AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed Groups
HaptoglobinsAcute-Phase ProteinsHemoglobinsAcute-Phase ReactionOrosomucoidSerum Amyloid A ProteinHemopexinBlood ProteinsCeruloplasminHemolysisalpha 1-AntitrypsinAntigens, Differentiation, MyelomonocyticTurpentineProflavineHemoglobinuriaImmunoelectrophoresisMacroglobulinsalpha-MacroglobulinsGenotypeChymotrypsinogenIronLiverElectrophoresis, Gel, Two-DimensionalKetosisProteomicsPolymorphism, GeneticPhenotypeCattleInterleukin-6TransferrinFibrinogenBiological MarkersBlood Protein ElectrophoresisPasteurellosis, PneumonicMastitis, BovineFucoseAnemia, HemolyticSerum AlbuminCattle DiseasesMannheimia haemolyticaHealthy VolunteersSubcutaneous TissueAmino Acid SequenceWeaningCebidaeInflammationAlbuminsAllelesAscorbic Acid DeficiencyGlycosylationElectrophoresis, Polyacrylamide Gel
ProteinRemoved by the reticuloendothelial systemReticuloendothelial systemPhenotypesHemolyticPreparations for a haptoglobin testHemoglobinResults show that your haptoglobinLevel of haptoglobinAbnormalAssayLiverSerum glycoproteinELISAHemolysisProteinsGlycoproteinInflammationPhenotypeRecombinantAcute phase reLevelsReactantsBiosensorKidneyConcentrationKarlanHaemolyticReticulocyteFucosylationIntravascularConcentrationsTestDiagnosticBloodHuman
Protein21
  • Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene. (wikipedia.org)
  • It is theorized that, because of this, haptoglobin has evolved into an acute-phase protein. (wikipedia.org)
  • Haptoglobin is a protein made by your liver. (medlineplus.gov)
  • Haptoglobin (Hp) is a genetically determined acute phase protein, the synthesis of which is increased during inflammation. (nih.gov)
  • Here, we show that haptoglobin, an acute phase protein, is an initiator of this MyD88-dependent inflammatory process in a mouse model of skin transplantation. (jci.org)
  • Various constructions of human haptoglobin (Hp) cDNA coding either for the complete alpha2FSbeta precursor protein or only for the beta subunit have been placed under the control of the λPR promoter in the bacterial expression vector pCQV2 (Queen, 1983). (rti.org)
  • In addition, the Hpalpha2 cDNA sequence, when fused upstream to the cDNA coding for alpha1-antitrypsin, constitutively promotesin vivo the efficient expression of an hybrid protein specifically recognized by antibodies raised against alpha1-antitrypsin or haptoglobin. (rti.org)
  • Haptoglobin (Hp) is a plasma protein with antioxidant and immunomodulatory properties. (bmj.com)
  • Haptoglobin Protein is produced by the Liver. (rtdiagnostics.net)
  • This test detects the levels of haptoglobin protein in the blood to diagnose Hemolytic Anemia. (rtdiagnostics.net)
  • Haptoglobin is an acute-phase protein (synthesized by the liver, induced by inflammatory cytokines like IL-6, IL-1 and TNF) that also has an antioxidant property (reduces oxidative stress), apart from its antibacterial activity, angiogenesis (formation of new blood vessels through VEGF signalling pathway) and tissue repair. (rtdiagnostics.net)
  • Haptoglobin protein binds to free haemoglobin, thus it prevents haemoglobin-induced inflammation and oxidative tissue damage, inhibits loss of iron from RBC lysis that occurs in our body and furthermore it prevents renal (kidney) damage. (rtdiagnostics.net)
  • The aim of the present study was to assess the influence of subclinical inflammation on specific humoral responses in dogs vaccinated against canine distemper and parvovirus based on serum levels of C-reactive protein (CRP) and haptoglobin (Hp). (biomedcentral.com)
  • In the blood plasma, haptoglobin is an acute phase protein that has a high affinity for binding haemoglobin released from erythrocytes, reducing iron loss and. (journalgazett.com)
  • Haptoglobin is a colorless protein of the alpha-globulin fraction of human serum. (medscape.com)
  • The haptoglobin test is used to measure the amount of a protein called haptoglobin in your blood. (teststips.com)
  • Recent research on alternative markers for inflammatory reactions in the lactating cow, e.g. in mastitis, includes investigations of the acute phase protein, haptoglobin (Hp). (slu.se)
  • Haptoglobin is a protein formed in your liver. (ehealthhall.com)
  • A protein produced by the liver, Haptoglobin is measured in patients with anemia (low red cell count) suspected to be due to Hemolysis (cell breakdown). (cura4u.com)
  • Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to attenuate toxic effects of cell-free hemoglobin (Hb). (biomedcentral.com)
  • The human protein haptoglobin inhibits IsdH-mediated heme-sequestering by Staphylococcus aureus . (bvsalud.org)
Removed by the reticuloendothelial system2
  • The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). (wikipedia.org)
  • Further, the haptoglobin-hemoglobin complex is being removed by the reticuloendothelial system. (prospecbio.com)
Reticuloendothelial system2
  • Since the reticuloendothelial system will remove the haptoglobin-hemoglobin complex from the body, haptoglobin levels will be decreased in case of intravascular hemolysis or severe extravascular hemolysis. (wikipedia.org)
  • The haptoglobin-Hb complex is cleared by the reticuloendothelial system. (southtees.nhs.uk)
Phenotypes7
  • The different haptoglobin phenotypes differ in their antioxidant, scavenging, and immunomodulatory properties. (wikipedia.org)
  • This aspect of haptoglobin may gain importance in immune suppressed conditions (such as liver cirrhosis) and the various phenotypes may result in different susceptibility levels towards bacterial infections. (wikipedia.org)
  • Some studies associate certain haptoglobin phenotypes with the risk of developing schizophrenia. (wikipedia.org)
  • Haptoglobin phenotypes have been shown in human medicine to be related to the prevalence of various diseases. (lu.se)
  • The present paper describes a method for investigation of canine haptoglobin phenotypes and of microheterogeneity caused by altered glycosylation. (lu.se)
  • The 3 phenotypes of haptoglobin include haptoglobin 1-1 (Hpl 1-1), haptoglobin 2-1 (Hpl 2-1), and haptoglobin 2-2 (Hpl 2-2). (medscape.com)
  • The phenotypes of the hemoglobin-haptoglobin (Hb-Hp) system were measured in 124 subjects, 100 patients with chronic pain in temporomandibular disorders and 24 normal, without any bodily pain during the years 2000 -2003. (bvsalud.org)
Hemolytic14
  • In clinical settings, the haptoglobin assay is used to screen for and monitor intravascular hemolytic anemia. (wikipedia.org)
  • However, during hyper-hemolytic conditions or with chronic hemolysis, haptoglobin is depleted and hemoglobin readily distributes to tissues where it might be exposed to oxidative conditions. (wikipedia.org)
  • A haptoglobin test is most often used to diagnose hemolytic anemia. (medlineplus.gov)
  • In hemolytic anemia, lactic dehydrogenase (LDH) levels typically increase while haptoglobin levels decrease. (medscape.com)
  • In a retrospective study from 1980, the sensitivity and specificity of haptoglobin in the diagnosis of hemolytic anemia was 83% and 96%, respectively. (medscape.com)
  • Overall, a serum haptoglobin level below 25 mg/dL equated to an 87% probability of predicting hemolytic disease. (medscape.com)
  • The haptoglobin diagnostic test detects hemolytic anemia, a condition with rapid destruction of RBCs. (redcliffelabs.com)
  • Haptoglobin testing is used mainly to help diagnose and monitor hemolytic anemia. (teststips.com)
  • By testing your plasma haptoglobin levels, your doctor can determine if you have hemolytic anemia or another type of anemia. (teststips.com)
  • Abnormal haptoglobin levels may be an indication of hemolytic anemia, hypersplenism, megaloblastic anemia, or the use of certain drugs such as corticosteroids or androgens. (teststips.com)
  • The haptoglobin test can be used to differentiate between primary and secondary hemolytic anemia when used with a cut-off level of 0.2 g/L. (teststips.com)
  • This leads to drop in haptoglobin levels in your blood and can also cause hemolytic anemia. (ehealthhall.com)
  • A haptoglobin test is carried out to detect and assess Hemolytic anemia and differentiate it from other forms of anemia. (ehealthhall.com)
  • Haptoglobin test cannot be used to diagnose the cause of hemolytic anemia. (ehealthhall.com)
Preparations for a haptoglobin test1
  • You don't need any special preparations for a haptoglobin test. (medlineplus.gov)
Hemoglobin19
  • In blood plasma, haptoglobin binds with high affinity to free hemoglobin released from erythrocytes, and thereby inhibits its deleterious oxidative activity. (wikipedia.org)
  • In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. (wikipedia.org)
  • Haptoglobin functions to bind the free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. (wikipedia.org)
  • When hemoglobin is released from RBCs within the physiologic range of haptoglobin, the potential deleterious effects of hemoglobin are prevented. (wikipedia.org)
  • In the process of binding to free hemoglobin, haptoglobin sequesters the iron within hemoglobin, preventing iron-utilizing bacteria from benefiting from hemolysis. (wikipedia.org)
  • Haptoglobin binds to hemoglobin in the bloodstream. (medlineplus.gov)
  • Together, the two proteins are known as the haptoglobin-hemoglobin complex. (medlineplus.gov)
  • That means more of the haptoglobin-hemoglobin complex will be cleared from the body. (medlineplus.gov)
  • Haptoglobin binds free hemoglobin (Hb) secreted from erythrocytes In blood plasma with high affinity and thus inhibits its oxidative activity. (prospecbio.com)
  • Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity). (joplink.net)
  • Grunden för analysen är en interaktion mellan analyt (hemoglobin) och biologisk ligand (haptoglobin) vilken resulterar i en optiskt detekterbar förändrad massa på sensorytan. (slu.se)
  • Haptoglobin is produced by the liver and collects the hemoglobin from destroyed red blood cells, then transporting it back to the liver, where heme is converted to bilirubin. (medscape.com)
  • [ 1 ] In the setting of increased RBC destruction, haptoglobin becomes depleted, and the free hemoglobin dimmers are filtered by the kidney, ultimately producing hemosiderin. (medscape.com)
  • [ 2 ] Macrophages destroy the hemoglobin-haptoglobin complex. (medscape.com)
  • [ 3 ] The hemoglobin-haptoglobin complex is removed from the bloodstream within minutes. (medscape.com)
  • The haptoglobin blood test measures the level of haptoglobin in your blood, haptoglobin is primarily produced by the liver which attaches to a certain type of hemoglobin in the blood. (teststips.com)
  • Haptoglobin is a serum glycoprotein, made by your liver and its purpose is to help bind and remove free hemoglobin from circulation. (teststips.com)
  • Haptoglobin joins to the free hemoglobin to form a complex compound called haptoglobin-hemoglobin. (ehealthhall.com)
  • In the present study, FPOP analysis was applied to study the hemoglobin (Hb) - haptoglobin (Hp) complex allowing identification of respective regions altered upon the complex formation. (bioinfor.com)
Results show that your haptoglobin1
  • If results show that your haptoglobin level is below 45 milligrams haptoglobin per deciliter of blood, it implies that your red blood cells are rapidly destroyed than they are formed. (ehealthhall.com)
Level of haptoglobin1
  • Measuring the level of haptoglobin in a patient's blood is ordered whenever a patient exhibits symptoms of anemia, such as pallor, fatigue, or shortness of breath, along with physical signs of hemolysis, such as jaundice or dark-colored urine. (wikipedia.org)
Abnormal2
  • Furthermore, abnormal glycosylation of haptoglobin has been reported as a consequence of liver disease, cancer and immunological disorders in man. (lu.se)
  • Moreover, a fucose-specific lectin was capable of binding to some of the abnormal haptoglobin fractions, mainly those found in association with anaemia. (lu.se)
Assay6
  • Haptoglobin Assay Laboratories manufactures the haptoglobin test for inflammation reagents distributed by Genprice. (mytaq.net)
  • Description: Enzyme-linked immunosorbent assay kit for quantification of Bovine Haptoglobin in samples from serum, plasma, tissue homogenates and other biological fluids. (mytaq.net)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Haptoglobin (Hpt) in samples from serum, plasma or other biological fluids. (scalegen.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Dog Haptoglobin (Hpt) in serum, plasma and other biological fluids. (scalegen.com)
  • The Sheep Haptoglobin ELISA Assay Kit is a highly sensitive two-site enzyme linked immunoassay (ELISA) for measuring HPT in biological fluid of Sheep. (eaglebio.com)
  • Sheep Haptoglobin ELISA Assay Kit is for research use only and not to be used for diagnostic procedures. (eaglebio.com)
Liver4
  • The haptoglobin may leave the body faster than the liver can make it. (medlineplus.gov)
  • Hoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway .Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassbly, and controlling the equilibrium between tolerance and immunity to non-self antigens. (joplink.net)
  • Certain medical underlying conditions can alter this Haptoglobin test result namely rheumatoid arthritis, ulcerative colitis, chronic liver disease etc. (rtdiagnostics.net)
  • Decreased haptoglobin levels can also occur in the absence of hemolysis, due to cirrhosis of the liver, disseminated ovarian carcinomatosis, pulmonary sarcoidosis, and elevated estrogen state. (nih.gov)
Serum glycoprotein1
  • Haptoglobin is a serum glycoprotein which binds free haemoglobin released on damage of red cells. (southtees.nhs.uk)
ELISA5
  • D ) Haptoglobin levels within lysates of syngeneic and allogeneic transplants (ELISA). (jci.org)
  • Description: A sandwich ELISA kit for detection of Haptoglobin from Dog in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (mytaq.net)
  • Description: Quantitative sandwich ELISA for measuring Sheep Haptoglobin (HP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (mytaq.net)
  • MOUSE HAPTOGLOBIN ELISA, 96T - 1 kit est en rupture de stock et sera expédié dès qu'il sera de retour en stock. (karlan.com)
  • Description: Quantitativesandwich ELISA kit for measuring Pig Haptoglobin, Hpt/HP in samples from serum, plasma, tissue homogenates. (scalegen.com)
Hemolysis4
  • Haptoglobin is an acute-phase reactant whose principal clinical utility is in defining conditions of hemolysis. (medscape.com)
  • Other tests used in combination with haptoglobin to confirm hemolysis include peripheral smear, LDH, indirect bilirubin, reticulocyte count, complete blood count, and Coomb's test. (medscape.com)
  • If hemolysis ceases, it is expected that haptoglobin levels will return to normal within a week. (teststips.com)
  • Decreased haptoglobin in conjunction with increased reticulocyte count and anemia may indicate hemolysis. (nih.gov)
Proteins4
  • Analysis of transplanted lysates identified haptoglobin as one of the proteins upregulated during transplantation. (jci.org)
  • In cattle, haptoglobin and serum amyloid A are the two acute phase proteins that show the largest increase in serum concentration as a result of inflammatory processes. (slu.se)
  • Two ruminant acute phase proteins (APPs), haptoglobin (Hp) and serum amyloid A (SAA), were evaluated as serum biomarkers (BMs) for sheep scab-a highly contagious ectoparasitic disease caused by the mite Psoroptes ovis, which is a major welfare and production threat worldwide. (gla.ac.uk)
  • Haptoglobin (Hpt), a plasma 2-glycoprotein belonging to the family of acute-phase proteins, binds to ApoA-I inhibiting the stimulation of the enzyme LCAT. (cnr.it)
Glycoprotein1
  • Preliminary results have identified four potential biomarkers for immobilization induced joint disease: haptoglobin, beta2-microglobulin, cartilage matrix glycoprotein, and a 25 kilodalton glycoprotein. (cdc.gov)
Inflammation2
Phenotype1
  • The results indicated the existence of only one canine haptoglobin phenotype with a characteristic microheterogeneity pattern in healthy dogs. (lu.se)
Recombinant1
  • Haptoglobin Human Recombinant produced in E. coli is a single polypeptide chain containing 352 amino acids (19-347) and having a molecular mass of 39.0 kDa. (prospecbio.com)
Acute phase re3
  • Haptoglobin has antibacterial activity and takes part in modulating many aspects of the acute phase response. (prospecbio.com)
  • Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. (joplink.net)
  • Haptoglobin levels rise as part of the acute phase response. (southtees.nhs.uk)
Levels7
  • This causes a decline in haptoglobin levels. (wikipedia.org)
  • This causes your haptoglobin blood levels to drop. (medlineplus.gov)
  • If your haptoglobin levels are too low, it may be a sign of a disorder of the red blood cells, such as anemia . (medlineplus.gov)
  • High haptoglobin levels may be a sign of an inflammatory disease. (medlineplus.gov)
  • But haptoglobin testing is not usually used to diagnose or monitor conditions related to high haptoglobin levels. (medlineplus.gov)
  • In haemolytic states, haptoglobin levels are usually extremely low or undetectable. (southtees.nhs.uk)
  • However, haptoglobin testing is rarely used to diagnose or monitor conditions associated with high haptoglobin levels. (teststips.com)
Reactants1
  • whereas, the serum level of other positive reactants, such as ceruloplasmin and haptoglobin, increases during such reactions. (cdc.gov)
Biosensor1
  • The method which uses optical biosensor technology is based on the haemoglobin binding properties of haptoglobin. (slu.se)
Kidney2
  • Haptoglobin is produced mostly by hepatic cells but also by other tissues such as skin, lung and kidney. (wikipedia.org)
  • Haptoglobin captures, and combines with free plasma hoglobin to allow hepatic recycling of he iron and to prevent kidney damage. (joplink.net)
Concentration2
  • The haptoglobin concentration has been shown to correlate to clinical signs as well as inflammatory processes found at post mortem examination. (slu.se)
  • An abnormally low concentration of haptoglobin in the blood circulation. (nih.gov)
Karlan1
  • The MSDS of MOUSE for HAPTOGLOBIN is available from Karlan upon request. (karlan.com)
Haemolytic1
  • A haptoglobin test is a common way to diagnose haemolytic anemia, a disorder that occurs when red blood cells are broken down faster than they can be replaced. (teststips.com)
Reticulocyte1
  • Serum haptoglobin test is typically ordered when a person has symptoms of anemia and is often ordered along with other lab tests such as complete blood count, reticulocyte count, and peripheral smear examination. (teststips.com)
Fucosylation1
  • The changes described were interpreted as alterations of the carbohydrate content, with or without fucosylation, of some haptoglobin fractions. (lu.se)
Intravascular1
  • Consequently haptoglobin is depleted from serum in states of intravascular haemolysis. (southtees.nhs.uk)
Concentrations1
  • E ) Haptoglobin concentrations found within skin lysates exhibit a positive correlation with IL-6/TNF-α production by DCs after DCs are cultured with lysates. (jci.org)
Test14
Diagnostic1
  • There are variations in haptoglobin level because of many factors such as the diagnostic facility and type of hospital used. (ehealthhall.com)
Blood2
  • Haptoglobin is used as an acute-phase marker of red blood cell (RBC) destruction. (medscape.com)
  • The normal haptoglobin level is between 45 and 165 milligrams of haptoglobin per deciliter of blood. (ehealthhall.com)
Human1
  • In addition, the haptoglobin gene is expressed in murine and human adipose tissue. (wikipedia.org)