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  • IHCs
  • Peak Ca 2+ and Ba 2+ currents of mature du/du inner hair cells (IHCs) were reduced by 30-40%, respectively, and gating properties, such as the voltage of half-maximum activation and voltage sensitivity, were altered, indicating that Ca v 1.3 channels normally coassemble with α 2 δ2 at IHC presynapses. (jneurosci.org)
  • Spiral Ganglion
  • Our group recently presented preliminary data https://www.researchgate.net/publication/294732622_Speech_Detection_in_the_Presence_Of_Background_Noise_Is_Effected_by_both_Spiral_Ganglion_and_Outer_Hair_Cell_Function in this realm at the 2016 annual meetings of the Association for Research in Otolaryngology, the American Auditory Society, and the American Academy of Audiology. (lww.com)
  • Neural
  • This analysis will lead to deeper understanding of the diverse behaviors of neural systems under periodic forcing and can inform the design of oscillatory network models of auditory signal processing. (frontiersin.org)
  • Tinnitus is regularly associated with hearing loss, which can be diagnosed in up to 90% of patients, and with the use of ototoxic drugs, infections, and medical conditions that can affect the hearing function triggering cochlear damage, with neural changes in the central auditory system [ 5 , 16 - 25 ]. (tinnitusjournal.com)
  • Deafness
  • This project is highly significant, since exploring the strategies of maintaining, rescuing, and repairing injured hair cells are essential to the biological remediation and prevention of hair cell-related hearing loss and deafness. (elsevier.com)
  • PUBLIC HEALTH RELEVANCE: Because the majority of Americans with hearing loss, some 30 million in all, have some kind of hair cell damage, understanding the cellular process of damage repair and exploring the possibilities of rescuing and repairing injured hair cells are essential to the biological remediation and prevention of hair cell-related hearing loss and deafness. (elsevier.com)
  • Not only was a group of de novo genes closely associated with known deafness loci identified, but the data also indicate that the hair cell tip link interacts directly with calcium binding proteins. (biomedcentral.com)
  • Functional
  • Comparatively little is known about the effects of aging per se on the IHC-afferent synapse, and normal synaptic aging has been largely overlooked as a contributor to auditory functional decline. (jneurosci.org)
  • Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E. Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells. (childrenshospital.org)
  • Liu XP, Koehler KR, Mikosz AM, Hashino E, Holt JR. Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells. (childrenshospital.org)
  • dysfunction
  • However, threshold sensitivity loss is not the only, and arguably not the primary, handicapping dysfunction of auditory aging. (jneurosci.org)
  • Although thresholds and hair cell counts are important metrics in the assessment of sensory dysfunction, they are less informative when the dominant pathology is not sensory in nature. (jneurosci.org)
  • audiology
  • Audiologists with skills and expertise in evaluating newborn and young infants with hearing loss should provide audiology diagnostic and auditory habilitation services (selection and fitting of amplification device). (aappublications.org)
  • somatosensory
  • Pubmed ID: 12486183 It is known that the dorsal cochlear nucleus and medial geniculate body in the auditory system receive significant inputs from somatosensory and visual-motor sources, but the purpose of such inputs is not totally understood. (jove.com)
  • Modulation of tinnitus follows complex interactions between auditory and somatosensory afferents and can be favored by underlying somatic disorders. (tinnitusjournal.com)
  • Projections
  • Direct Projections from Cochlear Nuclear Complex to Auditory Thalamus in the Rat The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. (jove.com)
  • In the present study, we have used auditory neurophysiology, double labeling with anterograde tracers, and retrograde tracers to investigate the ascending projections of the cochlear nuclear complex. (jove.com)
  • dorsal
  • We demonstrate that the dorsal cochlear nucleus and the small cell cap of the ventral cochlear nucleus have a direct projection to the medial division of the medial geniculate body. (jove.com)
  • amplification
  • Much experimental effort has focused on correlating such age-related threshold shifts with hair cell loss, and therapeutic interventions have concentrated on improving "audibility" through amplification. (jneurosci.org)
  • Thus, we hypothesized previously that transmembrane chloride movements via the lateral membrane conductance of the cell, G metL , could serve to underlie cochlear amplification in the mammal. (jneurosci.org)
  • The mechanics of these cells is important to the sound amplification and frequency selectivity of the ear. (asme.org)
  • membrane
  • Cell membrane tethers are formed naturally (e.g., in leukocyte rolling) and experimentally to probe membrane properties. (asme.org)
  • In cochlear outer hair cells, the plasma membrane is part of the trilayer lateral wall, where the membrane is attached to the cytoskeleton by a system of radial pillars. (asme.org)
  • We present a modeling study to simulate the membrane deflection, bending, and interaction with the cytoskeleton in the outer hair cell tether pulling experiment. (asme.org)
  • system
  • Briefly describe how different elements of the anatomy of the auditory system are involved in sound perception? (brainscape.com)
  • Oscillatory instability at the Hopf bifurcation is a dynamical phenomenon that has been suggested to characterize active non-linear processes observed in the auditory system. (frontiersin.org)
  • The mammalian auditory organs have a dual sensory system (inner vs. outer hair cells) with distinctly different cellular organizations and innervation patterns. (nih.gov)
  • function
  • Hair-cell survival/development and stereocilium morphology/function will be examined using immunohistochemistry (with confocal microscopy), time-lapse imaging, scanning electron microscopy, and electrophysiology. (elsevier.com)
  • capacitance
  • In vitro , we focused on the signature electrical characteristic of the motor, the nonlinear capacitance of the cell. (jneurosci.org)
  • inner hair
  • SIGNIFICANCE STATEMENT Inner hair cells possess calcium channels that are essential for transmitting sound information into synaptic transmitter release. (jneurosci.org)
  • Using a mouse model with a mutant, nonfunctional α 2 δ2 protein, we showed that the α 2 δ2 protein is necessary for normal calcium currents and exocytosis in inner hair cells. (jneurosci.org)
  • frequencies
  • Networks of oscillators poised near Hopf bifurcation points and tuned to tonotopically distributed frequencies have been used as models of auditory processing at various levels, but systematic investigation of the dynamical properties of such oscillatory networks is still lacking. (frontiersin.org)
  • Complex
  • Several lines of evidence suggest that the stereociliary stiffness may be modulated by the sensory cells themselves, most likely via the cuticular plate-rootlet complex. (nih.gov)