• Antibodies to Cardiolipin are reported to be associated with spontaneous thrombosis and thrombotic episodes and also with spontaneous abortion and placental infarction. (dobratechnologia.pl)
  • 1 The Venereal Disease Research Laboratory (VDRL) test is a manual agglutination assay that detects antibodies to cardiolipin extracted from bovine heart tissue. (dobratechnologia.pl)
  • With the clinical prerequisites of the presence of APS and a negative analysis for antibodies to cardiolipin and lupus anticoagulant. (lab24.pl)
  • Cardiolipin (IUPAC name 1,3-bis(sn-3'-phosphatidyl)-sn-glycerol, "sn" designating stereospecific numbering) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition. (wikipedia.org)
  • Cardiolipin (CL) is a kind of diphosphatidylglycerol lipid. (wikipedia.org)
  • The tafazzin protein is involved in altering a fat (lipid) called cardiolipin, which plays critical roles in the mitochondrial inner membrane. (medlineplus.gov)
  • Cardiolipin is an essential lipid that is important in energy metabolism. (brainfacts.org)
  • One important aspect of my research related to the heart is to define how cardiomyocytes respond to, and alter their function, in response to increased plasma lipid levels. (bergdahllab.com)
  • This protein plays a critical role in maintaining the levels of a particular lipid, called cardiolipin, located in the inner membrane of the mitochondria. (wikidoc.org)
  • Antibodies against cardiolipin belong to the group of anti-phospholipid antibodies specific for negatively charged phospholipids, components of biological membranes.Cardiolipin is an acidic phospholipid derived from glycerol and was named because of its isolation from bovine heart in 1941. (rapidtest.com)
  • We have utilized bovine heart cardiolipin as well as commercially available tetralinoleoyl cardiolipin oxidized with cytochrome c (cyt c) and hydrogen peroxide as well as with lipoxygenase to test the separation power of the system. (cdc.gov)
  • Acsl1 T-/- hearts contained 83% less tetralinoleoyl-cardiolipin (CL), the major form present in control hearts. (mitophysiology.org)
  • It is a blood plasma protein that binds to negatively charged phospholipids, in particular cardiolipin. (lab24.pl)
  • What is the purpose of a cardiolipin antibody test? (ganeshdiagnostic.com)
  • A cardiolipin antibody test detects cardiolipin antibodies in the blood. (dobratechnologia.pl)
  • Realtime driving directions to GiFi, Av. A cardiolipin antibody test detects cardiolipin antibodies in the blood. (dobratechnologia.pl)
  • In mammalian cells, but also in plant cells, cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane, where it is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism. (wikipedia.org)
  • Cardiolipin is the distinctive inner mitochondrial membrane phospholipid coupling structure with metabolism and signaling function. (barthsyndrome.org)
  • In addition, systemic effects of cardiolipin deficiency like neutropenia, T cell defects or other immune-related pathologies are important comorbidity factors in Barth syndrome patients in particular in respect to their higher susceptibility to recurrent infections. (barthsyndrome.org)
  • REAADS Anti-Cardiolipin (aCL) IgA is an ELISA for the determination of IgA anti-cardiolipin antibodies in human serum or plasma in individuals with systemic lupus erythematosus (SLE) and lupus-like disorders (anti-phospholipid syndrome). (diapharma.com)
  • Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly Systemic Lupus Erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. (dobratechnologia.pl)
  • Systemic implications of 'cardiolipin' , a phospholipid that gets released in large amounts from the heart following a myocardial infarction. (bergdahllab.com)
  • Finally, a molecule of CDP-DAG is bound to PG to form one molecule of cardiolipin, catalyzed by the mitochondria-localized enzyme cardiolipin synthase (CLS). (wikipedia.org)
  • In prokaryotes such as bacteria, diphosphatidylglycerol synthase catalyses a transfer of the phosphatidyl moiety of one phosphatidylglycerol to the free 3'-hydroxyl group of another, with the elimination of one molecule of glycerol, via the action of an enzyme related to phospholipase D. The enzyme can operate in reverse under some physiological conditions to remove cardiolipin. (wikipedia.org)
  • The Diagnostic Automation Cardiolipin IgA, G, M ELISA kit is a solid phase enzyme immunoassay employing highly purified cardiolipin plus native human Beta2-glycoprotein I for the combined semi-quantitative and qualitative detection of IgA, IgG and IgM antibodies against cardiolipin in human serum. (rapidtest.com)
  • It is caused by a mutation in the tafazzin gene (TAZ, also called G4.5) which leads to decreased production of an enzyme required to produce cardiolipin. (brainfacts.org)
  • Taz is an important enzyme responsible for synthesizing biologically relevant cardiolipin (for heart and skeletal muscle, cardiolipin rich in linoleic acid), a critical phospholipid of mitochondrial form and function. (johnshopkins.edu)
  • The importance of cardiolipin in mitochondrial function is evidenced by the X-linked inherited pathology Barth syndrome a result of cardiolipin remodeling deficiency. (barthsyndrome.org)
  • My previous work started to shed light on the effects of cardiolipin deficiency in CD8+ T cell immune response (Corrado et al. (barthsyndrome.org)
  • Defects in the adaptive branch of immunity might also further deteriorate muscle function if inflammation is modulated by cardiolipin deficiency. (barthsyndrome.org)
  • Of note, investigating further the effects of cardiolipin deficiency or modification (oxidation/saturation) in the adaptive immune response is pivotal in the context of current (Tazpower) or future trials impacting cardiolipin remodeling and/or oxidation. (barthsyndrome.org)
  • Grevengoed TJ, Martin SA, Katunga L, Cooper DE, Anderson EJ, Murphy RC, Coleman RA (2015) Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function. (mitophysiology.org)
  • The syndrome is characterized by muscular weakness, growth retardation, DILATED CARDIOMYOPATHY, variable NEUTROPENIA, 3-methylglutaconic aciduria (type II) and decreases in mitochondrial CARDIOLIPIN level. (bvsalud.org)
  • Our findings indicate that oxidized species of not only cardiolipin, but other phospholipid species, can be effectively separated from their non-oxidized counterparts in this two dimensional system. (cdc.gov)
  • Thus, ACSL1 is required for the normal composition of several phospholipid species in heart. (mitophysiology.org)
  • MCUB fine-tunes calcium uptake by mitochondria in injured heart tissue, in an attempt to limit calcium overload, which is a major contributor to cell death, particularly following a heart attack," explained John W. Elrod, PhD, Associate Professor in the Center for Translational Medicine at the Temple University Lewis Katz School of Medicine and senior investigator on the new study. (sciencedaily.com)
  • A lack of tafazzin results in abnormalities in the structure and function of mitochondria, leading to the heart defects and other problems seen in this disorder. (wikidoc.org)
  • His Lupus anticoagulant study deals with Anti-cardiolipin antibodies intersecting with Kaolin clotting time. (research.com)
  • The occurrence of anti-cardiolipin antibodies in patients with SLE and related diseases is typical for a secondary anti-phospholipid syndrome (APS). (rapidtest.com)
  • Cardiomyopathy and muscle weakness are life-threatening features of Barth syndrome, limiting patients' physical activity and often driving them to heart transplantation. (barthsyndrome.org)
  • Individuals with Barth syndrome may have elastic fibers in place of muscle fibers in some areas of the heart muscle, which contributes to the cardiomyopathy. (medlineplus.gov)
  • In rare cases, the cardiomyopathy gets better over time and affected individuals eventually have no symptoms of heart disease. (medlineplus.gov)
  • the most prominent is cardiotoxicity which can manifest acutely as well as years after treatment has been discontinued leading to left ventricular dysfunction, dilated cardiomyopathy and heart failure [ 2 - 4 ]. (oncotarget.com)
  • See the Cardiolipin Cardiolipin IgA, G, M ELISA Kit product insert for specific details on preparation, procedures, quality control, and test result interpretation. (rapidtest.com)
  • The increase in the heart respiratory chain proteome suggests an increase in mitochondrial oxidative capacity, which could compensate for the energy deficit caused by the inhibition of glycolysis. (nature.com)
  • We utilized three types of biological tissues and oxidative insults, namely rotenone treatment of lymphocytes to induce mitochondrial damage and cell death, pulmonary inhalation exposure to single walled carbon nanotube s, as well as total body irradiation, in order to identify cardiolipin oxidation products, critical to the cell damage/cell death pathways in these tissues following cellular stress/injury. (cdc.gov)
  • The heart is a highly oxidative muscle and any disruption in mitochondrial function can cause disturbed cardiac function and ultimately myocardial infarction. (bergdahllab.com)
  • Heart failure is thought to be the end result following the combination of mitochondrial derived oxidative stress and decreased energy production. (bergdahllab.com)
  • A greater understanding of the influence and mechanism of modified oxidative capacity of the cardiomyocytes is of importance, considering the heart consumes the most oxygen in the body. (bergdahllab.com)
  • Also, supplemental linoleic acid attenuated, to some degree, in vitro impaired contractile phenotype in TazKD soleus, and these findings appear to be partially mediated by improvements in cardiolipin content and resulting mitochondrial supercomplex formation. (johnshopkins.edu)
  • Once altered by tafazzin, cardiolipin is key in maintaining mitochondrial shape, energy production, and protein transport within cells. (medlineplus.gov)
  • As a result, tafazzin cannot alter cardiolipin, and levels of functional cardiolipin are reduced. (medlineplus.gov)
  • Anti-cardiolipin antibodies mainly recognize specific epitopes on a complex composed out of cardiolipin and Beta2-glycoprotein I which are expressed only when Beta2-glycoprotein I interacts with cardiolipin. (rapidtest.com)
  • The aCL antibodies bind to b2GPI, or a complex formed by this b2GPI is a platelet adhesin glycoprotein and cardiolipin. (medscape.com)
  • Our results indicate that selective cardiolipin (CL) oxidation is a result of a non-random free radical process. (cdc.gov)
  • As there are four distinct alkyl chains in cardiolipin, the potential for complexity of this molecule species is enormous. (wikipedia.org)
  • Cardiolipin bicyclic structure Structure of NAO NAO & CL arranged in a highly ordered way The detection, quantification, and localisation of CL species is a valuable tool to investigate mitochondrial dysfunction and the pathophysiological mechanisms underpinning several human disorders. (wikipedia.org)
  • Whether this might be mediated by the reduction or loss of cardiolipin or the accumulation of specific cardiolipin species, how this could happen and whether this could exacerbate or worsen muscle condition in Barth syndrome patients will be the core of this project. (barthsyndrome.org)
  • Cs-Lpin1 -/- mice exhibited diminished cardiac cardiolipin content and impaired mitochondrial respiration rates when provided with pyruvate or succinate as metabolic substrates. (bioblast.at)
  • Less efficient responses to T-cell mediated vaccines, lower susceptibility to acute organ rejection after heart transplant or altered inflammatory response when needed might be expected in Barth syndrome patients compared to non-affected age-matched individuals if our hypothesis holds true. (barthsyndrome.org)
  • In people with Barth syndrome, the heart problems can lead to heart failure. (medlineplus.gov)
  • The dietary supplement carnitine has aided some children with Barth syndrome but in others it has caused increasing muscle weakness and even precipitated heart failure. (brainfacts.org)
  • The 1996 discovery of the Barth gene is helping scientists and physicians better understand the metabolic and biochemical abnormalities seen in the disease and learn how genes cause heart disease, muscle weakness, and other problems in the body. (brainfacts.org)
  • It was first isolated from the beef heart in the early 1940s by Mary C. Pangborn. (wikipedia.org)
  • When genetically expressed prior to inducing a heart attack in mice, MCUB altered the channel to reduce calcium overload in the injured heart, ultimately curtailing tissue injury. (sciencedaily.com)
  • In the presence of venous or arterial thrombosis, especially at a young age, in particular heart attacks, strokes, transient disorders of cerebral blood circulation, pulmonary embolism, thrombosis of retinal vessels. (lab24.pl)
  • The new research, published online September 19 in the journal Circulation , identifies MCUB as a promising new target for the investigation and treatment of conditions that feature calcium overload and cell death -- conditions that include heart failure, heart attack, stroke, and neurodegeneration. (sciencedaily.com)
  • Users of oral hormone therapy (HT) (in the doses of the Women's Health Initiative) for more than five years are at slightly increased risk of breast cancer , heart disease , and stroke than are nonusers. (medicinenet.com)
  • Advances in methods to analyse cardiolipin and their clinical applications. (ucl.ac.uk)
  • However, in most animal tissues, cardiolipin contains 18-carbon fatty alkyl chains with 2 unsaturated bonds on each of them. (wikipedia.org)
  • Catabolism of cardiolipin may happen by the catalysis of phospholipase A2 (PLA) to remove fatty acyl groups. (wikipedia.org)
  • Since these alterations are induced by stress, such as heart cell injury, the researchers next investigated the role of MCUB after heart attack in mice. (sciencedaily.com)
  • In mice that suffered heart attack, the research team observed significant elevations in MCUB gene expression and decreases in MCU and the gatekeeper of the channel, MICU1. (sciencedaily.com)
  • The severity of heart disease is linked to accumulated Dox dosage during the course of the anticancer therapy ranging from 3-5% in patients that received a cumulative dose of 400mg/m 2 to 18-48% in patients receiving 700mg/m 2 (and 100% of mice receiving 71mg/ m 2 ) [ 1 , 6 , 7 ]. (oncotarget.com)
  • Compared with littermate control mice, PA content was higher in cs-Lpin1 -/- hearts, which also had an unexpected increase in diacylglycerol and triglyceride content. (bioblast.at)
  • Thus, 2DG in the murine heart appears to induce a metabolic configuration that is the opposite of SARS-CoV-2 infected cells, which could explain the compound's ability to restrict the propagation of the virus to the benefit of patients with COVID-19 disease. (nature.com)
  • Although ACSL1 determines the acyl-chain composition of heart CL, a high tetralinoleoyl-CL content may not be required for normal function. (mitophysiology.org)
  • Like an emergency response team that is called into action to save lives, stress response proteins in the heart are activated during a heart attack to help prevent cell death. (sciencedaily.com)
  • After the removal of unbound serum proteins by washing, antibodies specific for human IgA labeled with horseradish peroxidase (HRP) are added forming complexes with the cardiolipin bound antibodies. (diapharma.com)
  • Briefly, CD8+ T cells, responsible for fighting infections and safeguarding our organism from cancer, rely on the presence of cardiolipin and on its regulated synthesis and remodeling to properly activate, expand and eliminate pathogens or tumor cells. (barthsyndrome.org)
  • In contrast, anti-cardiolipin antibodies in patients with no other autoimmune diseases characterize the primary anti-phospholipide syndrome (APS). (rapidtest.com)
  • Cryonics patients frequently experience ischemic & reperfusion injury between the time when the heart stops and cryostorage begins. (benbest.com)
  • is associated with limited-use adverse effects specifically accumulative and dose-dependent heart toxicity which is the underlying cause for increasing the risk of mortality in cancer patients that use this kind of anticancer. (mosuljournals.com)
  • A phospholipid, or type of fat found in the blood, is called cardiolipin. (ganeshdiagnostic.com)
  • Cardiolipins are a type of Phospholipid, a fat in the blood, that plays an important role in blood clotting. (dobratechnologia.pl)
  • Test Code: 161950 Specimen Type: Blood Description: Anticardiolipin Antibody IgA, IgG, IgM Blood Test (Labcorp) This test looks for 3 types of Cardiolipin Antibodies, IgA, IgM, and IgG. (dobratechnologia.pl)
  • Anti-cardiolipin antibodies are by definition a major criterion for a diagnosis of APS. (dobratechnologia.pl)
  • It is hoped that follow-up studies defining the exact sites of molecular interaction will provide additional insight into how to target mitochondrial calcium overload in heart disease. (sciencedaily.com)
  • Over the last century, thanks to fatally flawed research suggesting saturated animal fat caused heart disease, the LA in the human diet has dramatically increased, from about 2 to 3 grams a day 150 years ago, to 30 or 40 grams a day. (onedaymd.com)
  • Based on longevity studies, DHA gives your body more usable DPA and EPA omega-3s and gives a "quarterly dividend" of consistently lower heart disease risk, the number one cause of death at over 650,000 per year in the USA. (source-omega.com)
  • The current review attempts to focus on collecting information related to the mechanism of stimulating heart disease resulting from the use of Dox. (mosuljournals.com)
  • Tests for cardiolipin antibodies typically produce a positive or negative outcome. (ganeshdiagnostic.com)
  • The name "cardiolipin" is derived from the fact that it was first found in animal hearts. (wikipedia.org)
  • Dr. Elrod's team also found that, while it can improve cell survival after heart injury, increased MCUB activity comes at the expense of mitochondrial energy production. (sciencedaily.com)
  • Many affected children die of heart failure or infection in infancy or early childhood, but those who live into adulthood can survive into their late forties. (medlineplus.gov)
  • High levels of homocysteine correlate strongly with most degenerative diseases of aging , especially heart attacks and strokes. (selfgrowth.com)
  • The blood test for cardiolipin antibodies, IgA, IgG, and IgM, is used to assess for antiphospholipid syndrome and occasionally other autoimmune illnesses, as well as to help discover the cause of recurrent miscarriage. (ganeshdiagnostic.com)
  • The cardiolipin antibodies blood test, IgA, IgG, and IgM is used to help investigate inappropriate blood clot formation, to help determine the cause of recurrent miscarriage, or as part of an evaluation for antiphospholipid syndrome or sometimes other autoimmune diseases. (dobratechnologia.pl)
  • Within two minutes without blood flow (due to heart stoppage or blood vessel occlusion) neurons lack the energy to power the sodium/potassium pump. (benbest.com)
  • Diluted serum samples, calibrator sera, and controls are incubated in cardiolipin coated microwells, allowing aCL antibodies present in the samples to react with the immobilized antigen. (diapharma.com)
  • Cardiolipin antibodies present in the sample will bind to the coated wells. (diapharma.com)
  • On the other hand, it is known that 2DG given continuously can have severe detrimental effects on the rodent heart. (nature.com)