• Within eastern Asia A*3303 is in linkage disequilibrium with on haplotype in particular, the specific genetic makeup is: A*3303 : C*0302 : B*5801 : DRB1*0301 : DQA1*0501 : DQB1*0201 It is interesting that the Cw allele in the Pakistani population is the same as the allele in the east Asian population C*0302. (wikipedia.org)
  • OBJECTIVE- HLA-DRB1* 03 -DQB1* 0201 /DRB1* 04 -DQB1* 0302 ( DR3/4-DQ8 ) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent. (diabetesjournals.org)
  • It is commonly found in linkage disequilibration within the A*3301-Cw*0802-B*1402 haplotype which can be extended to DRB1 and DQB1 in certain instances (See Below). (wikipedia.org)
  • The specific nomenclature for this type is: A*3301 : C*0802 : B*1402 : DRB1*0102 : DQA1*0102 : DQB1*0501 This haplotype appears to precede A33-B58 in Asia, bringing with it the DR7-DQ2 haplotype. (wikipedia.org)
  • The first haplotype is A33-Cw14-B44-DR13-DQ6.4 A*3303 : C*1403 : B*4403 : DRB1*1302 : DQA1*0102 : DQB1*0604 : DPB1*0401 This haplotype is found in Japan and Korea, and it is the most common 5 locus HLA type in Korea, high at 4.2%, 25 times higher than in China. (wikipedia.org)
  • HLA class I molecules consist of a 45-kD α chain encoded within the MHC that is noncovalently associated with the 12-kD β 2 -microglobulin chain (encoded on chromosome 15). (musculoskeletalkey.com)
  • For A33, the alpha "A" chain are encoded by the HLA-A*33 allele group and the β-chain are encoded by B2M locus. (wikipedia.org)
  • Our goal was to search for non -DR/DQ MHC genetic determinants that cause the additional risk in the DR3/4-DQ8 siblings who share both MHC haplotypes. (diabetesjournals.org)
  • Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. (nature.com)
  • The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)
  • HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
  • HLA class I and class II molecules are cell surface glycoproteins, anchored to the membrane by hydrophobic transmembrane segments. (musculoskeletalkey.com)
  • In the case of systemic lupus erythematosus (SLE) and related illnesses, many of the HLA class II alleles are associated with the presence of specific autoantibodies or clinical phenotypes. (musculoskeletalkey.com)
  • HLA-A33 (A33) is a human leukocyte antigen serotype within HLA-A serotype group. (wikipedia.org)
  • While clearly not showing the level of disequilibrium of the Super B8 haplotype, the level of disequilibrium is high, indicating an expansive migration into these regions at some time in the recent past, most likely in the period preceding the Yayoi period of Japan. (wikipedia.org)
  • HLA-A33 (A33) is a human leukocyte antigen serotype within HLA-A serotype group. (wikipedia.org)
  • The presence of portal tract infiltration with CD3+ T cells, serum autoantibodies, and abnormal expression of human leukocyte antigen (HLA) on biliary epithelial cells all support an immune-mediated process. (medscape.com)
  • The close association between primary sclerosing cholangitis and various human leukocyte antigen (HLA) haplotypes is well established. (medscape.com)
  • We aimed at investigating those possible differences involving DRB1*03∶01-carrying haplotypes in CD susceptibility. (nih.gov)
  • In Japanese patients with AIH, the A1-B8-DR3 haplotype is very uncommon and disease susceptibility is almost exclusively associated with DR4. (medscape.com)
  • The genes that confer actions, are likely to provide important information susceptibility to IDDM are located in the HLA region regarding the causes of IDDM and lead to approaches of chromosome 6. (nih.gov)
  • An influence of HLA-A, B, DR, DQ, and MICA on the occurrence of Celiac disease in patients with type 1 diabetes. (cdc.gov)
  • MICA-A5.1 allele is associated with atypical forms of celiac disease in HLA-DQ2-negative patients. (cdc.gov)
  • [ 42 , 99 ] Examining the associations found in different populations may provide a unique opportunity to discriminate relevant genes within a tightly linked genomic region. (medscape.com)
  • Watch out for certain meds, genes like HLA and CTLA-4, imbalanced iodine intake, and gender-specific factors. (nobleorigins.com)
  • Later studies confirmed these disease associations and their respective patterns of disease, [ 75 , 76 ] leading to the inclusion of HLA DR3/DR4 as diagnostic criteria in the Autoimmune Hepatitis Group Revised Scoring system. (medscape.com)
  • [ 101 , 102 ] As with AIH and PBC, DR3 has also been found in association with PSC independent of the presence of other autoimmune diseases known to be DR3-associated. (medscape.com)
  • HLA-B8 is also associated with other autoimmune disorders. (medscape.com)
  • [ 41 ] examined a fairly homogeneous population of 96 northern European Caucasian patients and found that HLA A1-B8-DR3 as well as HLA-DR4 were independently associated with type I AIH. (medscape.com)
  • They also noted that the A1-B8-DR3 haplotype occurred in younger patients who were more likely to relapse off therapy, while DR4 was associated with older patients with seemingly milder disease. (medscape.com)
  • Most of the initial HLA studies of type 1 AIH were conducted in American and European Caucasian patients. (medscape.com)
  • [ 103 ] DR2 is also found in patients with PSC, but primarily in DR3-negative patients. (medscape.com)
  • An increased frequency of HLA-B8 and HLA-DR3 is observed in patients with primary sclerosing cholangitis. (medscape.com)
  • These haplotypes indicate that interpreting population relationships by allele or even by low resolution haplotype information is error-prone and suggests the need for high resolution multigene haplotype studies. (wikipedia.org)
  • And yet there is trace DR3-DQ2 in Japanese, none in the Ainu nor many other indigenous Siberian groups. (wikipedia.org)
  • This haplotype carries the other common DQ2 haplotype, DQ2.2. (wikipedia.org)
  • One haplotype stands out, the A33-B58-DR3-DQ2 haplotype which is found in West Africa, in Sudan, and Pakistan, scattered along West Indias coast, the Turkic republics and appears to have recently introgressed into Korea (post-Yayoi period of Japan) and China. (wikipedia.org)
  • DQB1*0202 The second haplotype, like A33-B58 is found in Korea but not in Japan. (wikipedia.org)