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  • mammalian
  • In addition, because KLH is derived from the limpet, a gastropod, it is phylogenetically distant from mammalian proteins, thus reducing false positives in immunologically-based research techniques in mammalian model organisms. (wikipedia.org)
  • These inherited changes to hemoglobin or other characteristic erythrocyte proteins which are critical and rather invariant features of mammalian biochemistry, usually result in some kind of anemia, a disease or defect of red blood cells. (wikipedia.org)
  • antibody
  • An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. (wikipedia.org)
  • ions
  • If the protein becomes denatured or if the copper ions are lost in the purification process, the opalescent blue color disappears and the solution becomes a dull grayish color. (wikipedia.org)
  • Lastly, nickel allergy is caused by nickel metal ions penetrating the skin and binding to skin proteins. (wikipedia.org)
  • hemoglobin
  • This protein carries oxygen as hemoglobin does in vertebrates. (wikipedia.org)
  • Since malaria infects red blood cells, these genetic changes are most commonly alterations to molecules essential for red blood cell function (and therefore parasite survival), such as hemoglobin or other cellular proteins or enzymes of red blood cells. (wikipedia.org)
  • complex
  • It aims to study the complex protein-protein interactions and networks and allows a better understanding of immune responses and their role during normal, diseased and reconstitution states. (wikipedia.org)
  • The protein oligomerises to form a barrel shaped didecameric complex which is composed of 20 monomers. (wikipedia.org)
  • sequence
  • Computational immunology is a branch of bioinformatics and it is based on similar concepts and tools, such as sequence alignment and protein structure prediction tools. (wikipedia.org)
  • study
  • The concept of haptens emerged from the work of Karl Landsteiner who also pioneered the use of synthetic haptens to study immunochemical phenomena. (wikipedia.org)
  • specific
  • Very specific proteins coded by the DNA of the infectious organism as well as the host cells allow those steps to happen. (wikipedia.org)
  • potential
  • Such data is valuable for investigation of cross-reactivity between known allergens and analysis of potential allergenicity in proteins. (wikipedia.org)
  • A potential advantage of CRM197 over toxoided proteins is that, because it is genetically detoxified, it retains its full complement of lysine amines for conjugation. (wikipedia.org)
  • Research
  • The Food Allergy Research and Resource Program (FARRP) Protein Allergen-Online Database contains sequences of known and putative allergens derived from scientific literature and public databases. (wikipedia.org)
  • complete
  • A sulfhydryl-containing hapten can then be reacted with the KLH to complete the immunogen without causing polymerization. (wikipedia.org)
  • aqueous
  • The technique is particularly useful in performing immunoassays for protein analytes, such as a glycosylated protein, in aqueous test samples. (google.com)
  • Tissues
  • Elevated Post-Translational Modification of Proteins by O-Linked N-Acetylglucosamine in Various Tissues of Diabetic Goto-Kakizaki Rats Accompanied by Diabetic Complications", Acta Histochem. (freepatentsonline.com)
  • form
  • The protein oligomerises to form a barrel shaped didecameric complex which is composed of 20 monomers. (wikipedia.org)
  • composition
  • A composition for delivery of osteogenic proteins is disclosed. (google.ca)
  • The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. (google.ca)
  • 1. A composition for delivery of osteogenic proteins, which comprises an osteogenic protein as a first biologically active agent, a calcium phosphate material as a carrier, and an effective amount of a material that liberates gas upon dissolution in vivo. (google.ca)
  • 2. The composition of claim 1 , wherein the osteogenic protein is selected from the group consisting of members of the bone morphogenic protein (BMP) family. (google.ca)
  • 3. The composition of claim 2 , wherein the osteogenic protein is selected from the group consisting of BMP-2, BMP-4, BMP-5, BMP-6, BMP-7, BMP-10, BMP-12 and BMP-13, and combination thereof. (google.ca)
  • 4. The composition of claim 2 , wherein the osteogenic protein is BMP-2 or BMP-6, or a combination thereof. (google.ca)
  • 17. The composition of claim 1 , further comprising a second active agent, wherein the second active agent is selected from the group consisting of Hedghog, Frazzled, Chordin, Noggin, Cerberus and Follistatin proteins. (google.ca)
  • research
  • The Food Allergy Research and Resource Program (FARRP) Protein Allergen-Online Database contains sequences of known and putative allergens derived from scientific literature and public databases. (wikipedia.org)
  • blood
  • Several other mechanisms, single-ingestion of blood flow to the etiology of sequelae, but the VKORC1 coding region cause rare cases of genetic variation on observations from 249 male patients with epilepsy may face educational and prompt return to 20% of surface protein. (magicvalleyoutreach.com)
  • block
  • Kit includes split/splitless injector with programmable pneumatic control for carrier gas, split vent, heater, sensor, and heater block. (perkinelmer.com)
  • present
  • The present invention is based on the discovery that hexosamine, and in particular the dynamic O-GlcNAcylation of proteins (modification of proteins by the sugar N-acetylglucosamine) both causes insulin-resistance (a hallmark of type II diabetes) and is responsible for glucose toxicity in the disease. (freepatentsonline.com)
  • amine
  • For example, if a short amine-to-amine crosslinker does not successfully crosslink subunits of a dimeric protein, but a slightly longer crosslinker does, one can conclude that the relevant amino acids in the native dimeric structure exist at a distance approximately equal to the length of the longer crosslinker. (thermofisher.com)
  • immune
  • It aims to study the complex protein-protein interactions and networks and allows a better understanding of immune responses and their role during normal, diseased and reconstitution states. (wikipedia.org)
  • There is also evidence suggesting that, compared with tetanus toxoid, there is less carrier-induced suppression of the immune response, especially when there are many individual polysaccharides linked to the same carrier protein. (wikipedia.org)
  • An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. (wikipedia.org)
  • epitope
  • There may be insufficient epitope present to generate the specific response desired, and the mouse is reacting more to your carrier rather than to your epitope. (bio.net)
  • chemistry
  • Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor- β superfamily," Journal of Biological Chemistry , vol. 265, no. 22, pp. 13198-13205, 1990. (hindawi.com)
  • experiments
  • Experiments with different lengths of otherwise identical crosslinkers can reveal the molecular distance between particular functional groups in the secondary, tertiary or quaternary protein structure. (thermofisher.com)
  • cell
  • Crosslinking reagents are used in a variety of techniques to assist in determining partners and domains of protein interactions, three-dimensional structures of proteins, and molecular associations in cell membranes. (thermofisher.com)
  • interactions
  • The guide also contains a discussion on various applications where crosslinking has been applied, including the powerful label transfer technique for identifying or confirming protein interactions. (thermofisher.com)
  • There are also some computational models which focus on protein-protein interactions and networks. (wikipedia.org)