MalignanciesHematopoietic CellGraft-versus-HSCTDONORSDonorAutologousGVHDPeripheral blood stemPatientsMalignancyStem cellsTransplant UnitCord bloodDiseasesInfectionDisordersMyelodysplasticImmunotherapyRefractorySevere combined immunodOncologySurvivalPTCYCancerLeukemiaDiseaseTreatmentHospitalIntegralAdverse
Malignancies15
- 1998 Dr. Guo and her medical team developed "Study of HLA-matched nonmyeloablative transplantation in the treatment of hematological malignancies" successfully. (wikipedia.org)
- Allogeneic hematopoietic cell transplantation (allo-HCT) has lifesaving potential for patients with hematological malignancies and bone marrow disorders, the authors wrote. (genengnews.com)
- T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. (hindawi.com)
- However, T cell exhaustion might lead to the possibility of immune escape of hematological malignancies. (hindawi.com)
- Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
- However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
- Over the last few decades, the treatment of hematological malignancies has gained tremendous headway, but these diseases still have high morbidity and mortality [ 1 - 3 ]. (hindawi.com)
- Traditionally, the treatment of hematological malignancies is administrated by chemotherapy, radiotherapy, and stem cell transplantation. (hindawi.com)
- In recent years, with the increased understanding of the molecular genetic basis of these malignancies, immune-targeted therapy has become a new possibility for the treatment of hematological malignancies. (hindawi.com)
- It is noted that T cell has great potential for immunotherapy of hematological malignancies. (hindawi.com)
- In addition, the isolation and storage of umbilical cord blood hematopoietic stem cells have been used to rebuild the immune system for the treatment of hematological malignancies and might be promising for the dynamic equilibrium expansion of functional T cells [ 12 ]. (hindawi.com)
- When Dr Osborn returned to Australia, he undertook adult haematology training at the Royal Adelaide Hospital and continued to develop an interest in haematological malignancies in adolescents and young adults. (leukaemia.org.au)
- Fludarabine and melphalan-based conditioning for patients with advanced hematological malignancies relapsing after a previous hematopoietic stem cell transplant. (uchicago.edu)
- Nevertheless, targeting solid tumors is more challenging than targeting hematological malignancies because of tumor histopathological characteristics, shortage of specific antigens and local strong immunosuppressive microenvironment [ 4 ]. (ijbs.com)
- Current statistics report an increase in the incidence of hematological and oncological malignancies, 1 but treatment with immune-based therapies have also risen in both use and efficacy. (bmj.com)
Hematopoietic Cell13
- In a newly reported study, an experimental antibody treatment largely prevented gastrointestinal acute graft versus host disease (GI-aGVHD) in the intestines of mice and non-human primates (NHPs) given a bone marrow transplant-allogeneic hematopoietic cell transplant (allo-HCT)-but without causing broad immune suppression. (genengnews.com)
- We are leading pediatric HSCT in Japan (based on the Report of Japan Hematopoietic Cell Transplantation Data Center National Survey). (opho.jp)
- Low-dose post-transplant cyclophosphamide (PTCy) in conjunction with anti-thymocyte globulin (ATG) appears as a potentially effective graft-versus-host disease (GVHD) prevention strategy in haploidentical hematopoietic cell transplant (haplo-HCT). (biomedcentral.com)
- A Multicenter, Pivotal Phase 3 Study of Iomab-B Prior to Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia (SIERRA) Jacksonville, Fla., Rochester, Minn. (mayo.edu)
- The use of allogeneic hematopoietic cell transplantation (HCT) is the most potent immunotherapeutic treatment for hematologic diseases, but its practical use is impeded by acute and chronic graft-versus-host disease (GvHD). (cryostem.org)
- Hematopoietic cell transplantation (HCT) is an integral part of the treatment of acute myeloid leukemia (AML). (apbmt.org)
- Hematopoietic cell transplantation (HCT) is an effective treatment in patients with acute myeloid leukemia (AML). (apbmt.org)
- The Japanese Society of Hematopoietic Cell Transplantation (JSHCT) has been conducting a nationwide survey on HCT since 1993, in which HCTs performed at participating centers are registered with the JSHCT every year. (apbmt.org)
- Outcomes of patients with AML and MDS who relapse or progress after reduced intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)
- Performance status and comorbidity predict transplant-related mortality after allogeneic hematopoietic cell transplantation. (uchicago.edu)
- Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. (uchicago.edu)
- Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation. (uchicago.edu)
- Pretreatment C-reactive protein is a predictor for outcomes after reduced-intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)
Graft-versus-4
- 2011 Expression of NOV and BNIP3 gene in mouse myelomonocytic leukemia and its significance 2011 Relationship between WT1-specific T-cell subsets and graft-versus-host disease after nonmyeloablative allogeneic transplantation 2011 "WT1-specific CTL cells of recipient origin may exist in the peripheral blood of patients achieving full donor chimerism soon after nonmyeloablative transplantation", published on Clin Transplant. (wikipedia.org)
- 2009 Changes of lymphocyte subsets in acute leukemia patients after HLA-mismatched nonmyeloablative hematopoietic stem cell transplantation 2010 "Efficacy of bone marrow-derived mesenchymal stem cells in the treatment of sclerodermatous chronic graft-versus-host disease: clinical report", published in Biol Blood Marrow Transplant 2009 A modified haploidentical nonmyeloablative transplantation without T cell depletion for high-risk acute leukemia: successful engraftment and mild GVHD" published in Biol Blood Marrow Transplant. (wikipedia.org)
- The 3-year probability of total chronic graft-versus-host disease (GVHD) was 21.4% and 34.1% in the haploidentical and HLA-matched HSCT groups, respectively ( P =0.526). (blood-genomics.com)
- Mild Acute Graft-Versus-Host Disease Improves Outcomes After HLA-Haploidentical-Related Donor Transplantation Using Posttransplant Cyclophosphamide and Cord Blood Transplantation. (kyoto-u.ac.jp)
HSCT12
- We perform all types of hematopoietic stem cell transplantation (HSCT) including bone marrow transplantation, peripheral blood stem cell transplantation, and umbilical cord blood transplantation. (opho.jp)
- In addition, we perform HLA-haploidentical HSCT, including HCT with post-transplant cyclophosphamide (PTCY) for non/less-malignant hematological diseases, and T-cell replete HSCT for advanced leukemia. (opho.jp)
- The number of T-cell replete HLA-haploidentical HSCT for advanced cases was 6. (opho.jp)
- Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
- The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
- This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
- Given the potential importance of MAIT cells in control of microbial infections and protection of epithelial surfaces, we investigated MAIT cell reconstitution in 43 children who underwent hematopoietic stem cell transplantation (HSCT) after myeloablative conditioning for the treatment of malignant hematological disease. (cryostem.org)
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the optimal treatment for pediatric patients with high-risk or intermediate-acute myeloid leukemia. (blood-genomics.com)
- This study analyzed the clinical outcomes of 119 pediatric acute leukemia patients who underwent haploidentical HSCT ( n =68) or human leukocyte antigen (HLA)-matched HSCT ( n =51). (blood-genomics.com)
- Analysis of the 3-year cumulative recurrence rate suggested no significant difference between the haploidentical HSCT group and HLA-matched HSCT group (cumulative incidence, 32.7% vs. 31.2%, P =0.801). (blood-genomics.com)
- There was no difference in transplantation-related toxicity (TRT) in terms of infection, hepatic dysfunction, oral mucositis, and engraftment syndrome between the haploidentical HSCT and HLA-matched HSCT groups. (blood-genomics.com)
- The study suggests that haploidentical HSCT shows comparable OS, LFS, and GRFS to HLA-matched HSCT in pediatric patients with acceptable complications, and can therefore be recommended as an effective alternative for this population. (blood-genomics.com)
DONORS3
- 2004 The study of HLA haploidentical blood related and unrelated matched donors nonmyeloablative transplantation for the treatment of blood diseases. (wikipedia.org)
- For patients lacking matched sibling donors, haploidentical donors are an option. (blood-genomics.com)
- Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia. (uchicago.edu)
Donor5
- And even when a bone marrow transplant is curative for leukemia or lymphoma, GVHD-in which T cells in the donor graft attack the recipient's own tissues-can still be fatal. (genengnews.com)
- This lets the cells of the donor go into the bone marrow and produce normal immune cells. (zhihuiya.com)
- Patients who do not have a matched sibling donor but have a donor that matches in the National Marrow Donor Program. (zhihuiya.com)
- This is know as matched unrelated donor transplantation. (zhihuiya.com)
- Various factors including age, sex, performance status (PS), disease status, cytogenetic risk, donor type, graft source, sex mismatch between the donor and the recipient, and year of transplantation were all shown to impact OS 2 . (apbmt.org)
Autologous6
- [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
- Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (medscape.com)
- Autologous bone marrow concentrate combined with platelet-rich plasma enhance bone allograft potential to induce spinal fusion. (unicampus.it)
- Figure 1 shows the trend in the annual number of allogeneic and autologous HCTs in adults with AML reported in the Japanese transplantation registry. (apbmt.org)
- Autologous and allogeneic transplantation for aggressive NHL. (uchicago.edu)
- Second autologous stem cell transplantation for relapsed lymphoma after a prior autologous transplant. (uchicago.edu)
GVHD5
- In experiments with mouse models of GVHD, the researchers showed that blocking a particular Notch activator known as DLL4 effectively prevented GVHD when administered within the first days after transplantation. (genengnews.com)
- In this model, treatments can be evaluated initially as single agents for their activity in GVHD prophylaxis, unlike in human patients, where new interventions must be combined with drugs used for routine GVHD prevention. (genengnews.com)
- The team confirmed that the Notch pathway involvement in GVHD was conserved across species, and demonstrated in their animal models that just a single dose of the DLL4-blocking antibody given immediately before stem cell transplantation greatly increased survival and prevented signs of GVHD in the intestines, but without causing global immunosuppression. (genengnews.com)
- Recently, results of a prospective trial have been available which analyze the efficacy of combined use of low-dose ATG and 1-day high-dose PTCy (50 mg/kg at + 3 days) in preventing GVHD among haplo patients [ 17 ]. (biomedcentral.com)
- We previously reported this strategy in preliminary prospective study wherein reduced incidences of both acute and chronic GVHD were observed in comparison with non-combined regimens [ 18 ]. (biomedcentral.com)
Peripheral blood stem1
- The number of related HCTs has remained stable, while the use of peripheral blood stem cells (PBSCs) has now largely replaced that of bone marrow (BM). (apbmt.org)
Patients11
- 2010 Application of HLA-A*0201/WT1 pentamer combined with intracellular IFNgamma+ staining in detecting circulating WT1 specific T cells in leukemia 2010 "Comparison of Wilms' tumor antigen 1-specific T lymphocyte generation soon after nonmyeloablative allergenic stem-cell transplantation in acute and chronic leukemia patients", published in Int J Hematol. (wikipedia.org)
- This study uses transplantation to treat patients with problems in their immune system. (zhihuiya.com)
- Conditioning' treatments are given to patients to create space in their bone marrow. (zhihuiya.com)
- To create space in the bone marrow, patients are given two drugs, Campath-1H and busulfan. (zhihuiya.com)
- Dr. Dora Ho specializes in infection complications in immunocompromised patients, such as those with bone marrow transplant, solid organ transplant, cancers and other forms of immunodeficiency. (stanford.edu)
- Alternatively, high-dose cytarabine combined with idarubicin, daunorubicin, or mitoxantrone can be used as induction therapy in younger patients. (medscape.com)
- Hino Y, Muraosa Y, Oguchi M, Yahiro M, Yarita K, Watanabe A, Sakaida E, Yokote K, Kamei K: Drain outlets in patient rooms as sources for invasive fusariosis: an analysis of patients with haematological disorders. (chiba-u.ac.jp)
- Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia. (uchicago.edu)
- Allogeneic stem cell transplantation with alemtuzumab-based conditioning for patients with advanced chronic myelogenous leukemia. (uchicago.edu)
- Successful allogeneic transplantation of patients with suspected prior invasive mold infection. (uchicago.edu)
- Also, there was an association between absence of radiographic signs of osseointegration of the structural graft and failure in this series of patients with large bone defects. (bvsalud.org)
Malignancy1
- Despite the addition of recent drugs to the common regimen and improvement of post transplantation survival, these particular myeloid malignancy subtypes remain a challenge for hematologists around the globe. (mdpi.com)
Stem cells1
- The immune system cells come from the bone marrow where they grow from special cells called stem cells. (zhihuiya.com)
Transplant Unit1
- The bone marrow transplant unit in Bristol was a combined paediatric and adult unit at the time, and that really highlighted to me the unique challenges faced by teenagers and young adults who sit between paediatric and adult medicine. (leukaemia.org.au)
Cord blood1
- The use of umbilical cord blood (UCB) has been steadily increasing, and UCB transplantation (UCBT) currently accounts for one-third of all allogeneic HCTs. (apbmt.org)
Diseases2
- This study will use lower doses of a drug called busulfan and lower doses of radiation than what are currently being used in other kinds of bone marrow transplantation for other diseases. (zhihuiya.com)
- Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)
Infection2
- In the department of Hematology/Oncology we treat children with cancer (including leukemia), non-malignant hematological disorders, chronic active EB virus infection, and immune dysfunctions. (opho.jp)
- Fujishita K, Oka S, Kamei K, Tani K, Fujisawa Y, Kitamura W, Machida T, Imai T: A Disseminated Fusarium fujikuroi Species Complex Infection Prior to Allogeneic Hematopoietic Stem Cell Transplantation. (chiba-u.ac.jp)
Disorders1
- Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. (bvsalud.org)
Myelodysplastic2
- She is a pre-eminent expert in the use of hematopoietic stem cell transplantation for treating radiation injuries and blood disease, especially leukemia, aplastic anemia and myelodysplastic syndrome. (wikipedia.org)
- Impact of disease burden at time of allogeneic stem cell transplantation in adults with acute myeloid leukemia and myelodysplastic syndromes. (uchicago.edu)
Immunotherapy2
- Under the slogan of "cure without late complications," we have successfully minimized treatment-related late complications with reduced intensity conditioning (RIC) for hematopoietic stem cell transplantation and immunotherapy, which have smaller side effects. (opho.jp)
- Thus, it is imperative to develop more competent and safer immunotherapy approaches by optimizing the design of CAR vectors, exploring new targets, incorporating conditional safe switches and combining with other strategies. (ijbs.com)
Refractory1
- Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease: Should It Be Considered? (mdpi.com)
Severe combined immunod1
- Primary immunodeficiency, other immune dysfunctions, infants positive for expanded new born screening for severe combined immunodeficiency (SCID), etc. (opho.jp)
Oncology1
- It was when Dr Osborn went to the Bristol Royal Hospital for Children in the UK to train in stem cell transplantation that he first developed an interest in adolescent and young adult (AYA) oncology. (leukaemia.org.au)
Survival1
- Abstract Objective To evaluate the clinical and radiographic results and survival of the acetabular revision surgery of total hip arthroplasty with cemented implant without the use of reinforcement ring, associated with structural homologous bone grafting. (bvsalud.org)
PTCY1
- This protocol consisted of a myeloablative conditioning (MAC) regimen containing cytarabine, busulfan, Cy combined with standard-dose ATG/G-CSF (the so-called Beijing protocol), and followed by low-dose PTCy (14.5 mg/kg on days 3 and 4 after HCT) for haplo-HCT recipients. (biomedcentral.com)
Cancer2
- A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets. (jax.org)
- National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee. (uchicago.edu)
Leukemia2
- 2005 Treatment of Jining serious radiation accidents and extremely severe bone marrow and intestinal radiation 2006 Developed an original creativity of microtransplantation for the treatment of leukemia. (wikipedia.org)
- She has co-authored five monographs, including "Hematopoietic stem cell transplantation clinical and basic," "Modern leukemia study," "Clinical and basic research of radiation sickness," and two more books. (wikipedia.org)
Disease2
- Have problems from the disease that call for stem cell transplantation. (zhihuiya.com)
- Since its establishment in 2010, the Adult AML Working Group within the JSHCT has been using this registry data to complete several studies focusing on various aspects of HCT in adults with AML, with particular attention paid to patient-, disease-, and transplantation-related factors. (apbmt.org)
Treatment1
- The combined use of platelet rich plasma and hyaluronic acid: prospective results for the treatment of knee osteoarthritis. (unicampus.it)
Hospital1
- The talk is at the lecture theatre in the Institute of Transplantation at Freeman Hospital, and will be preceded at 8.45 by a short talk from Carlos Echevarria, a local clinical research fellow and PhD student. (musculoskeletalresearch.com)
Integral1
- Automated hematological analyzers are an integral part of it, providing much additional information other than blood counts. (hilarispublisher.com)
Adverse1
- The condition is among the leading causes of death and long-term adverse health consequences associated with bone marrow transplants. (genengnews.com)