Prior to H influenzae type B (Hib) vaccines, meningitis was the most common and serious manifestation of invasive disease. (medscape.com)
Underlying medical conditions, such as prematurity , cerebrospinal fluid (CSF) leak, congenital heart disease, and immunoglobulin deficiency, may predispose an individual to invasive disease caused by the nontypeable strains of H influenzae . (medscape.com)
Occasionally, the encapsulated non-Hib strains of H influenzae are implicated as causes of invasive disease. (medscape.com)
Recent findings from a series of H influenzae type f meningitis cases suggest that these organisms conceivably could emerge as important causes of invasive disease in children in the post-Hib vaccine era, although this trend has not yet become widespread. (medscape.com)
Treatment of Haemophilus infections depends on nature and location of the infection, but, for invasive disease, beta-lactam/beta-lactamase inhibitors, fluoroquinolones, and 2nd- and 3rd-generation cephalosporins are used. (msdmanuals.com)
HIV appears to be a risk factor for developing invasive disease due to H. influenzae type b, especially bacteremic pneumonia. (hopkinsguides.com)
Vaccine3
Prior to the availability of an effective vaccine, H influenzae type b (Hib) was the most common cause of pediatric bacterial meningitis in the United States. (medscape.com)
In particular, H. influenzae serotype b (Hib) strains were one of the major causes of bacterial meningitis in children worldwide until the introduction of an effective conjugate vaccine [ 6 , 7 ]. (biomedcentral.com)
Organism2
In 1920, the organism was named Haemophilus influenzae (from the Greek haemophilus, meaning "blood-loving") to reflect the fastidious growth requirement of the organism, as well as its apparent association with influenza. (medscape.com)
A nonserotypeable H influenzae biogroup III (identical to the H aegyptius group) organism has been demonstrated to be the cause of a disease called Brazilian purpuric fever (BPF) discovered in children in southern Brazil. (medscape.com)
Infectious diseases1
Although the type of infectious diseases caused by Haemophilus influenzae has changed considerably in recent years because of the widespread and routine immunization of children against type b organisms, H influenzae remains a significant pathogen. (medscape.com)
Recognized as a cause1
In recent years, H influenzae has been increasingly recognized as a cause of bacteremia and meningitis in neonates. (medscape.com)
Trevisan3
In 1889, in the first classification treatise naming bacteria under the Latin binomial system, Trevisan listed it as "Bacillus aegyptius. (wikipedia.org)
To download a certificate of analysis for Haemophilus aegyptius (Trevisan) Pittman and Davis ( 49250 ), enter the lot number exactly as it appears on your product label or packing slip. (atcc.org)
The certificate of analysis for that lot of Haemophilus aegyptius (Trevisan) Pittman and Davis ( 49250 ) is not currently available online. (atcc.org)
Strain1
Because the entire genome of a laboratory strain of H influenzae has been sequenced, additional insights into its molecular mechanisms of pathogenesis will undoubtedly be gained in the near future. (medscape.com)
Immunization2
H. influenzae is the most notable species, but a notable decline in past decades has been achieved due to active childhood immunization ( Hib ). (hopkinsguides.com)
However, H. influenzae type b remains rare, so immunization unwarranted in adults, including HIV+ pts. (hopkinsguides.com)
Infections3
Neonatal infections are usually caused by nontypeable H influenzae, which can be cultured with samples from the maternal genital tract, the presumed source of the infection. (medscape.com)
Occasionally, nonencapsulated strains cause invasive infections in children, but they may cause up to half of serious H. influenzae infections in adults. (msdmanuals.com)
It can also identify putative haemin-independent H. haemolyticus strains and determine the serotype of typeable Haemophilus strains. (biomedcentral.com)
H. influenzae serotype a (Hia) increasingly noted as a cause of severe, invasive infection. (hopkinsguides.com)
Pathogen2
Recently, H. influenzae was classified by the WHO as priority pathogen due to the wide spread of ampicillin resistant strains. (biomedcentral.com)
Furthermore, the global expansion of ampicillin resistant H. influenzae strains led to the WHO classification of a priority pathogen for research and development of new antibiotics [ 10 ]. (biomedcentral.com)
Brazilian3
During the mid-1980s to early 1990s, a highly virulent clonal group of Haemophilus aegyptius, localized in and around the São Paulo State of Brazil, was found to be responsible for Brazilian purpuric fever, an acute septicemic fulminant illness affecting children. (wikipedia.org)
H. influenzae biogroup aegyptius (formerly called H. aegyptius ) may cause mucopurulent conjunctivitis and bacteremic Brazilian purpuric fever. (msdmanuals.com)
H. influenzae biogroup aegyptius may cause severe conjunctivitis (aka Brazilian purpuric fever) mostly in children. (hopkinsguides.com)
Conjunctivitis1
Haemophilus influenzae biogroup aegyptius (Hae) is a causative agent of acute and often purulent conjunctivitis, more commonly known as pink eye. (wikipedia.org)
Otitis media1
Therefore, nontypeable H influenzae remains a major cause of otitis media in children. (medscape.com)
Pittman1
It was listed as "Hemophilus aegyptius" for the first time in the seventh edition of Bergey's Manual after Pittman and Davis explored and described the characteristic differences between this bacterium and H. influenzae. (wikipedia.org)
Species5
stand by a historical viewpoint that the two species are one and the same, with H. influenzae being the older name, and thus the name with higher priority. (wikipedia.org)
Many Haemophilus species are normal flora in the upper respiratory tract and rarely cause illness. (msdmanuals.com)
These genes were identified using a comparative genome analysis of 215 strains belonging to ten human-related Haemophilus (sub)species (training dataset). (biomedcentral.com)
The newly developed algorithm can differentiate between clinically relevant Haemophilus species including, but not limited to, H. influenzae , H. haemolyticus , and H. parainfluenzae . (biomedcentral.com)
The genus Haemophilus includes 10 (sub)species that exclusively or predominantly colonize and infect humans [ 3 ]. (biomedcentral.com)
Nontypeable1
the most common is H. influenzae , which has 6 distinct encapsulated serotypes (a through f) and numerous nonencapsulated, nontypeable strains. (msdmanuals.com)
Diagnosis1
Our new classification database and algorithm have the potential to improve diagnosis and surveillance of Haemophilus spp. (biomedcentral.com)
Clone1
After discovering another, and very similar, outbreak in Londrina (located a little under 200 miles from Promissao), scientists determined that a single H. influenzae biogroup aegyptius clone is responsible for all cases of BPF. (wikipedia.org)
Scientists were able to isolate H. influenzae biogroup aegyptius after studying the blood and cerebrospinal fluids of affected children. (wikipedia.org)
Infection5
First isolated in 1892 by Robert Pfeiffer from the sputum of patients with pandemic influenza infection, H influenzae was thought to be the infectious agent responsible for flu. (medscape.com)
Chancroid Chancroid is infection of the genital skin or mucous membranes caused by Haemophilus ducreyi and characterized by papules, painful ulcers, and enlargement of the inguinal lymph nodes. (msdmanuals.com)
In one series, accounted for ~30% of invasive H. influenzae infection in Manitoba. (hopkinsguides.com)
Other Haemophilus strains ( H. aphrophilus, now called Aggregatibacter aphrophilus ) occasional cause of infection in HIV. (hopkinsguides.com)
Strains type a and type f increasingly identified as causing severe H. influenzae infection. (hopkinsguides.com)
Distinct1
H influenzae encodes 3 distinct immunoglobulin A (IgA) proteases that may be involved as virulence factors by interfering with host mucosal defenses. (medscape.com)
Type1
Non-typeable H. influenzae strains more common now than type b. (hopkinsguides.com)
Clinical2
Nevertheless, subsequent findings revealed that H influenzae was responsible for a wide spectrum of clinical diseases. (medscape.com)
The algorithm was evaluated on 1329 public short read datasets (evaluation dataset) and used to reclassify 262 clinical Haemophilus spp. (biomedcentral.com)
Responsible1
H. influenzae responsible for 3-40% of HIV-related bacterial pneumonia. (hopkinsguides.com)
Major1
A major virulence factor of H influenzae is its polysaccharide capsule, which plays a central role in molecular pathogenesis and the immune response. (medscape.com)
Treatment1
In his classic paper, Weeks characterizes H. aegyptius by its high contagiousness, direct transmission from patient to volunteer, pathogenesis, pathology, treatment and epidemiology. (wikipedia.org)
Blood1
Members of the genus Haemophilus are small, pleomorphic gammaproteobacteria that are characterized by their dependency on the blood factors haemin (X-factor) and/or nicotinamide adenine dinucleotide (V-factor) for growth [ 1 , 2 ]. (biomedcentral.com)
Culture1
The sensitivity of Gram stain and culture probably ~50% in pts with H. influenzae pneumonia. (hopkinsguides.com)