AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesNamed GroupsHealth Care
Heart-Lung TransplantationLung TransplantationHeart TransplantationBronchiolitis ObliteransGraft RejectionHeartLungKidney TransplantationPrimary Graft DysfunctionTransplantationTransplantation, HomologousImmunosuppressive AgentsPostoperative ComplicationsLiver TransplantationLung DiseasesGraft SurvivalCytomegalovirus InfectionsTissue DonorsHeart RateOrgan TransplantationCollagen Type VRetrospective StudiesTreatment OutcomeImmunocompromised HostBronchoalveolar Lavage FluidTime FactorsCyclosporineImmunosuppressionBone Marrow TransplantationCytomegalovirusBronchoalveolar LavageGanciclovirCystic FibrosisBurkholderia gladioliRisk FactorsTacrolimusFollow-Up StudiesHematopoietic Stem Cell TransplantationHeart FailureTransplantsMycosesBronchoscopyWaiting ListsTransplantation ImmunologyOpportunistic InfectionsTissue and Organ ProcurementProspective StudiesHeart DiseasesBiopsySurvival Analysis
Donor2022OutcomesOrgans2021ImmunosuppressionDysfunctionInternational Society for Heart & Lung TransplaMortalitySurvivalSurgeonsPatientsAcuteDonors and recipientsAdultInfection in a Lung Transplant RecipientJournal of Heart and Lung TransplantationChronicDiseasesCentersBrigham and WomeISHLTProphylaxisTissue2018Double lung transplantationSingle lungSevereRegistryComplicationsInfectionsProcurementIdiopathic pulmonarLiver transplant recipientsPulmonary hypertension2020Bone marrow traPost-transplantTissuesCongenital heart dEmphysema20162023
Donor48
  • We conducted public health investigations of 8 organ trans- plant recipients who tested positive for severe acute respi- began to report potential donor-derived SARS-CoV-2 ratory syndrome coronavirus 2 infection. (cdc.gov)
  • All donor serum recipients experienced fever or lower respiratory tract were tested for the presence of SARS-CoV-2 RNA. (cdc.gov)
  • All index recipients had potential or donor-derived transmission events involving 8 de- confirmed community or healthcare exposure to per- ceased donors and 31 recipients were reported to sons infected with SARS-CoV-2. (cdc.gov)
  • Improved understanding of the mechanism of lung injury during brain death and during transition from donor to recipient may one day lead to techniques and preservation solutions that prevent ischemia-reperfusion injury. (medscape.com)
  • Lastly, Bowdish et al and other groups demonstrated that living-donor lobar lung transplantation can be successfully performed. (medscape.com)
  • The transplantation of a "foreign" organ, despite meticulous matching for donor-recipient compatibility, leads to a complex adaptive and innate immune system-mediated injury. (medscape.com)
  • Although rare, pulmonary embolism, infections, or neoplasms in the allograft may be diagnosed in this manner, which would affect the decision to use the donor lung. (medscape.com)
  • Toronto (February 16, 2022) - A study published in Science Translational Medicine performed at the Latner Thoracic Surgery Research Laboratories and UHN's Ajmera Transplant Centre has proved that it is possible to convert blood type safely in donor organs intended for transplantation. (eurekalert.org)
  • Consequently, donor organs are matched to potential recipients in the waitlist based on blood type, among other criteria. (eurekalert.org)
  • Human donor lungs not suitable for transplantation from type A donors were put in the EVLP circuit. (eurekalert.org)
  • One lung was treated with a group of enzymes to clear the antigens from the surface of the organ, while the other lung, from the same donor, remained untreated. (eurekalert.org)
  • This has major implications for donor selection and transplant management and care. (infectioncontroltoday.com)
  • If the donor has not completed a course of treatment, the current recommendation is to give the recipient five to 10 days of antiviral therapy, at therapeutic not prophylaxis doses. (infectioncontroltoday.com)
  • 1.6 Consider Valganciclovir prophylaxis for at least 3 months after starting treatment for acute allograft rejection if either donor or recipient are CMV positive (D+/R-, D+/R+ or D-/R+) [2C]. (bts.org.uk)
  • Focus theme: Donor and recipient size match. (smw.ch)
  • The daughter of the face donor kissed Carmen Blandin Tarleton at a 2013 new conference after the transplant. (bostonglobe.com)
  • But last month, six years after her transplant , the risks became painfully apparent when doctors discovered underlying tissue damage that will likely lead to the loss of her donor face. (bostonglobe.com)
  • But last year, a French surgeon performed a second transplant on a man from that country whose immune system rejected his original donor face eight years after his transplant. (bostonglobe.com)
  • If it progresses slowly, over months, and the Brigham approves her for a second transplant, she will eventually go on the wait list for a donor. (bostonglobe.com)
  • The healthy lung comes from a donor who has died. (medlineplus.gov)
  • Iwijn De Vlaminck, an assistant professor of biomedical engineering at Cornell and senior author of the study, said that previous work had identified that donor-derived cell-free DNA is a "good marker of transplant rejection" because increased levels of donor cfDNA indicates more damage to the graft and thus, rejection. (genomeweb.com)
  • That previous work, in both heart and lung transplantation, relied on genotyping both the organ donor and the recipient in order to distinguish which cfDNA fragments were being shed from the donor organ, and which were naturally occurring from the recipient. (genomeweb.com)
  • The idea was to find the most likely proportion of cfDNA that is donor derived given the recipient genotype and cfDNA sequences by iterating over different donor ancestral populations and accounting for sequencing and genotyping errors," Sharon said. (genomeweb.com)
  • One key factor though, Sharon said, is that the model assumes that the organ donor and the recipient are not related. (genomeweb.com)
  • For those cases, we took another step and modeled the relationship between the donor and the recipient and calculated for that," Sharon said. (genomeweb.com)
  • The statistical models help estimate the proportion of cfDNA fragments that are from the recipient and donor. (genomeweb.com)
  • The next step is then to determine what proportion of donor-derived cfDNA indicates transplant rejection. (genomeweb.com)
  • The researchers compared their so-called one-genome model to the two-genome method, where both donor and recipient genotypes are known. (genomeweb.com)
  • The heart cohort had lower levels of donor-derived cfDNA, so inferring the donor genotype was harder, the authors wrote in the study. (genomeweb.com)
  • They found that the statistical model was able to learn the relationship between the donor and recipient and that the one-genome method was comparable to the two-genome method. (genomeweb.com)
  • Late last month, Ferguson underwent open-heart surgery, and surgeons inserted a device that will mechanically pump his heart until a donor becomes available, according to ABC News. (bostonglobe.com)
  • The goal of this research is to better inform pre- and post-transplant clinical management and further refine donor-recipient organ matching to improve long-term outcomes and survival in lung transplant patients. (nih.gov)
  • The resources for the GRAfT-GTD study provide support at all clinical sites for patient recruitment, enrollment and bio-sample collection, while also supporting the laboratory of transplant genomics at NHLBI to perform measurements of ddcfDNA (donor derived - cell free DNA), computational analysis, host and manage the biorepository of clinical data and all bio-samples, and the data coordinating center for GRAfT at NHLBI. (nih.gov)
  • CPT 33933 describes the standard backbench preparation of a cadaver donor heart/lung allograft before transplantation, including the dissection of the allograft from surrounding soft tissues to prepare the aorta, superior vena cava, inferior vena cava, and trachea for implantation. (codingahead.com)
  • The lives of three Los Angeles-area kidney transplant patients were transformed by one of the West Coast's first three-way living donor kidney transplant chains, made possible through the generosity of a non-directed, altruistic kidney donor from New York City -- announced today at a joint news conference. (news-medical.net)
  • The kidney from the New York donor was delivered by the New York Organ Donor Network to UCLA's operating room for the July 30 transplant after being removed by Dr. Joseph Del Pizzo, director of laparoscopic and minimally invasive surgery in urology and associate professor of urology at NewYork-Presbyterian/Weill Cornell. (news-medical.net)
  • The "donor chain" is an innovative twist on efforts aimed at increasing the donor pool by giving people who are unable to donate to a loved one or friend the opportunity to still give a kidney through an exchange between incompatible donor-recipient pairs. (news-medical.net)
  • The domino effect of "chains" creates recipient-donor "clusters," with each subsequent cluster beginning with a "leftover" donor who starts the new cluster. (news-medical.net)
  • Hil started the registry when his youngest daughter needed a transplant and tests revealed that her body would have rejected his kidney, as well as kidneys from three uncles and the anonymous New York donor who ultimately started the chain at UCLA. (news-medical.net)
  • Donor chains have enormous potential to expand the donor pool and to provide better matched organs for the many individuals who are in desperate need of lifesaving transplants," Kapur said. (news-medical.net)
  • Kidney donor chains could have a significant impact on the country's organ donor shortage," said Dr. David Serur, medical director of The Rogosin Institute Transplant Center and associate professor of clinical medicine at NewYork-Presbyterian/Weill Cornell. (news-medical.net)
  • These cases generally occur in recipients who have never been infected with Epstein-Barr virus and have no immunity to the virus who receive lungs from a donor who has been infected with the virus. (secondwindstl.org)
  • Lung transplants can come from a living donor or from someone who has recently died. (msdmanuals.com)
  • Donation from a living donor is possible because the donor can live with one healthy lung. (msdmanuals.com)
  • Through an incision in the chest, the recipient's lung or lungs are removed and replaced with those of the donor. (msdmanuals.com)
  • none of the donor tissues were transplanted. (cdc.gov)
  • Subsequently, all 4 organ donor recipients were tested and had positive results for West Nile Virus RNA. (cdc.gov)
  • We identified West Nile Virus RNA in spleen/lymph node homogenate, skin, fat, muscle, tendon, and bone marrow samples obtained postmortem from a donor associated with transmission of West Nile Virus through solid organ transplantation. (cdc.gov)
20222
Outcomes10
  • He was part of a team that first reported a link between Cyclosporine A, prednisone and osteoporosis in heart transplant recipients, and published an article on the relationship between experience and outcomes in heart transplantation. (wikipedia.org)
  • Although one-year survival rates have improved, long-term outcomes for children receiving lung transplants have not (see the image below). (medscape.com)
  • Mayo Clinic researchers in the Transplant Center conduct ongoing studies and clinical trials in improving surgical procedures, improving outcomes and caring for people who need transplants. (mayoclinic.org)
  • Many lung transplant physicians advocate surveillance bronchoscopy with transbronchial lung biopsy and bronchoalveolar lavage (TBB/BAL) to monitor lung recipients despite limited evidence this strategy improves outcomes. (nih.gov)
  • Today, a main focus of the transplant community is the long-term outcomes of lung and heart allograft recipients. (terasaki.org)
  • His clinical research has primarily been directed toward surgical issues in complex congenital heart care and cardiac transplantation (focusing on advances with operative techniques, outcomes research and transplantation for congenital heart disease), with a particular emphasis on the development of mechanical ventricular assist devices for children, as well as stem-cell based valved conduits for pediatric application. (chop.edu)
  • We hypothesize that individuals of non-European ancestry experience inferior lung transplantation outcomes when compared to those of European ancestry. (nih.gov)
  • In our cohort of patients, we examine demographic and clinical characteristics, as well as differential levels of cell free DNA, to explore outcomes of allograft failure, acute cellular rejection, and chronic lung allograft dysfunction in individuals of European and non-European ancestry. (nih.gov)
  • Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)
  • Solid organ transplant recipients, who are medically immunosuppressed to prevent graft rejection, have increased melanoma risk, but risk factors and outcomes are incompletely documented. (cdc.gov)
Organs13
  • If the damage is severe in both organs, replacing the heart or lungs alone may not be possible. (physio-pedia.com)
  • A shift in the nature of complications from early to late graft dysfunction has been similarly observed after transplantation of other solid organs 2 . (ersjournals.com)
  • Having universal organs means we could eliminate the blood-matching barrier and prioritize patients by medical urgency, saving more lives and wasting less organs," adds Dr. Cypel, who is also a Thoracic Surgeon at UHN's Sprott Department of Surgery, a Professor in the Department of Surgery at U of T and the Canada Research Chair in Lung Transplantation. (eurekalert.org)
  • This disparity is also present for other organs, she adds, where a patient who is type O or B in need of a kidney transplant will be on the waitlist for an average of 4 to 5 years, compared to 2 to3 years for types A or AB. (eurekalert.org)
  • The EVLP system pumps nourishing fluids through organs, enabling them to be warmed to body temperature, so that they can be repaired and improved before transplantation. (eurekalert.org)
  • In a Federal Register notice published June 18, 2015, the National Institutes of Health of the U.S. Department of Health and Human Services seeks public comment on criteria for research involving transplantation of organs from HIV-positive donors to HIV-positive recipients. (unos.org)
  • The goals of the proposed criteria are to ensure that research using organs from HIV-positive donors is conducted in ways that protect the safety of research participants and the general public, and to ensure that the research results may be used to evaluate the safety of organ transplantation from HIV-positive donors to HIV-positive recipients. (unos.org)
  • Tarleton's doctors noted that most transplanted organs - including kidneys, lungs, and hearts - have limited life span. (bostonglobe.com)
  • Is involved in the selection of donors and recipients and the procurement of organs for transplantation. (mater.ie)
  • Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
  • In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
  • 5 United Nations General Assembly - Resolution A/RES/71/322 on Strengthening and promoting effective measures and international cooperation on organ donation and transplantation to prevent and combat trafficking in persons for the purpose of organ removal and trafficking in human organs, September 2017. (who.int)
20213
  • New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021. (ucsf.edu)
  • METHODS: In this retrospective cohort study we recruited 71 patients with a lung transplant between 2010 and 2014 which survived the first year after transplantation up to 1 July 2021. (smw.ch)
  • The ASCI is pleased to recognize the 40 recipients of its 2021 (Young Physician-Scientist Awards), which recognize excellent physician-scientists who are early in their first faculty appointment and have made notable achievements in their research. (the-asci.org)
Immunosuppression9
  • Outbreaks of health care-associated mucormycosis have been identified, most commonly in persons with marked immunosuppression, such as bone marrow and solid organ transplant recipients ( 1 , 2 ). (cdc.gov)
  • Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have made intermediate-term survival after lung transplantation an achievable goal. (ersjournals.com)
  • Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have contributed to increase the 1‐yr patient survival after lung transplantation (LTx) to 70-80% 1 . (ersjournals.com)
  • Thus, the mycophenolate mofetil dose or mycophenolic acid plasma concentration are not a primary factor related to organ rejection, but chronic lung allograft dysfunction may be influenced by other components of immunosuppression or other factors. (smw.ch)
  • Scheffert JL, Raza K. Immunosuppression in lung transplantation. (smw.ch)
  • Maintenance of immunosuppression after solid-organ transplant is essential in order to prevent short-and long-term complications such as acute cellular rejection and chronic lung allograft dysfunction. (nih.gov)
  • Melanoma exhibits increased incidence and aggressive behavior under transplant-related immunosuppression. (cdc.gov)
  • Because increased diagnostic accuracy can eliminate confusion between transplant rejection and organ injury, treatment can be more precise and the administration of unnecessary immunosuppression drugs can be prevented, he said. (medscape.com)
  • Immunosuppression by a kidney or heart transplant. (who.int)
Dysfunction15
  • 4 These diseases are not only the major causes of death but are also associated with chronic lung allograft dysfunction (CLAD). (nature.com)
  • However, chronic allograft dysfunction in the form of bronchiolitis obliterans remains a major hurdle that threatens both the quality of life and long-term survival of the recipients. (ersjournals.com)
  • INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. (smw.ch)
  • We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite mycophenolic acid affect the development of chronic lung allograft dysfunction. (smw.ch)
  • An event-time-analytical Cox proportional-hazards regression model with time-varying-covariates (18,431 measurements for MPA, mycophenolate mofetil dosage, lymphocytes) was used to predict chronic lung allograft dysfunction, with adjustment for sociodemographic factors and lung function at baseline. (smw.ch)
  • RESULTS: 37 patients did not develop chronic lung allograft dysfunction (age 41.3 ± 15.6 years, baseline FEV1 95.5 ± 19.1% predicted) and 34 patients developed chronic lung allograft dysfunction (age 50.9 ± 13.3 years, baseline FEV1 102.2 ± 25.4% predicted). (smw.ch)
  • 0.001), but only the traditional risk factor age predicted chronic lung allograft dysfunction. (smw.ch)
  • Continuously measured mycophenolic acid did not predict chronic lung allograft dysfunction (hazard ratio 0.98, 95% confidence interval 0.90-1.06, p = 0.64 over a period of 382.97 patient-years). (smw.ch)
  • CONCLUSION: Mycophenolate mofetil dosage and mycophenolic acid were not associated with chronic lung allograft dysfunction development. (smw.ch)
  • Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT. (smw.ch)
  • Short Airway Telomeres are Associated with Primary Graft Dysfunction and Chronic Lung Allograft Dysfunction. (ucsf.edu)
  • Management of primary graft dysfunction after lung transplantation with extracorporeal life support: an evidence-based review. (ucsf.edu)
  • The Association Between Frailty and Chronic Lung Allograft Dysfunction After Lung Transplantation. (ucsf.edu)
  • Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction. (ucsf.edu)
  • Via genome sequencing of both lung transplant recipients and donors, we examine genetic ancestral markers that are associated with graft rejection and dysfunction. (nih.gov)
International Society for Heart & Lung Transpla1
  • The American Society of Transplant Surgeons, the American Society of Transplantation, and the International Society for Heart & Lung Transplantation, recommended in November that all eligible transplant candidates and recipients be vaccinated against COVID-19, STAT reported last month . (bostonglobe.com)
Mortality2
  • Because of the high incidence of morbidity and mortality associated with invasive fungal infections, antifungal prophylaxis is often used in solid organ transplant recipients. (hindawi.com)
  • Melanoma-specific mortality was higher among transplant recipients than non-recipients (HR 2.98, 95%CI 2.26-3.93). (cdc.gov)
Survival16
  • 1 Nevertheless, the overall survival after a lung transplant is still inferior compared to other solid-organ transplantation modalities. (nature.com)
  • 12 These results supported that potential gut microbiome-targeted interventions could influence the survival of patients received solid organ transplantation. (nature.com)
  • Pediatric lung transplantation actuarial survival by era. (medscape.com)
  • After single LTx, survival after BOS onset is longer in recipients with emphysema compared with recipients with idiopathic pulmonary fibrosis 8 . (ersjournals.com)
  • Erasmus ME, van der Bij W. Death after lung transplantation: improving long term survival despite perilous early postoperative years. (smw.ch)
  • Survival in adult lung transplantation: where are we in 2020? (smw.ch)
  • This report compares rates of infection (INF), acute rejection (AR), bronchiolitis obliterans syndrome (BOS) and survival in lung allograft recipients managed with surveillance TBB/BAL (SB) versus those with clinically indicated TBB/BAL (CIB). (nih.gov)
  • CT12 Chapter 5: Factors Affecting Graft Survival Within 1-year Post-Transplantation in Heart and Lung Transplant: An Analysis of the OPTN/UNOS Registry. (terasaki.org)
  • Factors Affecting Graft Survival Within 1-year Post-Transplantation in Heart and Lung Transplant: An Analysis of the OPTN/UNOS Registry. (terasaki.org)
  • However, even early post-transplant survival (within the first post-transplant year) needs improvement, as early graft failure still accounts for many allograft losses. (terasaki.org)
  • Trends indicate that sicker patients are increasingly being transplanted, thereby limiting improvements in early post-transplant survival. (terasaki.org)
  • Given that sicker/riskier patients are now receiving more heart and lung transplants, future studies need to take place to better understand these patients so that they can have the same survival as patients entering transplant with less severe illnesses. (terasaki.org)
  • The focus of APO is to investigate whether early detection and treatment of rejection improves transplant survival. (nih.gov)
  • APO is also planning a clinical trial to assess whether early detection and treatment of rejection improves survival in lung transplant patients and also engaged in additional studies to understand molecular mechanisms of transplant rejection. (nih.gov)
  • The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
  • Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
Surgeons6
  • Surgeons and other healthcare professionals specializing in solid organ transplants have been issued with expert advice to guide them through the complex clinical issues posed by the global H1N1 influenza pandemic. (infectioncontroltoday.com)
  • There are so many unknowns and so many new things we are discovering,'' said Dr. Bohdan Pomahac, director of plastic surgery transplantation at the Brigham and one of Tarleton's surgeons. (bostonglobe.com)
  • Wildevuur CR, Benfield JR. A review of 23 human lung transplantations by 20 surgeons. (medigraphic.com)
  • Our multidisciplinary team includes transplantation surgeons, heart failure and transplantation cardiologist, respiratory and transplantation physicians, transplant coordinators, clinical nurse specialist, nursing, physiotherapist, psychologist, social workers and other medical personal depending on the patients underlying condition and associated conditions. (mater.ie)
  • Mayo Clinic pulmonologists, lung transplant surgeons and other specialists research lung transplant and other treatments for lung conditions. (mayoclinic.org)
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 0 0. (cdc.gov)
Patients39
  • Lung transplantation is a potentially curative therapy for patients with end-stage pulmonary disease. (nature.com)
  • donors to recipients ( 1 ) and if transplant recipients are at increased risk for severe illness from corona- The Study virus disease (COVID-19) from SARS-CoV-2 infec- Current OPTN policy requires all US transplant tion compared with immunocompetent patients ( 2 ). (cdc.gov)
  • That is, patients trade their end-stage lung disease for transplant lung disease, with the hope that it can be better managed. (medscape.com)
  • However, in patients who are severely immunocompromised, Aspergillus may hematogenously disseminate beyond the lungs. (medscape.com)
  • All four patients underwent solid organ transplantation during the same admission as their mucormycosis diagnosis and were receiving immunosuppressive medications as well as voriconazole for antifungal prophylaxis. (cdc.gov)
  • The three probable cases were in patients who were primary heart (two cases) and lung transplant (one case) recipients who underwent transplantation 31-93 days before mucormycosis diagnosis. (cdc.gov)
  • The three patients with probable health care-associated mucormycosis all received care in the same room (room A) of the 20-bed cardiothoracic intensive care unit (CTICU) in hospital A for 14-58 days between their transplantations and mucormycosis diagnoses. (cdc.gov)
  • An organ transplant is an established life-saving therapy for these patients. (physio-pedia.com)
  • Total artificial hearts are now available and have been implanted in a few patients. (physio-pedia.com)
  • Lung biopsies from these patients showed intraluminal polyps comprised of fibromyxoid granulation tissue and plaques of dense submucosal eosinophilic scar. (ersjournals.com)
  • BO and its clinical correlate bronchiolitis obliterans syndrome (BOS) affect up to 50-60% of patients who survive 5 yrs after surgery, irrespective of the type of transplant procedure 1 , 4 - 6 . (ersjournals.com)
  • With the current matching system, wait times can be considerably longer for patients who need a transplant depending on their blood type," explains Dr. Marcelo Cypel, Surgical Director of the Ajmera Transplant Centre and the senior author of the study. (eurekalert.org)
  • Patients who are type O wait on average twice as long to receive a lung transplant compared to patients who are type A, explains Dr. Aizhou Wang, Scientific Associate at Dr. Cypel's lab and first author of the study. (eurekalert.org)
  • Patients who are type O and need a lung transplant have a 20% higher risk of dying while waiting for a matched organ to become available," says Dr. Wang. (eurekalert.org)
  • He is one of the attending physicians on the inpatient lung transplantation service, where he cares for patients with advanced lung disease before and after lung transplantation. (ucsf.edu)
  • His outpatient clinical time is split between three clinics (1) the lung transplantation clinic, where he sees patients with advanced lung disease before and after transplantation, (2) the pulmonary hypertension clinic, where he sees patients with pulmonary hypertension and pulmonary emboli, and (3) the general pulmonary clinic, where he supervises the excellent care provided by fellows in the UCSF Pulmonary and Critical Care Fellowship Program. (ucsf.edu)
  • Nicholas Kolaitis' research focuses on ways to improve health-related quality of life for patients with advanced lung disease. (ucsf.edu)
  • The current virus pandemic can cause severe disease in transplant patients and could be transmitted from donors,' explains assistant professor Dr. Deepali Kumar, an expert in transplant-related infectious diseases from the University of Alberta, Canada. (infectioncontroltoday.com)
  • Transplant patients and donors should receive at least one dose of H1N1 vaccine. (infectioncontroltoday.com)
  • A total of 50% of the patients died by the ninth post-transplant year. (smw.ch)
  • More than 44 patients worldwide have received face transplants, including 15 in the United States. (bostonglobe.com)
  • Dr. Brian Gastman, a transplant surgeon at the Cleveland Clinic, which did the first US face transplant 11 years ago, said more patients are starting to experience chronic rejection. (bostonglobe.com)
  • The heart and lung transplant department performs heart and lung transplantation for patients whose heart or lungs are failing. (mater.ie)
  • Patients assessed for heart or lung transplantation have life-limiting heart or lung conditions. (mater.ie)
  • Assesses patients for their suitability for transplantation. (mater.ie)
  • She performs lung transplant surgery and lung volume reduction surgery for emphysema, and treats patients with tumors of the chest, including lung cancer, esophageal cancer, mediastinal tumors and mesothelioma. (ucsf.edu)
  • Looking retrospectively at 382 blood samples taken at various time points from 51 lung transplant patients, the researchers found that the two models were highly correlated. (genomeweb.com)
  • Analyzing 435 samples from 59 heart transplant patients, they found that the two methods were still highly correlated, although not as close as for the lung transplants. (genomeweb.com)
  • In a statement, the hospital said the COVID-19 vaccination requirement for transplant patients is based on the "best available evidence" related to immunocompromised patients who are at risk for COVID-19 infection following transplantation. (bostonglobe.com)
  • More lung and heart transplant patients are coming to transplant on dialysis. (terasaki.org)
  • In heart transplant, there is an increase in the number of heart retransplant patients and an increase in patients on extracorporeal membrane oxygenation. (terasaki.org)
  • For lung transplant, more patients are on a ventilator prior to transplant than in the past 25 years. (terasaki.org)
  • Does Transplantation Induce Aging In Patients? (medicaldaily.com)
  • Tomasulo CE, Chen JM, Smith CL, Maeda K, Rome JJ, Dori Y. Lymphatic disorders and management in patients with congenital heart disease. (chop.edu)
  • Unfortunately, half of these patients will die within 5 - 6 years after transplant because of transplant rejection. (nih.gov)
  • SARS-CoV-2 infection in two patients following recent lung transplantation. (cdc.gov)
  • recipients constituted 42% of those patients, while underlying malignancies were found in 26% (Table 1). (who.int)
  • Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
  • Halloran and his colleagues assessed endomyocardial biopsy samples from 462 patients who had undergone heart transplantation at one of eight centers. (medscape.com)
Acute8
  • I am a practicing pulmonologist and intensivist and I maintain a basic science laboratory investigating acute lung injury. (ucsf.edu)
  • The long-term goal of my laboratory is to use experimental modeling to discover mechanisms responsible for the development of acute lung injury and to test novel therapeutics in clinically relevant experimental models. (ucsf.edu)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
  • Greer M, Werlein C, Jonigk D. Surveillance for acute cellular rejection after lung transplantation. (smw.ch)
  • Urinary thromboxane B2 as an indicator of acute rejection in lung allotransplantation. (medigraphic.com)
  • Urinary thromboxane B2 excretion during acute rejection in cyclosporine treated experimental lung allotransplantation. (medigraphic.com)
  • Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
  • For chronic or acute liver failure, as well as some cardiorespiratory conditions, the only alternative to transplantation is death. (who.int)
Donors and recipients2
  • The project partners with the National Kidney Registry ( www.kidneyregistry.org ), which matches donors and recipients through a specialized computer program developed by businessman and registry founder Garet Hil. (news-medical.net)
  • If all incompatible donors and recipients were simply listed in one common pool, the problems related to incompatible and poorly matched donors and recipients would be a thing of the past," Hil said. (news-medical.net)
Adult3
Infection in a Lung Transplant Recipient1
  • We report a case of Mycobacterium marinum infection in a lung transplant recipient who presented with nodules on the hand and forearm following exposure to fish-tank water of a superficial hand burn. (elsevierpure.com)
Journal of Heart and Lung Transplantation2
Chronic2
  • 2) Eisenmenger syndrome, (3) congenital heart disease without Eisenmenger syndrome, (4) idiopathic pulmonary arterial hypertension (IPAH), (5) cystic fibrosis, (6) chronic obstructive pulmonary disease (COPD) and/or emphysema), and (7) diffuse interstitial lung disease. (unican.es)
  • Dr. Akchurin is a recipient of the K08 Career Development Award from the NIH NIDDK to decipher how iron metabolism alterations and iron therapy impact renal fibrosis and chronic kidney disease (CKD) progression, as well as CKD complications. (the-asci.org)
Diseases4
Centers3
  • A prospective multicenter cohort of LTRs was identified in the four lung transplant centers. (nature.com)
  • ters should educate transplant candidates and recipients These cases were referred to the Centers for Disease about infection prevention recommendations. (cdc.gov)
  • The hope is that this marks the first of many such collaborations among the nation's transplant centers," said Dr. Sandip Kapur, chief of transplant surgery and associate professor of surgery at NewYork-Presbyterian/Weill Cornell. (news-medical.net)
Brigham and Wome4
  • Laffel had previously served as an attending physician in the cardiac transplantation program at Brigham and Women's Hospital, as a founding editor of the peer-reviewed journal, Quality Management in Health Care, a consultant to healthcare provider organizations and President of Clinical Solutions. (wikipedia.org)
  • Carmen Blandin Tarleton and her doctors at Brigham and Women's Hospital knew a face transplant would be especially perilous. (bostonglobe.com)
  • About 100 protesters gathered outside Brigham and Women's Hospital Sunday afternoon in support of a Massachusetts man whose family has said he was dropped from its heart transplant waitlist because he hasn't been vaccinated for COVID-19. (bostonglobe.com)
  • Brigham and Women's Hospital has told Ferguson that he was ineligible for a transplant because he was not vaccinated against COVID-19, according to his family. (bostonglobe.com)
ISHLT4
Prophylaxis1
  • Here we present a rare case of invasive infection caused by Microascus trigonosporus species complex in a human, which developed during voriconazole prophylaxis in a lung transplant recipient. (hindawi.com)
Tissue8
  • Although advances in tissue typing and cross-match testing have helped to deter severe transplant rejection, rejection may result from direct cellular attack (cellular rejection) or be mediated by antibodies (humoral rejection). (medscape.com)
  • West Nile Virus transmission through tissue transplantation, for instance, skin, muscle, or connective tissues, has not been identified, and the risk for transmission by this route is not known. (cdc.gov)
  • Corneas, heart valves, and vascular tissue were not procured. (cdc.gov)
  • In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
  • Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
  • Organ and tissue donation and transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ or tissue. (who.int)
  • There is no information about reproductive tissue transplantation as a method of treating infertility in the African Region. (who.int)
  • 4 World Health Assembly - Resolution WHA63.22 on Human organ and tissue transplantation, May 2010. (who.int)
20182
  • Eur Heart J. 2018;39(7):586-95. (smw.ch)
  • Molecular diagnosis is more objective and reproducible than histology, and provides new understanding of an organ's reduced function in response to injury, he explained here at International Society for Heart and Lung Transplantation 2018 Scientific Sessions. (medscape.com)
Double lung transplantation2
Single lung3
Severe3
  • Severe allograft rejection (AR) and pulmonary infection (PI) are the most common complications within 1 year after the transplant. (nature.com)
  • A randomized trial comparing lung-volume- reduction surgery with medical therapy for severe emphysema. (medigraphic.com)
  • Heart Transplantation Heart transplantation is the removal of a healthy heart from a recently deceased person and then its transfer into the body of a person who has a severe heart disorder that can no longer be. (msdmanuals.com)
Registry3
  • Additionally, he is active in the International Society for Heart and Lung Transplantation as part of the Advocacy Committee, and in the Pulmonary Hypertension Association, where he serves on the steering committee for the Pulmonary Hypertension Association Registry. (ucsf.edu)
  • In this chapter, we review the experience of heart and lung transplantation as reported to the Organ Procurement Transplant Network/United Network of Organ Sharing registry and investigate the factors responsible for causing failure in the first post-transplant year. (terasaki.org)
  • Author Manuscript evaluated melanoma incidence among 139,991 non-Hispanic white transplants using linked U.S. transplant-cancer registry data (1987-2010). (cdc.gov)
Complications2
Infections6
  • SARS-CoV-2 Infections among Organ Recipients tion by a nucleic acid test (NAT). (cdc.gov)
  • On September 17, 2015, the Pennsylvania Department of Health (PADOH) notified CDC of a cluster of three potentially health care-associated mucormycete infections that occurred among solid organ transplant recipients during a 12-month period at hospital A. On September 18, hospital B reported that it had identified an additional transplant recipient with mucormycosis. (cdc.gov)
  • Some recipients struggle with infections and other side effects of the drugs they must take to suppress their immune systems, or require follow-up operations. (bostonglobe.com)
  • Transplant recipients who receive immunosuppressive therapy are at increased risk for opportunistic infections. (elsevierpure.com)
  • Before the procedure, the recipient is often given antibiotics to prevent infections from developing. (msdmanuals.com)
  • In 6 clusters of organ transplant-transmitted West Nile Virus infections reported to public health agencies in the United States, 12 of 16 recipients were infected. (cdc.gov)
Procurement1
Idiopathic pulmonar2
  • A 64-year-old male underwent bilateral lung transplantation at an outside hospital in 2011 for idiopathic pulmonary fibrosis with pulmonary hypertension. (hindawi.com)
  • Coagulation factor-XII induces interleukin-6 by primary lung fibroblasts: a role in idiopathic pulmonary fibrosis? (monash.edu)
Liver transplant recipients1
  • The group included 78 kidney-transplant recipients, 12 liver-transplant recipients, 8 lung-transplant or heart-transplant recipients, and 3 pancreas-transplant recipients. (cdc.gov)
Pulmonary hypertension3
  • pulmonary hypertension - where high blood pressure develops inside the blood vessels of the lungs, which can damage both the lungs and the heart. (physio-pedia.com)
  • Nicholas Kolaitis specializes in pulmonary and critical care medicine, with a focus on lung transplantation and pulmonary hypertension. (ucsf.edu)
  • Pulmonary Hypertension Pulmonary hypertension is a condition in which blood pressure in the arteries of the lungs (the pulmonary arteries) is abnormally high. (msdmanuals.com)
20203
  • During March-May 2020, a total of 8 potential recipient) died. (cdc.gov)
  • Transplant infectious disease : an official journal of the Transplantation Society 2020 12 0. (cdc.gov)
  • Available at http://www.transplant- observatory.org/download/2016-activity-data-report/ Accessed 11 March 2020. (who.int)
Bone marrow tra1
  • They analyzed 76 samples from eight bone marrow transplant recipients. (genomeweb.com)
Post-transplant1
  • After transplantation, lymphoma is often called post-transplant lymphoproliferative disease or PTLD because this represents the full spectrum of lymphoid proliferations seen after transplantation, ranging from an infectious mononucleosis-like illness to malignant non-Hodgkin's lymphoma. (secondwindstl.org)
Tissues1
Congenital heart d1
  • In the recent period the indications are mainly congenital heart disease and Eisenmenger syndrome, with some cases of CM + PH. (unican.es)
Emphysema1
20162
20231
  • Several data collection changes for lung and heart-lung candidates will be implemented Dec. 13, 2023. (unos.org)