Loading...
  • bone
  • Using stem cells and immune cells collected from the donor's circulating blood may result in quicker recovery of blood counts and may be more effective in treating the patient's disease than using bone marrow. (clinicaltrials.gov)
  • This reconstitution can be achieved by either using harvested bone marrow, or by reinfusing collected hematopoietic stem cells (HSCs). (biomedcentral.com)
  • The term haematopoietic stem cell (HSC) refers to cells made in the blood factory or bone marrow that have the potential to grow into almost any type of blood cell. (thedailystar.net)
  • The treatment that immediately precedes infusion of HSC is called conditioning therapy and is given to help kill tumour cells, "wipe out the memory" of the recipient's immune system, and create "space" within the bone marrow for the incoming stem cells to grow. (thedailystar.net)
  • It is an aggressive form of cancer in which certain white blood cells become cancerous and rapidly accumulate in the bone marrow, preventing normal marrow from growing and functioning properly. (fredhutch.org)
  • We believe that hematopoietic stem cell transplants appear to cause fewer complications than bone marrow transplants and that Mylotarg appears to cause fewer severe side effects than standard chemotherapy,' Sievers continued. (fredhutch.org)
  • Recognized internationally for its pioneering work in bone marrow transplantation, the Center has four scientific divisions collaborating to form a unique environment for conducting basic and applied science. (fredhutch.org)
  • The research interests are to understand the cellular and molecular basis of resistance to engraftment of transplanted allogeneic bone marrow (BM) cells and to understand the way in which BM grafts modify immune responses. (stanford.edu)
  • HSCs
  • This opens up a potential therapeutic strategy of transducing HSCs with genes conferring certain important biological properties, reinfusing them into a patient after high-dose therapy, and then, following reconstitution of the hematopoietic system by these transduced cells, taking advantage of these properties. (biomedcentral.com)
  • Conventional BM transplantation involves the transfer of heterogeneous populations of cells composed of rare hematopoietic stem cells (HSCs) and differentiated blood cell types. (stanford.edu)
  • 1) Identification of the cells and molecules responsible for resistance to engraftment of purified allogeneic HSCs. (stanford.edu)
  • 2) Use of transplants of purified HSCs to induce tolerance to allo- and autoantigens, and study of the mechanisms by which such tolerance is induced. (stanford.edu)
  • Biological
  • Nevertheless, the study raises many interesting questions, and provides a tantalizing hint that this technique can result in the engraftment of cells with added beneficial biological properties. (biomedcentral.com)
  • graft-versus-
  • Accurate determination of immune system compatibility is vital to minimise graft failure and lethal attack from donor cells against recipient's normal tissues (graft-versus-host disease or GvHD). (thedailystar.net)
  • radiation
  • Severe myeloid cytopenia is a serious complication of radiation or chemotherapy and leads to profound susceptibility to a variety of opportunistic infections. (rupress.org)
  • We have applied our expertise to develop novel ways to achieve engraftment of blood forming stem cells with the goal to replace chemotherapy and radiation. (stanford.edu)
  • cycles
  • Palifermin (180 µg per kg of body weight) or placebo was administered intravenously as a single dose 3 days before each chemotherapy cycle (maximum, 6 cycles). (annals.org)
  • systemic
  • Severe systemic sclerosis (SSc) is a serious autoimmune disorder in which a person's own immune cells attack organs in the body. (clinicaltrials.gov)