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  • viable
  • The delivered cells (via local or systemic administration) remain viable for a relatively short period (days-weeks) and then die. (wikipedia.org)
  • tissues
  • 1 , 2 , 3 , 4 , 5 These findings suggest the potential of bone marrow derived stem cells to transdifferentiate into a variety of organ tissues, including those of the eye. (pubmedcentralcanada.ca)
  • Symptoms caused by blood cancer cells infiltration into tissues: Lymphadenopathy Joint pain Swelling of the gums Hepatoslenomegaly Headache and vomiting: blood cancer infiltration into the wear performance of the central nervous system. (wikipedia.org)
  • repopulation
  • The homing of HSPCs to BM is a rapid process that takes place during the hours after transplantation and is an essential and necessary requirement for repopulation and engraftment [ 5 ]. (hindawi.com)
  • This view was first challenged by the 2002 discovery by the Muller-Sieburg group in San Diego, who illustrated that different stem cells can show distinct repopulation patterns that are epigenetically predetermined intrinsic properties of clonal Thy-1lo Sca-1+ lin− c-kit+ HSC. (wikipedia.org)
  • immunity
  • Persistent fever, infection prolonged healing: Most of the white blood cells are leukemia cells, no normal function, leading to decreased immunity, susceptible to infection. (wikipedia.org)
  • For example, T cells capable of fighting cancer cells via cell-mediated immunity may be injected in the course of immunotherapy. (wikipedia.org)
  • dendritic
  • Macrophages and dendritic cells are bone marrow derived antigen presenting cells (APC) which serve in the first step of the acquired immune responses. (pubmedcentralcanada.ca)
  • Recently, the presence of APCs such as macrophages and dendritic cells was reported in the cornea. (pubmedcentralcanada.ca)
  • 15 , 16 The CD45+/CD11b+/CD11c+ dendritic cells distributed in corneal epithelium 8 and corneal stroma, 9 , 17 and CD11b+/CD11c‐ macrophages in the corneal stroma. (pubmedcentralcanada.ca)
  • Multiple mutations on GATA2 gene have been recently implicated as the cause of primary immunodeficiency in patients with MonoMAC Syndrome, and cases of dendritic cell, monocyte, B NK lymphoid deficiency and leukemia. (wikipedia.org)
  • cytokines
  • Cells that have the capacity to release soluble factors such as cytokines, chemokines, and growth factors which act in a paracrine or endocrine manner. (wikipedia.org)
  • regulate
  • The identification of new mechanisms that regulate the trafficking of hematopoietic stem/progenitor cells (HSPCs) cells has important implications, not only for hematopoietic transplantation but also for cell therapies in regenerative medicine for patients with acute myocardial infarction, spinal cord injury, and stroke, among others. (hindawi.com)
  • It must balance enormous production needs (more than 500 billion blood cells are produced every day) with the need to precisely regulate the number of each blood cell type in the circulation. (wikipedia.org)
  • factors
  • Examples of this include cells that secrete factors which facilitate angiogenesis, anti-inflammation, and anti-apoptosis. (wikipedia.org)
  • The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells. (wikipedia.org)
  • marker
  • Using the ratio ρ = L / M {\displaystyle \rho =L/M} of lymphoid (L) to myeloid (M) cells in blood as a quantitative marker, the stem cell compartment can be split into three categories of HSC. (wikipedia.org)
  • blood
  • See " A Molecular Model of Blood Cell Renewal " , e349. (pubmedcentralcanada.ca)
  • Red blood cell substitutes. (pubfacts.com)
  • G-CSF stimulates the production of granulocytes, a type of white blood cell. (wikipedia.org)
  • Symptoms caused by bone marrow damage Bruising, spotting: the reason is lack of platelets, it is very common in BAL patients, most of patients die due to the Anemia: Because the decline of hematopoietic function, need blood transfusion therapy Persistent fever, infection prolonged healing: Diffuse hemorrhage: also called Septicemia, which is dangerous and might lead to death. (wikipedia.org)
  • Anemia: reduction metrocytes that could produce red blood cells, resulting in a lack of red blood cells. (wikipedia.org)
  • Following observation of the symptoms, the patients need to get complete blood counts and a bone marrow examination. (wikipedia.org)
  • genes
  • We also identified two genes that increase in both gene and protein expression during activation, and potentially represent new markers for proliferating stem cells. (pubmedcentralcanada.ca)
  • Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
  • Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. (wikipedia.org)
  • disorders
  • Severe sickle cell crises, in some cases resulting in death, have been associated with the use of filgrastim in patients with sickle cell disorders. (wikipedia.org)
  • patients
  • A multicenter retrospective comparison of induction chemoimmunotherapy regimens on outcomes in transplant-eligible patients with previously untreated mantle cell lymphoma. (edu.au)