[ 16 ] Just like the prototype member of the IL-12 family of cytokines, IL-23 is a heterodimer that consists of a unique p19 subunit plus the p40 subunit that it shares with IL-12 (Figure 1). (medscape.com)
So GPP case reports describe the use of ustekinumab, which targets the shared p40 subunit of IL-12 and IL-23, and an open-label phase 3 study has also reported treatment success in 7 of 9 patients with GPP receiving guselkumab, which specifically targets IL-23 by binding to the unique p19 subunit. (medscape.com)
Alpha subunit2
Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40 subunit. (wikipedia.org)
The RUNX genes encode the alpha subunit of the transcription factor PEBP2/CBF. (nih.gov)
Protein8
Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. (wikipedia.org)
IL-23 is a heterodimer composed of the disulfide-linked p19 protein and p40 protein, expressed by activated dendritic cells. (thermofisher.com)
The beta subunit consists of the non-RUNX protein PEBP2beta. (nih.gov)
The PKI protein binds directly to the catalytic subunit of PKA acting as a pseudo-substrate to cause PKA kinase inhibition. (cupidpeptides.com)
8) Ascl1-induced neuronal differentiation of P19 cells requires expression of a specific inhibitor protein of cyclic AMP-dependent protein kinase . (cupidpeptides.com)
18. Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms. (nih.gov)
Arrows point at induced proteins: 19 kDa periplasmic protein (p19), alkyl hydroperoxide reductase (AhpC), Superoxide dismutase (Fe) (SodB), Thioredoxin-disulfide reductase (TrxB), hypothetical protein (Cj0706), and molybdenum cofactor biosynthesis protein (MogA). (hdac-inhibitors.com)
Guselkumab is a biological agent that binds to the p19 subunit protein of interleukin (IL)-23 and selectively inhibits IL-23 signaling. (biomedcentral.com)
Neuronal differentiation4
Recently a requirement for PKIbeta and its inhibition of PKA (but not PKIalpha or PKIgamma isoforms) has been shown during neuronal differentiation of P19 cells suggesting other factors influence the system (8). (cupidpeptides.com)
2008. Mechanism of acetylcholine-induced calcium signaling during neuronal differentiation of p19 embryonal carcinoma cells in vitro. (plataforma-cpe.org)
2008. Pharmacological properties of purinergic receptors and their effects on proliferation and induction of neuronal differentiation of p19 embryonal carcinoma cells. (plataforma-cpe.org)
2007. P19 embryonal carcinoma cells as in vitro model for studying purinergic receptor expression and modulation on h-methyl-d-aspartate-glutamate and acetylcholine receptors during neuronal differentiation. (plataforma-cpe.org)
Interleukin2
It is one of the two subunits of the cytokine Interleukin-23. (wikipedia.org)
The IL-12p40, also known as Interleukin 12 subunit beta, is used by both IL-23 (where it partners with IL-23p19) and IL-12 (where it partners with IL-12A). (wikipedia.org)
20001
In 1998, the channel subunits that underlie the M-current were identified as members of the voltage-gated Kv7 (KCNQ) potassium channel family ( Jentsch, 2000 ). (jneurosci.org)
Genes3
A computational search for IL-12 homologue genes found p19, a gene that encodes a cytokine chain. (wikipedia.org)
Especially noteworthy is the high acid stress response of p19 gene compared with the other genes. (hdac-inhibitors.com)
The regulator Oxymatrine Fur was included in the qRT-PCR study because a search of putative Fur-regulated genes indicated that genes involved in iron-transport genes such as p19, cj0178, ceuB, cfrA, chuA, exbB, feoB and cfhuA and the iron-storage genes such as dps, ferritin (cft) and cj0241 all contained Fur box promoters [37]. (hdac-inhibitors.com)
Heterodimeric cytokine1
IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. (thermofisher.com)
Heterodimer2
Experimental work revealed that p19 formed a heterodimer by binding to p40, a subunit of IL-12. (wikipedia.org)
IFN-γ signaling), STAT-1 or IL-12p35 (i.e., the unique subunit of the heterodimer IL-12) are more susceptible to EAE and CIA. (medscape.com)
Inhibitor1
[ 3 ] And a phase 3 trial is ongoing in Japan to evaluate the efficacy and safety of another IL-23 p19 inhibitor, risankizumab, in patients with generalized pustular psoriasis. (medscape.com)
Proteins1
11. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. (nih.gov)
Subcellular2
Here we present a high-throughput workflow based on sequential cell fractionation to profile the global proteome and phospho-proteome dynamics across six distinct subcellular fractions. (nature.com)
This maturation of firing properties may in part be explained by the recruitment of voltage-gated Na + channels and K + channels to distinct subcellular microdomains ( Kim and Rutherford, 2016 ). (eneuro.org)
Experimental1
Knockout mice deficient in either p40 or p19, or in either subunit of the IL-23 receptor (IL-23R and IL12R-β1) develop less severe symptoms of experimental autoimmune encephalomyelitis (EAE) and inflammatory bowel disease highlighting the importance of IL-23 in the inflammatory pathway. (wikipedia.org)
Gene expression2
Although all different types of human cells share the same genome, their gene expression is spatially and temporally distinct. (molcells.org)
[ 33 ] Evidence that Th-17 cells really constitute a unique subset, distinct from the classical Th-1 and Th-2 cells, is also provided by the findings that Th-1- and Th-2-committed cells are resistant to proliferation towards the Th-17 phenotype and the production of IL-17 induced by IL-23 stimulation in vitro . (medscape.com)
2008. Role of acetylcholine receptors in proliferation and differentiation of p19 embryonal carcinoma cells. (plataforma-cpe.org)
Domains1
The NPM molecule contains distinct domains 17 that account for its multiple biochemical functions ( Figure 1A ). (haematologica.org)
For specific neutralization of IL-23 only, please see clone G23-8 (anti-mouse IL-23 p19). (thermofisher.com)
Enhancers are associated with chromatin modifications that are distinct epigenetic features in a tissue-specific manner. (molcells.org)
GHD in adults is recognized as a distinct clinical syndrome that encompasses reduced psychological well-being and specific metabolic abnormalities. (medscape.com)
Role1
Navβ4 subunits, which are proposed to play a key role in mediating I NaR elsewhere in the nervous system, were immunolocalized to the first heminode where spikes are generated in the auditory nerve, and to perisomatic nodes of Ranvier. (eneuro.org)
Members1
19. Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors. (nih.gov)