• The potential role of elastin in patients with myeloid leukemia treated with hematopoietic stem cell transplantation (HSCT) has not been investigated so far. (medscimonit.com)
  • Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
  • Despite a huge progress in HSCT techniques and posttransplant care, GVHD remains a significant obstacle in successful HSCT outcome. (hindawi.com)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) offers the only curative modality for many hematological disorders. (hindawi.com)
  • Inherited genetic variants such as single-nucleotide polymorphisms (SNPs) of candidate genes, encoding various cytokines, chemokines, and inflammatory regulators, have become a subject of interest of genetic studies searching for independent predictors of GVHD development and HSCT outcome [ 4 - 7 ]. (hindawi.com)
  • Adoptive transfer of hepatitis B virus (HBV) immunity may occur following allogeneic hematopoietic stem cell transplantation (allo-HSCT). (bvsalud.org)
  • Background & Aims: Gut graft-versus-host disease (GVHD) contributes significantly to lethality after allogeneic hematopoietic stem-cell transplantation (HSCT). (elsevierpure.com)
  • To help characterize whether human gut GVHD has similar biological characteristics, monocyte IL-1α and TNF-α production were evaluated after HSCT. (elsevierpure.com)
  • Methods: Patients with refractory hematologic malignancy (n = 17) underwent reduced-intensity conditioning, HLA-matched sibling HSCT, and cyclosporine A GVHD prophylaxis. (elsevierpure.com)
  • After HSCT, monocyte IL-1α and TNF-α levels were measured using intracellular flow cytometry (IC-FCM), and results were correlated with clinical GVHD. (elsevierpure.com)
  • Conclusions: Human gut GVHD after reduced-intensity allogeneic HSCT is associated with monocyte cytokine secretion initially involving IL-1α, followed by TNF-α. (elsevierpure.com)
  • Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
  • Patients who undergo HSCT experience a sequential suppression of host defenses, resulting in varying infectious risk at different phases of the transplantation process. (medscape.com)
  • Hematopoietic stem cell transplantation (HSCT) is a standard form of cellular therapy for patients suffering from malignant hematological diseases. (lidsen.com)
  • However, graft-versus-host disease (GVHD) is a very serious complication and a major cause of morbidity and mortality after allogeneic HSCT. (lidsen.com)
  • Graft-versus-host disease (GVHD) is a serious complication that may occur in patients receiving allogeneic hematopoietic stem cell transplant (HSCT). (lidsen.com)
  • Lower GI aGvHD represents a critical unmet need in patients undergoing allo-HSCT," said Yi-Bin Chen, MD, Director, Hematopoietic Cell Transplant & Cell Therapy Program, Mass General Cancer Center. (businesswire.com)
  • 1 The study enrolled 333 patients who were randomly assigned in a 1:1 ratio to one of two treatment groups receiving either an intravenous infusion of vedolizumab 300 mg or placebo on days -1 (before allo-HSCT), and on days +13, +41, +69, +97, +125, and +153 following allo-HSCT, alongside a background GvHD prophylaxis regimen. (businesswire.com)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) offers great opportunities for curing hematologic malignancies. (aai.org)
  • However, graft-versus-host disease (GVHD) is one of the major causes of HSCT failure. (aai.org)
  • The most common adverse event following allogeneic hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GVHD), which can increase morbidity and mortality in HSCT patients. (oncologynurseadvisor.com)
  • Recent studies are investigating the efficacy of rituximab (Rituxan) for GVHD in pediatric HSCT patients. (oncologynurseadvisor.com)
  • A limitation of this is that only a few experimental models mimic the ocular complications after hematopoietic stem cell transplantation (HSCT) and have focused on the acute GVHD process. (duke.edu)
  • Given the potential importance of MAIT cells in control of microbial infections and protection of epithelial surfaces, we investigated MAIT cell reconstitution in 43 children who underwent hematopoietic stem cell transplantation (HSCT) after myeloablative conditioning for the treatment of malignant hematological disease. (cryostem.org)
  • Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation. (biomedcentral.com)
  • Hematopoietic stem cell transplantation and associated risk factors precipitate endothelial injury, leading to HSCT-TMA and other endothelial injury syndromes such as hepatic veno-occlusive disease/sinusoidal obstruction syndrome, idiopathic pneumonia syndrome, diffuse alveolar hemorrhage, capillary leak syndrome, and graft-versus-host disease. (biomedcentral.com)
  • In this article, we review the role of the complement system in HSCT-TMA pathogenesis, with a focus on the lectin pathway. (biomedcentral.com)
  • which deals with oral problems in the patients after allogeneic hematopoietic stem cell transplantation (HSCT), expecially, short- and long-term dental disorders in children after intensive cytotoxic therapy, and inflammatory/atrophic changes of oral mucosa associated with acute and chronic graft-versus-host disease (GVHD), due to infections and autoaggressive processes. (cttjournal.com)
  • The authors conclude on good efficiency of haploidentical HSCT for this age group, being comparable to HLA-compatible transplantation. (cttjournal.com)
  • concerns application of Nivolumab in relapsed Hodgkin's disease (HD) following allogeneic HSCT. (cttjournal.com)
  • A long-term experience has generally shown that the results of allogeneic HSCT with cryopreserved graft are comparable to native hematopoietic transplants, in terms of severe acute and chronic GVHD, overall survival, and GVHD-relapse-free survival. (cttjournal.com)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) recipients are at risk of various complications during post-transplantation follow-up. (bvsalud.org)
  • In the present study, we aimed to assess ED utilization in HSCT recipients and associated risk factors during post-transplantation follow-up, identify subgroups of HSCT recipients presenting to the ED, analyze outcomes and prognostic factors for hospitalization and 30-day mortality after ED visits, and assess mortality hazard following an ED presentation. (bvsalud.org)
  • The study involved a retrospective single-center longitudinal analysis including 557 consecutive recipients of allogeneic HSCT at the Medical University of Vienna, Austria, between January 2010 and January 2020. (bvsalud.org)
  • We identified 3 latent patient groups in the ED, characterized mainly by the time from HSCT, chronic GVHD, and documented pulmonary infection. (bvsalud.org)
  • Allogeneic haematopoietic stem cell transplant (HSCT) recipients remain at high risk of adverse outcomes from coronavirus disease 2019 (COVID-19) and emerging variants. (bvsalud.org)
  • BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a well-established treatment modality for a variety of diseases. (koreamed.org)
  • PURPOSE: To identify the symptoms and signs of patients with dry eye disease (DED) after allogenic hematopoietic stem cell transplantation (HSCT) and analyze the correlations between these signs and symptoms. (koreamed.org)
  • BACKGROUND AND OBJECTIVES: Cells of innate immunity normally recover in the first weeks to months after allogenenic hematopoietic stem cell transplantation (allo-HSCT). (koreamed.org)
  • BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can cure leukaemia. (koreamed.org)
  • Donor cell-derived leukaemia (DCL) is an uncommon complication of allogeneic hematopoietic stem cell transplantation (HSCT). (lidsen.com)
  • On one end of the spectrum, invasive aspergillosis (IA) predominantly affects patients with profound defects in immune function, such as haematopoietic stem cell transplant (HSCT) or solid organ transplant recipients, and patients undergoing chemotherapy or taking corticosteroids. (bmj.com)
  • In the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT), this review outlines and analyzes recent developments in the understanding of the properties of tissue-resident memory T cells (TRMs). (blood-genomics.com)
  • The TRM distribution in graft-versus-host disease (GVHD)-targeted organs and correlations between allo-HSCT outcomes and various GVHD subtypes were also reviewed, mainly focusing on skin and gut GVHD. (blood-genomics.com)
  • Understanding TRMs in allo-HSCT is a rapidly growing field requiring future studies to address unresolved questions regarding TRM heterogeneity, plasticity, longevity, alloreactivity, and roles in GVHD and tolerance after allo-HSCT. (blood-genomics.com)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapy for various hematopoietic disorders. (ashpublications.org)
  • Graft-versus-host disease (GVHD) and infections are the major obstacles of HSCT, and their close relationship has been suggested. (ashpublications.org)
  • The degree of HLA disparity between donor and recipient is a well-known and widely accepted independent risk factor for GVHD development [ 2 ]. (hindawi.com)
  • The histocompatibility differences between the donor and the recipient, the presence of donor's immunocompetent cells, and the inability of the recipient to reject these cells were defined as the basic pathogenic prerequisites for GVHD development by Billingham in 1966 [ 10 ]. (hindawi.com)
  • Strikingly, 12 cases occurred in 1997 with the majority in recipients of allogeneic matched sibling donor stem cells. (nih.gov)
  • The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
  • In autologous transplantation, the donor and recipient is the same individual. (medscape.com)
  • When the donor is someone other than the recipient, the procedure is described as allogeneic transplantation. (medscape.com)
  • Allogeneic transplants are further categorized by the degree of human leukocyte antigen (HLA) match between the donor and recipient. (medscape.com)
  • The greater the mismatch between donor and recipient, the higher the risk of graft versus host disease (GVHD). (medscape.com)
  • Successfully transplanting cells and organs from a donor into an immunologically disparate recipient is one of the greatest treatment advances in the history of medicine. (lidsen.com)
  • This life-threatening disorder develops when donor (graft) immune cells cause inflammatory damage to recipient (host) tissues. (lidsen.com)
  • Intestinal aGvHD can occur after stem cell transplantation when the immune cells of the donor (the graft) consider the recipient's body (the host) as foreign and attack the organs and tissue. (businesswire.com)
  • Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
  • 1 After transplantation, donor T cells are activated by antigen-presenting cells. (oncologynurseadvisor.com)
  • Donor T-cells proliferate and inflammatory mediators are recruited. (oncologynurseadvisor.com)
  • Treatment focuses on blocking the expansion of donor T cells, as GVHD develops from the expansion of these cells. (oncologynurseadvisor.com)
  • The authors confirm chronic graft-versus-host disease (GVHD), a serious complication that occurs when donor cells attack the recipient's cells, as a potential source of sexual dysfunction and say they are the first to demonstrate an association between total body irradiation and sexual dysfunction in men. (science20.com)
  • The procedure involves the transplantation of cells taken either from a patient's own blood or bone marrow (autologous transplantation) or from a matched donor (allogeneic transplantation) which effectively "replaces" damaged cells with healthy cells. (science20.com)
  • Before undergoing an allogeneic stem cell transplant, the patient will receive high doses of chemotherapy or radiation to destroy the diseased cells and prepare the body for the donor cells. (researchandmarkets.com)
  • On October 29, 2019, the patient underwent allogeneic peripheral blood stem cell transplantation from a full match (6/6) unrelated donor (man, blood type O, aged 37) (Fig. 1 a) at Nanfang Hospital, Southern Medical University. (biomedcentral.com)
  • It also highlights investigations using murine GVHD models, nonhuman primates, and cutting-edge technologies to track clonotypes, establish transcriptome profiles, and identify donor- and recipient-derived TRMs. (blood-genomics.com)
  • Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8 + T cells drive gastrointestinal acute graft-versus-host disease[J]. Sci Transl Med , 2021, 13(576): eabc0227. (blood-genomics.com)
  • Mn stimulates macrophages via Dectin-2 to induce donor Th17 differentiation after allogeneic bone marrow transplantation. (ashpublications.org)
  • Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and methotrexate. (medscimonit.com)
  • Shortly before graft infusion, GVHD prophylaxis (immunosuppression) is started. (hindawi.com)
  • No recognizable alteration in supportive care, conditioning regimen, GVHD prophylaxis or cytokine usage was associated with this striking increase in the frequency of DAH after allografting. (nih.gov)
  • Graft versus host disease (GVHD) represents the most frequent cause of TRM. (hindawi.com)
  • However, T-cell depletion is associated with higher rates of graft rejection and increased vulnerability to viral and fungal infections while the T-cell population is diminished. (medscape.com)
  • Allogeneic hematopoietic stem cell transplantation is a curative therapy for hematological malignancies, but its efficacy is limited by graft-versus-host disease (GVHD). (lidsen.com)
  • Nevertheless, acute and chronic rejection, graft versus host disease, and the inability to identify suitable donors continue to be challenges and limit broader application of cell and organ transplantation to the many patients that could benefit. (lidsen.com)
  • Graft-versus-host disease (GVHD) is one of the major obstacles for the success of allogeneic hematopoietic stem cell transplantation. (aai.org)
  • Scholars@Duke publication: Novel Scoring Criteria for the Evaluation of Ocular Graft-versus-Host Disease in a Preclinical Allogeneic Hematopoietic Stem Cell Transplantation Animal Model. (duke.edu)
  • Ocular complications occur after transplantation in 60% to 90% of chronic graft-versus-host disease (GVHD) patients and significantly impair vision-related quality of life. (duke.edu)
  • The use of allogeneic hematopoietic cell transplantation (HCT) is the most potent immunotherapeutic treatment for hematologic diseases, but its practical use is impeded by acute and chronic graft-versus-host disease (GvHD). (cryostem.org)
  • T cell-mediated immunity is a critical component of graft-versus-tumour effect and in determining vaccine immunogenicity. (bvsalud.org)
  • Developed for decision-makers, this Graft vs. Host Disease - Epidemiology Forecast - 2032 report provides a detailed panorama on the incidence and prevalence of this severe complication of allogeneic stem cell transplantation in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan. (researchandmarkets.com)
  • Graft-versus-host disease is a potentially serious complication of allogeneic stem cell transplantation. (researchandmarkets.com)
  • As an allogeneic transplant recipient, the patient might experience either form of Graft vs. Host Disease, either form, or neither. (researchandmarkets.com)
  • BACKGROUND: This study aimed to assess the outcome of stem cell transplantation (SCT), including overall survival (OS), failure-free survival (FFS) and graft-versus-host disease (GvHD)-free/failure-free survival (GFFS), and to analyze prognostic. (koreamed.org)
  • Their relevance in terms of graft-versus-host disease (GVHD). (koreamed.org)
  • 1 Traditional factors used to gauge transplant risks include conditioning regimen intensity, 2 immunosuppression and HLA matching, 3 along with hematopoietic cell source, and graft cell yield. (haematologica.org)
  • Areas of interest include the role of the microbiota (the trillions of bacteria living in and on our bodies), nutrition, and exercise in modulating HCT outcomes such as graft-versus-host disease (GVHD) and infections. (dukecancerinstitute.org)
  • Both patients had consistent infectious pneumonia and graft-versus-host disease after stem cell transplantation. (biomedcentral.com)
  • Because the patient developed concomitant intestinal graft-versus-host disease (GVHD), cyclosporine, sirolimus, and mycophenolate mofetil were administered to maintain immunosuppression. (biomedcentral.com)
  • I'm Dr. Charles Turck, and joining me to discuss how we can modify treatment approaches for patients with steroid-refractory chronic graft versus host disease, or GVHD for short, are Drs. Ned Waller and George Chen. (globaloncologyacademy.org)
  • I'm Dr. Charles Turck and I'm speaking with doctors Ned Waller and George Chen about treatment approaches for patients with steroid-refractory chronic graft versus host disease, or GVHD. (globaloncologyacademy.org)
  • The link between tissue-resident memory T cells and graft-versus-host disease[J]. Blood&Genomics, 2022, 6(2): 81-90. (blood-genomics.com)
  • A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses[J]. Nat Med , 2005, 11(11): 1244−1249. (blood-genomics.com)
  • Fefer A. Graft-vs. -tumor responses[M]// Thomas' hematopoietic cell transplantation , New Jersey: Blackwell Publishing Ltd, 2003: 369-379. (blood-genomics.com)
  • Graft-vs-lymphoma effect in an allogeneic hematopoietic stem cell transplantation model[J]. Biol Blood Marrow Transplant , 1999, 5(6): 357−368. (blood-genomics.com)
  • An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues[J]. J Exp Med , 2006, 203(8): 2021−2031. (blood-genomics.com)
  • Tissue-resident PSGL1 lo CD4 + T cells promote B cell differentiation and chronic graft-versus-host disease-associated autoimmunity[J]. J Clin Invest , 2021, 131(1): e135468. (blood-genomics.com)
  • 2 Intestinal aGvHD results in the majority of morbidity and mortality associated with GvHD. (businesswire.com)
  • Successful outcomes following allogeneic hematopoietic cell transplant (HCT) may be offset by risks of transplant-related morbidity and mortality. (haematologica.org)
  • Twenty-three patients experienced acute GVHD and 17 developed chronic GVHD. (medscimonit.com)
  • Serial measurement of monocyte cytokines, in particular, TNF-α, by IC-FCM may represent a noninvasive method for GVHD monitoring, potentially allowing the identification of patients appropriate for early-intervention strategies. (elsevierpure.com)
  • Further investigation into the pathogenesis of this syndrome is essential as is prompt and immediate consideration of DAH in all patients with respiratory compromise early after BMT. (nih.gov)
  • To date, no standard treatment is established for GVHD and no therapies are FDA approved for this indication in pediatric or adult patients. (oncologynurseadvisor.com)
  • Although not a first-line treatment for GVHD, rituximab may offer an alternative treatment option for GVHD in pediatric patients. (oncologynurseadvisor.com)
  • Discovery and availability of biomarkers suitable for screening high risk patients using early, non-invasive, blood tests specific for GvHD-therapy resistance would significantly aid in the management of patients with this disease and would allow for rational drug development and drug approval by regulatory authorities. (cryostem.org)
  • Using proteomics, it has been shown that plasma concentration of Suppression of Tumorigenicity 2 (ST2), accurately stratified patients according to risk of non-response to acute GvHD therapy in large retrospective sets. (cryostem.org)
  • Stem cell transplantation is an increasingly effective form of treatment for patients with blood cancer such as leukemia, lymphoma, and myeloma. (science20.com)
  • Allogeneic transplantation was performed in five patients, two of whom achieved complete remission despite residual or refractory disease. (oncotarget.com)
  • Recipients of allogeneic transplantation had significantly improved overall survival compared to non-transplanted patients. (oncotarget.com)
  • After undergoing an allogeneic haematopoietic stem cell transplantation (alloHCT), patients need intensive physiological and psychological rehabilitation. (mdpi.com)
  • In immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK polyomavirus (BKPyV) can reactivate and cause several diseases, which can lead to death in their severe forms. (biomedcentral.com)
  • Starting with some background, Dr. Waller, about how many patients with chronic GVHD are refractory to steroids? (globaloncologyacademy.org)
  • There are about 10,000 patients transplanted in the U.S. every year with an allogeneic stem cell product, and about half of them will develop some form of chronic GVHD. (globaloncologyacademy.org)
  • They really map out patients' symptoms of chronic GVHD according to various target organs where GVHD can cause dryness, organ dysfunction, or contractures. (globaloncologyacademy.org)
  • And patients complain of a variety of different GVHD manifestations, particularly dry eyes, mouth sores, trouble swallowing, lung dysfunction, joint contractures, and these are used to define the overall severity of chronic GVHD as well as to map responses. (globaloncologyacademy.org)
  • Dr. Hong Zheng cares for patients with hematological malignancies, including leukemia and lymphoma, as well as patients undergoing hematopoietic stem cell transplantation. (psu.edu)
  • Furthermore, this review discusses significant results for TRM functions in GVHD patients. (blood-genomics.com)
  • 3 , 4 Since 2020, older or unfit patients are treated by a non-intensive approach combining the hypomethylating agent azacitidine and the B-cell lymphoma 2 (BCL2) inhibitor venetoclax given orally until progression. (dovepress.com)
  • Reduced-Intensity/Reduced-Toxicity Conditioning Approaches Are Tolerated in XIAP Deficiency but Patients Fare Poorly with Acute GVHD. (chop.edu)
  • The importance of proinflammatory T-cells and their cytokine production in patients with autoimmune arthritis has been widely described. (biomedcentral.com)
  • The aim of this study was to investigate the influence of MSCs on the phenotype, cytokine profile, and functionality of naive and non-naive CD4 + T-cells from healthy donors (HD) and patients with autoimmune arthritis under Th17-cytokine polarizing conditions in an explorative way using a transwell system prohibiting any cell-cell-contact. (biomedcentral.com)
  • In isolated naive CD4 + T-cells from HD and patients, MSCs suppressed the differentiation of naive towards an effector phenotype while memory and naive cells showed higher percentages in culture with MSCs. (biomedcentral.com)
  • In patients, MSCs significantly decreased the proportion of IL-9 and IL-17 producing effector T-cells. (biomedcentral.com)
  • The results of the study indicate significant immunomodulatory properties of MSCs, as under Th17-polarizing conditions MSCs are still able to control T-cell differentiation and proinflammatory cytokine production in both HD and patients with autoimmune arthritis. (biomedcentral.com)
  • IL-9 and Th9 cells are overexpressed in synovial tissue while proportion of Th9 cells are increased in peripheral blood from RA patients [ 28 ]. (biomedcentral.com)
  • In approximately 15% of patients, however, myelofibrosis is accompanied by significant extramedullary hematopoiesis, hepatosplenomegaly, and transfusion-dependent anemia, which are manifestations of stem cell failure. (basicmedicalkey.com)
  • Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
  • Patients with massive splenomegaly are particularly prone to thrombotic events because the associated increase in plasma volume masks the true extent of the red cell mass elevation measured by the hematocrit or hemoglobin level. (basicmedicalkey.com)
  • The use of salicylates as a tonic against thrombosis in PV patients is not only potentially harmful if the red cell mass is not controlled by phlebotomy, but is also an unproven remedy. (basicmedicalkey.com)
  • SCID can be broadly classified into 2 groups: SCID with B cells (70% of patients with SCID) and SCID without B cells. (medscape.com)
  • The versatile drug is now also approved for the treatment of B-cell Hodgkin lymphoma, non-Hodgkin lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis in the adult population. (oncologynurseadvisor.com)
  • We speculate that future studies will use this clinical scoring index in combination with what is recognized histologically and correlated with serum biomarkers identified in chronic/ocular GVHD. (duke.edu)
  • In recent experiments, we have also found that a four protein panel including ST2, CXCL9, MMP3 (matrix metaaloproteinase) and osteopontin is associated with the diagnosis of chronic GvHD. (cryostem.org)
  • In addition to further crystallizing transplantation's impact on survivors' sexual health, study data specifically associated diminished sexual function and satisfaction with transplant-related total body radiation in men and chronic GVHD with diminished sexual function in men and both sexual function and satisfaction in women. (science20.com)
  • In addition to documenting concrete effects of radiation on sexual function and satisfaction, investigators also observed negative sexual effects among those surveyed who had experienced chronic GVHD. (science20.com)
  • So another way to determine if the patient is steroid refractory is to determine if there's any progression in the signs or symptoms of chronic GVHD. (globaloncologyacademy.org)
  • As Dr. Chen indicated, the initial therapy for chronic GVHD is a dose of steroids, which is pretty substantial. (globaloncologyacademy.org)
  • So the goal for initial treatment of chronic GVHD is to establish some relief of the patient's symptoms, improvement in the thickening of the skin, lessening of mouth ulcers, improvement of dry eyes or joint contractures, and at the same time, initiate a plan to taper steroids so that we can avoid some of the long-term consequences. (globaloncologyacademy.org)
  • Data from this study indicate that OX40L-OX40 interactions play a central role in the pathogenesis of aGVHD induced by human T cells. (aai.org)
  • MiRNAs also play a role in the pathogenesis of these diseases and several known miRNAs that are involved in these diseases have also been shown to play a role in CD8+ regulation. (frontiersin.org)
  • Donors for allogeneic transplants may be related or unrelated to the recipient. (medscape.com)
  • Transplants from HLA-matched siblings are associated with a lower risk of GVHD and faster recovery of the recipient's immune system following transplantation. (medscape.com)
  • A 62 year-old Caucasian man with hypertension and a 4-year history of multiple myeloma, had been previously treated with lenalidomide, bortezomib and two autologous hematopoietic stem cell transplants. (biomedcentral.com)
  • Acute GVHD occurs most frequently 30-40 days after engraftment. (hindawi.com)
  • In this article, we report that the interaction between OX40L and OX40 is of critical importance for both induction and progression of acute GVHD (aGVHD) driven by human T cells. (aai.org)
  • Chemotherapy, radiation, or both are initiated prior to transplantation to enable engraftment of the transplanted cells, decrease tumor size, and reduce immunoreactivity of the recipient. (oncologynurseadvisor.com)
  • An environment for GVHD is formed when antigen-presenting cells are activated by the patient's disease and the pretreatment destruction of cells caused by chemotherapy and radiotherapy. (oncologynurseadvisor.com)
  • Remissions may be brought about with steroids, chemotherapy, targeted therapy, and stem cell transplant. (wikipedia.org)
  • Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)
  • Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease caused by human T-cell lymphotropic virus type 1 that predominantly affects Japanese and Caribbean populations. (oncotarget.com)
  • Adult T-cell leukemia/lymphoma (ATLL) is a rare mature T-cell malignancy first described in Japan in 1977 [ 1 ]. (oncotarget.com)
  • A group of researchers from Sao Paulo, Brazil reported on the development of HHV-6 infection in the striatum of a 32-year-old man with diffuse large B-cell non-Hodgkin's lymphoma. (hhv-6foundation.org)
  • When CD20 antagonists decrease the amount of circulating B cells, the body may not produce as many cytotoxic T cells that can potentially induce GVHD. (oncologynurseadvisor.com)
  • In autoimmune diseases, these target cells killed by autoreactive CD8+ T cells can release numerous autoantigens to induce the overproduction of autoantibodies, and finally lead to the death of self-cells. (frontiersin.org)
  • The consensus of researchers studying RILI is that ionizing radiation could induce damage to epithelial cells and endothelial cells, dysfunction of the blood-air barrier, and increase vascular permeability. (biomedcentral.com)
  • In the presence of TGF-β, IL-9 may induce differentiation of naive CD4 + T-cells towards Th17 cells, while IL-9 also affects thymus-derived natural Tregs (nTregs) and enhances their suppressive function in vitro [ 26 ]. (biomedcentral.com)
  • Periodic phlebotomies thereafter serve to maintain the red cell mass within the normal range and to induce a state of iron deficiency that prevents an accelerated reexpansion of the red cell mass. (basicmedicalkey.com)
  • The current understanding of aGVHD pathogenesis can be summarized as (1) initial tissue damage induced by the conditioning regimen followed by the denudation of auto- and alloantigens accompanied by massive inflammatory cytokine secretion ("cytokine storm") activating APCs, (2) auto- and alloantigen presentation mediated by APCs together with the costimulatory signaling prime donor's cytotoxic T lymphocytes and their proliferation, and (3) the migration of activated cellular effectors toward GVHD target tissues. (hindawi.com)
  • In certain circumstances, MAIT cells are also able to produce IL-22, a cytokine involved in gut epithelial protection during inflammatory intestinal damage. (cryostem.org)
  • The pathogenesis of cerebral malaria is biologically complex and involves multi-factorial mechanisms such as microvascular congestion, immunopathology by the pro-inflammatory cytokine and endothelial dysfunction. (koreamed.org)
  • Might HHV-6 contribute to some cases of cytokine release syndrome, pneumonia, and cytopenias in CAR-T Cell therapy? (hhv-6foundation.org)
  • Many of the clinical complications of PV relate directly to the increase in blood viscosity associated with red cell mass elevation and indirectly to the increased turnover of red cells, leukocytes, and platelets with the attendant increase in uric acid and cytokine production. (basicmedicalkey.com)
  • Mechanistically, blocking OX40L-OX40 interaction with an anti-hOX40L reduces infiltration of human T cells in target organs, including liver, gut, lung, and skin. (aai.org)
  • The diagnosis of GvHD relies almost entirely on clinical signs, and can only be confirmed by biopsy of target organs. (cryostem.org)
  • However, mounting evidence has suggested that CD8+ T cells, in particular, play an important role in the induction, progression, pathogenesis, and protection for autoimmune diseases ( 5 ). (frontiersin.org)
  • GVHD may develop in different tissues, including the eye. (lidsen.com)
  • Autoimmune diseases are usually complex and multifactorial, characterized by aberrant production of autoreactive immune cells and/or autoantibodies against healthy cells and tissues. (frontiersin.org)
  • Autoimmune diseases are complex diseases characterized by the loss of immunological tolerance to self-antigens and sustained aberrant immunological response against healthy cells and tissues, leading ultimately to the overproduction of autoreactive immune cells and/or autoantibodies ( 1 , 2 ). (frontiersin.org)
  • The mucosa-associated invariant T (MAIT) cells are innate-like T cells with restricted T cell receptor (TCR) usage, which are preferentially localized in mucosal tissues (liver, lung and gut) and respond to microbial infection by rapidly producing cytokines and cytotoxic effectors. (cryostem.org)
  • Introduction Mesenchymal stromal cells (MSCs) are adult, fibroblast-like multipotent cells characterized by the ability to differentiate into tissues of mesodermal origin, such as adipocytes, chondroblasts, and osteoblasts (Friedenstein et al. (pdffox.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Since mesenchymal stem cells (MSCs) have effective immune-modulatory features, inhibit T-lymphocyte proliferation, and have a high regenerative capacity, they can play a vital role in the reconstruction of injured tissues, including bronchioles, in pulmonary diseases. (biomedcentral.com)
  • Ocular surface inflammation and dry eye disease are the most common manifestations of ocular GVHD. (duke.edu)
  • Despite the heterogeneity in the pathogenesis of immune defects, common cutaneous manifestations and typical infections can provide clinical clues in diagnosing this pediatric emergency. (medscape.com)
  • Papillary atrophy, macroglossia, melanic pigmentation and squamous cell carcinoma are the most common oral manifestations on the tongue. (bvsalud.org)
  • Neither pre-transplant clinical characteristics nor transplant characteristics are reliably predictive of GvHD outcomes. (cryostem.org)
  • These outcomes are expected to have a major impact, because the panels of biomarkers are likely to be applied in future GvHD therapeutic trials as surrogate marker for clinical response, and the biomarkers have potential as GvHD-specific therapeutic targets. (cryostem.org)
  • Immunosuppression before and after allogeneic transplant has been found to dramatically improve allograft survival and, despite side effects, has been a mainstay of patient management. (lidsen.com)
  • The activation, differentiation, and development of CD8+ T cells is accompanied by large-scale changes in the coordinated expression of numerous inflammatory cytokines, transcription factors (TFs) and chemokines that are correlated with their survival, effector function, and self-renewal ( 7 ). (frontiersin.org)
  • 6 Comorbidity determined by the hematopoietic cell transplantation-comorbidity index (HCT-CI), 7 predicts for worse survival, generally through higher TRM. (haematologica.org)
  • GVHD occurs in about 30-50% and 70% of recipients allografted from matched related and matched unrelated donors, respectively [ 1 ]. (hindawi.com)
  • The activation, differentiation, and development of CD8+ T cells can be affected by numerous inflammatory cytokines, transcription factors, and chemokines. (frontiersin.org)
  • The surfaces of these cells typically express cluster of differentiation (CD)10, CD19, and CD34, which could be potential targets. (amgenoncology.com)
  • Mesenchymal stem cells (MSCs) are multipotent adult stem (or stromal) cells with the capacity of self-renewal and differentiation potential towards several mesodermal linages such as osteogenic, chondrogenic and adipogenic differentiation (more citations) [ 1 ]. (biomedcentral.com)
  • These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)
  • Further follow-up is required to establish whether this increase in the incidence of DAH in allogeneic transplantation is an isolated occurrence or an ongoing problem. (nih.gov)
  • Peptic ulcer disease can also be due to Helicobacter pylori infection, the incidence of which is increased in PV, while the pruritus associated with this disorder may be a consequence of mast cell activation by JAK2 V617F. (basicmedicalkey.com)
  • This article discusses the current status of clinical trials of rituximab to treat GVHD in the pediatric population. (oncologynurseadvisor.com)
  • which presents clinical results obtained, when treating these rare conditions with complex pathogenesis. (cttjournal.com)
  • In addition to their stem/progenitor properties, mesenchymal stromal cells (MSCs) possess broad immunoregulatory properties that are being investigated for potential clinical application in treating immune-based disorders. (pdffox.com)
  • Finally, we discuss progress toward clinical application of MSCs, focusing on GvHD as a case study. (pdffox.com)
  • Areas related to clinical and experimental transplantation are also of interest. (lidsen.com)
  • T-cell responses correlate directly with clinical symptoms, and were better predictors of HHV-6 disease than viral load or total CD3+ counts. (hhv-6foundation.org)
  • Adaptive immune cells, including B and T cells, have been demonstrated to be primary contributors to the overactive immune response and overproduction of antibodies. (frontiersin.org)
  • Diagnosis of GVHD is difficult because of its broad presentation that may manifest similar to other conditions such as drug reactions and viral infections. (oncologynurseadvisor.com)
  • What biomarkers for diagnosis and monitoring of treatment of GvHD? (cryostem.org)
  • Other laboratory studies that may aid in diagnosis include the red cell count, mean corpuscular volume, and red cell distribution width (RDW), particularly when the hematocrit or hemoglobin levels are less than 60% or 20 g/dL, respectively. (basicmedicalkey.com)
  • increases in monocyte TNF-α levels typically preceded the onset of gut GVHD symptoms. (elsevierpure.com)
  • Wharton's jelly mesenchymal stem cells (WJ-MSCs) are a class of stem cells with high differentiative potential, an immuno-privileged status and easy access for collection, which raise no legal or ethical. (koreamed.org)
  • Over the last few decades numerous studies have reported the beneficial effects of mesenchymal stem cells (MSCs) on tissue repair and regeneration. (biomedcentral.com)
  • The mechanisms of radiation-induced lung injury (RILI) and the mechanisms by which mesenchymal stem cells (MSCs) alleviate it. (biomedcentral.com)
  • Alveolar epithelial cells participate in the pathogenesis of fibrosis, producing pro-inflammatory mediators, and undergoing epithelial-to-mesenchymal transition (EMT). (biomedcentral.com)
  • Due to their immunomodulatory properties, mesenchymal stem cells (MSCs) have come into focus as a potential therapeutic concept. (biomedcentral.com)
  • In response to this challenge, the International Society for Cellular Therapy formulated minimal criteria for defining MSCs in order to create a broader consensus for more uniform characterization of these cells (Dominici et al. (pdffox.com)
  • This is the first analysis to describe ATLL pathological features, cytogenetics, and response to standard therapy and transplantation in the Caribbean cohort. (oncotarget.com)
  • An experienced multidisciplinary team in close consultation with the primary transplantation centre should perform the rehabilitation therapy. (mdpi.com)
  • Could some complications of CAR-T cell therapy be secondary to HHV-6 infection? (hhv-6foundation.org)
  • MSCs can not only differentiate into lung alveolar epithelial cells and secrete anti-inflammatory factors, but they also deliver some vehicles for gene therapy in repairing the injured lung, which provides new ideas for managing RILI. (biomedcentral.com)
  • Sun D, Heimall JR, Greenhawt MJ, Bunin NJ, Shaker MS, Romberg N. Cost Utility of Lifelong Immunoglobulin Replacement Therapy vs Hematopoietic Stem Cell Transplant to Treat Agammaglobulinemia. (chop.edu)
  • In preparation for receipt of the stem cells, recipients undergo myeloablation to eliminate their own myeloid cells. (medscape.com)
  • P = 0.0065) and was not associated with GVHD severity (P = 1.00). (elsevierpure.com)
  • The severity of DIHS/DRESS cases was significantly correlated with the frequency of CD134+ cells. (hhv-6foundation.org)
  • Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
  • Extracorporeal photopheresis inactivates antigen-presenting cells and T cells, whereas TNF antagonists decrease cellular activation and local tissue damage. (oncologynurseadvisor.com)
  • 4 One of the primary pathways in which T cells are activated is through antigen-presenting cells such as B cells. (oncologynurseadvisor.com)
  • Then, he moved to Stanford University for a postdoctoral fellowship on the role of transcription factor Pbx1, a leukemia proto-oncogene, on B cell development. (stanford.edu)
  • Her study is dedicated to improve the understanding of the complex immune response involved in leukemia pathogenesis and allogeneic hematopoietic stem cell transplantation, and subsequently develop effective leukemia therapeutics. (psu.edu)
  • Her laboratory studies involve targeting T-cell inhibitory mechanisms as a strategy to improve anti-leukemia immunity. (psu.edu)
  • The Role of Cytochrome P450 2J2 in Cancer: Cell Protector, Therapeutic Target, or Prognostic Marker? (lidsen.com)
  • This ability of MSCs to adopt a different phenotype in response to sensing an inflammatory environment is not captured in assays that are commonly used to characterize these cells, but it is crucial for understanding their therapeutic potential in immune-mediated disorders. (pdffox.com)
  • BK polyomavirus (BKPyV) is a member of the Polyomaviridae family, and it was first identified in 1971 by electron microscopy of the urine and uroepithelial cells of a renal transplant recipient [ 1 ]. (biomedcentral.com)
  • If the role of elastase in the pathogenesis of GVHD is confirmed, it will be possible to apply inhibitors of elastases in the treatment of this condition in the near future. (medscimonit.com)
  • This review presents a complex summary of GVHD pathogenesis with focus on references considering basic biological processes such as DNA damage response and cellular senescence. (hindawi.com)
  • This review summarizes the updated GVHD pathogenesis linking GVHD with biological processes such as DNA damage response (DDR) and cellular senescence (Figure 1 ). (hindawi.com)
  • Biological processes underlying GVHD pathogenesis are shown at the bottom of the scheme. (hindawi.com)
  • HHV-6, like some other herpesviruses, dysregulates autophagy in multiple cell types, with important biological consequences. (hhv-6foundation.org)
  • Endothelial injury triggers activation of the complement system-significantly through the lectin pathway-via altered cell-surface patterns on injured endothelial cells, initiating an inflammatory response [ 7 ]. (biomedcentral.com)
  • The authors have produced a clone of CAR cells which could be potentially applied for immunotherapy of prostate cancer. (cttjournal.com)