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  • adults
  • Now, that it has been found safe for older adults to donate their kidney, the kidney donation scenario can improve a little bit more. (medindia.net)
  • That said, it is also important to know the risks of kidney donation by older adults. (medindia.net)
  • This is not the kind of evidence that should influence guidelines about statin therapy in adults 65 and older," said Eckel, chair of atherosclerosis at the University of Colorado School of Medicine. (medicinenet.com)
  • From the antihypertensive trial data, the researchers drew a sample that included almost 3,000 adults 65 and older with high blood pressure , but no plaque buildup in the arteries that would occur due to high cholesterol . (medicinenet.com)
  • In fact, more deaths occurred in the pravastatin group than in the usual care group -- 141 versus 130 among adults 65 to 74, and 92 versus 65 among adults 75 and older. (medicinenet.com)
  • Twenty healthy older adults (60-79 years) with impaired endothelial function (brachial artery flow-mediated dilation 6%) underwent 6 weeks of oral supplementation with MitoQ (20 mg/d) or placebo in a randomized, placebo-controlled, double-blind, crossover design study. (lifeboat.com)
  • Clinically significant depressive symptomatology is common among community-dwelling older adults and is associated with deficits across multiple cognitive domains, however much of the literature has not modeled the unique effects of depression distinct from negative and low positive affect. (ku.edu)
  • Data was collected from a sample of healthy community dwelling older adults living in San Jose, Costa Rica. (ku.edu)
  • Cognitive performance of these Costa Rican older adults was similar to USage and education matched peers. (ku.edu)
  • Conclusion: Costa Rican older adults were happy, as evidenced by the high ratio of positive affect to relatively low negative affect. (ku.edu)
  • However, the structure-function relationship observed by MRE has not yet been explored in healthy older adults. (springer.com)
  • In this study, we examined the relationship between hippocampal (HC) viscoelasticity and episodic memory in cognitively healthy adults aged 66-73 years ( N = 11), as measured with the verbal-paired associates (VPA) subtest from the Wechsler Memory Scale (WMS-R). Given the particular dependence of verbal memory tasks on the left HC, unilateral HC MRE measurements were considered for the first time. (springer.com)
  • Age-related cognitive decline is a worldwide challenge, highlighting the need for safe, effective interventions that benefit cognition in older adults. (springer.com)
  • The aim of this review is to provide knowledge on the immediate effects of acute aerobic exercise on cognitive function of healthy older adults and to assess the methodological quality of studies investigating these effects. (springer.com)
  • Results from 14 of 15 studies showed that an acute bout of aerobic exercise can enhance at least one subsequent cognitive performance of healthy older adults when measured within 15 min post-exercise. (springer.com)
  • Though the self-paced step test appears to accurately estimate cardiopulmonary fitness in older adults, it is argued that stepping movements might cause orthopedics problems in knees as well as increase the fall risk to mobility-limited older adults [ 4 ]. (hindawi.com)
  • This age-related alteration has not been characterized in the lower extremity vasculature of women, and the potential for blunting of the conduit artery dilatory response to a sudden increase in shear stress [flow-mediated dilation (FMD)] has not been examined in older adults of either sex. (physiology.org)
  • In healthy older adults, we previously demonstrated impairments in two forms of response inhibition: reactive inhibition (outright stopping) and proactive inhibition (anticipatory response slowing) under high information load. (ssrn.com)
  • We aimed to address these hypotheses in 24 healthy older adults (aged 61-72 years) using fMRI in a double blind, counterbalanced, placebo-controlled, within-subject design. (ssrn.com)
  • To conclude, tyrosine negatively affected proactive response slowing and associated fronto-striatal activation in an age-dependent manner, highlighting the importance of catecholamines, perhaps particularly dopamine, for proactive response inhibition in older adults. (ssrn.com)
  • In the present study, we investigated the metabolic fate of strawberry polyphenols after chronic (90 days) supplementation of freeze-dried strawberry (24 g d −1 , equivalent to 2 cups of fresh strawberries) vs. control powder in 19 healthy older adults. (rsc.org)
  • Effects of a Fall Preventive Exercise Program on Intrinsic Fall Risk Factors in Healthy Older Adults. (clinicaltrials.gov)
  • Additional studies are needed to develop specifically tailored exercise programs for older adults that can easily be implemented into clinical practice. (clinicaltrials.gov)
  • Thus, the objective of the present trial is to assess the effects of a fall prevention program that was developed by an interdisciplinary expert panel on measures of balance, strength / power, body composition, cognition, psychosocial well-being, and falls self-efficacy in healthy older adults. (clinicaltrials.gov)
  • Discussion It is expected that particularly the supervised combination of balance and strength / power training will improve performance in variables of balance, strength / power, body composition, cognitive function, psychosocial well-being, and falls self-efficacy of older adults. (clinicaltrials.gov)
  • The purpose of this study is to determine whether healthy older adults, aged 65 to 80 years, consuming a probiotic each day for three weeks will have improved immune strength and digestive health. (clinicaltrials.gov)
  • It is hypothesized that older adults consuming the probiotics will see a shift in their microbiota towards the 'healthy' bacteria resulting in a greater proportion of immune cells, decreased inflammation, and better digestive health. (clinicaltrials.gov)
  • Methods
  • Methods: The present study used confirmatory factor analysis (CFA) and structural equation modeling (SEM) to examine the relative effects of Negative Affect, Positive Affect and Geriatric Depression on Verbal Memory, Verbal Reasoning, Processing Speed, and Working Memory in healthy aging Latinos. (ku.edu)
  • Methods/Design Healthy old people (N = 66) between the age of 65 to 80 years will participate in this trial. (clinicaltrials.gov)
  • people
  • A large clinical trial involving participants in Australia and the USA found a daily low-dose aspirin had no effect on prolonging life in healthy, elderly people. (jsonline.com)
  • Over a four-year span starting in 2010, the trial enrolled more than 19,000 people in Australia and the USA who were 70 and older, or 65 for African-American and Hispanic participants because their risks of dementia or cardiovascular disease are higher. (jsonline.com)
  • This list may be about famous people who could live to 100, but for some of these hard-working folks, 100-years-old may not even seem like a challenge. (ranker.com)
  • People 65 and older treated with pravastatin (Pravachol) as part of a major clinical trial had about the same risk of death as people in a placebo group, according to the results. (medicinenet.com)
  • Statins might even pose a risk to people 75 and older, added Han, an assistant professor of medicine and population health at New York University School of Medicine. (medicinenet.com)
  • The side effects of statins, which include muscle pains and fatigue , might weigh more heavily on older people, Han said. (medicinenet.com)
  • For example, the analysis of people 75 and older included only 375 people taking pravastatin and 351 in the control group. (medicinenet.com)
  • If you wanted to make the point that statins don't help older people and may harm them, then that would be the study you would pick to show that the hypothesis is going to fail," Rosenson said. (medicinenet.com)
  • The belief that healthy older brains are substantially smaller than younger brains may stem from studies that did not screen out people whose undetected, slowly developing brain disease was killing off cells in key areas, according to new research. (innovations-report.com)
  • In contrast to the 35 people who stayed healthy, the 30 people who declined cognitively over nine years showed a significant effect for age in the hippocampus and parahippocampal areas, and in the frontal and cingulate cortices. (innovations-report.com)
  • Daily low-dose aspirin can be of help to older people with an elevated risk for a heart attack. (scpr.org)
  • But for healthy older people, the risk outweighs the benefit. (scpr.org)
  • Results released Sunday from a major study of low-dose aspirin contain a disappointing answer for older, otherwise healthy people. (scpr.org)
  • The study involved more than 19,000 people ages 65 and older in the United States and Australia. (scpr.org)
  • But for other, healthy people, "the risks outweigh the benefits for taking low-dose aspirin," Murray says. (scpr.org)
  • But "for a long time there's been a need to establish appropriate criteria for when healthy people - elderly people - need aspirin. (scpr.org)
  • Critically ill patients with severe acid-base abnormalities have a very low likelihood of surviving their illness, but it's unclear whether more subtle changes in the body's acid-base status have an effect on the longevity of relatively healthy older people. (eurekalert.org)
  • What we found was that generally healthy older people with low levels of bicarbonate had a higher risk of death," said Dr. Raphael. (eurekalert.org)
  • While the study didn't prove cause and effect, Cyrus Cooper, director of the university's Medical Research Council Lifecourse Epidemiology Unit, said, "The link between dietary patterns and frailty in older people will open the door to effective interventions against the age-related decline in musculoskeletal function, which is such a growing cause of disability in aging populations worldwide. (upi.com)
  • Vitamin insufficiency is common amongst older people [ 1 , 2 ] and can lead to detriments to neurological function [ 3 ]. (hindawi.com)
  • For instance, suboptimal intake of vitamins and minerals including folate, vitamin B6, vitamin B12, and zinc has been associated with mild psychiatric symptoms [ 4 ] and mood disorders in older people [ 5 , 6 ]. (hindawi.com)
  • The potential for multivitamins to modify mood has been demonstrated in a meta-analysis of eight randomized controlled trials (RCTs) which indicated that multivitamin use over a period of ≥4 weeks can reduce mild symptoms of mood dysfunction in healthy people, free from clinical mood disorders [ 12 ]. (hindawi.com)
  • STEIN: So Murray and her colleagues studied more than 19,000 older people who took either a baby aspirin or a placebo every day for about five years, and the results were surprising. (kuvo.org)
  • The prevalence of obstructive sleep apnoea (OSA) increases with age, yet the risk factors for OSA in older people remain poorly understood. (ersjournals.com)
  • However, the clinical diagnosis of OSA in older people is problematic due to differences in the expression of symptoms such as excessive daytime sleepiness [ 4 ]. (ersjournals.com)
  • Improved phenotyping of OSA in older people will enable more efficient diagnosis and initiation of effective therapy. (ersjournals.com)
  • Older people could be "prescribed a dog" because it increases their physical activity by half an hour a day - especially in rainy Britain, according to new research. (hemeltoday.co.uk)
  • Lead author Dr Yu-Tzu Wu added: "We know physical activity levels decline as we age but we're less sure about the most effective things we can do to help people maintain their activity as they get older. (hemeltoday.co.uk)
  • The Scottish team said GPs should be encouraged to suggest older people get a dog or share one to encourage them to walk more. (hemeltoday.co.uk)
  • endothelial function
  • Our laboratory has shown that supplementation with the mitochondrial-targeted antioxidant MitoQ improves vascular endothelial function by reducing mitochondrial reactive oxygen species and ameliorates arterial stiffening in old mice, but the effects in humans are unknown. (lifeboat.com)
  • study
  • Kidney donation by healthy older donors is unlikely to increase their risk of death or heart disease in a meaningful way, according to a study published in the American Journal of Transplantation. (medindia.net)
  • THURSDAY, Sept. 29 (HealthDay News) -- Men over 75 with prostate cancer who are otherwise healthy are being undertreated for their condition, according to a new study. (bio-medicine.org)
  • This study suggests that men with certain medical conditions are being treated just as aggressively for their prostate cancer as men who are healthy, even though they are more likely to die of non-prostate cancer causes. (bio-medicine.org)
  • We found there was no discernible benefit of aspirin on prolonging independent, healthy life for the elderly," says Anne Murray , a geriatrician and epidemiologist at Hennepin Healthcare in Minneapolis, who helped lead the study. (scpr.org)
  • Washington, DC (January 14, 2016) -- Low blood levels of bicarbonate may indicate an elevated risk of premature death in generally healthy older individuals, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology ( CJASN ). (eurekalert.org)
  • This study will assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of MK0773 in healthy older men. (clinicaltrials.gov)
  • Thus, this study aimed to determine the effect of fasting calorie restriction (FCR) on metabolic parameters and DNA damage among healthy older adult men. (nih.gov)
  • However, this study suggests that making good dietary choices throughout adulthood -- by cutting down on highly processed foods and incorporating more fruit, vegetables and whole grains into your diet -- can have a significant beneficial effect on strength and physical performance later in life, helping to ensure a much healthier old age," Robinson said in a university news release. (upi.com)
  • The purpose of this study was to investigate the reliability and validity of a modified squat test and to establish a regression model for predicting aerobic fitness in the older adult. (hindawi.com)
  • Twenty-five healthy men aged 60 to 75 years completed this study. (hindawi.com)
  • This study investigated the effects of four weeks' multivitamin supplementation on mood in 76 healthy women aged 50-75 years. (hindawi.com)
  • In the present study, we assessed popliteal artery diameter and velocity (Doppler ultrasound) in 16 young (23 ± 1 yr) and 14 older (69 ± 1 yr) women after 5 min of distal calf occlusion (FMD), 3 min of hand immersion in ice water [cold pressor test (CPT)], and 5 min of distal calf occlusion combined with hand immersion in ice water (FMD+CPT). (physiology.org)
  • Adult
  • Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention. (nih.gov)
  • FCR improved metabolic parameters and DNA damage in healthy older adult men. (nih.gov)
  • Shortcomings are noted in currently available cardiopulmonary field tests for the older adult and thus relevant research is still ongoing. (hindawi.com)
  • The results revealed that the age-adjusted recovery HR index fitness had the highest intraclass correlation coefficients (ICC) of 0.9 and Pearson's correlation coefficients of 0.71, which suggested the modified squat test can reasonably assess cardiopulmonary fitness for the older adult. (hindawi.com)
  • Based on the characteristics of the older adult, the common test modes of field tests are stepping and walking tests. (hindawi.com)
  • 3 ] established a self-paced step test for the community-dwelling older adult, which is implemented at 40 cm height and requires stepping 20 times at different paces. (hindawi.com)
  • 5 , 6 ] developed a two-minute self-paced test involving stepping in place, which is safer for the older adult. (hindawi.com)
  • maximal
  • The GH/IGF-I axis and T levels decline markedly with aging, whereas accumulating evidence supports their indispensable role in maintaining physical function integrity.Several studies have reported that the administration of T improves lean body mass and maximal voluntary strength in healthy older men. (biomedsearch.com)
  • clinical
  • In view of this, Dr. Peter Reese, assistant professor of Medicine in Renal- Electrolyte and Hypertension Division, and director of Kidney Transplant Outcomes Clinical Research at the Perelman School of Medicine at the University of Pennsylvania, and his team set out to look into the safety of donating for older kidney donors. (medindia.net)
  • Evaluation of non-pharmacological therapies that improve autonomic control of the heart rate in older subjects has a clinical significance, because reduced heart rate variability (HRV) can be associated with higher cardiovascular morbidity and mortality rates. (bmj.com)
  • efficacy
  • Although it is clear that this combined approach is effective, this review concludes that further studies are needed to assess the long-term efficacy and safety of combined hormone replacement therapy in older men before the medical rationale of prescribing hormone replacement therapy for combating the sarcopenia of aging can be established. (biomedsearch.com)
  • risk
  • They had reported the risk of death from cardiovascular disease to be about 21 times higher in 55 to 64 year old diabetics who had undergone kidney transplantation and anywhere from 3 to 16 times in healthy older patients. (medindia.net)
  • mortality
  • This comes after earlier studies established the increased mortality rates from cardiovascular disease in older patients with successful kidney transplantation . (medindia.net)
  • investigate
  • To investigate, Kalani Raphael, MD (University of Utah) and his colleagues looked at how measurements of pH, carbon dioxide, and bicarbonate link with long-term survival in relatively healthy older individuals. (eurekalert.org)
  • assess
  • The modified squat test is a valid and reliable field test and thus can be an option to assess the cardiopulmonary fitness level of healthy older men in clinics or communities. (hindawi.com)
  • humans
  • These results confirm previous findings of diminished reactivity in the conduit arteries of older humans and provide the first evidence of reduced sympatholysis in the leg resistance vasculature of older women. (physiology.org)
  • function
  • Those who ate more fruits, vegetables and whole-grain cereals -- and fewer highly processed foods -- throughout adulthood did better on three tests of physical function in their early 60s than those with less healthy eating habits. (upi.com)
  • Hormone Replacement Therapy and Physical Function in Healthy Older Men. (biomedsearch.com)
  • affects
  • Our objective was to understand how mental health affects cognitive health in healthy aging Latinos. (ku.edu)
  • brain
  • As a result, previous findings may have overestimated atrophy and underestimated normal size for the older brain. (innovations-report.com)
  • Specifically, the team used an advanced brain-imaging technique to show that in older female - but not male - ApoE4 carriers with apparently normal cognitive skills for their age, a particular constellation of diverse brain regions that ordinarily operate in synch was showing signs of deteriorating synchronization. (stanford.edu)
  • findings
  • These findings will help inform prescribing doctors who have long been uncertain about whether to recommend aspirin to healthy patients who do not have a clear medical reason for doing so," John McNeil, head of the Department of Epidemiology and Preventive Medicine at Monash University in Australia, said in a statement. (jsonline.com)
  • To confirm the new findings, which I describe in a [[press release]], the team resorted to an independent database that contained records of another set of healthy older subjects' spinal-tap results. (stanford.edu)
  • effect
  • Accordingly, we sought to determine the effect of an acute elevation in sympathetic tone (cold pressor test, CPT) on both the ischemia-induced dilation of resistance vessels and the conduit artery response in the popliteal artery of young vs. older women, as the effect of age on lower-limb sympatholysis has not been characterized in women. (physiology.org)
  • women
  • However, few studies have focussed on healthy older women. (hindawi.com)
  • Over four weeks, subtle changes to stress produced by multivitamin supplementation in healthy older women may not be detected when only pre- and posttreatment mood is captured. (hindawi.com)
  • 0.05) in older women. (physiology.org)
  • Popliteal FMD, normalized to the shear stimulus, was attenuated by 60-70% in older women. (physiology.org)
  • In light of the above-mentioned studies ( 14 , 17 ), we hypothesized that both resistance vessel dilation and popliteal artery FMD would be blunted to a greater extent in older compared with young women, suggestive of reduced sympatholysis with age. (physiology.org)
  • individuals
  • Transplant centres everywhere should provide this new information to older individuals considering kidney donation,' noted Dr. Reese. (medindia.net)