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HLA AntigensHLA-DR3 AntigenHaplotypesHLA-DR AntigensHLA-DR4 AntigenAntigensHLA-DR Serological SubtypesHLA-DQ AntigensAntigens, BacterialHLA-DR2 AntigenAntigens, NeoplasmAntigens, SurfaceAntigens, ViralAllelesHistocompatibility Antigens Class IIPolymorphism, Single NucleotideLinkage DisequilibriumHistocompatibility TestingHLA-DR7 AntigenHLA-DRB1 ChainsGenetic Predisposition to DiseaseKeratoconjunctivitis SiccaHLA-DR1 AntigenGold Sodium ThiomalateEpitopesAntigens, ProtozoanMolecular Sequence DataH-2 AntigensGenotypeAntigens, Polyomavirus TransformingGenes, MHC Class IIHLA-A AntigensAntigens, CDAntigens, FungalHLA-B AntigensPolymorphism, GeneticAntigens, HelminthHistocompatibility AntigensHistocompatibility Antigens Class IGenetic VariationEpitopes, T-LymphocyteAmino Acid SequenceDiabetes Mellitus, Type 1HLA-D AntigensCarcinoembryonic AntigenAntigens, Viral, TumorAntibodies, MonoclonalCD4-Positive T-LymphocytesReceptors, Antigen, T-CellT-LymphocytesHLA-A2 AntigenFounder EffectPedigreeHLA-DQ beta-ChainsChromosome MappingGenetic MarkersMajor Histocompatibility ComplexArthritis, RheumatoidBase SequenceProliferating Cell Nuclear AntigenCase-Control StudiesGenetic LinkageHLA-C AntigensReceptors, Antigen, B-CellProstate-Specific AntigenO AntigensHLA-B8 AntigenAntigens, CD8Dipeptidyl Peptidase 4Enzyme-Linked Immunosorbent AssayImmunoglobulin GCross ReactionsAntigens, CD15Lymphocyte ActivationAntigens, Tumor-Associated, CarbohydrateHLA-A1 AntigenGenetics, PopulationMice, Inbred BALB CPhenotypeBlood Group AntigensAntigens, CD3Sequence Analysis, DNAHepatitis B Surface AntigensAntibody SpecificityCell LinePolymerase Chain ReactionMicrosatellite RepeatsMutationB-LymphocytesModels, GeneticHLA-DQ alpha-ChainsAntigens, CD4T-Lymphocytes, CytotoxicAntibody FormationEuropean Continental Ancestry GroupHomozygoteAntigen-Antibody ReactionsAntigens, CD45Asian Continental Ancestry GroupHLA-B27 Antigen
Human leukocyRheumatic diseasesAllelesPeptideDifferences amongImmune responseAntibodySignificantlyMajor histocoChainsGeneMethodsClassAsymptomaticGroupRecognitionCellsPatientsRiskAdditionCommonPositiveSusceptibilityPhenotypesGenesAntibodiesAllele groupTransplantRecipientsAmino acidGeneticHumanMoleculesCeliac disease100,000VariantsGlycemic controlSystemDisease
Human leukocy4
  • HLA-A*02 (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. (wikipedia.org)
  • The analysis of genetic factors other than CFTR may help our understanding of genotype-phenotype relationships in CF. As human leukocyte antigen (HLA) class II polymorphism has been associated with a number of diseases including autoimmune and inflammatory diseases, asthma, and allergy, we investigated the possibility that HLA polymorphism contributes to CF-associated pulmonary inflammation. (nih.gov)
  • The genetic susceptibility to celiac disease is conferred by well-identified haplotypes in the human leukocyte antigen (HLA) class II region (ie, DR3 or DR5/DR7 or HLA DR4). (medscape.com)
  • During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
Rheumatic diseases1
  • BACKGROUND: HLA-B27 positivity is normal in patients undergoing rheumatic diseases. (bvsalud.org)
Alleles1
Peptide2
  • Thus any alteration to the HLA that induces decreased binding to a certain peptide or increased binding to a certain peptide, is expressed as, respectively, increased susceptibility to disease or decreased susceptibility to disease. (wikipedia.org)
  • The polymorphisms associated with the "shared epitope" are located on the α-helical rim (DRB1 chain) of the peptide-binding cleft, where they may interact with either the bound peptide antigen or the T cell receptor. (musculoskeletalkey.com)
Differences among1
  • Finally, differences among 148 cases with HLA-B27 positivity and negativity suffering from ankylosing spondylitis (AS) were investigated. (bvsalud.org)
Immune response4
  • In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)
  • Our results suggest that genetic factors known to modulate the immune response might contribute to chronic infection with Pseudomonas, increased total IgE, and pulmonary outcome in CF. (nih.gov)
  • The HLA molecules and their counterparts in rodents were subsequently shown to be directly responsible for immune response differences between individuals and for determining the likelihood of graft rejection. (musculoskeletalkey.com)
  • The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)
Antibody3
  • The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. (wikipedia.org)
  • and CD-specific antibody tests have improved. (vdocuments.net)
  • Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)
Significantly1
  • HLA-A*02-C*16 and HLA-A*02-B*45 have been shown to contribute to significantly increased viral loads (greater than 100,000 copies per milliliter). (wikipedia.org)
Major histoco1
Chains1
  • HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
Gene2
  • For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. (wikipedia.org)
  • INTRODUCTION: Ankylosing spondylitis (AS), and carriage of HLA-B27 gene in otherwise healthy individuals, are reportedly associated with increased mortality. (bvsalud.org)
Methods1
  • METHODS: This study screened totally 1503 patients who underwent HLA-B27 examination, liver/kidney function tests, and complete blood routine examination in First Affiliated Hospital of Guangxi Medical University. (bvsalud.org)
Class4
  • HLA class II polymorphism in cystic fibrosis. (nih.gov)
  • Gluten is the single major environmental factor that triggers celiac disease, which has a narrow and highly specific association with class II haplotypes of HLA DQ2 (haplotypes DR-17 or DR5/7) and, to a lesser extent, DQ8 (haplotype DR-4). (medscape.com)
  • HLA class I molecules consist of a 45-kD α chain encoded within the MHC that is noncovalently associated with the 12-kD β 2 -microglobulin chain (encoded on chromosome 15). (musculoskeletalkey.com)
  • HLA class I and class II molecules are cell surface glycoproteins, anchored to the membrane by hydrophobic transmembrane segments. (musculoskeletalkey.com)
Asymptomatic2
  • Typically, such diagnoses are made by screening asymptomatic individuals who are at increased risk for celiac disease. (medscape.com)
  • children with symptoms suggestive of CD (group 1) and asymptomatic children at increased risk for CD (group 2). (vdocuments.net)
Group1
  • Among patients with EBV+ HL, only 35.5% of people expressed HLA-A*02 compared to 50.9% in the EBV-HL group and 53% in the control group. (wikipedia.org)
Recognition1
  • This high affinity increases the probability of CD8+ t-cell recognition of EBV peptides held by HLA-A*02 complexes. (wikipedia.org)
Cells2
  • HLA-A*02 appears to stimulate peripheral blood mononuclear cells in a manner that inhibits HIV replication. (wikipedia.org)
  • In each individual, T cells are generally restricted to recognize antigens presented by the person's own HLA molecules. (musculoskeletalkey.com)
Patients5
  • In addition, there are several HLA-A*02 haplotypes that appear to contribute heavily to higher or lower viral loads in HIV patients. (wikipedia.org)
  • Over time, patients with new-onset type 1 DM will lose weight, despite normal or increased appetite, because of depletion of water and a catabolic state with reduced glycogen, proteins, and triglycerides. (medscape.com)
  • Life expectancy was analysed in 377 axSpA patients having available pelvic radiographs and HLA-B27 status, comparing with matched Swiss population data. (bvsalud.org)
  • RESULTS: AS patients have increased standardised mortality rate (SMR) compared with the general population (1.37, 95% CI 1.11 to 1.62). (bvsalud.org)
  • OBJECTIVE: To describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status. (bvsalud.org)
Risk2
  • HLA-A*02 has been linked with decreased risk of developing Epstein-Barr virus (EBV)-positive Hodgkin lymphoma(HL). (wikipedia.org)
  • HLA-B27 carriage in the European-ancestry general population does not influence survival, or the risk of death due to vascular disease. (bvsalud.org)
Addition1
  • In addition, validation cohort included 147 cases with HLA-B27 positivity whereas 236 with HLA-B27 negativity. (bvsalud.org)
Common1
  • HLA-A*02 is globally common, but particular variants of the allele can be separated by geographic prominence. (wikipedia.org)
Positive1
  • This increase was significant for HLA-B27-positive AS (SMR 1.38, 95% CI 1.11 to 1.65). (bvsalud.org)
Susceptibility4
  • The genetic susceptibility to celiac disease is conferred by well-identified haplotypes in the human leukocyte antigen (HLA) class II region (ie, DR3 or DR5/DR7 or HLA DR4). (medscape.com)
  • Thus any alteration to the HLA that induces decreased binding to a certain peptide or increased binding to a certain peptide, is expressed as, respectively, increased susceptibility to disease or decreased susceptibility to disease. (wikipedia.org)
  • The genes that confer actions, are likely to provide important information susceptibility to IDDM are located in the HLA region regarding the causes of IDDM and lead to approaches of chromosome 6. (nih.gov)
  • Celiac disease is a multifactorial disorder resulting from the interaction of HLA-DQA1 and HLA-DQB1 allelic variants known to be associated with celiac disease susceptibility, less well-recognized variants in non-HLA genes, gliadin (a subcomponent of gluten), and other environmental factors. (nih.gov)
Phenotypes2
  • Results: Certain genomic (polymorphism of leukocyte HLA-DR antigens) and epigenomic (antibodies to α1 and α7 nAChR subunits, expression of Treg lymphocytes and concentration of cytokines) predictors were identified for various myasthenia phenotypes. (nih.gov)
  • The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. (wjgnet.com)
Genes1
  • The study aimed to identify genetic susceptible biomarkers associated with the TCE-induced hypersensitivity dermatitis in genes located in the human leukocyte antigen (HLA) region. (nih.gov)
Antibodies1
  • The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. (wjgnet.com)
Allele group2
  • HLA-A*02 is one particular class I major histocompatibility complex (MHC) allele group at the HLA-A locus. (wikipedia.org)
  • 11. HLA-A, -B, -DR allele group frequencies in 7007 kidney transplant list patients in 27 UK centres. (nih.gov)
Transplant11
  • Serotyping can identify as far as HLA-A*02, which is typically enough to prevent transplant rejection (the original motivation for HLA identification). (wikipedia.org)
  • 2. HLA antigen distribution in renal transplant recipients and donors. (nih.gov)
  • 4. Association Between HLA Type and Skin Cancer in Kidney Transplant Recipients. (nih.gov)
  • 5. Relation between skin cancer and HLA antigens in renal-transplant recipients. (nih.gov)
  • 7. HLA-A, -B, and -DRB1 allele and haplotype diversity in a cohort of Brazilian renal transplant candidates. (nih.gov)
  • 9. Association of HLA Antigen Mismatch With Risk of Developing Skin Cancer After Solid-Organ Transplant. (nih.gov)
  • 10. Influence of HLA antigens of renal transplant recipients on graft survival. (nih.gov)
  • 13. Evidence that matching for HLA antigens significantly increases transplant survival in 1001 renal transplants performed in the northwest region of England. (nih.gov)
  • 15. HLA-A, HLA-B, and HLA-DRB1 Allele and Haplotype Frequencies in Renal Transplant Candidates in a Population in Southern Brazil. (nih.gov)
  • 16. On a possible protective effect of HLA-A11 against skin cancer and keratotic skin lesions in renal transplant recipients. (nih.gov)
  • 18. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. (nih.gov)
Recipients2
  • Evidence that HLA-DR7-matched recipients are more susceptible to cytomegalovirus disease. (nih.gov)
  • Several factors including age, gender, ethnicity, quality and quantity of vaccine antigen, doses, and route of administration can influence immune response to vaccination, although the main cause of variation in the responsiveness among vaccine recipients is host genetic variability. (wjgnet.com)
Amino acid2
  • its incidence is increasing in the Ameri- amino acid other than aspartic acid in position 57 of cas and around the world. (nih.gov)
  • In addition, we compared and analyzed the structure character of amino acid residues of HLA molecules found in participants. (nih.gov)
Genetic1
  • Human leukocyte antigen (HLA) haplotype DQ2 or DQ8 identified by molecular genetic testing of HLA-DQA1 and HLA-DQB1 . (nih.gov)
Human1
  • HLA-A*02 (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. (wikipedia.org)
Molecules1
  • The adaptive immune response to gluten has been well described, with the identification of specific peptide sequences demonstrated in specific binding to HLA-DQ2 or DQ8 molecules and in stimulating gluten-specific CD4 T cells. (medscape.com)
Celiac disease3
  • Typically, such diagnoses are made by screening asymptomatic individuals who are at increased risk for celiac disease. (medscape.com)
  • [ 3 ] showed that undiagnosed celiac disease in the United States has dramatically increased in the past half century, going from 0.2% in the late 1940s to 0.9% 50 years later. (medscape.com)
  • Gluten is the single major environmental factor that triggers celiac disease, which has a narrow and highly specific association with class II haplotypes of HLA DQ2 (haplotypes DR-17 or DR5/7) and, to a lesser extent, DQ8 (haplotype DR-4). (medscape.com)
100,0001
  • Thus, the risk of IDDM increases with 100,000 per year in the northern and central parts of age during childhood and adolescence. (nih.gov)
Variants1
  • HLA-A*02 is globally common, but particular variants of the allele can be separated by geographic prominence. (wikipedia.org)
Glycemic control1
  • Real-time continuous monitoring of glucose-using continuous glucose monitors (CGMs)-can help patients improve glycemic control. (medscape.com)
System1
  • In 2010 the World Health Organization Naming Committee for Factors of the HLA System revised the nomenclature for HLAs. (wikipedia.org)
Disease1
  • 17. The influence of HLA A-B-DR matching on cytomegalovirus disease after renal transplantation. (nih.gov)