• During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
  • Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)
  • [ 3 , 4 ] As the human leucocyte antigen (HLA) molecules encoded by MHC class II are responsible for presenting peptide epitopes to CD4 + T helper cells, it is reasonable to postulate that polymorphism in the MHC class II region may explain the variation in outcome. (medscape.com)
  • Elution and binding studies suggest that HLA-DRB1*1302 is a relatively promiscuous peptide binder in comparison to other HLA class II molecules. (medscape.com)
  • Several factors including age, gender, ethnicity, quality and quantity of vaccine antigen, doses, and route of administration can influence immune response to vaccination, although the main cause of variation in the responsiveness among vaccine recipients is host genetic variability. (wjgnet.com)
  • Human leukocyte antigen (HLA) haplotype DQ2 or DQ8 identified by molecular genetic testing of HLA-DQA1 and HLA-DQB1 . (nih.gov)
  • Vaccine nonresponse is consistently associated with HLA-DRB1*0301 and *0401 in many populations. (medscape.com)
  • [ 10-12 ] The associations of HLA-DR7 (DRB1*07-) and HLA-DR3 (DRB1*0301) with persistent infection [ 13 , 14 ] are interesting because DRB1*0701 and DRB1*0301 have also been associated with failure to respond to HBsAg-based vaccine. (medscape.com)
  • The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. (wjgnet.com)
  • [ 28 , 29 ] The association of the DQB1*0301 allele with self-limiting HCV in the presence of different DRB1 alleles, suggests that this particular allele, rather than the corresponding haplotypes, may play an important role in the natural clearance of HCV viremia. (medscape.com)