• Optimised and flexible kits for and polymerase rapid isothermal amplification and detection of viral RNA, POC (lyo-compatible). (biosearchtech.com)
  • The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)
  • Moreover, proliferating cell nuclear antigen (PCNA) and CD31 showed co-localization with α-SMA, suggesting the differentiation of hBMSCs into epithelial cells and myofibroblasts/fibroblasts. (ijbs.com)
  • The objective of this study was to identify the expression and distribution of EPHA4 and Ephrin A3 genes in the development and morphogenesis of hair follicles in fine-wool sheep. (bvsalud.org)
  • In this study, we identified specific structural variants in the Boer goat based on genome-wide selection signals and analyzed the basis of the molecular heredity of related candidate genes in muscle development. (bvsalud.org)
  • Transfective expression in undifferentiated myoblasts produced slow TnT mRNA but not a detectable amount of truncated or intact slow TnT proteins, indicating a muscle cell-specific proteolysis of TnT when it is not integrated into myofilaments. (clinicforspecialchildren.org)
  • The health and appearance of our skin, hair and nails depends on the health of several structural proteins they share, namely collagen, keratin and elastin. (lifeextension.com)
  • In this protocol you will learn about factors both inside your body and from the external environment that can damage skin, hair and nail proteins. (lifeextension.com)
  • Learn about medical, dietary and lifestyle strategies to support healthy skin, hair and nail proteins. (lifeextension.com)
  • The appearance and integrity of our skin, hair, and nails are dependent upon a framework of structural proteins, especially keratin, collagen, and elastin. (lifeextension.com)
  • Intact slow TnT mRNA was readily detected in patient muscle, indicating unaffected transcription and RNA splicing. (clinicforspecialchildren.org)
  • The expression network of three candidate genes ( ARHGAP10, NR3C2, and EDNRA) regulating dose transcription was constructed by RNA sequencing. (bvsalud.org)
  • Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. (nih.gov)
  • Thyroid-stimulating immunoglobulins (TSIs) bind to and activate thyroid-stimulating hormone (TSH) receptors, causing the thyroid gland to grow and the thyroid follicles to increase synthesis of thyroid hormone. (medscape.com)
  • Rapid extraction of RT-PCR ready RNA from cultured mammalian cells. (biosearchtech.com)
  • Future simulations are required to determine whether these compounds are potent blockers of mammalian Nav channels and if they are specific to a particular channel sub-type. (erksignal.com)
  • It is held in the cytoplasm in an inactive state by specific inhibitors. (nih.gov)
  • MicroRNAs (miRNAs) are a large class of non-coding RNAs that play important roles in the proliferation and differentiation of adipocytes. (bvsalud.org)
  • The downregulation of psoriasin expression by small interfering RNA revealed that psoriasin mediates the expression of involucrin, desmoglein 1, transglutaminase 1 and CD24 in normal differentiation. (medicaljournals.se)
  • Transposable elements are able to affect conserved and divergent chromatin looping and contribute to cell- and species-specific gene regulation [ 11 ]. (biomedcentral.com)
  • In addition to classical gene regulatory networks noted above, we have recently identified a central role for additional biologic mechanisms, namely gene regulation by chromatin regulators and by noncoding RNAs. (stanford.edu)
  • To uncover potential regulators of sheep fecundity, RNA-seq was used to comparatively analyze miRNA expression profiles of endometrium between high prolificacy sheep (HP, litter size = 3) and low prolificacy sheep (LP, litter size = 1) with FecB genotype. (bvsalud.org)
  • The ancillary domain, which mediates binding to ECM components and specific protease substrates, consists of a conserved central thrombospondin type 1 sequence repeat motif (TSR), a cysteine-rich domain and a spacer domain. (encyclopedia.pub)
  • While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
  • T cell memory is antigen-specific, and can provide durable host-wide protection. (frontiersin.org)
  • In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
  • Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell-type-specific protein markers. (aacrjournals.org)
  • Using RNA expression profiling, we identified the membrane protein leucine-rich repeat containing 15 (LRRC15) as highly expressed in multiple solid tumor indications with limited normal tissue expression. (aacrjournals.org)
  • However, the four ADAMTS proteases show differences in the number and localization of predicted sites for posttranslational modifications, such as N-glycosylation ( http://www.cbs.dtu.dk/services/NetNGlyc/ ), O-fucosylation, and furin processing which could specify individual substrates, define protein-protein interactions, or govern autocatalytic properties that collectively distinguish these four ADAMTS proteases from each other. (encyclopedia.pub)
  • The TCGA findings on XRCC5 RNA expression in different tumor categories have been summarized in the Human Protein Atlas. (ms-validatedantibodies.com)
  • remain a free mobile robot localization using landmarks nearly of instituting interactions by making up for our structural Fraud Alerts. (tanganyikawildernesscamps.com)
  • Aging causes changes in the structural foundations of skin, hair, and nail tissue. (lifeextension.com)
  • CsrA activity is primarily controlled through sequestration by multiple small regulatory RNAs. (shengsci.com)
  • The annotation of genes from genome sequencing projects has provided considerable insight into the existence of species-specific gene expansion. (biomedcentral.com)
  • Within each tissue, downstream PCP effectors link the signal to tissue specific readouts such as stereocilia orientation in the inner ear and hair follicle orientation in vertebrates or the polarization of ommatidia and wing hairs in Drosophila melanogaster. (uni-wuerzburg.de)
  • Fortunately, lifestyle changes and targeted nutritional interventions-particularly collagen peptides, solubilized keratin, and Polypodium leucotomos extract-can support skin, hair and nails from the inside out. (lifeextension.com)
  • Although aging affects the whole body, our skin, hair, and nails provide a window through which the manifestations of aging can be viewed by others. (lifeextension.com)
  • Studies in infectious disease models have provided a wealth of information regarding memory CD8 T cell generation and localization. (frontiersin.org)
  • Overexpression of Cmb causes the formation of a multiple hair cell phenotype (MHC), similar to loss of rok and mwh. (uni-wuerzburg.de)
  • A,B) Four-cell embryos were injected with 0.5 ng of Rspo2 RNA into both animal- ventral blastomeres and cultured until stage 28. (xenbase.org)
  • Commonalities in cell-specific and/or temporal-specific aspects of gene expression do not appear to be main factors governing alignment within the locus. (biomedcentral.com)
  • The results could lay a theoretical basis for understanding the molecular mechanism that regulates hair follicle development. (bvsalud.org)
  • Each of these layers is characterized by specific features in terms of gene expression, function and cellular mor-phology (1). (medicaljournals.se)
  • In this review we examine the structure, expression patterns, and biological actions of the pregnancy-specific PRL and GH families. (biomedcentral.com)
  • Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)
  • Oral ingestion of solubilized keratin plus vitamins and minerals significantly improved various aspects of skin appearance, decreased hair loss, and increased nail strength. (lifeextension.com)
  • The prolactin (PRL) and growth hormone (GH) gene families represent species-specific expansions of pregnancy-associated hormones/cytokines. (biomedcentral.com)
  • PRL gene families of rodents and ruminants and the GH gene family of primates represent excellent examples of species-specific gene expansion. (biomedcentral.com)
  • These observations suggest that Rspo2 is a context-specific regulator of TCF3 phosphorylation and Wnt signaling. (xenbase.org)
  • Here we investigate CsrA activity control in the absence of antagonizing small RNAs by examining the CsrA regulon in t. (shengsci.com)
  • RNA was isolated from stage 18 control embryos or embryos depleted of Rspo2 . (xenbase.org)
  • H) Dorsal marginal zones (DMZ) were dissected at stage 10 from the control and Rspo2 RNA- or RMOATG-injected embryos and cultured until stage 12. (xenbase.org)
  • Specific PCP effectors in the wing such as Multiple wing hairs (Mwh) and Rho Kinase (Rok) are required to position the hair at the correct position and to prevent ectopic actin hairs. (uni-wuerzburg.de)
  • Such tumor-specific T RM cells are recognized as both necessary and sufficient for long-lived protection against tumors in peripheral tissue locations. (frontiersin.org)
  • Animal pole explants were dissected at stage 9 from embryos overexpressing Rspo2 RNA or uninjected controls. (xenbase.org)
  • The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni. (shengsci.com)
  • Simple, rapid extraction of PCR-ready DNA for screening and genotyping type applications from hair follicles, quill-end cells of feathers, tissue-culture cells, buccal cells and other sample types. (biosearchtech.com)
  • Our data indicate that Cmb is a novel PCP effector that promotes to wing hair formation, a function that is antagonized by Mwh. (uni-wuerzburg.de)
  • Embryos were injected into four animal blastomeres with Wnt8 DNA (50 pg) and Rspo2 RNA (0.5 ng), as indicated, and ectoderm explants were prepared at stage 9 and cultured until stage 13. (xenbase.org)
  • Automation-compatible products for high-quality RNA extraction and purification from a range of clinical samples, including upper respiratory specimens. (biosearchtech.com)
  • The best evidence for a shelterin-specific role in telomerase regulation comes from analysis of TPP1, which interacts with the telomerase catalytic subunit through the N-terminal OB-fold domain of TPP1 [ 15 - 18 ]. (prolekarniky.cz)
  • This interaction is crucial for recruiting telomerase to telomeres, as assessed by co-localization of telomerase RNA to telomeres through in situ hybridization analysis [ 19 ]. (prolekarniky.cz)
  • As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)
  • HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)
  • The telomerase recruitment defect conferred by TIN2-R282H is likely through a mechanism independent of TIN2's role in anchoring TPP1 at telomeres, since TPP1 localization to telomeres is unaffected by the mutation. (prolekarniky.cz)