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  • marrow
  • Using Notch receptor blocking antibodies, we report that Notch2 blockade, but not Notch1 blockade, sensitizes hematopoietic stem cells and progenitors (HSPCs) to mobilization stimuli and leads to enhanced egress from marrow to the periphery. (haematologica.org)
  • In addition, we found that Notch2-blocked or Notch2-deficient marrow HSPCs show an increased homing to the marrow, while mobilized Notch2-blocked, but not Notch2-deficient stem cells and progenitors, displayed a competitive repopulating advantage and enhanced hematopoietic reconstitution. (haematologica.org)
  • CD34+ cells in the blood and marrow of natalizumab-treated patients expressed less of the stem cell marker CD133, were enriched for erythroid progenitors (CFU-E) and expressed lower levels of adhesion molecules. (docplayer.net)
  • lymphoid
  • The frequency of myeloid-lymphoid-initiating cells (ML-ICs) and SCID-repopulating cells (SRCs) was significantly higher in blood from AC-SCD patients than in blood from patients with steady-state SCD or from normal donors. (jci.org)
  • tyrosine kinase in
  • In this article, the authors describe the current indications for alloSCT during the tyrosine kinase inhibitor era and explore the role of these drugs in multiple situations, including before and after transplant. (emjreviews.com)
  • relapse
  • Pediatric acute myeloid leukemia (AML) constitutes a minor portion of all pediatric cancers but remains a therapeutic challenge, with unacceptably low rates of event-free survival (EFS) and a high incidence of relapse when treated with traditional cytotoxic chemotherapy. (hematologyandoncology.net)
  • We are exploring the role of regulatory T cells (Tregs) in the development of GVHD and GVL reactions, and have initiated a clinical trial to augment GVL reactivity using an antibody to CTLA4Ig, a molecule that controls immune reactions.We are also investigating vaccination strategies for preventing relapse in allogeneic transplant patients. (dana-farber.org)
  • disease
  • Using MLL as an example, we explore important questions of wider significance that are still under debate, including the importance of cell of origin, to what extent leukaemia oncogenes impose specific regulatory programs and the relevance of leukaemia stem cells for disease development and prognosis. (springer.com)
  • 97% patients with T cell lymphoblastic leukemia for minimal residual disease detection independent of the initial phenotype. (amedeo.com)
  • therapy
  • The FOSSIL Study: FLAG or standard 7+3 induction therapy in secondary acute myeloid leukemia. (amedeo.com)
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • In addition to these agents, promising data from other inhibitors of FLT3, IDH1, and B-cell lymphoma 2 (BCL2) will be discussed.SummaryResponse, survival, and symptom burden of AML therapy are all improving through novel agents. (deepdyve.com)
  • Safety and efficacy of a lentiviral vector containing cthree anti-HIV genes-CCR5 ribozyme, tat-rev siRNA, and TAR decoy-in SCID-hu mouse-derived t cells," Molecular Therapy , vol. 15, no. 6, pp. 1182-1188, 2007. (hindawi.com)
  • Efficient entry inhibition of human and nonhuman primate immunodeficiency virus by cell surface-expressed gp41-derived peptides," Gene Therapy , vol. 15, no. 17, pp. 1210-1222, 2008. (hindawi.com)
  • Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus," Gene Therapy , vol. 13, no. 13, pp. 1037-1047, 2006. (hindawi.com)
  • Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34 + cells," Nature Medicine , vol. 15, no. 3, pp. 285-292, 2009. (hindawi.com)
  • This paper will discuss some controversial issues of importance for achieving cell therapy safety and success. (hindawi.com)
  • These cells are strong candidates to be applied in cellular therapy, requiring even more studies to master this new technology. (hindawi.com)
  • PubMed searches for publications with the exact terminology "stem cell therapy" indicate a strong growth in the number of publications in this area over the last 19 years, shown in Figure 1 . (hindawi.com)
  • The information was retrieved from PubMed indexed articles using the exact terminology "stem cell therapy. (hindawi.com)
  • Aiming for a personalized cell therapy, some criteria or parameters must be observed. (hindawi.com)
  • Besides enabling the production of biological components of human interest, such as vaccines and hormones, cell cultures help in the advancement of stem cell research by allowing the improvement of the stem cells for cellular therapy. (hindawi.com)
  • adult
  • Hematopoiesis is sustained by a renewable pool of stem cells that interacts with distinct, sequential and specific microenvironments during normal development and throughout adult life. (stembook.org)
  • Stem cells, both embryonic and adult, due to the potential for application in tissue regeneration have been the target of interest to the world scientific community. (hindawi.com)
  • chemotherapy
  • range, 53-73 years) received highly purified CD56 + CD3 − natural killer (NK) cells from haploidentical killer immunoglobulin-like receptor-ligand mismatched donors after fludarabine/cyclophosphamide immunosuppressive chemotherapy, followed by IL-2. (bloodjournal.org)
  • Initial enthusiasm for the use of autologous transplant with the use of high-dose chemotherapy and stem cells for solid tumors has waned with the realization that dose intensification often fails to improve survival, even in tumors with a lineardose response to chemotherapy. (docplayer.net)
  • microenvironment
  • We examine and discuss recent findings that shed new light into the molecular connections that feed a complex network between stem cells and their microenvironment, implicating parallel mechanisms for non-hematopoietic stem cells. (stembook.org)
  • Such efforts require a deeper understanding of the cell biology of HSC and HPC, the microenvironment that nurtures these cells, and greater mechanistic insight into cell surface receptors and intracellular signaling pathways regulating HSC/HPC function. (stembook.org)
  • therapeutic
  • After the year 2000, with the introduction of imatinib, the number of transplants performed for CML-CP substantially decreased and, although it remains an important therapeutic option for eligible patients, the place of alloSCT in the management of CML has become limited. (emjreviews.com)
  • These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming. (biomedsearch.com)
  • regimens
  • Similarly, conditioning regimens have also changed from myeloablative to non-myeloablative incorporating less toxic regimens in many transplant centers across the globe, allowing more transplants in the older age group (45-65) and high risk categories. (frontiersin.org)
  • regenerative medicine
  • Small molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. (biomedsearch.com)
  • The study of the stem cells potential has stimulated the onset of new areas, as the regenerative medicine and tissue bioengineering. (hindawi.com)