Determine the efficacy of rituximab, carboplatin, cyclophosphamide, etoposide or etoposide phosphate and cytarabine administered in conjunction with osmotic blood-brain barrier disruption and high-dose sodium thiosulfate, in terms of complete response rate, in patients with refractory or recurrent primary CNS lymphoma. (survivornet.com)
On days 2 and 3, patients receive carboplatin intra-arterially over 10 minutes, cyclophosphamide IV over 10 minutes, and etoposide or etoposide phosphate IV over 10 minutes in conjunction with blood-brain barrier disruption. (survivornet.com)
To evaluate tolerability and maintenance of dose intensity of 2 weekly treatment with vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide, etoposide (VDC/IE) in patients with advanced small round cell sarcomas including Ewing family tumours (EFT), desmoplastic small round cell tumours (DSRCT) and undifferentiated high grade round cell sarcomas (UHGRCS). (biomedcentral.com)
The Children's Oncology Group (COG) study, INT-0154, using a regimen of vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide and etoposide (VDC/IE), randomized patients to an increased treatment intensity by higher doses of cyclophosphamide and ifosfamide and a decreased length of treatment to 11 cycles over 30 weeks in the test arm compared with a standard 17 cycles over 48 weeks but with equivalent total drug doses in each arm. (biomedcentral.com)
2 The management of primary mediastinal B-cell lymphoma (PMBCL) includes DA-REPOCH (dose-adjusted rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin), which demonstrated superior outcomes (5-year overall survival rate was 97%) in the single arm phase 2 study from the national cancer institute obviating the need for radiation therapy (XRT). (silverchair.com)
Chemotherapy7
Etoposide injection should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. (medlineplus.gov)
Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer. (wikipedia.org)
Etoposide is used as a form of chemotherapy for cancers such as Kaposi's sarcoma, Ewing's sarcoma, lung cancer, testicular cancer, lymphoma, nonlymphocytic leukemia, and glioblastoma multiforme. (wikipedia.org)
Unlike chemotherapy, it doesn't cause harm to healthy cells. (healthline.com)
The current European Ewing tumour Working Initiative of National Groups 1999 (EURO-EWING 99) study has enrolled over 3,200 patients in a study evaluating an intensive induction regimen (VIDE, vincristine, ifosfamide, doxorubicin and etoposide) and, in selected cohorts of randomized patients, high dose chemotherapy with stem cell rescue. (biomedcentral.com)
Although chemotherapy offers succeeded for some levels and responded well using types of tumors however in many instances it is struggling to remove all malignancy cells and could cause collateral harm to regular cells and cells. (baxkyardgardener.com)
Like chemotherapy drugs, radiation therapy destroys cancer cells but also harms healthy cells. (thetruthaboutcancer.com)
Phosphate2
tell your doctor and pharmacist if you are allergic to etoposide, etoposide phosphate (Etopophos), any other medications, or any of the ingredients in etoposide or etoposide phosphate injection. (medlineplus.gov)
Vinblastine, Vincristine and Taxol (tubulin-binding agent), teniposide and etoposide (topoisomerase II inhibitor) irinotecan and topotecan (topoisomerase I inhibitor), are traditional types of plant-derived substances with varied applications in malignancy therapeutics6C9. (baxkyardgardener.com)
Topoisomerase5
Etoposide is in the topoisomerase inhibitor family of medication. (wikipedia.org)
Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme, which is an enzyme that aids in relaxing negative or positive supercoils in DNA. (wikipedia.org)
Results Reducing MCM2 or MCM3 proteins does not impact cell growth Our previous results showed an involvement of MCM proteins in the DNA damage response through its co-localization with -H2AX foci, and through connection with chromatin redesigning proteins in response to DNA damage induced from the topoisomerase II inhibitor Etoposide [28]. (ampkpathway.com)
Etoposide is a glycosidic derivative of podophyllotoxin that exerts its cytotoxic effect through stabilization of the normally transient covalent intermediates formed between DNA substrate and topoisomerase II, leading to single- and double-strand DNA breaks. (medscape.com)
Derivative of podophyllotoxin1
Etoposide is a semisynthetic derivative of podophyllotoxin from the rhizome of the wild mandrake (Podophyllum peltatum). (wikipedia.org)
Rituximab1
RATIONALE: Monoclonal antibodies, such as rituximab, can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. (survivornet.com)
Use during pregnancy will likely harm the fetus. (wikipedia.org)
Caring for a pregnant patient with a malignancy requires striking the difficult balance between treating the mother and, at the same time, minimizing possible harm to the fetus. (silverchair.com)
Medication2
This medication bears a heightened risk of causing significant patient harm when it is used in error. (unboundmedicine.com)
Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules. (rapid-medico.com)
Drugs are made to kill cancer, but they also harm healthy cells. (epnet.com)
Radiation therapy1
Etoposide injection is used in combination with other medications to treat cancer of the testicles that has not improved or that has worsened after treatment with other medications or radiation therapy. (medlineplus.gov)
Unborn baby1
It is not known whether this medicine will harm an unborn baby. (wellspan.org)
Adverse effects1
This tdm, one should see the family phy- outcomes in people with many reagents, most of the current level of suspicion of lung function) and careful clinical monitoring, and red light, in some cases it may cause anemia or could cause harm or adverse effects of simple and inexpensive, however, we can align complementary qsar and helped them to body weight in practical circumstances, as operator during weighing [1, 12]. (moorelifeurgentcare.com)
Decrease5
Etoposide can cause a severe decrease in the number of blood cells in your bone marrow. (medlineplus.gov)
apalutamide will decrease the level or effect of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
enzalutamide will decrease the level or effect of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
ivosidenib will decrease the level or effect of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
The alteration of MCM proteins induced a change in the activation of important factors of the DDR in response to Etoposide treatment, including influencing the phosphorylation of -H2AX, CHK1 and CHK2 following Etoposide-induced DNA damage without inducing changes in cell viability, but resulting in a small decrease in DNA replication. (ampkpathway.com)
Cells3
Etoposide injection is also sometimes used to treat Hodgkin's lymphoma (Hodgkin's disease), non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection), and certain types of leukemia (cancer of the white blood cells), including acute myeloid leukemia (AML, ANLL) and acute lymphoblastic leukemia (ALL) in children. (medlineplus.gov)
In response to DNA harm during S phase, cells rapidly block replication initiation in addition to the slowing of the progressing replication forks [17,18]. (ampkpathway.com)
Published another study showing that fenbendazole was a potent compound for inhibiting the growth of cancer cells without doing any harm to or affecting the growth of normal cells. (kivu.com)
Sometimes used to treat1
Etoposide is also sometimes used to treat certain types of ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed). (navigatingcare.com)
Include1
Questions assess global levels of psychiatric distress and include items about drug use and self-harm ideation. (dnapk-signaling.com)
Etoposide injection may cause side effects. (medlineplus.gov)
Drug2
Etoposide was first synthesized in 1966 and U.S. Food and Drug Administration approval was granted in 1983. (wikipedia.org)
Emergency Central , emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109244/11.0/etoposide. (unboundmedicine.com)
Common1
Assessing accuracy and quality of CAM Web sites poses unique challenges as there is less documented research on the efficacy of CAM products, yet use is common and the potential for harm remains. (jmir.org)
Medical2
Etoposide injection comes as a comes as a solution (liquid) or as a powder to be mixed with liquid to be slowly injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
Etoposide was approved for medical use in the United States in 1983. (wikipedia.org)
Types1
etoposide decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
Health2
However, this can harm their health as an adult. (cancer.net)
Online health information can harm as well as heal. (jmir.org)