• In human, H3K4 methylase complex contains core subunits (shown in red) similar to that of COMPASS and complex specific subunits (shown in black). (nih.gov)
  • Therefore, (A) in the absence of H2B monoubiquitination, COMPASS can still interact with the transcribing Pol II via the Paf1 complex and monomethylate H3K4. (nih.gov)
  • roles
  • The latter results suggest that Trr, Trx, and Ash1 may play more specific roles in regulating key cellular targets and pathways and/or act as global H3K4 HMTs earlier in development. (genetics.org)
  • development
  • The ratio or amount of methylated H3K4 can be quantified through HRP conjugated secondary antibody-color development system and is proportional to the intensity of color development. (epigentek.com)