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  • metabolites
  • It was anticipated that free radicals of carbene metabolites formed from halothane would add to the single 9,10 double bond of the identical oleic-acid chains in dioleoylphosphatidylcholine. (cdc.gov)
  • Significant covalent binding of radioactive metabolites to phospholipids was noted following incubation of reconstituted vesicles with carbon-14 labeled halothane under argon. (cdc.gov)
  • ventricular
  • Methods and Results - This study investigated the influence of sex on drug-induced polymorphic ventricular tachycardia (PVT) in Langendorff-perfused male and female mice hearts (n=54) by injecting a bolus of halothane (1.75 mmol/L) in the perfusate while recording ECGs or optical action potentials (APs). (ahajournals.org)
  • inhibit
  • Halothane was shown consistently to inhibit glutamatergic excitation, [2-whereas its effects on GABAergic inhibition have been more contradictory. (asahq.org)
  • mammalian
  • Halothane affects synaptic transmission mediated by glutamate and gamma-aminobutyric acid (GABA), the major excitatory and inhibitory transmitters in the mammalian central nervous system. (asahq.org)
  • liver
  • Feng D, Wang Y, Xu Y, Luo Q, Lan B, Xu L. Interleukin 10 deficiency exacerbates halothane induced liver injury by increasing interleukin 8 expression and neutrophil infiltration. (medscape.com)
  • Kobayashi E, Kobayashi M, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. Halothane-induced liver injury is mediated by interleukin-17 in mice. (medscape.com)
  • Study
  • The study confirmed two truisms that our mentors have taught us and we, as well as our mentors, have on occasion experienced: halothane is not always well tolerated in infants, and halothane is often poorly tolerated in dehydrated infants. (lww.com)
  • male
  • In optically mapped male hearts, halothane reduced APD 75 (17.61±1.6 ms) and then elicited VTs (n=6 of 6), but in female hearts, halothane elicited PVTs (n=1 of 6) or arrested the hearts (n=5 of 6). (ahajournals.org)
  • group
  • Group 1 was control group exposed only to room air, group 2 was exposed to 50 parts per million (ppm) N2O and 1ppm halothane, and group 3 was exposed to 500ppm N2O and 10ppm halothane. (cdc.gov)