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  • amine
  • For example, if a short amine-to-amine crosslinker does not successfully crosslink subunits of a dimeric protein, but a slightly longer crosslinker does, one can conclude that the relevant amino acids in the native dimeric structure exist at a distance approximately equal to the length of the longer crosslinker. (thermofisher.com)
  • mammalian
  • In addition, because KLH is derived from the limpet, a gastropod, it is phylogenetically distant from mammalian proteins, thus reducing false positives in immunologically-based research techniques in mammalian model organisms. (wikipedia.org)
  • These inherited changes to hemoglobin or other characteristic erythrocyte proteins which are critical and rather invariant features of mammalian biochemistry, usually result in some kind of anemia, a disease or defect of red blood cells. (wikipedia.org)
  • molecular weight
  • Both encode large glycosylated proteins consisting of around 3400 amino acids and a molecular weight of around 390,000 Daltons, excluding the glycosylation. (wikipedia.org)
  • ions
  • If the protein becomes denatured or if the copper ions are lost in the purification process, the opalescent blue color disappears and the solution becomes a dull grayish color. (wikipedia.org)
  • Lastly, nickel allergy is caused by nickel metal ions penetrating the skin and binding to skin proteins. (wikipedia.org)
  • chemistry
  • Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor- β superfamily," Journal of Biological Chemistry , vol. 265, no. 22, pp. 13198-13205, 1990. (hindawi.com)
  • cellular
  • Protein-protein interactions are the basis for nearly all cellular pathways, and the discovery and characterization of protein interactions is increasingly important in proteomics research. (thermofisher.com)
  • Since malaria infects red blood cells, these genetic changes are most commonly alterations to molecules essential for red blood cell function (and therefore parasite survival), such as hemoglobin or other cellular proteins or enzymes of red blood cells. (wikipedia.org)
  • experiments
  • Experiments with different lengths of otherwise identical crosslinkers can reveal the molecular distance between particular functional groups in the secondary, tertiary or quaternary protein structure. (thermofisher.com)
  • cell
  • Crosslinking reagents are used in a variety of techniques to assist in determining partners and domains of protein interactions, three-dimensional structures of proteins, and molecular associations in cell membranes. (thermofisher.com)
  • form
  • The protein oligomerises to form a barrel shaped didecameric complex which is composed of 20 monomers. (wikipedia.org)
  • large
  • An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. (wikipedia.org)
  • Applications
  • The guide also contains a discussion on various applications where crosslinking has been applied, including the powerful label transfer technique for identifying or confirming protein interactions. (thermofisher.com)
  • Other haptens that are commonly used in molecular biology applications include fluorescein, biotin, digoxigenin, and dinitrophenol. (wikipedia.org)
  • cells
  • Very specific proteins coded by the DNA of the infectious organism as well as the host cells allow those steps to happen. (wikipedia.org)
  • study
  • Crosslinkers can be used to study the structure and composition of proteins in purified or complex samples. (thermofisher.com)
  • The concept of haptens emerged from the work of Karl Landsteiner who also pioneered the use of synthetic haptens to study immunochemical phenomena. (wikipedia.org)
  • sequence
  • Computational immunology is a branch of bioinformatics and it is based on similar concepts and tools, such as sequence alignment and protein structure prediction tools. (wikipedia.org)
  • Research
  • The Food Allergy Research and Resource Program (FARRP) Protein Allergen-Online Database contains sequences of known and putative allergens derived from scientific literature and public databases. (wikipedia.org)
  • A. H. Reddi and N. S. Cunningham, "Initiation and promotion of bone differentiation by bone morphogenetic proteins," Journal of Bone and Mineral Research , vol. 8, no. 2, pp. (hindawi.com)
  • A. Lahiji, A. Sohrabi, D. S. Hungerford, and C. G. Frondoza, "Chitosan supports the expression of extracellular matrix proteins in human osteoblasts and chondrocytes," Journal of Biomedical Materials Research A , vol. 51, no. 4, pp. 586-595, 2000. (hindawi.com)