Multiple myelomaHematopoieticTransplantGranulocyte colonyTransplantsHSCTProgenitorMobilizationHigh-dose chemotherapyMarrowTumor cellsCancersPerson'sInvolvesSyngeneicTypicallyDifferentiateDonationLeukemiaDonorImmune systemVialChemotherapy or radiationInfusionPatient'sCountsMalignantDisordersHemoglobinInfectionsCytotoxicHealthyRadiationPatientFoundSuccessfulWhiteResultGrowthHumanRemainsMakeSourcesForm
Multiple myeloma3
- Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as any blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma. (wikipedia.org)
- Autologous stem cell transplant (ASCT) remains an important option for eligible multiple myeloma (MM) patients as part of initial therapy. (bvsalud.org)
- [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
Hematopoietic19
- 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
- CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
- 4 CD34 expression is historically related to hematopoietic cells and it is considered as the marker of HSCs. (bdbiosciences.com)
- For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
- The BD ® Stem Cell Enumeration (SCE) Kit provides simultaneous enumeration of viable dual-positive CD45+/CD34+ hematopoietic stem cell populations in CD34+ absolute counts (cells/µL) as well as the percentage of the total viable leucocyte count that is CD34+ (%CD34). (bdbiosciences.com)
- Studies suggest that PBSCT has a better outcome in terms of the number of hematopoietic stem cell (CD34+ cells) yield. (wikipedia.org)
- Immature hematopoietic stem cells in the circulating blood that are similar to those in the bone marrow are collected by apheresis from a donor (PBSC collection). (wikipedia.org)
- The administered hematopoietic stem cells then migrate to the recipient's bone marrow, through a process known as stem cell homing, where the transplanted cells override the previous bone marrow. (wikipedia.org)
- The history of hematopoietic stem cell transplantation is marked by remarkable milestones. (revistadehematologia.org.mx)
- 1957). This pioneering work laid the foundation for the exploration of hematopoietic stem cells and their role in treating diseases of the blood and immune system. (revistadehematologia.org.mx)
- At the time they performed the first transplants surprisingly little was known about hematopoietic stem cells, immune responses to transplants or the complex human leucocyte antigen system. (revistadehematologia.org.mx)
- This was the first report of a hematopoietic stem cell transplantation (HSCT) conducted in Mexico, only 4 years after the pioneer work by E. Donnall Thomas in Cooperstown, New York, USA (Ruiz-Argüelles et al. (revistadehematologia.org.mx)
- Changes in the sources and handling of hematopoietic stem cells were introduced. (revistadehematologia.org.mx)
- 1987). Umbilical cord blood was recognized as an alternative source of hematopoietic stem cells (Gluckman et al. (revistadehematologia.org.mx)
- 1989). Hematopoietic stem cells could be harvested easier from peripheral blood after mobilization with G-CSF (Sheridan et al. (revistadehematologia.org.mx)
- 1992). Since then, hematopoietic stem cells, with their unique ability to differentiate into various blood cell types, have proven to be a revolutionary tool in the treatment of numerous hematological disorders. (revistadehematologia.org.mx)
- Blood cancer' is the umbrella term used for a variety of malignant diseases of the blood-forming (hematopoietic) system. (dkms.org)
- Bone marrow also contains immature blood-forming stem cells known as hematopoietic stem cells, or HSCs. (medicaljump.com)
- Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
Transplant5
- An early example of a successful peripheral stem cell transplant was carried out in the wake of the 1999 Tokaimura nuclear accident. (wikipedia.org)
- In April 1960, Dr. Álvaro Gómez-Leal, presented during the first meeting of the Agrupación Mexicana para el Estudio de la Hematología, A.C., data on a transplant of allogeneic stem cells in a patient with acute leukemia done in Monterrey, Mexico: the patient received high-dose chemotherapy followed by stem cells from the bone marrow of his brother, improving and obtaining remission for months but relapsing and subsequently died. (revistadehematologia.org.mx)
- A total of 5548 patients were identified, 3111 autologous stem cell transplant (ASCT) patients and 2437 non-ASCT. (bvsalud.org)
- A bone marrow transplant replaces your damaged stem cells with healthy cells. (medicaljump.com)
- Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
Granulocyte colony3
- 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
- Granulocyte colony stimulating factor (GCSF) are naturally occurring glycoproteins that stimulate white blood cell proliferation. (wikipedia.org)
- Filgrastim (recombinant methionyl human granulocyte-colony stimulating factor) is produced by r-DNA technology in E. coli (K12). (medicines.org.uk)
Transplants2
- Below, you will find answers to frequently asked questions about DKMS, bone marrow and blood stem cell donation, transplants, and fundraising efforts. (dkms.org)
- Autologous transplants involve the use of a person's own stem cells. (medicaljump.com)
HSCT4
- this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
- The successful application of HSCT for diseases such as leukemia, lymphoma, myeloma, and inherited blood disorders underscored its broad applicability in clinical practice (Snowden et al. (revistadehematologia.org.mx)
- The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
- This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
Progenitor5
- 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
- Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
- Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
- Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)
- The mobilisation and apheresis procedures should be performed in collaboration with an oncology-haematology centre with acceptable experience in this field and where the monitoring of haematopoietic progenitor cells can be correctly performed. (medicines.org.uk)
Mobilization2
- This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
- Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
High-dose chemotherapy1
- Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
Marrow10
- 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
- PBSCT is now a much more common procedure than its bone marrow harvest equivalent due to the ease and less invasive nature of the procedure. (wikipedia.org)
- This allows the bone marrow to recover, proliferate and continue producing healthy blood cells. (wikipedia.org)
- Cells from the patient's sister's bone marrow were administered, and in the following weeks successfully began dividing and differentiating into white blood cells. (wikipedia.org)
- Bone Marrow Transplantation. (wikipedia.org)
- Dr. George Mathé explored the transplantation of bone marrow cells from healthy donors to treat patients accidentally irradiated at high dose, expanding the possibilities of this life-saving technique (Mathé et al. (revistadehematologia.org.mx)
- Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
- This procedure involves transplanting blood stem cells, which travel to the bone marrow where they produce new blood cells and promote growth of new marrow. (medicaljump.com)
- The HSC found in the bone marrow will make new blood cells throughout your lifespan. (medicaljump.com)
- Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (medscape.com)
Tumor cells1
- With succeeding generations of tumor cells, differentiation is typically lost, growth becomes less regulated, and tumors become less responsive to most chemotherapeutic agents. (wikidoc.org)
Cancers2
- All blood cancers involve the degeneration of certain blood cells, which multiply uncontrollably and suppress the healthy blood-forming system. (dkms.org)
- Therefore, in the 1940s, several patients with advanced lymphomas (cancers of certain white blood cells) were given the drug by vein, rather than by breathing the irritating gas. (wikidoc.org)
Person's1
- a condition that occurs when there is not enough hemoglobin in a person's blood. (thewomenofhope.org)
Involves1
- Since allogeneic PBSCT involves transformation of blood between different individuals, this naturally carries more complications than autologous PBSCT. (wikipedia.org)
Syngeneic1
- citation needed] The transplantation may be autologous (an individual's own blood cells), allogeneic (blood cells donated by someone else with matching HLA), or syngeneic (blood cells donated by an identical twin). (wikipedia.org)
Typically2
- The apheresis procedure typically lasts for 4-6 hours, depending on the blood volume of the donor. (wikipedia.org)
- They typically involve harvesting your cells before beginning a damaging therapy to cells like chemotherapy or radiation. (medicaljump.com)
Differentiate1
- However, these stem cells are unspecialized, meaning they have the potential to multiply through cell division and either remain stem cells or differentiate and mature into many different kinds of blood cells. (medicaljump.com)
Donation1
- The increase in white blood cell proliferation as a result of the Filgrastim ensures a better results from the donation. (wikipedia.org)
Leukemia2
- What is blood cancer/leukemia? (dkms.org)
- As chemotherapy affects cell division, tumors with high growth fractions (such as acute myelogenous leukemia and the aggressive lymphomas , including Hodgkin's disease ) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time. (wikidoc.org)
Donor3
- For example, calculations must be made to ensure consistency in the amount of total blood volume between the donor and recipient. (wikipedia.org)
- If the total blood volume of the donor is less than that of the recipient (such as when a child is donating to an adult), multiple PBSCT sessions may be required for adequate collection. (wikipedia.org)
- Healthy stem cells can come from a donor, or they can come from your own body. (medicaljump.com)
Immune system1
- a protein that is present in the blood, made by cells of the immune system to fight infection. (thewomenofhope.org)
Vial1
- Each vial contains 30 million units (MU)/300 micrograms (µg) of filgrastim in 1 ml (0.3 mg/ml). (medicines.org.uk)
Chemotherapy or radiation1
- In such cases, stem cells can be harvested, or grown, before you start chemotherapy or radiation treatment. (medicaljump.com)
Infusion1
- Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
Patient's1
- However, several weeks later, the cells were found to have been mutated by the radiation still present within the patient's body, and were observed carrying out autoimmune responses. (wikipedia.org)
Counts2
- 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
- During a military operation in World War II, a group of people were accidentally exposed to mustard gas and were later found to have very low white blood cell counts. (wikidoc.org)
Malignant2
- Cancer is the uncontrolled growth of cells coupled with malignant behavior: invasion and metastasis . (wikidoc.org)
- Unfortunately, scientists have yet to identify specific features of malignant and immune cells that would make them uniquely targetable (barring some recent examples, such as the Philadelphia chromosome as targeted by imatinib ). (wikidoc.org)
Disorders2
- This helps your body make enough white blood cells, platelets, or red blood cells to avoid infections, bleeding disorders, or anemia. (medicaljump.com)
- Rising demand for biosimilars in different therapeutic applications such as rheumatoid arthritis and blood disorders. (tapanray.in)
Hemoglobin1
- Hemoglobin is a substance in the red blood cells that enables the blood to transport oxygen through the body. (thewomenofhope.org)
Infections1
- This prevents the blood from performing vital functions, such as fighting infections, transporting oxygen or stopping bleeding. (dkms.org)
Cytotoxic1
- As these drugs cause damage to cells they are termed cytotoxic . (wikidoc.org)
Healthy1
- Those healthy cells are then stored and used in transplantation. (medicaljump.com)
Radiation1
- The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Patient1
- The company highlighted: "With the launch of Zarxio, we look forward to increasing patient, prescriber and payor access to filgrastim in the US by offering a high-quality, more affordable version of this important oncology medicine. (tapanray.in)
Found1
- Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
Successful1
- This breakthrough, for which Dausset was awarded the Nobel Prize in Physiology or Medicine in 1980, opened the door to safer and more successful organ and stem cell transplantation. (revistadehematologia.org.mx)
White1
- It was reasoned that an agent that damaged the rapidly growing white blood cells might have a similar effect on cancer. (wikidoc.org)
Result1
- 5 An incorrectly high result could lead to an infusate with less than the recommended threshold dose of CD34+ cells. (bdbiosciences.com)
Growth2
- This means that other fast dividing cells such as those responsible for hair growth and for replacement of the intestinal epithelium (lining) are also often affected. (wikidoc.org)
- Drugs affect "younger" tumors (i.e. more differentiated) more effectively, because mechanisms regulating cell growth are usually still preserved. (wikidoc.org)
Human1
- The work of Jean Dausset, whose discovery of the human leukocyte antigen (HLA) system revolutionized our understanding of tissue compatibility for transplantation (Dausset J, 1958). (revistadehematologia.org.mx)
Remains1
- Everyone who registered with Delete Blood Cancer remains on file with DKMS and on the national registry. (dkms.org)
Make1
- Most cells are already differentiated and can only make copies of themselves. (medicaljump.com)
Sources1
- Single-platform flow cytometric absolute cell counting protocols have been shown to provide increased robustness of CD34 enumeration by limiting potential sources of imprecision. (bdbiosciences.com)
Form1
- Filgrastim is a synthetic form of GCSF produced in E.coli. (wikipedia.org)