H5n1 infection in humans. Medical search. Frequent questions

The vast majority of infections were with H7N9 (n=1,562) and H5N1 (n=238) viruses, and most (n=1583, 86%) were reported from December through April. (who.int)
Since the last update of 26 August 2013, China has reported no new cases of human infection with avian influenza A(H7N9) virus , but reported one death in a previously reported case. (flutrackers.com)
As of 7 October 2013, 135 human cases of influenza A(H7N9) virus infection were reported to WHO. (flutrackers.com)
This influenza A(H7N9) virus comprises genes of at least four different avian influenza viruses, some segments mimicking human-like influenza-signatures. (thieme-connect.de)
Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. (thieme-connect.de)
Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical and characterisation of viral genome. (thieme-connect.de)
Global concerns regarding novel Influenza A (H7N9) virus infections. (thieme-connect.de)
Genomic signature and protein sequence analysis of a novel influenza A (H7N9) virus that causes an outbreak in humans in China. (thieme-connect.de)
Clinical findings in 111 cases of influenza A (H7N9) virus infections. (thieme-connect.de)
Most bird flu viruses don't infect humans, but some strains - particularly H5N1 and H7N9 - can, in rare cases, spread to humans and cause serious illnesses. (everydayhealth.com)
But the H7N9 and H5N1 viruses have become resistant to the antiviral drugs amantadine (Gocovri) and rimantadine (Flumadine) . (everydayhealth.com)
This is highlighted by confirmed cases of human infections by highly pathogenic H5N1 viruses, and more recently, the H7N9 outbreak in China [ 5 ]. (springer.com)
On March 29, 2013, the Chinese Center for Disease Control and Prevention completed laboratory confirmation of three human infections with an avian influenza A(H7N9) virus not previously reported in humans ( 1 ). (cdc.gov)
No evidence of sustained human-to-human transmission has been found, and no human cases of H7N9 virus infection have been detected outside China, including the United States. (cdc.gov)
Clinicians should consider the diagnosis of avian influenza A(H7N9) virus infection in persons with acute respiratory illness and relevant exposure history and should contact their state health departments regarding specimen collection and facilitation of confirmatory testing. (cdc.gov)
As of April 29, 2013, China had reported 126 confirmed H7N9 infections in humans, among whom 24 (19%) died ( 1 ). (cdc.gov)
Chinese public health officials have investigated human contacts of patients with confirmed H7N9. (cdc.gov)
The only subtypes known to be able to cross the species barrier to humans are H5N1 and H7N9. (dailynewsegypt.com)
Unlike other types of flu, H5N1 and H7N9 usually do not spread between people. (dailynewsegypt.com)
The H7N9 subtype first infected humans in China in March 2013. (dailynewsegypt.com)
Most cases of avian influenza in humans have been caused by Asian strains H5N1 and H7N9, but other types have also caused some human infections. (msdmanuals.com)
In early 2013, an extensive outbreak of H7N9 avian influenza in humans occurred in several provinces of southeastern China. (msdmanuals.com)
H5N1 and H7N9 as well as other strains have caused a few lethal outbreaks and could potentially cause a pandemic if they become able to spread more easily. (medscape.com)

On rare occasions, these bird viruses can cross over and infect other species, including cats, pigs and humans and can be a potential cause of pandemics. (who.int)
There are three different types of influenza virus - A, B, and C. Type A viruses infect humans and several types of animals, including birds, pigs, and horses. (bcm.edu)
The disease, which has spread across Asia and Europe and can occasionally infect humans, emerged in Canada for the first time in six years when it was identified in Newfoundland in December 2021. (northislandgazette.com)
Three U.N. agencies this month warned that an ongoing rise in avian flu outbreaks globally raised concerns that the virus might adapt to infect humans more easily, and urged countries to strengthen disease surveillance and improve hygiene at poultry farms. (jpost.com)
Avian influenza H5N1 virus is known to cross the species barrier and infect humans and felines. (flu.org.cn)
Can bird flu viruses infect humans? (dailynewsegypt.com)
Even if the strain does not infect humans, avian flu is can be disastrous: outbreaks kill thousands of animals at a time and impacts the livelihoods of many people, local and national economies and international trade. (dailynewsegypt.com)
So far, little is known about how this virus evolves and adapts to infect humans. (mdpi.com)
When H5N1 does infect humans, historical data gathered shows it has a 56% mortality rate. (yahoo.com)
arrier to infect humans. (citizen-news.org)
Of the few avian influenza viruses that have crossed the species barrier to infect humans, H5N1 has caused the largest number of cases of severe disease and death in humans. (citizen-news.org)

The symptoms following infection with low pathogenic AIV may be as discrete as ruffled feathers, transient reductions in egg production or weight loss combined with a slight respiratory disease. (wikipedia.org)
Between December 15, 2014, and May 29, 2015, the US Department of Agriculture (USDA) confirmed more than 200 findings of birds infected with highly-pathogenic avian influenza (HPAI) A (H5N2), (H5N8), and (H5N1) [1] viruses. (cdc.gov)
2. With the confirmation of avian influenza in some countries of the African Region early this year, the risk of human infection due to the highly pathogenic avian influenza virus H5N1 will persist, as will the threats of occurrence of an influenza pandemic. (who.int)
From the Interior, to the Fraser Valley and Vancouver Island, the Canadian Food Inspection Agency (CFIA) has identified high-pathogenic strains (HPAI) of H5N1 - the most deadly variety of avian influenza or "bird flu"- in 42 B.C. flocks. (prpeak.com)
Since highly pathogenic Asian bird flu strains emerged worldwide in the past two decades, many worried H5N1 would jump to people like the incredibly deadly Spanish Flu 100 years earlier, said Ydenberg. (prpeak.com)
The concern right now centres on the highly pathogenic H5N1 circulating worldwide. (wltribune.com)
The background document examines the state-of-science on all highly pathogenic avian influenza (AI) viruses, including H5N1, and the possible transfer t humans and other mammals via the food chain. (foodnavigator.com)
Since the first occurrence of HPAI H5N1 human cases in Hong Kong in 1997, the public health threat of high pathogenic avian influenza (HPAI) has been a major global issue [ 1 ]. (biomedcentral.com)
There have been no cases of the highly pathogenic bird flu reported in humans in South Korea, the ministry said. (jpost.com)
Highly pathogenic avian influenza (HPAI) H5N1 has spread across Asia, Europe, and Africa. (flu.org.cn)
Gross and microscopic lesions from dog infected with highly pathogenic avian influenza (HPAI) H5N1. (flu.org.cn)
Supported by the Cambodian National Animal Health and Production Research Insititute, the researchers pay frequent visits to the live poultry markets to monitor the circulation of avian influenza viruses, in particular highly pathogenic A(H5N1) viruses. (pasteur.fr)
Their reasoning is simple: the influenza A(H5N1) virus is highly pathogenic in poultry, meaning once infected they usually die within 24 to 72h. (pasteur.fr)
Talks described the current outbreak of highly pathogenic avian influenza (HPAI - H5N2) epidemic in the Oudtshoorn area and the vigorous systematic response by the Animal Health Division of the Dept of Agriculture, the ongoing HPAI - H5N1 epidemic in Asia and Eastern Mediterranean region and H5N1 in humans and other flu viruses of this season. (sun.ac.za)
The most highly pathogenic and most commonly-known strain is H5N1. (dailynewsegypt.com)
Highly pathogenic influenza A virus H5 subtype remains a risk for transmission in humans. (mdpi.com)
Results showed that the H5N6 AIVs were highly pathogenic to chickens and caused not only systemic infection in multiple tissues, but also 100% mortality within 3-5 days post-infection. (frontiersin.org)
Since 2003, multiple highly pathogenic avian influenza A (HPAI) H5 subtypes, including H5N1, H5N2, H5N6, and H5N8, have generated severe epidemics and thus not only tremendous economic losses in the domestic poultry industry, but also serious threats to human health worldwide ( Jhung and Nelson, 2015 ). (frontiersin.org)

An influenza pandemic occurs when there is emergence of a new subtype that has not previously circulated in humans. (who.int)
So far, the majority of the human H5N1 (haemagluttinin type 5 and neuraminidase subtype 1) infections have been linked to close contact with infected domestic birds during home slaughtering, de-feathering, butchering and preparation for cooking. (who.int)
Its statement did not say whether the strain was of the H5N1 subtype which is potentially lethal to humans and has killed at least 50 people in Asia since 2003. (thepoultrysite.com)
Some 864 human infections and 456 deaths with the H5N1 subtype have been reported in 19 countries since 2003. (shtfplan.com)
Infection with a virus of one subtype confers little or no protection against viruses of other subtypes. (canada.ca)
Furthermore, over time, antigenic variation (antigenic drift) within a subtype may be so marked that infection or vaccination with one strain may not induce immunity to distantly related strains of the same subtype. (canada.ca)
Influenza virus was isolated from lung, liver, kidney, and urine specimens, and the viral subtype was determined to be H5N1 by reverse transcription (RT)-PCR ( 6 ). (flu.org.cn)
In this technique, recombinant HA protein (the H5 subtype) was used to bind bacteriophage particles that bear on their surfaces variable chains of human antibodies. (virology.ws)
All cases of human infection with an influenza A subtype other than H1 or H3 must be reported. (msdmanuals.com)
The fact that the H1N1 candidate vaccine was effective against H5N1 infection - a different influenza subtype - suggests the antibodies the vaccine induces can be protective against other "group 1" influenza subtypes, including H1 and H5. (medscape.com)

Since the first confirmed human infection with avian influenza A(H5N1) virus was reported in Hong Kong Special Administrative Region in 1997, sporadic zoonotic avian influenza viruses causing illness in humans have been identified globally, with the WHO Western Pacific Region as one of the hotspots. (who.int)
Update: isolation of avian influenza A(H5N1) viruses from humans--Hong Kong, 1997-1998. (who.int)
Influenza A (H5N1) in Hong Kong: an overview. (who.int)
The H5N1 virus was first identified in Hong Kong in 1997 where it infected 18 people and caused six deaths. (who.int)
The increasing number of fatal cases due to H5N1 infections prompted the government of Hong Kong to initiate policies forbidding the slaughtering of live chickens or other poultry in wet markets [ 13 ]. (biomedcentral.com)
In 1997, the H5N1 virus first infected humans during an outbreak among poultry in Hong Kong. (dailynewsegypt.com)
Currently, killing and incinerating H5N1-infected birds has been the first line of defense since 1997 when H5N1 first showed up in very ill Hong Kong patients. (earthfiles.com)

The overall risk to human health associated with the ongoing A(H5N1) outbreaks in wild birds and poultry has not changed and remains low at this time. (cdc.gov)
In previous A(H5N1) outbreaks and zoonosis the NA stalk region often had deletions (e.g., a 20 amino acid deletion at positions 49-68 relative to A/goose/Guangdong/1/1996) that enhances replication and/or pathogenesis in terrestrial poultry and mice ( 4-6 ). (cdc.gov)
Past outbreaks of avian flu have often originated in crowded conditions in southeast and east Asia, where humans, pigs, and poultry live in close quarters. (wikipedia.org)
There have been a number of farming practices that have changed in response to outbreaks of the H5N1 virus, including: vaccinating poultry against bird flu vaccinating poultry workers against human flu limiting travel in areas where H5N1 is found increasing farm hygiene reducing contact between livestock and wild birds reducing open-air wet markets limiting workers contact with cock fighting reducing purchases of live fowl improving veterinary vaccine availability and cost. (wikipedia.org)
In poultry and wild birds, H5N1 and H5N6 subtypes were the most widely distributed, with outbreaks reported from ten and eight countries and areas, respectively. (who.int)
Hopefully, the knowledge gained in response to the H5N1 and 2009 H1N1 outbreaks, and continued research to more completely understand influenza virus, as well as improvements in vaccine and drug development, will enable us to minimize the effects of future influenza outbreaks. (bcm.edu)
There were no human illnesses reported in connection with these outbreaks. (webwire.com)
An increase in poultry outbreaks inevitably brings the virus into closer and more frequent proximity to humans, which is always a risk with viruses like influenza that can rapidly evolve," Dr. Holly Shelton, head of the Influenza Viruses Group at The Pirbright Institute, told The Telegraph. (shtfplan.com)
H5N1 has spread among poultry and wild birds for years but there have been sporadic outbreaks reported globally in mammals such as cats, mink and otters. (jpost.com)
With new reports of H5N1 virus continuing across Asia, Europe, and Africa, this finding highlights the need for monitoring of domestic animals during outbreaks. (flu.org.cn)
Avian flu outbreaks caused by non-human infecting subtypes occur quite often. (dailynewsegypt.com)
Since then, dozens of countries in Asia, Africa and Europe have reported H5N1 outbreaks. (dailynewsegypt.com)
There have been eight H5N1 outbreaks in china so far, but so far no human cases have been reported. (earthfiles.com)

Bird flu, or avian flu, is a type of infection that occurs mainly in birds. (everydayhealth.com)
Bird flu is transmitted to humans when these viruses, which are part of a group called avian influenza A viruses, travel from the saliva, mucus , or droppings of an infected bird into a person's eyes, nose, or mouth. (everydayhealth.com)
While bird flu infections are rare, most of them occur in people who've had unprotected contact with an infected bird or a contaminated surface. (everydayhealth.com)
There have been a few cases of H5N1 in humans who've eaten food made with raw, contaminated poultry blood, but there's no evidence that people have been infected with bird flu from eating properly cooked poultry. (everydayhealth.com)
The average incubation period of bird flu H5N1 is two to five days, though it can last up to 17 days. (everydayhealth.com)
Bird flu in humans can be treated with antiviral drugs, which can hamper the viruses' ability to replicate and help people recover from the illness. (everydayhealth.com)
Kazakhstan's Agriculture Ministry said on Tuesday that a bird flu outbreak in seven northern villages had been confirmed to be dangerous to humans and the west of the sprawling country was under threat from the disease. (thepoultrysite.com)
I have been watching the H5N1 bird flu for a very long time. (shtfplan.com)
South Korean authorities have placed a cat shelter in the capital Seoul under quarantine after detecting the H5N1 strain of bird flu in two cats at the facility, the country's agriculture ministry said. (jpost.com)
New York, NY, and Tel Aviv, ISRAEL, Feb. 14, 2023 (GLOBE NEWSWIRE) -- via NewMediaWire -- Todos Medical, Ltd. (OTCQB: TOMDF), a comprehensive medical diagnostics and related solutions company, today announced that its CLIA/CAP-certified laboratory Provista Diagnostics has initiated a validation plan for PCR-based Avian Influenza A (H5N1, bird flu) human testing. (yahoo.com)
The significant investment we have made to automate COVID PCR testing at Provista is now allowing us deploy this capability to help monitor for Bird Flu (H5N1, Avian Flu) in the human population," said Gerald E. Commissiong, President & CEO of Todos Medical. (yahoo.com)
November 13, 2005 Washington, D. C. - The Centers for Disease Control and World Health Organization confirm that the 21st person has been infected with H5N1 bird flu in Thailand. (earthfiles.com)
So far, twenty-one people in Thailand have been infected by the H5N1 bird flu and 13 have died. (earthfiles.com)
On Friday, November 11, the fear was realized when a flamingo found on a Kuwaiti beach was confirmed to have the H5N1 deadly strain of bird flu - the first known case in the Arab world. (earthfiles.com)
Now scientists in Vietnam, where bird flu has killed 42 people, report their investigation shows the H5N1 avian flu virus has "mutated into a more dangerous form that could breed more effectively in mammals. (earthfiles.com)
Cao Bao Van, Director of the Molecule Biology Department of the Pasteur Institute, which is Vietnam's bird flu research center, reported this weekend that DNA analysis of 24 samples of the H5N1 virus taken from poultry and humans showed significant changes of the deadly virus's surface proteins, known as "antigen variation. (earthfiles.com)
But such surface protein changes can lead to human-to-human transmission of the bird flu virus, similar to what happened in 1918 when the Spanish Flu killed more than 50 million people around the planet. (earthfiles.com)
The World Organisation for Animal Health (OIE) had warned in early 2022 that the current wave of bird flu had a greater risk of spreading to humans owing to the high number of variants. (medscape.com)
The man was helping kill poultry that probably had the H5N1 bird flu. (medscape.com)
China had previously recorded the first known human infection with the H3N8 strain of bird flu. (medscape.com)
From the first human cases of the current bird flu strain to preparations for a potential pandemic, avian influenza news garnered great interest this week, becoming the top trending clinical topic. (medscape.com)
But birds have, and so these novel flus that exist in waterfowl and other birds (but not humans) are referred to as bird flu or avian flu (even though all flus are bird flus). (typepad.com)
However, should something happen that would make a novel bird flu like H5N1 easier to spread, such as having the virus mutate to a form that likes the nose and upper airway receptors (so that it's easy to catch and easy to spread by sneezing), or prefers the temperature of the human nose, it could start to spread in a human population. (typepad.com)

One study analyzed the clinical data of adult patients with pandemic H1N1 2009 infection admitted to the ICU. (medscape.com)
Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. (cdc.gov)
Rapid-test sensitivity for novel swine-origin influenza A (H1N1) virus in humans. (cdc.gov)
Unlike the avian H5N1 flu, the H1N1 swine flu is capable of being transmitted easily from person to person. (bcm.edu)
Fortunately, however, H1N1 is far less deadly than the H5N1 virus. (bcm.edu)
The ALI HBE cells and the human monocytes were co-infected with influenza A Hemagglutinin Type 1 and Neuraminidase Type 1 (H1N1) and Hemagglutinin Type 5 and Neuraminidase Type 1 (H5N1) strains. (news-medical.net)
The BA.1- and BA.5-induced interferon responses were seen to protect ALI HBE cells and human monocytes from influenza A H1N1 and H5N1 infections. (news-medical.net)
Specific to pandemic influenza threats, the Hemopurifier has been validated to capture the H5N1 avian flu virus, H1N1 swine flu virus, and the reconstructed 1918 influenza virus, which represents a model for the strain of influenza that killed an estimated 50 million victims. (prnewswire.com)
however, only H1N1 and H3N2 circulate among humans seasonally. (medscape.com)

On March 29, 2023, Chile reported its first human infection with HPAI A(H5N1) virus. (cdc.gov)
While these recently-identified HPAI H5 viruses are not known to have caused disease in humans, their appearance in North American birds may increase the likelihood of human infection in the United States. (cdc.gov)
For more information on the origin of the recently-identified HPAI H5 viruses in the United States, their clinical presentation in birds, and their suspected clinical presentation in humans, please see https://www.cdc.gov/flu/avianflu/hpai/hpai-background-clinical-illness.htm . (cdc.gov)
Until more is known about these newly-identified HPAI H5 viruses, public health recommendations are largely consistent with guidance for influenza viruses associated with severe disease in humans (e.g. (cdc.gov)
HPAI H5N1 viruses that have caused human infections with high mortality in other countries). (cdc.gov)
Clinicians should consider the possibility of HPAI H5 virus infection in persons showing signs or symptoms of respiratory illness who have relevant exposure history. (cdc.gov)
State health departments are encouraged to investigate potential human cases of HPAI H5 virus infection as described below and should notify CDC within 24 hours of identifying a case under investigation. (cdc.gov)
After the reported spread of HPAI H5N1 virus in Asia, a large, interagency avian influenza virus, or AIV, surveillance effort was implemented throughout the United States during April 2006 to March of 2011. (cdc.gov)
HPAI H5N1 is the type currently affecting parts of Asia and Eastern Europe. (webwire.com)
The Asian strain of H5N1 has not been detected in the U.S. HPAI has been detected three times in the United States: in 1924, 1983 and 2004. (webwire.com)
As of Saturday, over 240 wild birds in South and North Carolina, Virginia, Maryland, Georgia, Connecticut, New Hampshire, Delaware and Florida had been found to be infected with Eurasian H5 HPAI, with a number of cases specified as H5N1. (shtfplan.com)
Fully understanding the different awareness, attitudes and protective behaviors adopted by workers in live-poultry markets (LPMWs) and local community residents (CRs) to face the challenges of LPAI and HPAI is very important to minimize viral adaptations to human populations. (biomedcentral.com)
Regardless of novel LPAI or HPAI virus reassortants that pose public health risks, prompt and clear risk communication focusing on both correct information about AIVs and the most appropriate preventive measures are important for effective prevention of human infection. (biomedcentral.com)
However, HPAI H5N1 viruses reappeared in 2003, spread across continents, and sickened 826 patients from 2003 to March 31, 2015 [ 5 ]. (biomedcentral.com)
Here, we report a case of HPAI H5N1 infection in a domestic dog following ingestion of the carcass of an infected duck. (flu.org.cn)
The dog´s owner stated that the dog had eaten duck carcasses from an area with reported HPAI H5N1 infections in ducks. (flu.org.cn)

Histologic and pathologic findings for the 3 raptors were consistent with those described in previous reports of H5N8 infections, and the severity of the lesions correspond to virus concentrations detected in the tissues by molecular assays. (cdc.gov)

Transmission and infection of H5N1 from infected avian sources to humans has been a concern since the first documented case of human infection in 1997, due to the global spread of H5N1 that constitutes a pandemic threat. (wikipedia.org)
Early 1997 strain of H5N1 avian influenza virus shows golden-brown in this electron micrograph. (earthfiles.com)

On 17 April 2023, the US CDC provided information on the genomic analysis of the samples from the first human infected with avian influenza A(H5N1) in Chile. (poultrymed.com)
People who become infected with avian influenza (H5N1) can become seriously ill quickly," says an information page on the Public Health Agency of Canada's website. (wltribune.com)
Marine mammals can also become infected with avian influenza strains (eg, H10N7 in harbor seals), with subsequent human infection reported. (msdmanuals.com)
Humans can become infected with avian influenza viruses through inhalation of or direct contact with secretions (saliva, mucous, or feces) from infected birds. (msdmanuals.com)

Since April 2014, new infections of H5N6 avian influenza virus (AIV) in humans and domestic poultry have caused considerable economic losses in the poultry industry and posed an enormous threat to human health worldwide. (frontiersin.org)
In previous research using gene sequence and phylogenetic analysis, we reported that H5N6 AIV isolated in February 2015 (ZH283) in Pallas's sandgrouse was highly similar to that isolated in a human in December 2015 (A/Guangdong/ZQ874/2015), whereas a virus (i.e. (frontiersin.org)

In the same way that many humans pull through an annual bout of the flu, many strains of the avian varieties rarely cause more than the sniffles, lethargy or fever in birds. (prpeak.com)
Yet when some avian strains do acquire the ability to overcome species barrier, they might become adapted to humans, replicating efficiently and causing diseases, leading to potential pandemic. (springer.com)
Further understanding and determining host tropism would be important in identifying zoonotic influenza virus strains capable of crossing species barrier and infecting humans. (springer.com)
Similar to H5N1 strains, this further affirms the potential of avian influenza strains capable of directly infecting human, causing severe illnesses. (springer.com)
Infections due to some of these strains have been detected in humans. (msdmanuals.com)
Because all influenza viruses are capable of rapid genetic change, avian strains could possibly acquire the ability to spread more easily from person-to-person via direct mutation or via reassortment of genome subunits with human strains during replication in a human, animal or, avian host. (msdmanuals.com)

In these conditions a virus is more likely to mutate into a form that more easily infects humans. (wikipedia.org)
It is spreading very rapidly in birds in North America right now, and some experts are concerned that it could mutate into a version that could begin spreading easily in humans. (shtfplan.com)
Scientists are worried that the H5N1 form of the virus, which can be transmitted from poultry to humans, may mutate so that it can be transmitted from human to human and start a influenza pandemic. (foodnavigator.com)
There is concern among leading scientists that the current strain of H5N1 could mutate to become more transmissible towards humans. (yahoo.com)

During November 2014-April 2015, a total of 165 case-patients with influenza virus A(H5N1) infection, including 6 clusters and 51 deaths, were identified in Egypt. (cdc.gov)
Between November 1st and 2nd in Russia, two more birds died from H5N1, bringing the total in that country to more than 4,000 bird deaths - either from the H5N1 virus or slaughtering. (earthfiles.com)

Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands. (thieme-connect.de)
Every few decades or so, a new version of the influenza virus emerges in the human population that causes a serious global outbreak of disease called a pandemic . (bcm.edu)
So let us hope that this current outbreak can be brought under control, and let us hope that H5N1 doesn't start spreading among humans any time soon. (shtfplan.com)
We report a fatal H5N1 infection in a dog following ingestion of an H5N1-infected duck during an outbreak in Thailand in 2004. (flu.org.cn)

If the H5N1 virus were to change and become easily transmissible from person to person while retaining its capacity to cause severe disease, the consequences for public health could be very serious. (prpeak.com)
H5N1 is "not very transmissible" between humans because it's a "zoonotic virus and therefore the virus is very adapted to animals and not to humans," Briand said. (wltribune.com)

H5N1 vaccines for chickens exist and are sometimes used, although there are many difficulties, and it's difficult to decide whether it helps more or hurts more. (wikipedia.org)
Sequencing and phylogenetic analysis of the hemaggluttinin (HA) and neuraminadase (NA) genes of the dog´s virus showed that they were similar to those of H5N1 viruses isolated from tigers, chickens, ducks, and humans infected in Thailand during the same time that the dog was infected ( Figure 2A and B ). In addition, analysis of 6 other genes from KU-08 showed similar results (data not shown). (flu.org.cn)
In order to better understand differences in the outcome of infectious bursal disease virus (IBDV) infection, we inoculated a very virulent (vv) strain into White Leghorn chickens of inbred line W that was previously reported to experience over 24% flock mortality, and three inbred lines (15I, C.B4 and 0) that were previously reported to display no mortality. (imperial.ac.uk)
China reported on November 11, more H5N1 infections of poultry there that killed 300 chickens in Liaoning Province northeast of Beijing. (earthfiles.com)
While ducks and other birds can get H5N1 and live, it's especially deadly to chickens and domestic poultry. (typepad.com)

Regional analyses of human infections with avian influenza subtypes revealed distinct patterns and variations in epidemiology across countries, age, and time. (who.int)
Influenza A viruses are classified into subtypes on the basis of two surface antigens: hemagglutinin (H) and neuraminidase (N). Three subtypes of hemagglutinin (H1, H2 and H3) and two subtypes of neuraminidase (N1 and N2) are recognized among influenza A viruses that have caused widespread human disease. (canada.ca)
Most subtypes of avian influenza that have caused human infections are H5, H7, and H9 viruses. (msdmanuals.com)

In domestic poultry, infection with avian influenza viruses causes two main forms of disease, distinguished by low and high extremes of virulence. (citizen-news.org)
Avian influenza infections are often asymptomatic in wild birds but may cause highly lethal illness in domestic poultry. (msdmanuals.com)

No case of human infection with the H5N1 virus has been discovered in Russia so far. (thepoultrysite.com)
Out of 2500 people exposed to birds infected with H5N1, only this one case of human infection has been confirmed. (medscape.com)
The Ministry of Health in Indonesia has confirmed the country's 50th case of human infection with the H5N1 avian influenza virus. (blessedquietness.com)

The one circulating now in Asia and Africa and Europe in birds is H5N1, a particularly nasty character that kills more than 56% of those people who get it. (typepad.com)

Timing of influenza A(H5N1) in poultry and humans and seasonal influenza activity worldwide, 2004-2013. (who.int)

Researchers have linked Zika virus infection with Guillain-Barre syndrome, a severe neurological disorder that can cause paralysis. (prnewswire.com)

The mortality rate for H5N1 has been estimated to be 60 percent. (everydayhealth.com)
H5N1 infection in humans can cause severe disease and has a high mortality rate," states the WHO. (prpeak.com)

The World Health Organization says although H5N1 has "spread widely in wild birds and poultry for 25 years," there are now several international reports of spillover infections to mammals - including minks, otters, foxes and sea lions. (wltribune.com)

Hammond A, Fitzner J, Collins L, Ong S, K V. Human cases of influenza at the human-animal interface, January 2015-April 2017. (who.int)
Since the last WHO Influenza at the Human Animal Interface update on 26 August 2013, four new laboratory-confirmed human cases of influenza A(H5N1) virus infection were reported to WHO from Cambodia (3)and Indonesia (1). (flutrackers.com)
virus as the cause and found laboratory-confirmed cases of influenza C virus and human Coronavirus OC 43 for the first time in both Cote d'Ivoire and in a Sub-Saharan African country. (bvsalud.org)

IgG, IgA, and IgM are commonly produced after viral infection. (virology.ws)
Antibodies are critical for preventing many viral infections, and may also contribute to the resolution of infection. (virology.ws)
We discuss the different vectored vaccines that have been or are currently in clinical trials, with a forward-looking focus on immunogens that may be protective against seasonal and pandemic influenza infection, in the context of viral-vectored vaccines. (mdpi.com)
In terms of public health, this is a strategic location to quickly detect any viral emergence in order to alert the authorities to prevent the spread in animals and potentially in humans. (pasteur.fr)
One-step reverse-transcription quantitative polymerase chain reaction (qRT-PCR) was used to detect intracellular and extracellular SARS-CoV-2 ribonucleic acid (RNA) in the infected ALI HBE culture and human monocytes to confirm viral replication. (news-medical.net)
Furthermore, human monocytes were protected from influenza A infections even after an abortive Omicron infection, indicating that complete viral replication is not required for an interferon-mediated antiviral state. (news-medical.net)
The studies were conducted with the Zika viral strain that has recently spread from South America to ravage Puerto Rico and likely responsible for the first wave of infections that have begun to occur in the United States. (prnewswire.com)
Our ability to quickly scale up testing for airborne pathogens will be crucial going forward as we encounter airborne viral illnesses more regularly as a result of climate change and the general decline in human immunity stemming from broad SARS-CoV-2 transmission. (yahoo.com)
Most URIs are self-limited viral infections that resolve without prescription drugs. (medscape.com)

16 y who have symptoms of influenza infection or colds, aspirin is not recommended because of an association with Reye syndrome . (medscape.com)
What are the symptoms for humans? (wltribune.com)
Unlike normal seasonal influenza, where infection causes only mild respiratory symptoms in most people, the disease caused by H5N1 follows an unusually aggressive clinical course, with rapid deterioration and high fatality. (citizen-news.org)
Therapy addressing specific symptoms is the mainstay for most upper respiratory infections (URIs). (medscape.com)

The Indonesian experts are saying that, that in the above instance, there was a, "common genetic predisposition to infection with H5N1 virus with severe and fatal outcomes. (blessedquietness.com)

The HA is also the primary target of neutralizing antibodies elicited by infection or vaccination, and the HA of virus from this specimen is very closely related (99% identity) to the A/Astrakhan/3212/2020-like pre-pandemic candidate vaccine viruses (e.g. (cdc.gov)
The FDA has approved a vaccine for H5N1 influenza. (medscape.com)
A newly developed influenza vaccine against the H5N1 subunit of the avian influenza virus, which has pandemic potential, has been shown to be highly immunogenic in younger and older adults . (medscape.com)
Researchers are conducting the first-in-human trial of a universal influenza vaccine candidate, the National Institutes of Health (NIH) announced April 3. (medscape.com)

Two markers for mammal adaptation have been detected in the PB2 gene (PB2 D701N and Q591K) which have been described to improve the replication and impact pathogenesis in mammals and are assumed to have been acquired after infection within the human host. (poultrymed.com)
This isn't the first time the highly transmittable H5N1 virus has been detected in mammals. (scrippsnews.com)
However, the report in Eurosurveillance notes that mink could serve as a 'potential mixing vessel for the interspecies transmission' among birds, mammals, and even humans. (scrippsnews.com)
The H5N1 avian flu virus has mutated into a more dangerous form that could breed more effectively in mammals. (earthfiles.com)

Not limited to poultry, the virus has also been shown to cross the species barrier infecting humans ( 1 ) and felines, including domestic cats ( 2 ) and tigers ( 3-5 ). (flu.org.cn)

Phylogenetic analysis of the hemagglutinin (A) and neuraminidase (B) gene sequences of the H5N1 influenza virus isolated from a dog´s lung. (flu.org.cn)

Majority of influenza A viruses reside and circulate among animal populations, seldom infecting humans due to host range restriction. (springer.com)

15 May 2015 - The recent increase in the number of people affected by the avian influenza virus H5N1 in Egypt is not related to virus mutations but rather to more people becoming exposed to infected poultry, according to a recent mission of six organizations assessing the H5N1 situation in the country. (who.int)
So far, the H5N1 virus mutations have not made it possible for the virus to spread in human sneezing and coughing. (earthfiles.com)

CFIA says there have been no cases of wild birds passing the virus to humans in Canada, but transmission from pet birds to humans is still a risk. (prpeak.com)
This Asian strain of H5N1 has been transmitted from birds to humans, most of whom had extensive, direct contact with infected birds. (webwire.com)
Now, the reason the news from Indonesia is so concerning is that we have a novel virus (H5N1) that has not just spread from birds to humans ( B2H ), but has spread in a family from human to human ( H2H ) and likely from human to human to human ( H2H2H ) or even perhaps H2H2H2H. (typepad.com)

The widespread persistence of H5N1 in poultry populations poses two main risks for human health. (citizen-news.org)
Spread to humans was contained by culling domestic bird populations. (msdmanuals.com)

The majority of these infections have occurred in poultry, including backyard and commercial flocks. (cdc.gov)

In March 2013, the first cases of avian influenza virus infections in humans were reported by the authorities of the PR of China to the World Health Organization. (thieme-connect.de)
These infections were reported to the World Health Organization (WHO) on March 31, 2013, in accordance with International Health Regulations. (cdc.gov)
The World Health Organization reported in the spring of 2005 that at least 6,000 wild migratory geese at a nature reserve in central China, suddenly died from an H5N1 strain. (earthfiles.com)
As of October 3, 2016, at least 856 cases of human infection with avian influenza A (H5N1) virus in 16 countries had been reported to the World Health Organization, among which 452 had ended in death, for an apparent case fatality rate of 52.8% ( WHO, 2016 ). (frontiersin.org)

From the first case of H5 avian influenza in humans in the United States to reports of ongoing, widespread disease in birds , the potential of a possible pandemic variant has many keeping a watchful eye on the disease. (medscape.com)

H5N1 pandemic vaccines and technologies to rapidly create them are in the H5N1 clinical trials stage but can not be verified as useful until after there exists a pandemic strain. (wikipedia.org)
These results suggest that early and aggressive treatment action should be taken in patients with a high clinical suspicion of severe influenza infection. (medscape.com)
Dear Editor, Children with COVID-19 infection can present with a variable spectrum of clinical manifestations, and sometimes mucocutaneous manifestations can be the only manifestation of. (annals.edu.sg)

But when humans have been infected, "they are more likely to have severe disease," she said, and people have died 30 to 50 per cent of the time. (wltribune.com)
We hypothesize that a more rapid induction of pro-inflammatory cytokine responses in bursal cells following IBDV infection leads to more severe disease in line W birds than in line 15I. (imperial.ac.uk)
The first is the risk of direct infection when the virus passes from poultry to humans, resulting in very severe disease. (citizen-news.org)

But even though killing and incinerating infected birds has been standard operating procedure for nearly ten years, the H5N1 virus has continued to spread through migratory birds. (earthfiles.com)
Recently scientists announced that the 1918 virus also originated in birds and has similarities to the H5N1 now spreading through migratory birds. (earthfiles.com)

A second risk, of even greater concern, is that the virus - if given enough opportunities - will change into a form that is highly infectious for humans and spreads easily from person to person. (citizen-news.org)

Has H5N1 spread to humans? (wltribune.com)

It is likely that avian influenza viruses of any antigenic specificity can cause influenza in humans whenever the virus acquires mutations, enabling it to attach to human-specific receptor sites in the respiratory tract. (msdmanuals.com)

Anatomy21

Organisms43

Diseases20

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Psychiatry and Psychology16

Phenomena and Processes77

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena5

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H7N923

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Bird flu23

H1N19

Hpai16

H5N81

19972

Infected with avian influenza4

H5N62

Strains6

Mutate4

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Outbreak4

Transmissible2

Chickens5

Subtypes3

Domestic poultry2

Case of human infection3

Africa and Europe1

Poultry and humans1

Linked Zika virus infection1

Mortality rate2

Wild birds and poultry1

Cases of influenza3

Viral9

Symptoms4

Fatal1

Vaccine4

Mammals4

Species barrier1

Neuraminidase1

Circulate among1

Virus mutations2

Birds to humans3

Populations2

Occurred in poultry1

World Health Organ4

Avian influenza in humans1

Clinical3

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Migratory birds2

Highly1

Spread to humans1

Mutations1