• Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. (nih.gov)
  • Spleen tyrosine kinase (Syk), a tyrosine kinase that regulates B cell function and innate immunity, has been implicated in the pathogenesis of chronic inflammation and tissue repair. (elsevierpure.com)
  • Inhibition of spleen tyrosine kinase attenuates fibrous airway obliteration following allograft transplant in a mouse intrapulmonary transplant model of obliterative bronchiolitis. (elsevierpure.com)
  • As an upstream signature component of FcεRI signaling, inhibition of spleen tyrosine kinase (Syk) abrogated the IgE-induced HASM proliferation. (harvard.edu)
  • By analyzing the PC variations in the RS group, significantly lower numbers of PCs were detected in the spleens of patients who received rituximab before splenectomy (P=0.0004). (elsevierpure.com)
  • The classical monocytes were mobilized from the host spleen, and splenectomy attenuated the recruitment of classical monocytes as well as the entry of neutrophils into injured lung tissue, which was associated with improved graft function. (wustl.edu)
  • A 63-year-old man presents to the emergency room with a ruptured spleen and an emergency splenectomy was done. (cap.org)
  • abstract = "A retrospective review was performed to determine the utility of selective spleen scintigraphy (SSS) in the evaluation of equivocal defects on liver/spleen (LS) image. (elsevierpure.com)
  • recommended daily allowance}, abstract = { In this study the determination of micro mineral elements (selenium, iron and zinc) in meat, spleen and liver of beef were carried out. (undip.ac.id)
  • The cellular populations of the spleen were analyzed by immunohistochemistry. (elsevierpure.com)
  • When human progenitor populations from spleen, bone marrow and cord blood were employed as a source of progenitors for co-culture above splenic stromal lines, myelopoiesis was supported. (edu.au)
  • If spleen cell populations from mice stressed twice daily for 8 days were depleted of macrophages and CD4 or CD8 cells. (elsevierpure.com)
  • Our results suggest that MZ macrophage populations are particularly sensitive to persistent low-level IFN-γ-mediated inflammation and thatBrucellainfection could reduce the ability of the spleen to perform certain MZM- and MMM-dependent tasks, such as antigen delivery to lymphocytes and control of systemic infection. (unamur.be)
  • The findingssupport the hypothesis that G-CSF mobilizes two distinct stem cell populations, one from the bone marrow andthe other from the spleen. (fliphtml5.com)
  • The spleen is known as an important filter for blood-borne pathogens that are trapped by specialized macrophages in the marginal zone (MZ): the CD209+MZ macrophages (MZMs) and the CD169+marginal metallophilic macrophages (MMMs). (unamur.be)
  • The spleen is infiltrated by macrophages with engorged cytoplasm, which has a 'crinkled tissue paper' appearance-due to accumulation of glucocerebroside. (cap.org)
  • We herein report the outcomes of four cases of LA spleen-preserving distal pancreatectomy (Warshaw technique [WT]) in living pancreas donors. (elsevierpure.com)
  • Many of the morphological changes characteristic of primary myelofibrosis typically seen in the bone marrow are also seen in the spleen. (cap.org)
  • Today, Glenn is not only alive, but a 2012 biopsy at Harvard confirmed that his bone marrow contains no leukemic cells. (scienceblogs.com)
  • After 8 wk, the spleen cells of these athymic, bone marrow-reconstituted chimeras contain Thy-1 + precytolytic T lymphocytes (CTL) that are able to respond to antigen only if supernatant from Con A-activated T cells is added to culture. (mssm.edu)
  • CD19-Cre spleen infection by intraperitoneal virus was also impaired. (ucp.pt)
  • In addition, the abnormal shaped red blood cells cause damage to the spleen, an organ that helps fight against infection (4). (bartleby.com)
  • Does hepatic graft weight affect the reduction of spleen size after living donor liver transplantation? (tmu.edu.tw)
  • Objective Our aim was to evaluate whether the reduction in spleen volume at 6 months after living donor liver transplantation (LDLT) was affected by the size of the right lobe liver graft. (tmu.edu.tw)
  • Dive into the research topics of 'Does hepatic graft weight affect the reduction of spleen size after living donor liver transplantation? (tmu.edu.tw)
  • A detailed comparison of different types of ceramic nanoparticles has found that those made of silica can efficiently transport therapeutic genes to the spleen and trigger a potent immune response capable of attacking tumors. (news-medical.net)
  • Both duplicate receptors are expressed in peripheral tissues (gills, heart, intestine and muscle), immune tissue (spleen) and also in the central nervous system. (umn.edu)
  • Unfortunately, as an organ the spleen gets no respect, Even so, its presence or absence should be checked. (blogspot.com)
  • Harvard University's Wyss Institute of Biological Inspired Engineering has created organs on chips that contain human cells grown in a state of the art system to mimic the structure and functions of human organs and organ systems. (bitesizevegan.org)
  • Uniquely low ADC of spleen allows differentiating IPASs from pancreatic NETs. (johnshopkins.edu)
  • The spleen also uniquely contributes toGraft Versus Host Disease (GVHD) complete B cell memory [11]. (fliphtml5.com)
  • Might it be the doctors who, in the course of removing your spleen, decode a few cells and turn them into a patented product? (google.com)
  • Most of the cells were brain cells, but they also studied liver, heart and spleen cells from one donor. (alleninstitute.org)
  • Murine spleen has been shown to harbour stromal cells that support hematopoiesis with production of myeloid antigen-presenting cells. (edu.au)
  • Spleen cells of mice stressed for 14 days showed a decreased mitogenesis when depleted HI adherent cells and reconstituted with adherent cells from control mice, Further more, the adherent cells from these mice had decreased ability to support mitogenesis of adherent cell‐depleted spleen cells from control mice as well as a decreased IL‐1 production. (elsevierpure.com)
  • Therefore, MuHV-4 had to emerge lytically from B cells to colonize the spleen. (ucp.pt)
  • The modified virus was able to colonize a first wave of B cells in lymph nodes but spread poorly to B cells in secondary sites such as the spleen. (ucp.pt)
  • Hereditary Spherocytosis is a condition that is passed down from parent to child and it affects the red blood cells and the spleen" (Genetics Home Reference). (bartleby.com)
  • Spherocytosis causes the red blood cells to change shape, therefore making it difficult to move through the spleen (Wint). (bartleby.com)
  • However over time little pieces of their membranes are removed when the cells pass through the spleen. (bartleby.com)
  • We evaluated spleens (n = 26), appendices (n = 10) and branchial cleft cysts (n = 6) for TdT-positive cells in pediatric patients. (haematologica.org)
  • In spleen, appendix and branchial cleft cysts the range of TdT-positivity was 0-13, 0-96 and 0-6 TdT+ cells/hpf, respectively. (haematologica.org)
  • In spleens, scattered TdT+ cells were seen most frequently in periarteriolar lymphoid sheath regions. (haematologica.org)
  • Citation: Mera T, Heimfeld S, Faustman DL (2014) The Spleen Contributes Stem Cells to Peripheral Blood Stem Cell Transplants. (fliphtml5.com)
  • We hypothesize that the reason why CD34+-enriched PBSCTsare not more effective is because the enrichment and purification process leaves out G-CSF-mobilized stem cells fromanother source, the spleen, which holds a unique reservoir of Hox11+ stem cells. (fliphtml5.com)
  • The stem cells of the spleen allow for full maturation of immature transitional B cells into naive B cells. (fliphtml5.com)
  • Further studies revealed that when spleen cells from these thymectomized chimeras were stimulated with Con A, they produced normal levels of interleukin 2. (mssm.edu)
  • Objective: Although the liver-to-spleen volume ratio (LSVR) based on CT reflects portal hypertension, its prognostic role in cirrhotic patients has not been proven. (korea.ac.kr)
  • Objectives: To evaluate and compare the accuracy of absolute apparent diffusion coefficient (ADC) and normalised ADC (lesion-to-spleen ADC ratio) in differentiating pancreatic neuroendocrine tumour (NET) from intrapancreatic accessory spleen (IPAS). (johnshopkins.edu)
  • Lesion to spleen ADC ratio of ≥1.25 was 80.4% sensitive, and 81.8% specific while ratio of ≥1.29 was 74.5% sensitive and 100% specific in the differentiation. (johnshopkins.edu)
  • Both absolute-ADC and normalised-ADC (lesion-to-spleen ADC-ratio) demonstrate high accuracy in differentiating IPASs from NETs. (johnshopkins.edu)
  • The 2 groups were compared at 6 months after LDLT for mean postoperative spleen volume (SV) and mean SV change ratio 5, which was defined as [(SVpreop - SV6m)/SVpreop] × 100%, where SVpreop and SV6m represent SV calculated based on CT examinations preoperatively and at 6 month follow-up after LDLT, respectively. (tmu.edu.tw)
  • AARSTAD, HJ , Thiele, DL & SELJELID, R 1991, ' The Effect of Various Contexts of Stress on the Mouse Spleen Lymphocytes and Macrophage Co‐stimulatory Activity ', Scandinavian Journal of Immunology , vol. 33, no. 4, pp. 461-472. (elsevierpure.com)
  • The center's director, Christopher Walsh , M.D., Ph.D., and other scientists at Harvard Medical School and Boston Children's Hospital used those mutations to decode the early history of human development, looking all the way back to eight-cell and even two-cell embryos. (alleninstitute.org)
  • We recognized in the course of that epilepsy work that these mutations occur ubiquitously," said Walsh, who is also a neurologist and geneticist at Boston Children's Hospital and Harvard Medical School and an investigator of the Howard Hughes Medical Institute. (alleninstitute.org)
  • August 10, 2011 - This is the story as told by a trio of physicians at Partners HealthCare System and Harvard Medical School. (blogspot.com)
  • Harvard Medical School researchers are working on a new, simpler way to distinguish malignant tumors from non-cancerous masses when screening for breast cancer. (news-medical.net)
  • The Body MRI Fellowship at Beth Israel Deaconess Medical Center is a Harvard Medical School-affiliated, one-year advanced subspecialty program designed to prepare fellows to become expert diagnostic consultants and practitioners in the field of Body MRI. (bidmc.org)
  • ROESCH, J & BRET, J 1962, ' [Our experiences with arteriography of the spleen in the diagnosis of spleen diseases] ', Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin , vol. 97, pp. 239-255. (elsevierpure.com)
  • During the late phase ofBrucellainfection, we observed a loss of both MZMs and MMMs, with a durable disappearance of MZMs, leading to a reduction of the ability of the spleen to take up soluble antigens, beads, and unrelated bacteria. (unamur.be)
  • Nanoparticles (gray) attached to a red blood cell are able to escape detection by the body's liver and spleen, paving the way for more effective, less toxic drug delivery. (harvard.edu)
  • Conclusions: Based on our observational study, quantitative liver and spleen volumes may be associated with transplant-free survival in patients with PSC and may have the potential for predicting the outcome but this should be validated by randomized clinical trial studies. (johnshopkins.edu)
  • How to cite (Vancouver): Lestiani DD, Santoso M, Setyowati EY, Kurniawati S, Adventini N, Damastuti E. Essential trace elements in meat, spleen and liver of Brahman Cross steers reared in intensive production system in Bandung, Indonesia. (undip.ac.id)
  • Thus the characteristic megakaryocytic nucleus with condensed cloud like nucleus (as opposed to large megakaryocytes with branched nuclear lobes seen in essential thrombocytosis) is seen in the spleen of this patient. (cap.org)
  • That book is entitled N-of-1: One man's Harvard-documented remission of incurable cancer using only natural methods . (scienceblogs.com)
  • Wyss researchers were later awarded a grant to develop a "spleen on a chip" to treat sepsis. (bitesizevegan.org)
  • Contact, publication, and social network information about Harvard faculty and fellows. (harvard.edu)
  • Both, of course, are Harvard faculty. (scienceblogs.com)
  • Aim: To evaluate the association between single time-point quantitative liver and spleen volumes in patients with PSC and transplant-free survival, independent of Mayo risk score. (johnshopkins.edu)
  • This graph shows the total number of publications written about "Lymphangioma, Cystic" by people in Harvard Catalyst Profiles by year, and whether "Lymphangioma, Cystic" was a major or minor topic of these publication. (harvard.edu)
  • furthermore, the Concanavalin A‐stimulated spleen cell mitogenesis was decreased after 1 day of stress in mice stressed once daily as opposed lo after H and 14 days of stress in mice stressed twice daily. (elsevierpure.com)
  • With two mice per cage, we observed a decreased spleen cell mitogenesis after 14 days of stress. (elsevierpure.com)
  • With four mice per cage, the spleen cell mitogenesis was decreased after 8 and 14 days of stress. (elsevierpure.com)
  • The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)
  • For comparison, we obtained spleen specimens from eight controls who were nontransplantation patients. (elsevierpure.com)
  • Similar stromal lines have now been isolated from long-term cultures (LTC) of human spleen. (edu.au)
  • The job of the spleen in a healthy human body is to clean the blood of bacteria. (bartleby.com)
  • The inability of the LS image to exclude or delineate an abnormality in the spleen was attributed to an overlying left lobe of the liver in five, and to technique in one. (elsevierpure.com)
  • Samples of meat, spleen and liver were collected from 16 steers aged 24-36 months with four types of feeding treatment, feeding without Se (group I) and feeding with additional supplementary of 0.3 ppm selenium for 25, 50 and 75 days (group II, III and IV, respectively). (undip.ac.id)
  • A study of malaria on the Kano Plains, Kisumu District, Kenya : a community study of current knowledge, attitudes and control practices : parasite and spleen rates : mosquito bionomics and the feasability of vector-control at the community level / by Dismas Ongore. (who.int)
  • Thus, we have uncovered a crucial role for classical monocytes, mobilized from the spleen, in mediating neutrophil extravasation, with potential implications for targeting of recipient classical monocytes to ameliorate pulmonary ischemia-reperfusion injury in the clinic. (wustl.edu)
  • Today Mitragotri is, appropriately, the Hiller Professor of Bioengineering and Hansjörg Wyss Professor of Biologically Inspired Engineering at the Wyss Institute and the Harvard John A. Paulson School of Engineering and Applied Sciences. (harvard.edu)
  • But doctors know if the spleen is gone, Pneumococcal organisms may quickly spawn. (blogspot.com)
  • Sign up for daily emails to get the latest Harvard news. (harvard.edu)
  • After all this time in training in Boston, she and her husband Pedro Sr., also a Harvard-trained physician, were finally back in Venezuela near family. (stjude.org)