• Asante EA , Linehan J , Desbruslais M , Joiner S , Gowland I , Wood A , BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein. (cdc.gov)
  • This study was carried out in 6 and 12 months old transgenic PLP-α-syn and WT male and female mice. (frontiersin.org)
  • Disease progression was exacerbated in APP(Swe)/PS1 mice (transgenic mice expressing a chimeric amyloid precursor protein [APPSwe] and human presenilin 1 [PS1]) harboring CCR2-deficient BMCs. (nih.gov)
  • Secondly came her revolutionary work with teratocarcinoma, and thirdly, Mintz developed the first transgenic mice-that is to say, mice with foreign (often human) DNA as part of their makeup. (nfcr.org)
  • Transgenics would later blossom into multi-million dollar industries, not only in medical science but also in animal husbandry and agriculture: Crops genetically modified to resist drought or pests are direct descendants of Mintz's work on mice in the lab. (nfcr.org)
  • Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation. (nature.com)
  • Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant. (jci.org)
  • We recently described transgenic mice that express point-mutant human K18 (Ku, N.-O., S. Michie, R.G. Oshima, and M.B. Omary. (jci.org)
  • Here we show that mutant K18 expressing transgenic mice are highly susceptible to hepatotoxicity after acute administration of acetaminophen (400 mg/Kg) or chronic ingestion of griseofulvin (1.25% wt/wt of diet). (jci.org)
  • The predisposition to hepatotoxicity results directly from the keratin mutation since nontransgenic or transgenic mice that express normal human K18 are more resistant. (jci.org)
  • Reproducible multi-stage progression to invasive squamous carcinoma of the epidermis has been achieved in transgenic mice expressing the HPV16 early-region genes, including the E6/E7 oncogenes, under the control of the human keratin-14 promoter/enhancer. (elsevierpure.com)
  • Although 100% of K14-HPV16 transgenic animals develop hyperplastic and/or dysplastic lesions in several inbred backgrounds, including C57BL/6, BALB/c, and SSIN/SENCAR, only mice backcrossed into the FVB/n background progress to malignant squamous cell carcinomas of two pathological grades, well differentiated and moderate/poorly differentiated (WDSC or MPDSC, respectively), each displaying characteristic patterns of malignant behavior. (elsevierpure.com)
  • The transition to the malignant state, in 21% of FVB/n transgenic mice, is characterized by alteration of the repertoire of keratin intermediate filament proteins expressed within neoplastic epidermis, such that WDSCs maintain expression of keratins common to terminally differentiating stratified keratinocytes (K10), whereas MPDSCs are distinguished from WDSCs by activation of embryonic and mucosal keratins (K13, K8, and K19). (elsevierpure.com)
  • This study addresses the effects of two nutraceutical compounds on the expression of COX2 and tumor-associated inflammation in human papillomavirus type 16 (HPV16)-transgenic mice. (iiarjournals.org)
  • Results: Rutin reduced COX2 expression in the dermis (immunostaining score 7.83 versus 11.25 in untreated HPV16-transgenic mice) and epidermis (4.5 versus 10.0). (iiarjournals.org)
  • To investigate the possible effects of the expression of this tightly regulated gene in vivo, we produced transgenic mice in which CD40L expression was deregulated. (nki.nl)
  • The most common transgenic animals that you will see in the world today are mice that have received genetic modifications so that they naturally produce human antibodies. (connectusfund.org)
  • Out of the 11 monoclonal antibody drugs approved by the Food and Drug Administration from 2006-2011, 7 of them were derived through the use of transgenic mice. (connectusfund.org)
  • To facilitate the study of these neurons, transgenic mice were generated that express enhanced green fluorescent protein (EGFP) in subpopulations of GABAergic neurons. (jneurosci.org)
  • Dr. Greg Enders developed TetOp16 transgenic mice which would allow for cell, tissue or organ-specific expression of p16INK4a, thereby allowing a broad control of cell proliferation in mice. (foxchase.org)
  • TetOp16 transgenic mice allow for the inducible expression of p16INK4a. (foxchase.org)
  • In these transgenic mice, the nucleic acid sequence encoding human p16INK4a has been linked to an inducible promoter or an operon capable of activation by the reverse tetracycline-controlled transactivator (rtTA), mediating p16 transcription. (foxchase.org)
  • p16 expression can be induced in a regulated fashion in the doubly transgenic mice by administering antibiotic doxycycline or tetracycline. (foxchase.org)
  • TetOp16 transgenic mice offer a way to selectively manipulate cell proliferation by allowing for temporal and spatial regulation of p16INK4a expression. (foxchase.org)
  • Fukuchi Y, Miyakawa Y, Kobayashi K, Kuramochi T, Shimamura K, Tamaoki N, Nomura T, Ueyama Y, Ito M. (1998) Cytokine dependent growth of human TF-1 leukemic cell line in human GM-CSF and IL-3 producing transgenic SCID mice. (taconic.com)
  • Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2. (bvsalud.org)
  • Here, we successfully developed a SARS-CoV-2 hACE2 transgenic mouse (HFH4-hACE2 in C3B6 mice ) infection model. (bvsalud.org)
  • It was striking that the mice which completely lacked bacteria developed much less plaque in the brain", says researcher Frida Fåk Hållenius, at the Food for Health Science Centre. (lu.se)
  • Ethics of transgenic cows - in this unit plan, students develop their knowledge of transgenics so they can formulate an argument and make ethical decisions about using transgenic cows to make medicines to treat human diseases. (sciencelearn.org.nz)
  • Transgenic Wars , a French investigative film by Paul Moreira, exposes the reality of raising transgenic crops in Argentina. (herbshealthhappiness.com)
  • The costs of meeting regulatory requirements and market restrictions guided by regulatory criteria are substantial impediments to the commercialization of transgenic crops. (nature.com)
  • Long-accepted plant breeding methods for incorporating new diversity into crop varieties, experience from two decades of research on and commercialization of transgenic crops, and expanding knowledge of plant genome structure and dynamics all indicate that if a gene or trait is safe, the genetic engineering process itself presents little potential for unexpected consequences that would not be identified or eliminated in the variety development process before commercialization. (nature.com)
  • Not only has it affected the livelihood of Argentinian farmers (transgenic crops require a reduced amount of manpower to manage them, hence many Argentinians losing their jobs), it may also be costing them their lives. (herbshealthhappiness.com)
  • The present study investigates allergenicity of osmotin protein used for developing transgenic crops. (utmb.edu)
  • This technology has made the scientific community aware of the critical role of transgenic, not only as a means of producing stress tolerant crops but also as a platform for the production of therapeutics through molecular farming. (routledge.com)
  • 3 Those reviews, which focused almost entirely on the genetic aspects of biotechnology, concluded that GM crops pose no unique hazards to human health. (cornucopia.org)
  • ‌The OECD biosafety consensus documents identify elements of scientific information used in the environmental safety and risk assessment of transgenic organisms which are common to OECD member countries and some non-members associated with the work. (oecd.org)
  • Transgenic organisms are living organisms whose genetic material has been artificially modified to introduce specific traits or characteristics. (tutorialspoint.com)
  • Transgenic organisms have become increasingly important in various fields, including agriculture, medicine, and biotechnology. (tutorialspoint.com)
  • Genetic and molecular analyses are essential in understanding the mechanisms underlying transgenesis and in evaluating the potential risks and benefits associated with the use of transgenic organisms. (tutorialspoint.com)
  • In transgenic organisms, genetic analysis is used to determine the presence and expression of the foreign DNA sequences that have been introduced into the genome. (tutorialspoint.com)
  • PCR can be used to detect the presence of the foreign DNA sequences in transgenic organisms. (tutorialspoint.com)
  • Molecular analysis involves the study of the molecular mechanisms underlying gene expression and regulation in transgenic organisms. (tutorialspoint.com)
  • The use of transgenic organisms has both potential benefits and risks. (tutorialspoint.com)
  • To evaluate the potential risks and benefits associated with the use of transgenic organisms, it is important to conduct thorough risk assessments and to carefully monitor the effects of transgenic organisms on both the environment and human health. (tutorialspoint.com)
  • Transgenic organisms have the potential to interact with wild populations and alter the ecological balance of an ecosystem. (tutorialspoint.com)
  • This can occur through gene flow, which is the transfer of genetic material from transgenic organisms to wild populations. (tutorialspoint.com)
  • This is partly because environmental risk assessment for transgenic plants is new and partly because the social context in which regulatory decisions about transgenic organisms must now be made is dramatically different from the social context in which these agencies are accustomed to working. (nationalacademies.org)
  • The Animal and Plant Health Inspection Service (APHIS) began its involvement in the regulation of transgenic organisms in the mid-1980s. (nationalacademies.org)
  • i) The virulence of the biocontrol agent must be enhanced to overcome evolutionary barriers either by mixing with synergistic chemicals or with one or more organisms, and/or by mutagenic or transgenic enhancing of virulence of the biocontrol fungus. (weizmann.ac.il)
  • Tooth loss might not alter molecular pathogenesis in an aged transgenic Alzheimer's disease model mouse. (bvsalud.org)
  • Group also seeking stronger protection for subjects of chimeric and transgenic research. (aldf.org)
  • These include unintended effects on the environment, such as the spread of transgenes to wild populations, and unintended effects on human health, such as allergic reactions to transgenic proteins. (tutorialspoint.com)
  • Using this tag, we prepared mild detergent lysates from transgenic mouse brain cortical membrane preparations and isolated a number of previously identified APP-interacting proteins. (jneurosci.org)
  • Thus, this study demonstrates that using proteomic methods on our transgenic model can uncover important in vivo APP-interacting proteins that will provide insights into the biology of APP. (jneurosci.org)
  • Thus, this study demonstrates that our transgenic model can uncover important in vivo APP-interacting proteins that will contribute to our understanding of APP processing in in vivo settings. (jneurosci.org)
  • Scientists at AgResearch in New Zealand have successfully produced healthy transgenic cows that make modified milk or human therapeutic proteins in their milk. (sciencelearn.org.nz)
  • Since 2000, scientists at AgResearch have been successfully producing transgenic cows that make modified milk or produce therapeutic proteins to treat human diseases. (sciencelearn.org.nz)
  • Find out more about Transgenic cows making modified milk and Transgenic cows making therapeutic proteins . (sciencelearn.org.nz)
  • We transformed carrot plants with Agrobacterium tumefaciens to generate plants (which can be eaten raw) transgenic for an immunodominant antigen of the measles virus, a major pathogen in man. (lih.lu)
  • These results demonstrate that transgenic carrot plants can be used as an efficient expression system to produce highly immunogenic viral antigens. (lih.lu)
  • The obtainment of transgenic edible plants carrying recombinant antigens is a desired issue in search for economic alternatives viewing vaccine production. (scielo.br)
  • HBsAg was the first viral antigen chosen to be produced in transgenic plants, firstly in tobacco [3] and subsequently in lupin callus and lettuce adapted to colder climates [4]. (scielo.br)
  • Development of transgenic crop plants, their utilization for improved agriculture, health, ecology and environment and their socio-political impacts are currently important fields in education, research, and industry and also of interest to policy makers, social activists and regulatory and funding agencies. (routledge.com)
  • This includes Biosafety Level 1 materials and transgenic animals or plants. (uwm.edu)
  • As indicated in Chapter 1 , regulatory agencies charged with assessing the safety of transgenic plants face a daunting task. (nationalacademies.org)
  • Highly Invasive Transitional Cell Carcinoma of the Bladder in a Simian Virus 40 T-antigen Transgenic Mouse Model. (cdc.gov)
  • Li G, Wang Y, Liu B, Zhang G (2014) Transgenic Bacillus thuringiensis (Bt) Rice Is Safer to Aquatic Ecosystems than Its Non-Transgenic Counterpart. (plos.org)
  • For example, if a transgenic organism has been modified to express a fluorescent protein, PCR can be used to amplify the DNA sequence encoding the protein and confirm its presence in the organism's genome. (tutorialspoint.com)
  • Transgenic animals are creatures who have had their genome altered because of the transfer of a gene or genes from another breed or species. (connectusfund.org)
  • Well, transgenics involves inserting entire DNA sequences of one organism into the genome of another. (newyorkspaces.com)
  • We generate your transgenic C. elegans lines: Extrachromosomal arrays, integrated lines or genome editing? (magnitudebiosciences.com)
  • The extra gene (transgene) is present in every cell in the transgenic cow. (sciencelearn.org.nz)
  • Gene editing technologies offer a promising alternative to the widely criticized process of transgenics. (newyorkspaces.com)
  • The data obtained on the tocopherol content demonstrate that the seed specific expression of P. frutescens (gamma)-TMT gene resulted in a dramatic change in the tocopherol composition of the transgenic soybean seed compared to wild-type seed. (usda.gov)
  • The risk assessment gave little consideration to potential health effects in infants and children, thus contravening federal pesticide law. (cornucopia.org)
  • Index of articles in the Science in Society Archive on the topic health with respect to biotechnology: eating GM food, Glyphosate, transgenic mosquitos etc. (i-sis.org.uk)
  • If we think at all about biotechnology, most of us probably focus on direct threats to human health, such as prospects for converting pathogens to biologic weapons or the implications of new technologies for editing the human germline. (cornucopia.org)
  • Secondly, the epidemic of an apparently new animal prion disease, BSE, in the UK has raised legitimate public concerns of a risk to human health from eating infected tissues. (europa.eu)
  • High fiber diet has been frequently reported to be beneficial for maintaining the health of colon tissues. (nova.edu)
  • 3) To estimate the efficacy of the species barriers limiting transmission of BSE and scrapie to humans to address the risk to public health within the EU posed by BSE and other animal prion diseases. (europa.eu)
  • We will develop and evaluate transgenic mouse, cell culture and in vitro models which, as well as allowing an experimental estimation of the risks of transmission of BSE to humans and a complete assessment of the transmission characteristics and phenotypic range of the human prion diseases, should provide the tools to study the mechanisms and pathways of prion neurodegeneration. (europa.eu)
  • In its 2017 report to the EPA, AgResearch noted that it still has around 40 transgenic cows in its Waikato containment facility. (sciencelearn.org.nz)
  • Transgenic animals make it possible for scientists to study the functioning of particular genes at the level of the entire organism. (connectusfund.org)
  • Ethical frameworks and transgenics activity - use ethical frameworks to explore some of the ethical issues raised by using transgenic cows to produce medicines to treat human diseases. (sciencelearn.org.nz)
  • Role-play ethics and transgenics activity - in this activity, students use role playing to explore different stakeholders' perspectives on the issue of using transgenic cows to make medicines to treat human diseases. (sciencelearn.org.nz)
  • Five years after the first meeting at the Faculty of Medical Sciences of Córdoba, we - scientists, doctors and members of health teams from sprayed villages of Argentina -gathered in the Aula Magna of the Faculty of Medicine of the University of Buenos Aires (UBA), to verify that what we said then is emphatically true and getting worse by the day. (i-sis.org.uk)
  • A workshop cosponsored by the National Institute of Environmental Health Sciences and the studies and/or human reports (Table 1). (cdc.gov)
  • However, there are also potential risks associated with the use of transgenics. (tutorialspoint.com)
  • There has still been no commercial release of these lines yet due to public concerns about human health and environmental risks. (plos.org)
  • However, the safety certificates did not lead to final commercial release because there were fierce public debates on the health and environmental risks of Bt rice [6] . (plos.org)
  • New Zealanders need to weigh up the risks and benefits associated with transgenic cows and decide what they consider to be acceptable. (sciencelearn.org.nz)
  • The present analysis is designed to facilitate additional improvements in the APHIS system, which will be necessary to meet future challenges of assessing potential environmental risks of a large number of diverse and novel transgenic products. (nationalacademies.org)
  • Nobody knows what risks they pose to people's health and the environment. (newmediaexplorer.org)
  • Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. (cdc.gov)
  • The Lund University Transgenic Core Facility (LUTCF) is a core resource whose primary goal is to deliver most up-to-date methodologies in transgenic technology to both our researchers and external users. (lu.se)
  • Transgenic Research. (wikipedia.org)
  • Our research institute gratefully acknowledges funding from the Dutch Ministry of Health, Welfare and Sport, the Dutch Cancer Society, and individual donors. (nki.nl)
  • The pros and cons of transgenic animals often try to balance the ethics of treating an animal appropriately with the potential benefits that the research can produce. (connectusfund.org)
  • Researchers can take advantage of three common methods of producing transgenic animals for their research. (connectusfund.org)
  • One of the aims of the research programme is to show that transgenic cows pass on their transgenes to subsequent generations. (sciencelearn.org.nz)
  • Applications for transgenic research are open to the public for comment, and all applications are considered in consultation with Māori. (sciencelearn.org.nz)
  • The future of transgenic cow research in New Zealand depends upon funding, regulations and public opinion. (sciencelearn.org.nz)
  • AgResearch received approval in 2010 to extend its transgenic cow research. (sciencelearn.org.nz)
  • Temple Health refers to the health, education and research activities carried out by the affiliates of Temple University Health System (TUHS) and by the Lewis Katz School of Medicine at Temple University. (foxchase.org)
  • It was a big issue about objectification of the body when it is a health problem but also part of the scientific research. (helsinkidesignweek.com)
  • 1999. Arsenic: health effects, mechanisms of actions, and research issues. (cdc.gov)
  • The research is a result of an international collaboration between Associate Professor Frida Fåk Hållenius and doctoral student Nittaya Marungruang, both at the Food for Health Science Centre in Lund, and a research group at the Ecole Polytechnique Federale de Lausanne in Switzerland. (lu.se)
  • Moreover, GMOs didn't take long to target health issues controversies and negative backlash from nutrition advocates. (newyorkspaces.com)
  • Most facilities still use the first method, and then the transgenic animals are mated to ensure that their offspring acquire the desired genetic profile. (connectusfund.org)
  • The tremendous impact generated by genetic engineering and consequently of transgenic now allows us to manipulate plant genomes at will. (routledge.com)
  • Some transgenic animals are produced for their specific economic traits. (connectusfund.org)
  • Transgenic techniques are discussed for developing resistance to newly emerging diseases, pests, nutrient- and water-use efficiency, root traits, and improved tolerance to increasing temperature. (routledge.com)
  • Health Perspect 111:579-583 (2003). (cdc.gov)
  • However, testing your compounds for impact on environmental and human health can lead to overly complex, ethically challenging and time-consuming studies with animal models. (magnitudebiosciences.com)
  • Transgenic animal mutagenicity assays. (who.int)
  • [3] Dietary supplements marketed as antioxidants have not been shown to maintain health or prevent disease in humans. (wikipedia.org)
  • Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. (cdc.gov)
  • Researchers use ear tags and microchips to identify transgenic cows and their calves. (sciencelearn.org.nz)
  • 2. There are three different methods available to use to create transgenic animals. (connectusfund.org)
  • New Zealand has very strict regulations for working with transgenic animals. (sciencelearn.org.nz)
  • Explore the ethics of generating transgenic animals. (sciencelearn.org.nz)
  • Transgenic bovine cells are selected and fused with bovine oocytes that have had all of their chromosomes removed. (sciencelearn.org.nz)
  • Ethics of modifying cows with human genes activity - in this activity, students explore different stakeholders' perspectives on using transgenic cows to make medicines and weigh up the consequences, both benefits (pluses) and harms (minuses). (sciencelearn.org.nz)
  • APHIS's regulatory process has never led to the release of a transgenic plant that clearly caused environmental damage. (nationalacademies.org)
  • In addition, there seems to be no doubt that the IVM can induce a more responsible use of insecticides, conditioning it to a more accurate evaluation of economic and environmental costs, always appraised by the benefit estimates for the public health(6,9). (bvsalud.org)
  • The implications of the discovery, later to be dubbed "transgenics," were earthshaking-literally creating whole new oncology disciplines and venues of study. (nfcr.org)
  • The study identified an interesting link between certain bacteria in the gut and important aspects of bone health such as strength, density and composition. (medicaldaily.com)
  • 9. Stewart R, Stenman U, Hakeberg M, Hägglin C, Gustafson D, Skoog I. Associations between oral health and risk of dementia in a 37-year follow-up study: the prospective population study of women in Gothenburg. (bvsalud.org)
  • Making a transgenic cow is a multi-step process. (sciencelearn.org.nz)
  • Together with medical, epidemiological, ethical, and practical considerations, economic considerations are also taken into account in the allocation process of health care resources. (scielo.br)
  • Our transgenics process: Simple, efficient, reliable. (magnitudebiosciences.com)