• The effects of halothane and isoflurane on myocardial contraction and relaxation in diseased myocardium are not completely understood. (silverchair.com)
  • However, the negative inotropic effects of halothane and isoflurane were not different for cardiomyopathic or healthy hamsters when their concentrations were corrected for minimum alveolar concentration (MAC) values in each strain. (silverchair.com)
  • Halothane and isoflurane induced no significant lusitropic effect under high load. (silverchair.com)
  • Halothane and isoflurane had greater negative inotropic effects in cardiomyopathic than in healthy hamsters. (silverchair.com)
  • The relationship between the hydrolysis rate of a monolayer of dipalmitoylphosphatidylcholine [ 14 C-choline] (DPPC) by phospholipase C (Plase C) and monolayer surface pressure (SP) as altered by either halothane, isoflurane, or by physical compression at 37°C was studied. (northwestern.edu)
  • Higher SP between 25 and 30 dyne/cm, whether induced by halothane, isoflurane or physical compression, increased the rate of hydrolysis by 5-fold to a peak rate of about 1600 cpm/min at 25-30 dynes/cm. (northwestern.edu)
  • The consumption of Halothane/Isoflurane has been found to be around 3.5 ml/hour19. (capnography.com)
  • the inhalational anesthetic is most often halothane, but other anesthetics (eg, isoflurane , sevoflurane , desflurane ) may also be involved. (msdmanuals.com)
  • Shorter-acting volatile agents (eg, sevoflurane and desflurane) are associated with a higher incidence of ED than longer-acting agents (eg, halothane and isoflurane) are. (medscape.com)
  • Within the airway wall sensory receptors alter bronchial smooth muscle tone through the parasympathetic vagal pathways. (isanagpur.org)
  • HALOTHANE and the volatile anesthetic agents can modulate ion channel function or ion transport in different tissues. (asahq.org)
  • Anesthetics, volatile: halothane. (silverchair.com)
  • Epithelial type II cells from adult rat lungs were exposed to halothane concentrations of 1, 2, and 4% from 0.5-4 h. (asahq.org)
  • The decrease in sodium, potassium-adenosine triphosphatase activity was maximal for 30 min of exposure and reached 50, 42, and 56% for halothane concentrations of 1, 2, and 4%, respectively, and did not change for longer exposure times. (asahq.org)
  • Altered respiratory rate variable bronchorrhea metabolic metabolic acidosis acetazolamide acidifying agents ammonium chloride arginine hydrochloride hydrochloric acid that is severe, however, standard doses of pcp appears to occur following ingestion. (oaksofwellington.com)
  • [1,2] Recently, however, halothane was shown to inhibit Na/calcium (Ca) exchanger and Ca channels in heart cells [3] and to decrease ion transport in canine tracheal epithelium, an effect that may contribute to decreased mucous clearance in the perioperative period. (asahq.org)
  • Although both ketamine and halothane inhibit potassium currents through the Kv2.1 channel, their mechanisms of action at this potential target may be different. (silverchair.com)
  • Halothane given with succinylcholine for induction anesthetic is associated with masseter spasm. (medscape.com)
  • Should Changes in Hematology and Biochemistry alter the Anesthetic Protocol? (vin.com)
  • Once blood-work has been assessed the question arises "Should the anesthetic technique be altered if abnormal results are unexpectedly found in an animal that has no history or clinical signs of disease? (vin.com)
  • We describe a genetic and behavioral analysis of several alleles of har38, a mutant with altered sensitivity to the general anesthetic halothane. (wikigenes.org)
  • Inhalation anesthetic molecules such as halothane cause these lipid regions to mix, potentially affecting the function of ion channel proteins found imbedded in the membrane. (nist.gov)
  • Methods Halothane-anesthetised rats had the brain stem transected at the pretrigeminal level. (erowid.org)
  • Methods: Halothane- anesthetized cats underwent left middle cerebral artery (MCA) occlusion for 4 hours. (elsevierpure.com)
  • Sodium, potassium-adenosine triphosphatase, and amiloride-sensitive Na channel activities are impaired by halothane in alveolar type II cells in vitro. (asahq.org)
  • 11, 12 Clinically, MH status may be assessed by exposure in the laboratory of a patient's muscle biopsy specimen to incremental doses of specific trigger agents (caffeine, halothane) and measuring the in vitro contracture response using the contracture test (IVCT). (bmj.com)
  • In addition, the effects of halothane were assessed in the absence of extracellular calcium (Ca) with or without 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid, an intracellular Ca chelating agent. (asahq.org)
  • Halothane alters surfactant biosynthesis and metabolism of alveolar type II cells. (asahq.org)
  • Moreover, the data suggest that ethanol exposure can alter basal DA and 5-HT in the nucleus accumbens and that vulnerability to ethanol-induced changes in monoamine neurotransmission may be a factor in genetically determined ethanol preference. (aspetjournals.org)
  • Type I (mild) halothane hepatotoxicity occurs within hours of halothane exposure. (medscape.com)
  • Type II (fulminant) halothane hepatotoxicity usually occurs 5-7 days following exposure, although it can be delayed by up to 4 weeks. (medscape.com)
  • Exposure of epithelial type II cells to halothane reduced the activity of sodium, potassium-adenosine triphosphatase, and amiloride-sensitive Na channels, whereas Na cotransporters were unchanged. (asahq.org)
  • [1-3] Because of the hypnotic effects of these agents, attention has focused mainly on the central nervous system, and several studies have reported that halothane exposure depressed voltage-gated sodium (Na) channels and potassium (K) channels. (asahq.org)
  • Using voltage-clamp techniques, the authors examined the effect of two general anesthetics (ketamine and halothane) on a rat brain potassium channel of known amino acid sequence, and further assessed whether the inhibition of the channel is altered by a partial deletion of the C-terminal sequence of this channel. (silverchair.com)
  • Pharmacodynamics of inhaled anesthetics reduce the rate of mucus clearance by decreasing ciliary beat frequency, metachronism (wave of motion produced by cilia towards the trachea) as well as altering the characteristics of mucus. (anesthesiageneral.com)
  • Scientists from NIST and the National Institutes of Health have found hints that anesthesia may affect the organization of fat molecules, or lipids, in a cell's outer membrane-potentially altering the ability to send signals along nerve cell membranes. (nist.gov)
  • The combination of therapeutic doses of intravenous dantrolene sodium and verapamil in halothane/ a -chloralose anesthetized swine has resulted in ventricular fibrillation and cardiovascular collapse in association with marked hyperkalemia. (druglib.com)
  • Use dependence of ketamine and halothane action was observed in both Kv2.1 and the mutant channel, attributable to augmentation of C-type inactivation. (silverchair.com)
  • The purpose of this study was to examine the effects of halothane on Na transport activities. (asahq.org)
  • This failed to alter the above effects of i.v. LSD, VH and thalamic cells were unaffected by 5HT. (erowid.org)
  • M. Nishimoto, U. Komatsu, N. Tamai, M. Yamanaka, S. Kaneshina, K. Ogli, H. Matsuki, A Comparative Study of Specific and Nonspecific Interactions in Bovine Serum Albumin: Thermal and Volume Effects of Halothane and Palmitic Acid, Colloid Polym. (biomembeng-tokushima-u.com)
  • Inhalants are breathable chemical vapors that produce psychoactive (mind-altering) effects. (councilonalcoholism.net)
  • Physical findings in type II halothane hepatotoxicity include delayed pyrexia (up to 75% of patients). (medscape.com)
  • In some experiments, cells that were exposed to 1% halothane for 1 h were allowed to recover after replacement of the medium for 15 and 30 min. (asahq.org)
  • [5] The experiments were apparently conducted using isolated working hearts from halothane-anesthetized murine models. (biotechpeptides.com)
  • Two major types of hepatotoxicity are associated with halothane administration. (medscape.com)
  • 20% of baseline amplitude in all groups) during MCA occlusion and was not altered by bFGF administration. (elsevierpure.com)
  • [4] Taken together, these studies suggest that halothane interferes with ion transport in many different cell types. (asahq.org)
  • The National Halothane Study, a retrospective analysis, reviewed the incidence and mortality rates of postoperative hepatic necrosis from 1959-1962. (medscape.com)
  • Based on this study, the risk of fatal halothane hepatotoxicity was estimated to be 1 in 35,000. (medscape.com)
  • Halothane accelerated the time constant of current inactivation, whereas ketamine affected this parameter minimally in both channel types. (silverchair.com)