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ApomorphineHaloperidolDopamine AgonistsReceptors, DopamineAntipsychotic AgentsDopamine AntagonistsClozapineCatalepsyReceptors, Dopamine D2PimozidePiribedilStereotyped BehaviorDopamineStartle ReactionEmeticsPenile ErectionTranquilizing AgentsRisperidoneLevodopaAntiparkinson AgentsQuinpiroleSulpirideReceptors, Dopamine D3Motor ActivityCorpus StriatumAmphetamineHydroxydopaminesReceptors, Dopamine D1DomperidoneSpiperoneDopamine AgentsDose-Response Relationship, DrugSensory Gating2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineBehavior, AnimalPhencyclidineBenzodiazepinesCarbidopaRats, Sprague-DawleyDyskinesia, Drug-InducedOxidopamineBenzazepinesErgolinesPromethazineYawningSchizophreniaParkinson DiseaseSubstantia NigraAdministration, SublingualBromocriptineParkinson Disease, SecondaryHomovanillic AcidPsychomotor AgitationBis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfideFlupenthixolLisurideFluphenazineSerotonin Receptor AgonistsHarmineReceptors, sigmaThioridazineCaudate NucleusDrug Interactions3,4-Dihydroxyphenylacetic AcidPenisRats, WistarInfusion PumpsMetoclopramideScopolamine HydrobromideChlorpromazineDextroamphetaminePhenothiazinesTrifluperidolRacloprideSerotonin AntagonistsNucleus AccumbensEmergency Services, PsychiatricDibenzothiazepinesRats, Inbred StrainsFenclonineErectile DysfunctionPirenzepineInjections, SubcutaneousReceptors, SerotoninBrain
DopaminergicRisperidoneStereotypyAmphetamineAgonists apomorphineRatsPhysostigmine-inducedMethamphetaminePilocarpineDoseParkinson'sStriatumReceptorsMetoclopramideSchizophreniaIloperidoneTreatmentEffectsEffectIncreaseDopamine receptorClozapineApokynBlockadeLocomotorInjectionDosesDrugsMiceSignificantlyResults
Dopaminergic7
  • APOMINE Solution for Infusion contains apomorphine which belongs to a group of medicines called dopaminergic compounds. (news-medical.net)
  • The possible involvement of the dopaminergic system in the actions of T. catigua extract was substantiated by data showing the potentiation of apomorphine-induced hypothermia and by the prevention of haloperidol-induced catalepsy. (hindawi.com)
  • Haloperidol displaced 3H spiperone in both dopaminergic regions and frontal cortex. (erowid.org)
  • Vasar, E. Apomorphine aggressiveness: the role of dopaminergic and opiate mechanisms in limbic structures. (sakuhuvikeskus.ee)
  • The present experiments were performed to clarify the possible role of the dopaminergic and cholinergic systems in mediating the effects of chronic treatment with haloperidol, physostigmine and scopolamine on yawning induced by apomorphine, physostigmine or pilocarpine. (baillement.com)
  • The feasible involvement of the dopaminergic craft in the actions of T. catigua exarticle was substantiated nearvia iota instructing the potentiation of apomorphine-induced hypothermia and in the environs the prevention of haloperidol-induced catalepsy. (upb.ro)
  • The dopaminergic agonists apomorphine, bromocryptine, ergometrine and A-6,7-DTN mimic the action of dopamine on this neurone, all having a similar voltage-dependence to that of dopamine. (silverchair.com)
Risperidone3
Stereotypy3
  • Also, their efficacy in inhibiting tryptamine seizures correlated with their binding activity in the frontal cortex, and the ratio of their inhibition of 3H-haloperidol binding in the striatum to 3H spiperone binding in the frontal cortex paralleled the ratio of the efficacy of their antagonism of apomorphine stereotypy to that of tryptamine seizures. (erowid.org)
  • However, physostigmine showed the most rapid onset- and peaktime of yawning induced by a high dose of physostigmine (0.75 mg/kg, i.p.) as well as that of pilocarpine (8 mg/kg, i.p.), and potentiated apomorphine (1 mg/kg, i.p.)-induced stereotypy, as compared with that observed in the saline group. (baillement.com)
  • Paradoxical sleep (PS) deprivation induces several changes on human's and rat's behavior, such as increased apomorphine-induced stereotypy and aggressive behavior in rats, and improvement of endogenous depression symptoms in humans. (baillement.com)
Amphetamine3
Agonists apomorphine1
Rats8
  • Also, rats (240+20 g) pretreated with the drugs had 1.25 mg/kg, i.v. apomorphine, and 40 mg/kg, i.v. tryptamine, t hr later. (erowid.org)
  • Method The rotational responses of male SPF rats with unilateral damage to their nigro-striatal system (induced by the injection of 10 mcg 5,6 dihydroxytryptamine (5,6-HT) or 3.5 mcg 6-hydroxydopamine (6-OH - dopamine) into the right medial forebrain bundle) to 1-5 mg/kg of (+)-methamphetamine, 0.05-3 mg/kg apomorphine or 100,200 or 1,500 mcg LSD/kg i.p. were determined. (erowid.org)
  • Methamphetamine produced ipsilateral and apomorphine contralateral circling in rats pretreated with either of the neurotoxics. (erowid.org)
  • The rotational responses to LS13 were significantly decreased by 1 mg haloperidol/kg injected i.p. 10 min after the 200 mcg/kg dose of LSD, both in 6-OH-dopamine and 5,6-HT pretreated rats. (erowid.org)
  • The effect of lithium on chronic haloperidol enhanced apomorphine aggression in rats. (sakuhuvikeskus.ee)
  • Following PS deprivation, rats were injected with apomorphine or pilocarpine and number of yawns was recorded. (baillement.com)
  • Atropine increased yawning of PS deprived rats induced by pilocarpine, but not by apomorphine. (baillement.com)
  • Iloperidone has also been shown to reduce the effects of apomorphine induced climbing behavior in mice as well as the effects of head twitching induced by 5-HT in rats. (bionity.com)
Physostigmine-induced4
  • Haloperidol decreased the apomorphine- and physostigmine-induced yawning but not the pilocarpine-induced yawning. (baillement.com)
  • Physostigmine reduced only the pilocarpine-induced yawning without affecting the apomorphine- and physostigmine-induced yawning. (baillement.com)
  • Physostigmine-induced yawning is potentiated by fluphenazine, a long-acting neuroleptic, but decreased with a high dose of apomorphine. (baillement.com)
  • This conclusion is based on a study by Yamada and Furukawa, who showed that scopolamine, a cholinoceptor antagonist, inhibits apomorphine-, pilocarpine-, and physostigmine-induced yawning. (baillement.com)
Methamphetamine1
Pilocarpine4
  • Chronic treatment with haloperidol, physostigmine and scopolamine exerted different effects on the frequency of yawning induced by apomorphine (0.25 mg/kg, i.p.), physostigmine (0.2 mg/kg, i.p.) and pilocarpine (4 mg/kg, i.p.) as compared with chronic treatment with saline. (baillement.com)
  • Scopolamine potentiated the physostigmine- and pilocarpine-induced yawning but not the apomorphine-induced yawning. (baillement.com)
  • The results suggest that yawning induced by physostigmine, but not by pilocarpine, may be modified by long-term treatment with haloperidol. (baillement.com)
  • PS deprivation also inhibits yawning elicited by apomorphine, physostigmine, and pilocarpine. (baillement.com)
Dose2
  • the D 1 antagonist Sch 23390, but not the D 2 antagonist haloperidol, dose dependently antagonized the SKF 38393 cue. (utmb.edu)
  • In animals chronically treated with saline, floowed by low dose of apomorphine (0.25 mg/kg), yawning began within 5 min (mean, 4.3 mm), reached a maximum after 10-20 min (mean, 15 mm) and usually ceased within 60 min. (baillement.com)
Parkinson's1
  • Apomorphine is used in the treatment of Parkinson's disease to reduce the number and severity of bouts of freezing and stiffness (or "off" periods). (news-medical.net)
Striatum1
  • Methods Rat striatum or frontal cortex was incubated for 10 min with 3H-spiperone,3H-haloperidol or 3H-LSD. (erowid.org)
Receptors1
  • Adaptational changes in GABA-B, benzodiazepine and cholecystokinin receptors elicited by long-term haloperidol administration. (sakuhuvikeskus.ee)
Metoclopramide1
Schizophrenia1
Iloperidone1
  • Psychosis induced using PCP, apomorphine, and cirazoline, were all prevented with the concurrent administration of iloperidone. (bionity.com)
Treatment1
  • Repeated injections of haloperidol (Dunstan and Jackson, 1977) or treatment with 6-hydroxydopamine (Kato et a! (baillement.com)
Effects1
  • haloperidol decreases effects of ropinirole by pharmacodynamic antagonism. (medscape.com)
Effect1
  • Atropine effect was quite specific, because it did not reverse apomorphine-induced yawning. (baillement.com)
Increase1
Dopamine receptor2
  • Yawning was induced by subcutaneous (s.c.) injection of apomorphine (a dopamine receptor agonist) and the number of yawns was recorded for a period of 30 min. (ac.ir)
  • A behavioural and biochemical comparison of dopamine receptor blockade produced by haloperidol with that produced by substituted benzamide drugs. (semanticscholar.org)
Clozapine1
  • Objectives: We have carried out a pharmacological characterization of the Roman high- (RHA-I) and low-avoidance (RLA-I) rat strains with different acutely administered propsychotic (DOI, MK-801) and antipsychotic drugs (haloperidol, clozapine), as well as apomorphine, on prepulse inhibition (PPI) of startle and locomotor activity (activity cages). (uab.cat)
Apokyn2
  • ingredients.tell your doctor if you are receiving apomorphine (Apokyn). (nih.gov)
  • APOKYN (apomorphine hydrochloride injection) is indicated for the acute, intermittent treatment of hypomobility, "off" episodes ("end-of-dose wearing off" and unpredictable "on/off" episodes) in patients with advanced Parkinson's disease. (nih.gov)
Blockade2
Locomotor2
  • The novelty- and apomorphine-induced locomotor and rearing behaviours of AZE in mice were explored in an open-field observational test system. (hindawi.com)
  • AZE (100-1000 mg/kg) produced a significant decrease in the frequency of novelty- and apomorphine-induced locomotor activities in mice. (hindawi.com)
Injection1
  • These highlights do not include all the information needed to use APOMORPHINE HYDROCHLORIDE INJECTION safely and effectively. (nih.gov)
Doses4
  • Higher doses of apomorphine, known to stimulate postsynaptic D1 and D2 receptors and pretreatment with the D2 antagonist haloperidol decreased QUIN-lever responding. (nih.gov)
  • Curcumin alone produced no yawning, whereas at doses of 30 and 60 mg/kg, it increased yawning induced by 0.1 mg/kg of apomorphine. (ac.ir)
  • Curcumin at the high doses (30 and 60 mg/kg) produced yawning when apomorphine (0.1 mg/kg) action was partially blocked with 0.5 mg/kg of haloperidol. (ac.ir)
  • Conclusion: The results showed that curcumin at high doses increased apomorphine-induced yawning. (ac.ir)
Drugs1
  • 5. Ritanserin and ICI 170,809 had no effect on apomorphine-induced stereotypy or hyperactivity, indicating that these drugs do not produce non-specific behavioural activation. (ox.ac.uk)
Mice3
  • The effects of AZE in apomorphine-induced cage climbing test, extract-induced catalepsy, and haloperidol-induced catalepsy on mice were also investigated. (hindawi.com)
  • The extract also significantly decreased the frequency and duration of apomorphine-induced climbing activities in mice. (hindawi.com)
  • Climbing behaviour induced by apomorphine in mice: a potential model for the detection of neuroleptic activity. (semanticscholar.org)
Significantly1
  • LSD (372 nmol/kg, 0.16 mg/kg) injected 90 min before training produced a cue that was not fully blocked by 5-HT(2A) antagonists, but instead was significantly inhibited by haloperidol. (erowid.org)
Results1