray or an echocardiogram . (verywellhealth.com)
  • LSA, a 34-year-old male police officer, came to the office to report that he had been discharged 16 days after being treated for chest injury by firearm. (bjcvs.org)
  • Chest X-rays showed one projectile in anterior cardiac topography, near the apex of the heart and another in the right rectus abdominis, near the thoracoabdominal transition. (bjcvs.org)
  • thickness
  • Within 48 hours after injury, the left ventricular free wall and septum were significantly enlarged, with an increase in heart weight and relative wall thickness compared to controls. (innovations-report.com)
  • novel
  • Scientists at Singapore's Institute of Medical Biology (IMB) and Bioprocessing Technology Institute (BTI) and The Netherlands' University Medical Center Utrecht say that their findings may pave the way for a novel way to improve survival and recovery rate after a heart attack. (medindia.net)
  • found
  • Writing about their experiments in the journal Stem Cell Research, the team has revealed that heart function among the pigs administered the secretion from the stem cells was also found to improve during the study. (medindia.net)
  • They found three RNAs with potential for use as markers of heart injury. (medicalxpress.com)