Hbeag virus replication. Medical search. Frequent questions

HBeAg is an antigen that can be found between the icosahedral nucleocapsid core and the lipid envelope (the outer most layer of the hepatitis b virus). (wikipedia.org)
While both HBeAg and HBcAg are made from the same reading frame (multiple protein products can be produced from the same DNA sequence and when the genes "ORF Core" and "Pre C" are translated together, the result is HBeAg), HBeAg is secreted and accumulates in serum as an immunologically distinct soluble antigen. (wikipedia.org)
During the initial phase of infection, patients are also seropositive for hepatitis B e antigen (HBeAg). (apollohospitals.com)
Treatment of adult patients with chronic hepatitis B associated with evidence of hepatitis-B viral replication (presence of DNA of hepatitis-B virus (HBV-DNA) and hepatitis-B antigen (HBeAg), elevated alanine aminotransferase (ALT) and histologically proven active liver inflammation and / or fibrosis. (europa.eu)
Over time, we observed substantial decreases in the prevalence of HBV e antigen (HBeAg) and increasing prevalence of the precore G1899A mutation and HBV-DNA levels in HBeAg-positive patients. (cdc.gov)
We obtained patients' age and sex and assessed platelet count, cirrhosis status, HBV e antigen (HBeAg) and HB e antibody (anti-HBe) status, HBV genotype, HBV DNA level, basal core promoter mutations, and precore stop codon mutations. (cdc.gov)
A third antigen, the HBeAg is found in the soluble forms in virus-positive sera and is related to the core antigen. (virology-online.com)
Hepatitis D infection can only occur with a concomitant infection with Hepatitis B virus because the Hepatitis D virus uses the Hepatitis B virus surface antigen to form a capsid. (findmeacure.com)
The presence of antibody against hepatitis B viral e antigen is used as an indicator for (1) early HBs antigenemia before the peak of viral replication and (2) early convalescence when HBeAg has declined below detectable levels. (bioneovan.com)
There are a number of blood tests to diagnose and monitor people with Hepatitis B, which primarily focus on detecting the Hepatitis B surface antigen, HBsAg, a toxic substance on the surface of the virus that prompts the immune system to produce antibodies to fight the infection. (theswaddle.com)
During the initial phase of infection, patients also test positive for the antigen, HBeAg. (theswaddle.com)
Use of hepatitis B virus core-related antigen to evaluate natural history of chronic hepatitis B. J Gastroenterol Hepatol. (rjptonline.org)
Analysis of clinical and virologic features in Hepatitis B e Antigen (HbeAg)-negative and HbeAg-positive Egyptian chronic hepatitis B patients. (rjptonline.org)
The hepatitis e antigen, or HBeAg, is a marker of an actively replicating HBV virus infection. (orderwithme.com)
The virus was formerly and anilines referred to as Australian antigen. (researchwap.com)
Temprano participants were tested for hepatitis B surface antigen (HBsAg), which indicates HBV infection, and those who tested positive received hepatitis B 'e' antigen (HBeAg) tests and HBV DNA viral load tests to determine if there was ongoing active viral replication. (hivandhepatitis.com)
From January 2010 to December 2013, data from 179 treatment-naive patients with CHB who were hepatitis B e antigen (HBeAg)-positive and had visited the first affiliated hospital of Wenzhou Medical University were assessed. (biomedcentral.com)
Blood, body fluids, and secretions also contain HBe antigen ( HBeAg ), sharing a part of the common protein structure with HBcAg (some mutant strains do not produce HBeAg). (empendium.com)
The aim of this study is to determine the efficacy of lamivudine in the prevention of recurrent HBV infection after a course of HBIG in patients who were hepatitis B surface antigen (HBsAg) positive and hepatitis Be antigen (HBeAg) negative before OLT. (elsevierpure.com)
The virus was not discovered until 1965 when Baruch Blumberg , then working at the National Institutes of Health (NIH), discovered the Australia antigen (later known to be Hepatitis B surface antigen, or HBsAg) in the blood of Australian aboriginal people. (wikidoc.org)
These particles are not infectious and are composed of the lipid and protein that form part of the surface of the virion, which is called the surface antigen ( HBsAg ), and is produced in excess during the life cycle of the virus. (wikidoc.org)
Also, the following tests should be used to monitor people with HBV at least annually, according to WHO: alanine aminotransferase (ALT) level, AST (for APRI), hepatitis B surface antigen (HBsAg), Hepatitis B e antigen (HBeAg), and HBV DNA levels, where HBV DNA testing is available. (aacc.org)
for nonimmune persons, disease transmission from a needlestick exposure is up to 100 times more likely for exposure to hepatitis B e antigen (HBeAg)--positive blood than to HIV-positive blood (14). (cda.org)
In patients who are positive for hepatitis B e antigen (HBeAg-positive patients) without cirrhosis, treatment should be continued - for at least 6-12 months after confirmed BeAg seroconversion (i.e. (who.int)
HBV) DNA loss with d detection of antibodies against HBeAg) or - until Hepatitis B surface antigen (HBsAg) seroconversion or - until loss of efficacy (see section 4.4). (who.int)
A functional cure, or hepatitis B virus (HBV) surface antigen (HBsAg) loss, is difficult to achieve in patients with hepatitis B virus e antigen (HBeAg)-positive chronic hepatitis B. The HBV vaccine and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been reported to help reduce HBsAg levels and promote HBsAg loss. (xiahepublishing.com)
Prior to the initiation of ART, all patients who test positive for hepatitis B surface antigen (HBsAg) should be tested for hepatitis B virus (HBV) deoxyribonucleic acid (DNA) using a quantitative assay to determine the level of HBV replication. (medscape.com)

Chronic infection is accompanied by the persistence of HBsAg for at least 6 months (with or without concurrent HBeAg). (apollohospitals.com)
OBI could be due to mutant viruses undetectable by HBsAg assays or a strong suppression of viral replication and gene expression under the pression of the host immune system. (bvsalud.org)
The Predictive Value of Baseline HBsAg Level and Early Response for HBsAg Loss in Patients with HBeAg-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment[J]. Biomedical and Environmental Sciences, 2017, 30(3): 177-184. (besjournal.com)
Serum HBV DNA and serological indicators (HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. (besjournal.com)
Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. (besjournal.com)
A positive HBsAg test result means that you are infected and can spread the hepatitis B virus to others through your blood. (orderwithme.com)
In the HBsAg-positive group, 14% were also HBeAg-positive and the median HBV DNA level was 523 copies/mL, with 27% being above a cut-off of 7000 copies/mL. (hivandhepatitis.com)
The risk of vertical mother-to-child transmission without interventions (see Chronic Hepatitis B ) is ~90% for HBeAg-positive mothers and ~10% for HBeAg-negative HBsAg-positive mothers. (empendium.com)
Thirty HBsAg-positive, HBeAg-negative patients underwent OLT from January 1993 to June 1997. (elsevierpure.com)
These results suggest that lamivudine administered after a posttransplantation course of HBIG can effectively prevent the recurrence of HBV infection in patients who are HBsAg positive and HBeAg negative before OLT. (elsevierpure.com)
Fucus fucoidan helps to reduce serum HBV, HBsAg and HBeAg levels. (anculife.com)
Chronic HBV infection can be classified into five phases: (I) HBeAg-positive chronic infection, (II) HBeAg-positive chronic hepatitis, (III) HBeAg-negative chronic infection, (IV) HBeAg-negative chronic hepatitis and (V) HBsAg-negative phase. (biomedpharma-sy.com)
The induction of long-term suppression of HBV replication represents the main endpoint of current treatment strategies, while HBsAg loss is an optimal endpoint. (biomedpharma-sy.com)
The aims of this thesis were to develop methods for genotyping and resistance mutation analysis, to investigate the impact of genotypes on clinical outcome, and to investigate the role of the regulation of viral transcripts for replication and HBsAg production. (gu.se)
Patients negative for HBeAg had 2.15 log lower levels of cccDNA in liver tissue, 4.84 log lower serum levels of HBV DNA and 1.45 log lower serum levels of HBsAg, than HBeAg-positive patients. (gu.se)
In patients with HBeAg-positive chronic hepatitis B and seroconversion after nucleot(s)ide analog treatment, immunomodulatory/antiviral treatment regimens effectively improved HBsAg loss, and the regimen including GM-CSF and HBV vaccination was most effective. (xiahepublishing.com)

In contrast, patients with early HBV infection have a prolonged immune tolerance phase and a prolonged immune clearance phase, indicating that their diseases tend to progress after HBeAg seroconversion. (hepatitisprohelp.com)
The seroconversion from HBeAg positivity to anti-HBe positivity indicates a reduced level of infectious virus because virus replication has decreased. (bioneovan.com)
Loss of HBeAg and appearance of anti-HBe in serum is called seroconversion, which is an important clinical event in the course of HBV disease. (medscape.com)
Seroconversion is associated with a lower level of HBV DNA or a low replicating state of the virus. (medscape.com)
HBeAg seroconversion was not associated with liver function tests, modes of transmission, duration of chronicity, marital status, gender and age. (rjptonline.org)
Multivariate regression analysis demonstrated that dyslipidemia (OR = 1.993, Ρ = 0.038) and male gender (OR = 2.317, Ρ = 0.029) were risk factors associated with HBeAg seroconversion. (biomedcentral.com)
During antiviral therapy, dyslipidemia affects HBeAg seroconversion in CHB patients treated with NAs, but does not affect the virological response. (biomedcentral.com)
Following HBeAg seroconversion, certain patients exhibit a low replication phase, which is characterized by normal serum ALT concentration and minimal liver histological changes, suggesting slower liver damage [ 4 ]. (biomedcentral.com)
Thus, seroconversion is utilized as the target in HBeAg-positive CHB patients. (biomedcentral.com)
By week 144, two patients had experienced HBeAg seroconversion. (gilead.com)
Is it necessary to delay antiviral therapy for 3-6 months to anticipate HBeAg seroconversion in patients with HBeAg-positive chronic hepatitis B in endemic areas of HBV genotype C? (e-cmh.org)
Spontaneous HBeAg seroconversion occurs frequently in the immune reactive phase in HBeAg-positive chronic hepatitis B (CHB). (e-cmh.org)
However, HBeAg seroconversion occurs infrequently in patients infected with hepatitis B virus (HBV) genotype C. The aim of the present study was to determine whether the waiting policy is necessary in endemic areas of HBV genotype C infection. (e-cmh.org)
Only one patient (1.1%) achieved spontaneous HBeAg seroconversion. (e-cmh.org)
Spontaneous HBeAg seroconversion in patients with HBeAg-positive CHB is rare within 6 months. (e-cmh.org)
During the natural course of CHB infection, spontaneous HBeAg seroconversion, defined as loss of HBeAg and detection of anti-HBe in a person who was HBeAg positive and anti-HBe negative, 4 occurred frequently in the immune reactive phase in patients with HBeAg-positive CHB ranging from 2-17% per year depending on serum alanime aminotranferase (ALT) levels. (e-cmh.org)
13 , 22 , 23 Therefore, in HBeAg-positive CHB patients with elevated serum ALT, most guidelines recommend observation for 3-6 months before antiviral therapy to anticipate spontaneous HBeAg seroconversion. (e-cmh.org)
However, spontaneous HBeAg seroconversion occurred infrequently in patients with genotype C compared to those with other genotypes. (e-cmh.org)
In HBeAg negative patients without cirrhosis treatment should be continued - at least until HBs seroconversion or - until there is evidence of loss of efficacy. (who.int)
A total of 287 patients with HBeAg positive chronic hepatitis B and seroconversion after nucleot(s)ide analog treatment were assigned randomly to three treatment groups for 48 weeks, TDF alone (control), PEGIFN-α2b + TDF, and PEGIFN-α2b + TDF + GM-CSF + HBV vaccine. (xiahepublishing.com)

hepatitis B virus (HBV) DNA levels and alanine aminotransferase (ALT) levels before and after YMDD mutation were measured. (zju.edu.cn)
HA410 trade name] is indicated for the treatment of chronic hepatitis B in adults with: · compensated liver disease and evidence of immune active disease, i.e. active viral replication, persistently elevated serum alanine aminotransferase (ALT) levels and histological evidence of active inflammation and/or fibrosis. (who.int)

The virus remains infectious for prolonged periods on environmental surfaces and is transmissible in the absence of visible blood ( 1 ). (cdc.gov)
this means the person infected with Hepatitis B can likely transmit the virus on to another person (i.e. the person is infectious). (wikipedia.org)
HBeAg is dispensable for replication, as mutant viruses with defects in the pre-C region are both infectious and pathogenic. (wikipedia.org)
The presence of HBeAg indicates that the blood and body fluids of the infected individual are highly infectious. (metromaleclinic.com)
HBeAg usually indicates a high level of replication of the virus, signifying that the blood and bodily fluids of that person are highly infectious. (theswaddle.com)
HBV can be present in hepatocytes in two forms: as replicating virus, leading to production of infectious particles, or as a nonreplicative form after integrating into the host DNA. (medscape.com)
Those with a positive HBeAg have active replication in their liver cells, more of the virus circulating in their blood, and as a result, they are more infectious, with a higher likelihood of transmitting HBV to others. (orderwithme.com)
In particular, HBeAg reflects active replication of hepatitis B virus, with the presence of a solid infectious state. (biomedcentral.com)
Management of Hepatitis B Virus Infection: 2018 Guidelines from the Canadian Association for the Study of Liver Disease and Association of Medical Microbiology and Infectious Disease Canada. (empendium.com)
Hepatitis B is an infection caused by the hepatitis B virus (HBV), which is transmitted through percutaneous (i.e., breaks in the skin) or mucosal (i.e., direct contact with mucous membranes) exposure to infectious blood or body fluids. (cda.org)
The virus is also environmentally stable, remaining infectious on environmental surfaces for at least 7 days (16). (cda.org)
SLIDE 2] Viral Hepatitis: Historical Perspective Before the discovery of hepatitis A virus (HAV) and hepatitis B virus (HBV) during the 1960s and 1970s, patients with viral hepatitis were classified based on epidemiologic studies as having either infectious (transmitted person to person by the fecal-oral route) or serum (transmitted by transfusion of blood products) hepatitis. (cdc.gov)
When diagnostic tests for hepatitis A virus (HAV) and hepatitis B virus (HBV) infection were developed, HAV was found to be the major cause of infectious hepatitis and HBV was found to be the major cause of serum hepatitis. (cdc.gov)

Persons with chronic hepatitis B virus (HBV) infection are at increased risk for liver cancer and cirrhosis and are 70%-85% more likely to die prematurely than the general population ( 1 - 4 ). (cdc.gov)
A potentially life-threatening liver infection, Hepatitis B is caused by the Hepatitis B virus which can result in chronic infection to the point of high risk of death from cirrhosis and liver cancer. (apollohospitals.com)
In some cases, the virus can also cause a chronic liver infection that can develop into cirrhosis of the liver or liver cancer . (apollohospitals.com)
Chronic carriers have an increased risk of developing liver disease such as cirrhosis or liver cancer, because the hepatitis B virus steadily attacks the liver. (findmeacure.com)
Chronic infection with Hepatitis B virus may be either asymptomatic or may be associated with a chronic inflammation of the liver (chronic hepatitis), leading to cirrhosis over a period of several years. (findmeacure.com)
887,000 died that year of liver cirrhosis (scarring) and primary liver cancer caused by the Hepatitis B virus. (theswaddle.com)
Approximately 400 million individuals are infected with hepatitis B virus (HBV) globally [ 1 , 2 ] and 1 million patients die annually due to HBV-associated complications, such as liver cirrhosis and hepatocellular carcinoma [ 3 , 4 ]. (hindawi.com)
Chronic Hepatitis B(CHB) is a serious sequel after Hepatitis B Virus infection, although the rate of chronicity is inverse with age but it may be associated with a significant proportion of deaths related to cirrhosis and liver cancer. (rjptonline.org)
More than 75% of cirrhosis and hepatocellular carcinoma in the Region is attributable to hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. (who.int)
Hepatitis B virus (HBV) is the most common cause of chronic liver disease including liver cirrhosis and hepatocellular carcinoma. (e-cmh.org)
2 , 3 , 4 , 5 The potent antiviral treatment in patients with CHB can suppress the viral replication and prevent progression to cirrhosis, hepatic failure and HCC. (e-cmh.org)
The Phase 2 clinical study for 2158 is a multi-center, randomized, placebo-controlled trial in treatment-naïve patients with HBeAg positive or HBeAg negative chronic hepatitis B infection without cirrhosis. (biospace.com)

Proposed cutoffs for consideration for antiviral therapy is 100,000 copies/mL or 20,000 IU/mL in HbeAg-positive patients with chronic hepatitis and 10,000 copies/mL or 2,000 IU/mL in HbeAg-negative patients. (medscape.com)
Loss of detectable HBV DNA by a solution phase hybridization assay is an earlier indicator of response to antiviral therapy than loss of HBeAg. (medscape.com)
Ninety patients with HBeAg-positive CHB were followed prospectively without administering antiviral therapy for 6 months. (e-cmh.org)

Hepatitis B is a liver disease caused by the hepatitis B virus that ranges from an acute mild illness lasting for a few weeks to a serious chronic illness that can eventually lead to liver disease or cancer. (healthywomen.org)
Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). (metromaleclinic.com)
Causes:T he disease is caused by the hepatitis B virus (HBV) that attacks the liver. (findmeacure.com)
it is caused by the Hepatitis B virus. (theswaddle.com)

Serum assessments, blood biochemistry, HBV serological markers, HBV DNA before treatment and HBeAg serological conversion and virological responses at different timepoints after treatment were compared between the two groups. (biomedcentral.com)

HBeAg refers to a high viral replication and associated with more infectivity to others. (rjptonline.org)
HBeAg and HBV DNA are markers of intense viral replication and high infectivity of the patient. (empendium.com)

People who develop antibody in response to vaccination are protected from both acute and chronic hepatitis if they experience an exposure to these viruses after vaccination. (healthywomen.org)
It has been demonstrated that antineutrophil cytoplasmic antibody (ANCA) positivity could be detected in many cases of vasculitis associated with viruses. (hindawi.com)
anti-HBs or HBsAb (Hepatitis B surface antibody) - A "positive" or "reactive" anti-HBs (or HBsAb) test result indicates that a person is protected against the hepatitis B virus. (orderwithme.com)

HBeAg is a hepatitis B viral protein, produced by the HBcAg reading frame. (wikipedia.org)

There was significant association between HBeAg serostatus and HBV-DNA viral load (p=0.042), as more than half of the cases (55.6%) had high levels of HBV serum DNA (=2000 IU/ml) and positive HBeAg compared to 24.7% of cases with negative HBeAg. (rjptonline.org)
The aim of this study was to evaluate the impact of biofield modality on hepatitis B virus (HBV) and hepatitis C virus (HCV) in terms of viral load as surrogate marker. (longdom.org)

The virus spreads through blood and other body fluids, and attacks liver cells. (theswaddle.com)

HBeAg is considered a marker for cccDNA replication. (wikipedia.org)
Hence the reason why the presence of both proteins together acts as a marker of viral replication, and why antibodies to these antigens are a marker of declining replication. (wikipedia.org)
The presence of HBeAg in the serum of patients can serve as a marker of active replication in chronic hepatitis. (wikipedia.org)
HBeAg is usually a marker of high levels of replication of the virus. (metromaleclinic.com)

Hepatitis B virus (HBV) testing plays an important role in detection, classification, and management of HBV disease . (medscape.com)

These viruses are involved in the etiopathogenesis of ANCA positive vasculitis [ 7 - 15 ]. (hindawi.com)
Dusheiko G. Treatment of HBeAg positive chronic hepatitis B:interferon or nucleoside analogues. (besjournal.com)
What does it mean to be HBeAg positive? (orderwithme.com)
Patients at high risk for recurrent HBV infection (HBeAg positive and HBV DNA positive) were excluded. (elsevierpure.com)
In the final study, real-time PCR was used to analyse the levels of cccDNA and viral RNA in biopsies and cell lines with focus on differences between HBeAg positive and negative stage. (gu.se)

Hepatitis B is a double-stranded DNA virus and prototype member of the hepadnaviridae family. (longdom.org)
The HBV is an enveloped virus in the family Hepadnaviridae with a circular and partially double-stranded DNA genome of approximately 3.2 kbp in length. (biomedcentral.com)
The hepatitis B virus is responsible for causing hepatitis B. HBV is a double stranded DNA virus belonging to the family Hepadnaviridae . (wikidoc.org)

Hepatitis B virus (HBV) replication is dependent on the activity of its reverse transcriptase, an error-prone enzyme, which results in the accumulation of genomic mutations. (cdc.gov)
Replication involves a reverse transcriptase. (virology-online.com)
Lamivudine is a nucleoside analogue and reverse transcriptase inhibitor used in the therapy of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infection. (nih.gov)

HBeAg is the soluble component of the core, with is released during active infection. (slideserve.com)

Three factors were significantly associated with HBeAg status: an increased prevalence of anti-HBe (p = 0.004) and increased prevalence of precore G1896A (p = 0.003) and G1899A (p = 0.019) mutations. (cdc.gov)
Multivariate analysis showed that patient age and changes in the prevalence of HBeAg were independent of each other (adjusted p = 0.025 and 0.021, respectively). (cdc.gov)
However, multivariate analysis that included G1730C, HBeAg, and age showed that the changing prevalence of G1730C was not independent of HBeAg and age (adjusted p = 0.222, 0.049, and 0.027, respectively). (cdc.gov)
These data indicate that the decreasing prevalence of HBeAg was not due to the increasing age of treatment-naive patients but due to an authentic phenotypic change of HBV over the years. (cdc.gov)
High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil. (cdc.gov)
In this study, the prevalence rate, associated risk factors and genetic diversity of hepatitis C virus (HCV) infection were determined among people who use crack from an international drug trafficking route in Central-West, Brazil. (cdc.gov)
Opportunistic testing of people at risk of hepatitis B virus infection should be undertaken, particularly for people born in intermediate- and high-prevalence countries, and Aboriginal and Torres Strait Islander people ( 1 ). (hepatitisb.org.au)

Lamivudine is a nucleoside analogue capable of inhibiting HBV replication. (elsevierpure.com)

4334 has a best-in-class preclinical profile with single-digit nanomolar potency against the production of new virus, as well as the formation of covalently closed circular DNA (cccDNA). (biospace.com)
[ 5 ] yet they cannot clear the replication template of HBV ie covalently closed circular DNA. (medscape.com)

Although the rate of acute hepatitis B virus (HBV) infections have declined approximately 89% during 1990-2011, from 8.5 to 0.9 cases per 100,000 population in the United States, the risk for occupationally acquired HBV among HCP persists, largely from exposures to patients with chronic HBV infection. (cdc.gov)
The hepatitis viruses all cause acute inflammation of the liver, and some infections related to hepatitis B and C may become chronic. (healthywomen.org)
All of the hepatitis viruses can cause acute hepatitis, which, in adults, usually resolves on its own over time. (healthywomen.org)
Hepatitis A is an acute liver disease caused by the hepatitis A virus that lasts for a few weeks to a few months. (healthywomen.org)
Overview of Acute Viral Hepatitis Acute viral hepatitis is diffuse liver inflammation caused by specific hepatotropic viruses that have diverse modes of transmission and epidemiologies. (msdmanuals.com)
Symptoms of the acute illness caused by the virus include liver inflammation, vomiting, jaundice , and rarely, death. (findmeacure.com)
Acute infection with hepatitis B virus is associated with acute viral hepatitis - an illness that begins with general ill-health, loss of appetite, nausea, vomiting, body aches, mild fever, dark urine, and then progresses to development of jaundice. (findmeacure.com)
[ 1 ] However, HbeAg testing is indicated primarily during follow-up of chronic infection rather than acute infection because of its variable level during the acute phase. (medscape.com)

Hepatitis D virus (HDV) is an incomplete virus that when co-infected with hepatitis B virus (HBV) can cause disease that is more severe and can lead to fulminant hepatic necrosis. (medscape.com)

Hepatitis A virus (HAV) and hepatitis E virus (HEV) are important causes of maternal infections in endemic regions, and HEV can be associated with considerable maternal morbidity and mortality. (medscape.com)
In such cases, antiviral drug therapy imposes an iatrogenic selection pressure on HBV, and the selected viruses carrying mutations can cause infections. (cdc.gov)
Chronic hepatitis B virus (HBV) and hepatitis D virus (HDV) infections are major causes of liver disease and hepatocellular carcinoma worldwide. (mdpi.com)
Children less than 6 years of age who become infected with the hepatitis B virus are the most likely to develop chronic infections. (metromaleclinic.com)
Outbreak of hepatitis B and hepatitis C virus infections associated with a cardiology clinic, West Virginia, 2012-2014. (cdc.gov)
OBJECTIVE: To stop transmission of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in association with myocardial perfusion imaging (MPI) at a cardiology clinic. (cdc.gov)
Pathogenesis of virus infections. (rjptonline.org)
But of interest is one Repatitis virus - one of the most common infections diseases, causing an estimated 1.5millon deaths world wide each year - Hepatitis B. Hepatitis B is caused by the Repatitis B virus (HBV), a double - stranded circular DNA virus of complex structure. (researchwap.com)
Globally, an estimated 71 million people were living and 31% of deaths from chronic HCV infections are attrib- with chronic hepatitis C virus (HCV) infection, utable to a history of injection drug use. (who.int)
More detailed information regarding the epidemiologic features and prevention measures for hepatitis B are presented in two previously published slide sets: 1) "Elimination of hepatitis B virus transmission in the United States: routine childhood vaccination," and 2) "Prevention of perinatal and early childhood hepatitis B virus infections in the United States," both of which are available from the National Technical Information Service (800-CDC-1824). (cdc.gov)

The core protein allosteric modulators (CpAMs) have shown great potential as highly effective antiviral drugs against hepatitis B virus (HBV) in preclinical studies and clinical trials. (bvsalud.org)
It also implies clinical improvement and can help predict long-term clearance of the virus. (medscape.com)
Unique features of hepatitis b virus-related hepatocellular carcinoma in pathogenesis and clinical significance. (rjptonline.org)
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. (empendium.com)
EASL Clinical Practice Guidelines on hepatitis E virus infection. (empendium.com)
Another investigation showed that fucus fucoidan may assist in inhibiting HBV replication both in laboratory and clinical trials by contributing to the activation of the EKR signaling pathway and by supporting increased interferon production. (anculife.com)
SOUTH SAN FRANCISCO, Calif., Sept. 01, 2021 (GLOBE NEWSWIRE) -- Assembly Biosciences , Inc. (Nasdaq: ASMB), a clinical-stage biotechnology company developing innovative therapeutics targeting hepatitis B virus (HBV), today announced its decision to discontinue development of ABI-H2158 (2158) following the observation of elevated ALT levels consistent with drug-induced hepatotoxicity in an ongoing Phase 2 trial. (biospace.com)
Assembly Bio is a clinical-stage biotechnology company committed to bringing finite and curative therapies to the 270 million people living with hepatitis B virus (HBV) worldwide. (biospace.com)

Treatment only suppresses the replication of the virus and hence most patients who start treatment must continue it for life. (apollohospitals.com)
We examined the characteristic changes of hepatitis B virus (HBV) in antiviral drug treatment-naive patients referred for pretreatment evaluation in Taiwan during 2008-2012. (cdc.gov)
In conclusion, our findings underscore the potential of QL-007 as an effective agent against HBV replication and introduce it as a novel CpAM for the antiviral treatment of chronic hepatitis B. (bvsalud.org)
In addition to these compounds, the Company's medicine BARACLUDE ® (entecavir) is approved for the treatment of chronic hepatitis B (CHB) in adults with evidence of active viral replication and either evidence of persistent elevations in aminotransferases (ALT or AST), or histologically active disease. (aol.com)
People with HIV and hepatitis B virus (HBV) coinfection have more than double the risk of death if they have ongoing high-level HBV replication, indicating a need for prompt treatment, according to an analysis from the Temprano trial presented at an HIV and viral hepatitis coinfection session at the 21st International AIDS Conference (AIDS 2016) last month in Durban. (hivandhepatitis.com)
Current studies suggest that dyslipidemia affects the antiviral efficacy of hepatitis C virus (HCV) therapies, while recent studies suggest that serum lipids influence the response rates of chronic hepatitis B (CHB) patients receiving PEGylated interferon-alpha (Peg IFN-α) treatment. (biomedcentral.com)
BOSTON, Oct 28, 2003 (BUSINESS WIRE) -- Gilead Sciences (Nasdaq:GILD) today announced that treatment with its once-daily, oral antiviral agent Hepsera(R) (adefovir dipivoxil 10 mg) was associated with sustained reductions in levels of hepatitis B virus (HBV) DNA through 144 weeks (approximately three years) among patients chronically infected with lamivudine-resistant HBV and co-infected with HIV. (gilead.com)
In the United States, Hepsera is indicated for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease. (gilead.com)
The World Health Organization (WHO) recently released its first-ever guidelines for treatment of hepatitis B virus (HBV), which affects 240 million people worldwide and results in approximately 650,000 deaths per year, predominantly in low- and middle-income countries. (aacc.org)
HA410 trade name] is indicated in combination with other antiretroviral medicinal products for the treatment of human immunodeficiency virus (HIV-1) infection in patients weighing 30 kg or more. (who.int)

evidence of lamivudine-resistant hepatitis B virus. (who.int)
I. Malmström S, Hannoun C, Lindh M. (2007) Mutation analysis of lamivudine resistant hepatitis B virus strains by TaqMan PCR. (gu.se)

Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. (zju.edu.cn)

Large numbers of virus particles are detectable in feces during the incubation period, beginning as early as 10-14 days after exposure. (slideserve.com)

More than 90% of healthy adults who contract hepatitis B virus recover naturally from the virus within the first year. (apollohospitals.com)
Hepatitis A Hepatitis A is caused by an enterically transmitted RNA virus that, in older children and adults, causes typical symptoms of viral hepatitis, including anorexia, malaise, and jaundice. (msdmanuals.com)
More than 95% of people who become infected as adults or older children will stage a full recovery and develop protective immunity to the virus. (findmeacure.com)

Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years. (rjptonline.org)
The S-RNA/pgRNA ratio was higher in HBeAg-negative patients, which may reflect specific down-regulation of pgRNA, or enhanced S-RNA production. (gu.se)
All patients with HBV/HIV coinfection must be assessed for hepatitis A virus (HAV) immunity and vaccinated if negative. (medscape.com)

Relationship Between Serum DNA Replication, Clinic opathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy. (besjournal.com)

New Phase 2 data on an investigational triple direct-acting antiviral (DAA) regimen of daclatasvir (NS5A replication complex inhibitor), asunaprevir (NS3 protease inhibitor) and BMS-791325 (NS5B non-nucleotide polymerase inhibitor) in patients with hepatitis C (HCV) genotypes 1a and 1b. (aol.com)
[1] The virus is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes presented on its envelope proteins and ten genotypes (A-J) according to overall nucleotide sequence variation of the genome . (wikidoc.org)

A pioneer in the development of a new class of potent, oral core inhibitor drug candidates, Assembly Bio's approach aims to break the complex viral replication cycle of HBV to free patients from a lifetime of therapy. (biospace.com)

Since HBeAg is produced only during replication of the virus, it can also be used to indirectly determine the state of HBV in the hepatocyte. (medscape.com)

to check the knowledge presented by the nursing staff on the mode of transmission of hepatitis B virus (HBV) and the resulting damage to human health and to identify the knowledge of the nursing staff on prevention measures used to avoid occupational infection by this virus and, further, to investigate the immunization situation of the nursing staff against HBV. (bvsalud.org)
Because HDV infection is dependent on HBV for replication, immunization to prevent HBV infection, through either pre- or postexposure prophylaxis, can also prevent HDV infection. (cdc.gov)

The prevention of recurrent hepatitis B virus (HBV) infection after orthotopic liver transplantation (OLT) with hepatitis B immunoglobulin (HBIG) is expensive and requires indefinite parenteral administration. (elsevierpure.com)
Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation. (zju.edu.cn)

Mylan Laboratories Ltd.), HA410 · compensated liver disease and evidence of immune active disease, i.e. active viral replication, persistently elevated serum ALT levels and histological evidence of active inflammation and/or fibrosis. (who.int)
Malmström S, Larsson SB, Hannoun C, Lindh M. Hepatitis B virus RNA levels in human liver biopsies and in transfected and non-transfected hepatoma cell lines. (gu.se)

We concluded that HBeAg sero-negativity among the studied cases can predict the inactive or reactive phase of chronic hepatitis B, if the latter is associated with high viral loads, so that further studies are needed to find out associated precore mutants. (rjptonline.org)
There is a 2.5-times higher mortality in patients with HBV DNA greater than 7000 copies/mL enrolled in the Temprano trial,' the investigators concluded, recommending that, 'Early ART needs to be provided to all HIV infected-patients and especially to coinfected patients with high HBV replication. (hivandhepatitis.com)

HBeAg may be generated from the core protein by proteolytic cleavage. (virology-online.com)
HBeAg is a non-structural protein that is encoded by the pre-C/C gene. (biomedcentral.com)

Infection with hepatitis B virus (HBV) is an important cause of liver disease and affects 350 million people worldwide, causing 600,000 deaths/year. (gu.se)

The virus is transmitted through blood and bodily fluids that contain blood.This can occur through direct blood-to-blood contact, unprotected sex, and illicit drug use. (findmeacure.com)

Chronic hepatitis B virus (HBV) infection can lead to substantial morbidity and mortality. (cdc.gov)
Higher mortality in HIV-HBV co-infected persons with elevated HBV replication in the Temprano Trial. (hivandhepatitis.com)

Hepatitis C virus (HCV) infection disproportionately affects people who inject drugs and men who have sex with men, but data on female sex workers (FSW) are limited. (who.int)

This chapter discusses who should be tested for hepatitis B virus (HBV) infection, and details the specific tests for HBV infection and the interpretation of test results. (hepatitisb.org.au)

Anatomy18

Organisms87

Diseases15

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes64

Information Science4

Health Care2

Antigen27

HBsAg16

Seroconversion20

Alanine aminotransferase2

Infectious13

Cirrhosis12

Antiviral therapy3

Caused by the Hepatitis B vir4

Serological markers1

Infectivity2

Antibody3

HBcAg1

Viral load2

Body fluids1

Marker4

Detection1

Positive5

Hepadnaviridae3

Reverse transcriptase3

Soluble1

Prevalence7

Nucleoside1

Covalently closed circular2

Acute8

Infected with hepatitis B vir1

Infections10

Clinical8

Treatment10

Lamivudine-resistant hepatitis B vir2

Mutations1

Particles1

Adults3

Negative3

Prognosis1

Genotypes2

Aims1

Hepatocyte1

Immunization2

Recurrent2

Levels2

High2

Protein2

Liver disease1

Blood and bodily fluids1

Mortality2

Affects1

Tested for hepatitis B vir1